Gene: Dlg1 (discs large MAGUK scaffold protein 1) Rattus norvegicus
Analyze
Symbol:
Dlg1
Name:
discs large MAGUK scaffold protein 1
RGD ID:
2505
Description:
Exhibits several functions, including PDZ domain binding activity; ionotropic glutamate receptor binding activity; and kinesin binding activity. Involved in several processes, including cell adhesion; neurotransmitter receptor localization to postsynaptic specialization membrane; and positive regulation of potassium ion transport. Localizes to several cellular components, including basal plasma membrane; paranode region of axon; and postsynaptic density, intracellular component. Predicted to colocalize with ionotropic glutamate receptor complex. Biomarker of Parkinson's disease. Human ortholog(s) of this gene implicated in invasive ductal carcinoma. Orthologous to human DLG1 (discs large MAGUK scaffold protein 1); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; INTERACTS WITH 6-propyl-2-thiouracil; aflatoxin B1; ammonium chloride.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
discs large homolog 1; discs large homolog 1, scribble cell polarity complex component; discs, large homolog 1; disks large homolog 1; Dlgh1; Drosophila discs-large tumor suppressor homologue (synapse associated protein); SAP-97; SAP97; synapse-associated protein 97
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
DLG1 (discs large MAGUK scaffold protein 1) HGNC
Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther
Mus musculus (house mouse):
Dlg1 (discs large MAGUK scaffold protein 1) HGNC
NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Dlg1 (discs large MAGUK scaffold protein 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
DLG1 (discs large MAGUK scaffold protein 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
DLG1 (discs large MAGUK scaffold protein 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Dlg1 (discs large MAGUK scaffold protein 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
DLG1 (discs large MAGUK scaffold protein 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):
DLG1 (discs large MAGUK scaffold protein 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Dlg1 (discs large MAGUK scaffold protein 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Other homologs 2
Homo sapiens (human):
DLG2 (discs large MAGUK scaffold protein 2) HGNC
OrthoDB
Alliance orthologs 3
Mus musculus (house mouse):
Dlg1 (discs large MAGUK scaffold protein 1)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB)
Homo sapiens (human):
DLG1 (discs large MAGUK scaffold protein 1)
Alliance
DIOPT (Ensembl Compara|HGNC|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB)
Danio rerio (zebrafish):
dlg1l (discs, large (Drosophila) homolog 1, like)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB)
Danio rerio (zebrafish):
dlg1 (discs, large homolog 1 (Drosophila))
Alliance
DIOPT (OMA|PANTHER|PhylomeDB)
Caenorhabditis elegans (roundworm):
dlg-1
Alliance
DIOPT (Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PhylomeDB)
Drosophila melanogaster (fruit fly):
dlg1
Alliance
DIOPT (Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB)
Allele / Splice:
Dlg1Tn(sb-T2/Bart3)2.133Mcwi
Genetic Models:
F344-Dlg1Tn(sb-T2/Bart3)2.133Mcwi
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information:
Annotation category: partial on reference assembly
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 11 72,164,566 - 72,378,895 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 11 72,163,749 - 72,378,895 (-) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 11 75,239,783 - 75,349,409 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 Rnor_5.0 11 75,389,409 - 75,454,358 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 11 70,735,283 - 70,930,374 (-) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 11 70,792,871 - 70,987,963 (-) NCBI Celera 11 68,335,260 - 68,524,109 (-) NCBI Celera Cytogenetic Map 11 q22 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - ClinVar
autistic disorder ISO RGD:731903 8554872 ClinVar Annotator: match by term: Autistic disorder of childhood onset ClinVar PMID:21681106 , PMID:30208311 schizophrenia ISO RGD:731903 8554872 ClinVar Annotator: match by term: Schizophrenia ClinVar PMID:21681106 , PMID:30208311
Imported Annotations - CTD
cleft palate ISO RGD:731903 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:11238884 schizophrenia ISO RGD:731903 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:12421351 more ...
(-)-epigallocatechin 3-gallate multiple interactions ISO RGD:731903 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of DLG1 mRNA CTD PMID:22079256 1,2-dimethylhydrazine multiple interactions ISO RGD:10475 6480464 [1, 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of DLG1 mRNA CTD PMID:22206623 1,2-dimethylhydrazine affects expression ISO RGD:10475 6480464 1, 2-Dimethylhydrazine affects the expression of DLG1 mRNA CTD PMID:22206623 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:731903 6480464 Tetrachlorodibenzodioxin results in increased expression of DLG1 mRNA CTD PMID:20106945 , PMID:21632981 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:10475 6480464 Tetrachlorodibenzodioxin affects the expression of DLG1 mRNA CTD PMID:21570461 , PMID:24680724 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:10475 6480464 Tetrachlorodibenzodioxin results in increased expression of DLG1 mRNA CTD PMID:15034205 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:10475 6480464 AHR protein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of DLG1 mRNA] CTD PMID:15034205 3,4-methylenedioxymethamphetamine decreases methylation ISO RGD:10475 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in decreased methylation of DLG1 promoter CTD PMID:26251327 3,4-methylenedioxymethamphetamine decreases expression ISO RGD:10475 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in decreased expression of DLG1 mRNA CTD PMID:26251327 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO RGD:731903 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of DLG1 mRNA CTD PMID:28628672 4,4'-diaminodiphenylmethane increases expression ISO RGD:10475 6480464 4, 4'-diaminodiphenylmethane results in increased expression of DLG1 mRNA CTD PMID:18648102 5-fluorouracil multiple interactions ISO RGD:731903 6480464 DLG1 protein affects the susceptibility to [Fluorouracil co-treated with irinotecan analog] CTD PMID:18927307 6-propyl-2-thiouracil decreases expression EXP 6480464 Propylthiouracil results in decreased expression of DLG1 mRNA CTD PMID:24780913 aflatoxin B1 multiple interactions EXP 6480464 [sulforafan co-treated with Aflatoxin B1] affects the expression of DLG1 mRNA CTD PMID:25450479 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of DLG1 mRNA CTD PMID:16483693 antirheumatic drug increases expression ISO RGD:731903 6480464 Antirheumatic Agents results in increased expression of DLG1 mRNA CTD PMID:24449571 Aroclor 1254 decreases expression ISO RGD:10475 6480464 Chlorodiphenyl (54% Chlorine) results in decreased expression of DLG1 mRNA CTD PMID:23650126 arsenous acid decreases expression ISO RGD:10475 6480464 Arsenic Trioxide results in decreased expression of DLG1 mRNA CTD PMID:24831965 benzo[a]pyrene decreases expression ISO RGD:731903 6480464 Benzo(a)pyrene results in decreased expression of DLG1 mRNA CTD PMID:20064835 benzo[a]pyrene decreases methylation ISO RGD:731903 6480464 Benzo(a)pyrene results in decreased methylation of DLG1 promoter CTD PMID:27901495 benzo[a]pyrene increases expression ISO RGD:10475 6480464 Benzo(a)pyrene results in increased expression of DLG1 mRNA CTD PMID:15034205 benzo[a]pyrene multiple interactions ISO RGD:10475 6480464 AHR protein inhibits the reaction [Benzo(a)pyrene results in increased expression of DLG1 mRNA] CTD PMID:15034205 benzo[a]pyrene diol epoxide I decreases expression ISO RGD:731903 6480464 7 more ... CTD PMID:19150397 bis(2-chloroethyl) sulfide affects expression EXP 6480464 Mustard Gas affects the expression of DLG1 mRNA CTD PMID:15651846 bis(2-ethylhexyl) phthalate multiple interactions EXP 6480464 [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of DLG1 mRNA CTD PMID:25607892 bisphenol A multiple interactions EXP 6480464 [bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in decreased expression of DLG1 mRNA CTD PMID:25607892 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of DLG1 mRNA CTD PMID:25181051 bisphenol F multiple interactions ISO RGD:731903 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of DLG1 mRNA CTD PMID:28628672 Brodifacoum decreases expression EXP 6480464 bromfenacoum results in decreased expression of DLG1 protein CTD PMID:28903499 Butylparaben multiple interactions EXP 6480464 [bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in decreased expression of DLG1 mRNA CTD PMID:25607892 cadmium dichloride multiple interactions ISO RGD:10475 6480464 [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of DLG1 mRNA CTD PMID:19840844 calcidiol decreases expression EXP 6480464 Calcifediol deficiency results in decreased expression of DLG1 mRNA CTD PMID:17293106 carbon nanotube decreases expression ISO RGD:10475 6480464 Nanotubes, Carbon results in decreased expression of DLG1 mRNA CTD PMID:25620056 chlorpyrifos decreases expression EXP 6480464 Chlorpyrifos results in decreased expression of DLG1 mRNA CTD PMID:18668222 cobalt dichloride increases expression ISO RGD:731903 6480464 cobaltous chloride results in increased expression of DLG1 mRNA CTD PMID:17553155 cobalt dichloride decreases expression ISO RGD:731903 6480464 cobaltous chloride results in decreased expression of DLG1 mRNA CTD PMID:17553155 , PMID:19320972 cyclosporin A decreases expression ISO RGD:731903 6480464 Cyclosporine results in decreased expression of DLG1 mRNA CTD PMID:25562108 DDE multiple interactions EXP 6480464 [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of DLG1 mRNA CTD PMID:25607892 dexamethasone multiple interactions ISO RGD:731903 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of DLG1 mRNA CTD PMID:28628672 diarsenic trioxide decreases expression ISO RGD:10475 6480464 Arsenic Trioxide results in decreased expression of DLG1 mRNA CTD PMID:24831965 diazinon affects expression EXP 6480464 Diazinon affects the expression of DLG1 mRNA CTD PMID:22546817 dibutyl phthalate multiple interactions EXP 6480464 [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of DLG1 mRNA CTD PMID:25607892 dioxygen increases expression ISO RGD:10475 6480464 Oxygen deficiency results in increased expression of DLG1 mRNA CTD PMID:24205000 dioxygen affects methylation ISO RGD:10475 6480464 Oxygen deficiency affects the methylation of DLG1 promoter CTD PMID:24205000 dorsomorphin multiple interactions ISO RGD:731903 6480464 [NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DLG1 mRNA CTD PMID:27188386 doxorubicin decreases expression ISO RGD:731903 6480464 Doxorubicin results in decreased expression of DLG1 mRNA CTD PMID:29803840 elemental selenium decreases expression ISO RGD:731903 6480464 Selenium results in decreased expression of DLG1 mRNA CTD PMID:19244175 enzacamene multiple interactions EXP 6480464 [bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in decreased expression of DLG1 mRNA CTD PMID:25607892 epoxiconazole multiple interactions EXP 6480464 [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of DLG1 mRNA CTD PMID:25607892 ethanol multiple interactions ISO RGD:10475 6480464 Ethanol affects the expression of and affects the splicing of DLG1 mRNA CTD PMID:30319688 ethanol affects expression ISO RGD:10475 6480464 Ethanol affects the expression of DLG1 mRNA CTD PMID:30319688 finasteride increases expression EXP 6480464 Finasteride results in increased expression of DLG1 mRNA CTD PMID:24136188 folic acid multiple interactions ISO RGD:10475 6480464 [1, 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of DLG1 mRNA CTD PMID:22206623 formaldehyde decreases expression ISO RGD:731903 6480464 Formaldehyde results in decreased expression of DLG1 mRNA CTD PMID:20655997 geldanamycin increases expression ISO RGD:731903 6480464 geldanamycin results in increased expression of DLG1 mRNA CTD PMID:26705709 hydrogen peroxide multiple interactions ISO RGD:731903 6480464 [Hydrogen Peroxide co-treated with Theophylline] results in increased expression of DLG1 protein CTD PMID:18951874 indometacin multiple interactions ISO RGD:731903 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of DLG1 mRNA CTD PMID:28628672 irinotecan decreases expression ISO RGD:731903 6480464 Irinotecan analog results in decreased expression of DLG1 mRNA CTD PMID:18927307 irinotecan multiple interactions ISO RGD:731903 6480464 DLG1 protein affects the susceptibility to [Fluorouracil co-treated with Irinotecan analog] CTD PMID:18927307 linuron multiple interactions EXP 6480464 [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of DLG1 mRNA CTD PMID:25607892 methapyrilene decreases expression EXP 6480464 Methapyrilene results in decreased expression of DLG1 mRNA CTD PMID:30467583 methyl methanesulfonate increases expression ISO RGD:731903 6480464 Methyl Methanesulfonate results in increased expression of DLG1 mRNA CTD PMID:23649840 methylmercury chloride decreases expression ISO RGD:731903 6480464 methylmercuric chloride results in decreased expression of DLG1 mRNA CTD PMID:26272509 N-methyl-N'-nitro-N-nitrosoguanidine multiple interactions ISO RGD:10475 6480464 [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of DLG1 mRNA more ... CTD PMID:19840844 nicotinamide multiple interactions ISO RGD:10475 6480464 [Niacinamide results in decreased activity of SIRT1 protein] which results in decreased expression of DLG1 mRNA, Niacinamide inhibits the reaction [geranylgeranylacetone results in increased expression of DLG1 mRNA] CTD PMID:21232033 okadaic acid multiple interactions ISO RGD:10475 6480464 [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of DLG1 mRNA CTD PMID:19840844 oxaliplatin multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of DLG1 mRNA CTD PMID:25729387 oxidopamine affects localization EXP 6480464 Oxidopamine affects the localization of DLG1 protein CTD PMID:15703272 oxidopamine decreases expression EXP 6480464 Oxidopamine results in decreased expression of DLG1 protein CTD PMID:15703272 oxidopamine multiple interactions EXP 6480464 [Oxidopamine co-treated with Levodopa] results in increased expression of DLG1 mRNA, [Oxidopamine co-treated with Levodopa] results in increased expression of DLG1 protein CTD PMID:15703272 p-chloromercuribenzoic acid decreases expression ISO RGD:731903 6480464 p-Chloromercuribenzoic Acid results in decreased expression of DLG1 mRNA CTD PMID:26272509 p-chloromercuribenzoic acid multiple interactions ISO RGD:731903 6480464 [NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DLG1 mRNA CTD PMID:27188386 paracetamol decreases expression ISO RGD:731903 6480464 Acetaminophen results in decreased expression of DLG1 mRNA CTD PMID:21420995 perfluorooctane-1-sulfonic acid decreases expression ISO RGD:731903 6480464 perfluorooctane sulfonic acid results in decreased expression of DLG1 mRNA CTD PMID:27153767 phorbol 13-acetate 12-myristate multiple interactions ISO RGD:10475 6480464 [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of DLG1 mRNA CTD PMID:19840844 pioglitazone multiple interactions ISO RGD:731903 6480464 pioglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of DLG1 mRNA] CTD PMID:20847119 potassium chromate decreases expression ISO RGD:731903 6480464 potassium chromate(VI) results in decreased expression of DLG1 mRNA CTD PMID:22079256 potassium chromate multiple interactions ISO RGD:731903 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of DLG1 mRNA CTD PMID:22079256 prochloraz multiple interactions EXP 6480464 [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of DLG1 mRNA CTD PMID:25607892 procymidone multiple interactions EXP 6480464 [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of DLG1 mRNA CTD PMID:25607892 quercetin decreases expression ISO RGD:731903 6480464 Quercetin results in decreased expression of DLG1 mRNA CTD PMID:21632981 resveratrol multiple interactions ISO RGD:10475 6480464 [resveratrol results in increased activity of SIRT1 protein] which results in increased expression of DLG1 mRNA, resveratrol promotes the reaction [geranylgeranylacetone results in increased expression of DLG1 mRNA] CTD PMID:21232033 SB 431542 multiple interactions ISO RGD:731903 6480464 [NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DLG1 mRNA CTD PMID:27188386 selenium atom decreases expression ISO RGD:731903 6480464 Selenium results in decreased expression of DLG1 mRNA CTD PMID:19244175 sodium arsenite decreases expression ISO RGD:731903 6480464 sodium arsenite results in decreased expression of DLG1 mRNA CTD PMID:28595984 sulforaphane multiple interactions EXP 6480464 [sulforafan co-treated with Aflatoxin B1] affects the expression of DLG1 mRNA CTD PMID:25450479 sulindac increases expression EXP 6480464 Sulindac results in increased expression of DLG1 mRNA CTD PMID:24136188 teprenone increases expression ISO RGD:10475 6480464 geranylgeranylacetone results in increased expression of DLG1 mRNA, geranylgeranylacetone results in increased expression of DLG1 protein CTD PMID:21232033 teprenone multiple interactions ISO RGD:10475 6480464 geranylgeranylacetone promotes the reaction [[HSF1 protein binds to DLG1 promoter] which results in increased expression of DLG1 mRNA] more ... CTD PMID:21232033 tert-butyl hydroperoxide multiple interactions ISO RGD:731903 6480464 [rosiglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of DLG1 mRNA more ... CTD PMID:20847119 tert-butyl hydroperoxide increases expression ISO RGD:731903 6480464 tert-Butylhydroperoxide results in increased expression of DLG1 mRNA CTD PMID:20847119 theophylline multiple interactions ISO RGD:731903 6480464 [Hydrogen Peroxide co-treated with Theophylline] results in increased expression of DLG1 protein CTD PMID:18951874 thimerosal decreases expression ISO RGD:731903 6480464 Thimerosal results in decreased expression of DLG1 mRNA CTD PMID:27188386 topotecan decreases expression EXP 6480464 Topotecan results in decreased expression of DLG1 mRNA CTD PMID:25729387 topotecan multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of DLG1 mRNA CTD PMID:25729387 trichostatin A increases expression ISO RGD:731903 6480464 trichostatin A results in increased expression of DLG1 mRNA CTD PMID:24935251 , PMID:26272509 troglitazone multiple interactions ISO RGD:731903 6480464 [troglitazone co-treated with tert-Butylhydroperoxide] results in decreased expression of DLG1 mRNA, troglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of DLG1 mRNA] CTD PMID:20847119 tungsten decreases expression ISO RGD:10475 6480464 Tungsten results in decreased expression of DLG1 mRNA CTD PMID:30912803 valproic acid decreases expression ISO RGD:731903 6480464 Valproic Acid results in decreased expression of DLG1 mRNA CTD PMID:23179753 more ... vinclozolin multiple interactions EXP 6480464 [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of DLG1 mRNA CTD PMID:25607892 vorinostat decreases expression ISO RGD:731903 6480464 vorinostat results in decreased expression of DLG1 mRNA CTD PMID:27188386 zoledronic acid increases expression ISO RGD:731903 6480464 zoledronic acid results in increased expression of DLG1 mRNA CTD PMID:20977926
Biological Process actin filament organization ISO RGD:731903 1624291 (PMID:14699157) RGD PMID:14699157 actin filament organization ISS UniProtKB:Q12959 1600115 GO_REF:0000024 UniProt GO_REF:0000024 actin filament organization IEA UniProtKB:Q12959 , ensembl:ENSP000003457311600115 GO_REF:0000107 Ensembl GO_REF:0000107 activation of protein kinase activity ISO RGD:10475 1624291 (MGI:MGI:3697750, PMID:17187070) RGD MGI:MGI:3697750 , PMID:17187070 activation of protein kinase activity IEA UniProtKB:Q811D0 , ensembl:ENSMUSP000000642801600115 GO_REF:0000107 Ensembl GO_REF:0000107 amyloid precursor protein metabolic process ISO RGD:10475 1624291 MGI:MGI:109548 (MGI:MGI:3699445 , PMID:17301176) RGD MGI:MGI:3699445 , PMID:17301176 amyloid precursor protein metabolic process IEA UniProtKB:Q811D0 , ensembl:ENSMUSP000000642801600115 GO_REF:0000107 Ensembl GO_REF:0000107 astral microtubule organization ISO RGD:731903 1624291 (PMID:20551903) RGD PMID:20551903 astral microtubule organization IEA UniProtKB:Q12959 , ensembl:ENSP000003457311600115 GO_REF:0000107 Ensembl GO_REF:0000107 bicellular tight junction assembly ISO RGD:731903 1624291 (PMID:17332497) RGD PMID:17332497 bicellular tight junction assembly IEA UniProtKB:Q12959 , ensembl:ENSP000003457311600115 GO_REF:0000107 Ensembl GO_REF:0000107 branching involved in ureteric bud morphogenesis ISO RGD:10475 1624291 MGI:MGI:2680670 more ... RGD MGI:MGI:3688770 more ... branching involved in ureteric bud morphogenesis IEA UniProtKB:Q811D0 , ensembl:ENSMUSP000000642801600115 GO_REF:0000107 Ensembl GO_REF:0000107 cell adhesion IEP 1298878 RGD cell-cell adhesion ISO RGD:731903 1624291 (PMID:14699157) RGD PMID:14699157 cell-cell adhesion IBA PANTHER:PTN001501163 more ... 13792537 PMID:21873635 GO_Central cell-cell adhesion ISS UniProtKB:Q12959 1600115 GO_REF:0000024 UniProt GO_REF:0000024 cell-cell adhesion IEA UniProtKB:Q12959 , ensembl:ENSP000003457311600115 GO_REF:0000107 Ensembl GO_REF:0000107 cellular protein-containing complex localization ISO RGD:731903 1624291 (PMID:20551903) RGD PMID:20551903 cellular protein-containing complex localization IEA UniProtKB:Q12959 , ensembl:ENSP000003457311600115 GO_REF:0000107 Ensembl GO_REF:0000107 chemical synaptic transmission IBA FB:FBgn0001624 more ... 13792537 PMID:21873635 GO_Central cortical actin cytoskeleton organization ISO RGD:731903 1624291 (PMID:14699157) RGD PMID:14699157 cortical actin cytoskeleton organization ISS UniProtKB:Q12959 1600115 GO_REF:0000024 UniProt GO_REF:0000024 cortical actin cytoskeleton organization IEA UniProtKB:Q12959 , ensembl:ENSP000003457311600115 GO_REF:0000107 Ensembl GO_REF:0000107 cortical microtubule organization ISO RGD:731903 1624291 (PMID:20551903) RGD PMID:20551903 cortical microtubule organization IEA UniProtKB:Q12959 , ensembl:ENSP000003457311600115 GO_REF:0000107 Ensembl GO_REF:0000107 embryonic skeletal system morphogenesis ISO RGD:10475 1624291 MGI:MGI:2680670 (MGI:MGI:1930428 , PMID:11238884) RGD MGI:MGI:1930428 , PMID:11238884 embryonic skeletal system morphogenesis IEA UniProtKB:Q811D0 , ensembl:ENSMUSP000000642801600115 GO_REF:0000107 Ensembl GO_REF:0000107 endothelial cell proliferation ISO RGD:731903 1624291 (PMID:14699157) RGD PMID:14699157 endothelial cell proliferation ISS UniProtKB:Q12959 1600115 GO_REF:0000024 UniProt GO_REF:0000024 endothelial cell proliferation IEA UniProtKB:Q12959 , ensembl:ENSP000003457311600115 GO_REF:0000107 Ensembl GO_REF:0000107 establishment of centrosome localization ISO RGD:731903 1624291 (PMID:20551903) RGD PMID:20551903 establishment of centrosome localization IEA UniProtKB:Q12959 , ensembl:ENSP000003457311600115 GO_REF:0000107 Ensembl GO_REF:0000107 establishment or maintenance of epithelial cell apical/basal polarity IBA FB:FBgn0263289 more ... 13792537 PMID:21873635 GO_Central hard palate development ISO RGD:10475 1624291 MGI:MGI:2680670 more ... RGD MGI:MGI:1930428 more ... hard palate development IEA UniProtKB:Q811D0 , ensembl:ENSMUSP000000642801600115 GO_REF:0000107 Ensembl GO_REF:0000107 immunological synapse formation ISO RGD:10475 1624291 (MGI:MGI:3528803, PMID:15699074) RGD MGI:MGI:3528803 , PMID:15699074 immunological synapse formation IEA UniProtKB:Q811D0 , ensembl:ENSMUSP000000642801600115 GO_REF:0000107 Ensembl GO_REF:0000107 lens development in camera-type eye ISO RGD:10475 1624291 MGI:MGI:2680670 (MGI:MGI:2682188 , PMID:14645510) RGD MGI:MGI:2682188 , PMID:14645510 lens development in camera-type eye IEA UniProtKB:Q811D0 , ensembl:ENSMUSP000000642801600115 GO_REF:0000107 Ensembl GO_REF:0000107 maintenance of postsynaptic density structure IEA GO:0098919 1600115 GO_REF:0000108 GOC GO_REF:0000108 membrane raft organization ISO RGD:10475 1624291 (MGI:MGI:3528803, PMID:15699074) RGD MGI:MGI:3528803 , PMID:15699074 membrane raft organization IEA UniProtKB:Q811D0 , ensembl:ENSMUSP000000642801600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of epithelial cell proliferation ISO RGD:10475 1624291 MGI:MGI:2680670 (MGI:MGI:2682188 , PMID:14645510) RGD MGI:MGI:2682188 , PMID:14645510 negative regulation of epithelial cell proliferation IEA UniProtKB:Q811D0 , ensembl:ENSMUSP000000642801600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of ERK1 and ERK2 cascade ISO RGD:731903 1624291 (PMID:20551903) RGD PMID:20551903 negative regulation of ERK1 and ERK2 cascade IEA UniProtKB:Q12959 , ensembl:ENSP000003457311600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of mitotic cell cycle ISO RGD:731903 1624291 (PMID:10656683) RGD PMID:10656683 negative regulation of mitotic cell cycle ISS UniProtKB:Q12959 1600115 GO_REF:0000024 UniProt GO_REF:0000024 negative regulation of mitotic cell cycle IEA UniProtKB:Q12959 , ensembl:ENSP000003457311600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of p38MAPK cascade ISO RGD:731903 1624291 (PMID:20551903) RGD PMID:20551903 negative regulation of p38MAPK cascade IEA UniProtKB:Q12959 , ensembl:ENSP000003457311600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of protein kinase B signaling ISO RGD:10475 1624291 (MGI:MGI:4454957, PMID:20448149) RGD MGI:MGI:4454957 , PMID:20448149 negative regulation of protein kinase B signaling IEA UniProtKB:Q811D0 , ensembl:ENSMUSP000000642801600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of T cell proliferation ISO RGD:10475 1624291 MGI:MGI:3699270 (MGI:MGI:3768613 , PMID:17724087) RGD MGI:MGI:3768613 , PMID:17724087 negative regulation of T cell proliferation IEA UniProtKB:Q811D0 , ensembl:ENSMUSP000000642801600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of transcription by RNA polymerase II ISO RGD:731903 1624291 (PMID:20551903) RGD PMID:20551903 negative regulation of transcription by RNA polymerase II IEA UniProtKB:Q12959 , ensembl:ENSP000003457311600115 GO_REF:0000107 Ensembl GO_REF:0000107 neurotransmitter receptor localization to postsynaptic specialization membrane IDA 13702333 PMID:12805297 SynGO neurotransmitter receptor localization to postsynaptic specialization membrane IMP 13702333 PMID:12805297 SynGO neurotransmitter receptor localization to postsynaptic specialization membrane ISO RGD:10475 1624291 (MGI:MGI:4431118, PMID:20133708) RGD MGI:MGI:4431118 , PMID:20133708 neurotransmitter receptor localization to postsynaptic specialization membrane IBA MGI:MGI:107231 more ... 13792537 PMID:21873635 GO_Central neurotransmitter receptor localization to postsynaptic specialization membrane IEA UniProtKB:Q811D0 , ensembl:ENSMUSP000000642801600115 GO_REF:0000107 Ensembl GO_REF:0000107 peristalsis ISO RGD:10475 1624291 MGI:MGI:3699270 (MGI:MGI:3699022 , PMID:17172448) RGD MGI:MGI:3699022 , PMID:17172448 peristalsis IEA UniProtKB:Q811D0 , ensembl:ENSMUSP000000642801600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of actin filament polymerization ISO RGD:10475 1624291 (MGI:MGI:3528803, PMID:15699074) RGD MGI:MGI:3528803 , PMID:15699074 positive regulation of actin filament polymerization IEA UniProtKB:Q811D0 , ensembl:ENSMUSP000000642801600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of cell population proliferation ISO RGD:10475 1624291 MGI:MGI:3710242 (MGI:MGI:3709697 , PMID:17435047) RGD MGI:MGI:3709697 , PMID:17435047 positive regulation of cell population proliferation IEA UniProtKB:Q811D0 , ensembl:ENSMUSP000000642801600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of potassium ion transport IMP 2306822 RGD positive regulation of potassium ion transport IEA UniProtKB:Q12959 , ensembl:ENSP000003457311600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of potassium ion transport ISO RGD:731903 1624291 (PMID:12970345) RGD PMID:12970345 positive regulation of protein localization to plasma membrane ISO RGD:731903 1624291 (PMID:12970345) RGD PMID:12970345 positive regulation of protein localization to plasma membrane IEA UniProtKB:Q12959 , ensembl:ENSP000003457311600115 GO_REF:0000107 Ensembl GO_REF:0000107 protein localization ISO RGD:10475 1624291 MGI:MGI:107570 (MGI:MGI:3526601 more ... RGD MGI:MGI:3526601 more ... protein localization to plasma membrane ISO RGD:731903 1624291 (PMID:17332497) RGD PMID:17332497 protein localization to plasma membrane IEA UniProtKB:Q12959 , ensembl:ENSP000003457311600115 GO_REF:0000107 Ensembl GO_REF:0000107 receptor clustering IBA PANTHER:PTN001501163 , RGD:619895 13792537 PMID:21873635 GO_Central receptor localization to synapse IBA MGI:MGI:107231 more ... 13792537 PMID:21873635 GO_Central regulation of cell shape ISO RGD:731903 1624291 (PMID:20551903) RGD PMID:20551903 regulation of cell shape IEA UniProtKB:Q12959 , ensembl:ENSP000003457311600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of membrane potential ISO RGD:10475 1624291 MGI:MGI:107570 more ... RGD MGI:MGI:3526601 , PMID:15277200 regulation of membrane potential ISO RGD:731903 1624291 (PMID:12970345) RGD PMID:12970345 regulation of myelination ISO RGD:10475 1624291 (MGI:MGI:4454957, PMID:20448149) RGD MGI:MGI:4454957 , PMID:20448149 regulation of myelination IEA UniProtKB:Q811D0 , ensembl:ENSMUSP000000642801600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of NIK/NF-kappaB signaling NOT ISO RGD:731903 1624291 (PMID:20551903) RGD PMID:20551903 regulation of potassium ion export across plasma membrane IEA UniProtKB:Q811D0 , ensembl:ENSMUSP000000642801600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of potassium ion export across plasma membrane ISO RGD:10475 1624291 (MGI:MGI:5816439, PMID:25447080) RGD MGI:MGI:5816439 , PMID:25447080 regulation of potassium ion import IEA UniProtKB:Q811D0 , ensembl:ENSMUSP000000642801600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of potassium ion import ISO RGD:10475 1624291 (MGI:MGI:5816439, PMID:25447080) RGD MGI:MGI:5816439 , PMID:25447080 regulation of protein localization IMP 2306826 localization of Kv4.2 to the postsynaptic compartment RGD regulation of protein localization to synapse ISO RGD:10475 1624291 (MGI:MGI:5514106, PMID:23676497) RGD MGI:MGI:5514106 , PMID:23676497 regulation of protein localization to synapse IEA UniProtKB:Q811D0 , ensembl:ENSMUSP000000642801600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of protein localization to synapse IEA UniProtKB:Q12959 , ensembl:ENSP000003457311600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of protein localization to synapse ISO RGD:731903 1624291 (PMID:23676497) RGD PMID:23676497 regulation of ventricular cardiac muscle cell action potential ISO RGD:10475 1624291 (MGI:MGI:5816439, PMID:25447080) RGD MGI:MGI:5816439 , PMID:25447080 regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization IEA UniProtKB:Q811D0 , ensembl:ENSMUSP000000642801600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization ISO RGD:10475 1624291 (MGI:MGI:5816439, PMID:25447080) RGD MGI:MGI:5816439 , PMID:25447080 reproductive structure development ISO RGD:10475 1624291 MGI:MGI:3710242 (MGI:MGI:3709697 , PMID:17435047) RGD MGI:MGI:3709697 , PMID:17435047 reproductive structure development IEA UniProtKB:Q811D0 , ensembl:ENSMUSP000000642801600115 GO_REF:0000107 Ensembl GO_REF:0000107 smooth muscle tissue development ISO RGD:10475 1624291 MGI:MGI:3699270 (MGI:MGI:3699022 , PMID:17172448) RGD MGI:MGI:3699022 , PMID:17172448 smooth muscle tissue development IEA UniProtKB:Q811D0 , ensembl:ENSMUSP000000642801600115 GO_REF:0000107 Ensembl GO_REF:0000107 T cell activation ISO RGD:10475 1624291 (MGI:MGI:3528803 more ... RGD MGI:MGI:3528803 more ... T cell activation IEA UniProtKB:Q811D0 , ensembl:ENSMUSP000000642801600115 GO_REF:0000107 Ensembl GO_REF:0000107 T cell cytokine production ISO RGD:10475 1624291 (MGI:MGI:3528803, PMID:15699074) RGD MGI:MGI:3528803 , PMID:15699074 T cell cytokine production IEA UniProtKB:Q811D0 , ensembl:ENSMUSP000000642801600115 GO_REF:0000107 Ensembl GO_REF:0000107 tissue morphogenesis ISO RGD:10475 1624291 MGI:MGI:3699270 (MGI:MGI:3699022 , PMID:17172448) RGD MGI:MGI:3699022 , PMID:17172448 ureteric bud development ISO RGD:10475 1624291 MGI:MGI:3710242 (MGI:MGI:3709697 , PMID:17435047) RGD MGI:MGI:3709697 , PMID:17435047 Cellular Component apical plasma membrane IEA UniProtKB-SubCell:SL-0015 1600115 GO_REF:0000044 UniProt GO_REF:0000044 basal plasma membrane IDA 1298878 RGD basement membrane ISO RGD:10475 1624291 (MGI:MGI:5523731, PMID:24191021) RGD MGI:MGI:5523731 , PMID:24191021 basement membrane IEA UniProtKB:Q811D0 , ensembl:ENSMUSP000000642801600115 GO_REF:0000107 Ensembl GO_REF:0000107 basolateral plasma membrane ISO RGD:731903 1624291 (PMID:8922391) RGD PMID:8922391 basolateral plasma membrane IBA FB:FBgn0263289 more ... 13792537 PMID:21873635 GO_Central basolateral plasma membrane ISS UniProtKB:Q12959 1600115 GO_REF:0000024 UniProt GO_REF:0000024 basolateral plasma membrane IEA UniProtKB:Q811D0 , ensembl:ENSMUSP000000642801600115 GO_REF:0000107 Ensembl GO_REF:0000107 basolateral plasma membrane IEA UniProtKB:Q12959 , ensembl:ENSP000003457311600115 GO_REF:0000107 Ensembl GO_REF:0000107 basolateral plasma membrane ISO RGD:10475 1624291 (MGI:MGI:1930428 more ... RGD MGI:MGI:1930428 more ... basolateral plasma membrane IDA 8554011 PMID:11726633 UniProt bicellular tight junction ISO RGD:731903 1624291 (PMID:17332497) RGD PMID:17332497 bicellular tight junction IEA UniProtKB:Q12959 , ensembl:ENSP000003457311600115 GO_REF:0000107 Ensembl GO_REF:0000107 cell junction ISO RGD:10475 1624291 (MGI:MGI:5299396, PMID:21920314) RGD MGI:MGI:5299396 , PMID:21920314 cell junction IBA FB:FBgn0001624 more ... 13792537 PMID:21873635 GO_Central cell junction ISO RGD:731903 1624291 (PMID:12857860), (PMID:17237226) RGD PMID:12857860 , PMID:17237226 cell projection membrane ISO RGD:10475 1624291 (MGI:MGI:3689461, PMID:16621792) RGD MGI:MGI:3689461 , PMID:16621792 cell projection membrane IEA UniProtKB:Q811D0 , ensembl:ENSMUSP000000642801600115 GO_REF:0000107 Ensembl GO_REF:0000107 cell-cell junction ISO RGD:731903 1624291 (PMID:21615688) RGD PMID:21615688 cytoplasm ISO RGD:731903 1624291 (PMID:17237226), (PMID:21615688) RGD PMID:17237226 , PMID:21615688 cytoplasmic side of plasma membrane ISO RGD:731903 1624291 (PMID:21615688) RGD PMID:21615688 cytoplasmic side of plasma membrane IEA UniProtKB:Q12959 , ensembl:ENSP000003457311600115 GO_REF:0000107 Ensembl GO_REF:0000107 cytosol IDA 10400858 PMID:19587293 MGI dendrite IDA 12907557 PMID:17301176 SynGO-UCL endoplasmic reticulum ISO RGD:731903 1624291 (PMID:21615688) RGD PMID:21615688 endoplasmic reticulum IEA UniProtKB:Q12959 , ensembl:ENSP000003457311600115 GO_REF:0000107 Ensembl GO_REF:0000107 endoplasmic reticulum membrane IEA UniProtKB-SubCell:SL-0097 1600115 GO_REF:0000044 UniProt GO_REF:0000044 glutamatergic synapse IDA 13702352 PMID:11029631 SynGO glutamatergic synapse IMP 13702333 PMID:12805297 SynGO glutamatergic synapse ISO RGD:10475 1624291 (MGI:MGI:4431118, PMID:20133708) RGD MGI:MGI:4431118 , PMID:20133708 glutamatergic synapse IEA UniProtKB:Q811D0 , ensembl:ENSMUSP000000642801600115 GO_REF:0000107 Ensembl GO_REF:0000107 glutamatergic synapse IDA 13702333 PMID:12805297 SynGO Golgi apparatus ISO RGD:731903 1624291 (PMID:21615688) RGD PMID:21615688 Golgi apparatus IEA UniProtKB:Q12959 , ensembl:ENSP000003457311600115 GO_REF:0000107 Ensembl GO_REF:0000107 immunological synapse ISO RGD:10475 1624291 (MGI:MGI:3528803, PMID:15699074) RGD MGI:MGI:3528803 , PMID:15699074 immunological synapse IEA UniProtKB:Q811D0 , ensembl:ENSMUSP000000642801600115 GO_REF:0000107 Ensembl GO_REF:0000107 immunological synapse IEA UniProtKB:Q12959 , ensembl:ENSP000003457311600115 GO_REF:0000107 Ensembl GO_REF:0000107 immunological synapse ISO RGD:731903 1624291 (PMID:20551903) RGD PMID:20551903 ionotropic glutamate receptor complex colocalizes_with IBA MGI:MGI:1277959 , PANTHER:PTN001501163 13792537 PMID:21873635 GO_Central lateral loop ISO RGD:10475 1624291 (MGI:MGI:4441217, PMID:20237282) RGD MGI:MGI:4441217 , PMID:20237282 lateral loop IEA UniProtKB:Q811D0 , ensembl:ENSMUSP000000642801600115 GO_REF:0000107 Ensembl GO_REF:0000107 lateral plasma membrane ISO RGD:10475 1624291 (MGI:MGI:3688770, PMID:16105026) RGD MGI:MGI:3688770 , PMID:16105026 lateral plasma membrane IEA UniProtKB:Q811D0 , ensembl:ENSMUSP000000642801600115 GO_REF:0000107 Ensembl GO_REF:0000107 membrane raft ISO RGD:10475 1624291 (MGI:MGI:3528803, PMID:15699074) RGD MGI:MGI:3528803 , PMID:15699074 membrane raft IEA UniProtKB:Q811D0 , ensembl:ENSMUSP000000642801600115 GO_REF:0000107 Ensembl GO_REF:0000107 microtubule ISO RGD:731903 1624291 (PMID:21615688) RGD PMID:21615688 microtubule IEA UniProtKB:Q12959 , ensembl:ENSP000003457311600115 GO_REF:0000107 Ensembl GO_REF:0000107 microvillus IDA 10400858 PMID:19587293 MGI MPP7-DLG1-LIN7 complex ISO RGD:731903 1624291 (PMID:17237226) RGD PMID:17237226 MPP7-DLG1-LIN7 complex IEA UniProtKB:Q12959 , ensembl:ENSP000003457311600115 GO_REF:0000107 Ensembl GO_REF:0000107 myelin sheath abaxonal region ISO RGD:10475 1624291 (MGI:MGI:4441217, PMID:20237282) RGD MGI:MGI:4441217 , PMID:20237282 myelin sheath abaxonal region IEA UniProtKB:Q811D0 , ensembl:ENSMUSP000000642801600115 GO_REF:0000107 Ensembl GO_REF:0000107 neuromuscular junction ISO RGD:10475 1624291 (MGI:MGI:3610629, PMID:9674605) RGD MGI:MGI:3610629 , PMID:9674605 neuromuscular junction IBA FB:FBgn0001624 more ... 13792537 PMID:21873635 GO_Central neuromuscular junction IEA UniProtKB:Q811D0 , ensembl:ENSMUSP000000642801600115 GO_REF:0000107 Ensembl GO_REF:0000107 neuron projection IDA 2306826 RGD neuron projection IBA MGI:MGI:1277959 more ... 13792537 PMID:21873635 GO_Central node of Ranvier ISO RGD:10475 1624291 (MGI:MGI:4441217, PMID:20237282) RGD MGI:MGI:4441217 , PMID:20237282 node of Ranvier IEA UniProtKB:Q811D0 , ensembl:ENSMUSP000000642801600115 GO_REF:0000107 Ensembl GO_REF:0000107 nucleus ISO RGD:731903 1624291 (PMID:17237226) RGD PMID:17237226 nucleus IEA UniProtKB:Q12959 , ensembl:ENSP000003457311600115 GO_REF:0000107 Ensembl GO_REF:0000107 paranode region of axon IDA 10400858 PMID:19587293 MGI perinuclear region of cytoplasm ISO RGD:731903 1624291 (PMID:21615688) RGD PMID:21615688 perinuclear region of cytoplasm IEA UniProtKB:Q12959 , ensembl:ENSP000003457311600115 GO_REF:0000107 Ensembl GO_REF:0000107 plasma membrane IDA 2306822 cardiac atrial myocytes RGD plasma membrane IEA UniProtKB-KW:KW-1003 1600115 GO_REF:0000043 UniProt GO_REF:0000043 plasma membrane TAS 1600115 Reactome:R-RNO-9617322 Reactome Reactome:R-RNO-9617322 plasma membrane ISO RGD:10475 1624291 (MGI:MGI:3526601 more ... RGD MGI:MGI:3526601 more ... postsynaptic density IDA 2306826 RGD postsynaptic density IEA UniProtKB:Q811D0 , ensembl:ENSMUSP000000642801600115 GO_REF:0000107 Ensembl GO_REF:0000107 postsynaptic density IDA 12907557 PMID:17301176 SynGO-UCL postsynaptic density TAS 8553546 PMID:1127911 UniProt postsynaptic density ISO RGD:10475 1624291 (MGI:MGI:3699445, PMID:17301176) RGD MGI:MGI:3699445 , PMID:17301176 postsynaptic density IDA 2306827 integral to PSD RGD postsynaptic density membrane IBA MGI:MGI:1277959 , PANTHER:PTN000563569 13792537 PMID:21873635 GO_Central postsynaptic density, intracellular component IDA 13702352 PMID:11029631 SynGO postsynaptic membrane TAS 1298879 RGD presynaptic membrane IDA 1298878 RGD synapse ISO RGD:10475 1624291 (MGI:MGI:3654396, PMID:16882004) RGD MGI:MGI:3654396 , PMID:16882004 synaptic membrane ISO RGD:10475 1624291 (MGI:MGI:5514106, PMID:23676497) RGD MGI:MGI:5514106 , PMID:23676497 synaptic membrane IEA UniProtKB:Q811D0 , ensembl:ENSMUSP000000642801600115 GO_REF:0000107 Ensembl GO_REF:0000107 synaptic membrane IEA UniProtKB:Q12959 , ensembl:ENSP000003457311600115 GO_REF:0000107 Ensembl GO_REF:0000107 synaptic membrane ISO RGD:731903 1624291 (PMID:23676497) RGD PMID:23676497 T-tubule IDA 1581466 RGD Molecular Function ion channel binding ISO RGD:731903 1624291 UniProtKB:P22460 (PMID:12970345) RGD PMID:12970345 ion channel binding IEA UniProtKB:Q12959 , ensembl:ENSP000003457311600115 GO_REF:0000107 Ensembl GO_REF:0000107 ionotropic glutamate receptor binding IPI RGD:621531 2304049 RGD ionotropic glutamate receptor binding IPI RGD:2737 1642315 RGD ionotropic glutamate receptor binding IPI RGD:2738 1642315 RGD kinesin binding IPI RGD:621520 8553481 RGD L27 domain binding ISO RGD:731903 1624291 UniProtKB:Q5T2T1 (PMID:17332497) RGD PMID:17332497 L27 domain binding IEA UniProtKB:Q12959 , ensembl:ENSP000003457311600115 GO_REF:0000107 Ensembl GO_REF:0000107 mitogen-activated protein kinase kinase binding ISO RGD:731903 1624291 UniProtKB:P36507 (PMID:21615688) RGD PMID:21615688 mitogen-activated protein kinase kinase binding IEA UniProtKB:Q12959 , ensembl:ENSP000003457311600115 GO_REF:0000107 Ensembl GO_REF:0000107 molecular adaptor activity ISO RGD:10475 1624291 (MGI:MGI:3528803, PMID:15699074) RGD MGI:MGI:3528803 , PMID:15699074 molecular adaptor activity IEA UniProtKB:Q811D0 , ensembl:ENSMUSP000000642801600115 GO_REF:0000107 Ensembl GO_REF:0000107 PDZ domain binding IPI RGD:62261 1581350 RGD PDZ domain binding IPI RGD:621660 1581350 RGD PDZ domain binding IPI RGD:733316 1581350 RGD phosphatase binding ISO RGD:731903 1624291 UniProtKB:P60484 (PMID:10646847) RGD PMID:10646847 phosphatase binding ISS UniProtKB:Q12959 1600115 GO_REF:0000024 UniProt GO_REF:0000024 phosphatase binding IEA UniProtKB:Q12959 , ensembl:ENSP000003457311600115 GO_REF:0000107 Ensembl GO_REF:0000107 potassium channel regulator activity ISO RGD:731903 1624291 (PMID:12970345) RGD PMID:12970345 potassium channel regulator activity ISO RGD:10475 1624291 (MGI:MGI:5816439, PMID:25447080) RGD MGI:MGI:5816439 , PMID:25447080 potassium channel regulator activity IEA UniProtKB:Q811D0 , ensembl:ENSMUSP000000642801600115 GO_REF:0000107 Ensembl GO_REF:0000107 potassium channel regulator activity IEA UniProtKB:Q12959 , ensembl:ENSP000003457311600115 GO_REF:0000107 Ensembl GO_REF:0000107 protein binding IPI UniProtKB:P42260 8553546 PMID:1127911 UniProt protein binding IPI UniProtKB:P35347 13702239 PMID:26352593 IntAct protein binding ISO RGD:731903 1624291 UniProtKB:A1A5B4 more ... RGD PMID:10656683 more ... protein binding ISO RGD:10475 1624291 PR:O08586 more ... RGD MGI:MGI:2446044 more ... protein binding IPI UniProtKB:Q64273 13432265 PMID:22509027 IntAct protein binding IPI UniProtKB:E9Q4K7 11354197 PMID:27070899 IntAct protein binding IPI UniProtKB:P34926 8553274 PMID:9786987 IntAct protein binding IPI UniProtKB:B1AYL1 8554333 PMID:23022437 IntAct protein binding IPI UniProtKB:O14490 8554566 PMID:22117215 IntAct protein binding IPI UniProtKB:Q810C5 8554416 PMID:21119615 IntAct protein binding IPI UniProtKB:O08560 8553523 PMID:19229292 IntAct protein binding IPI UniProtKB:P89079 8554336 PMID:16511562 IntAct protein binding IPI UniProtKB:Q460M5 8554054 PMID:16495444 IntAct protein binding IPI UniProtKB:P31016 8554542 PMID:16332687 IntAct protein binding IPI UniProtKB:P60484 8554534 PMID:15951562 IntAct protein binding IPI UniProtKB:Q9Y297 8554395 PMID:12902344 IntAct protein binding IPI UniProtKB:Q8VDU0 8554566 PMID:22117215 IntAct protein binding IPI UniProtKB:Q9QYP1 8554698 PMID:16819975 UniProt protein binding IPI UniProtKB:P31977 8554011 PMID:11726633 UniProt protein C-terminus binding IPI RGD:621660 1581466 RGD protein C-terminus binding IEA UniProtKB:Q12959 , ensembl:ENSP000003457311600115 GO_REF:0000107 Ensembl GO_REF:0000107 protein C-terminus binding IPI UniProtKB:Q01814-1 8554332 PMID:11274188 UniProt protein C-terminus binding IPI UniProtKB:P23634-6 8554332 PMID:11274188 UniProt protein C-terminus binding ISO RGD:731903 1624291 UniProtKB:Q01814-1 (PMID:11274188) RGD PMID:11274188 protein C-terminus binding IPI RGD:621531 2306831 RGD protein C-terminus binding IPI RGD:68393 2306822 requires the SAL amino acid motif in Kcnd2 RGD protein C-terminus binding IPI RGD:733316 1581466 RGD protein C-terminus binding IPI RGD:62261 1581466 RGD protein kinase binding IPI RGD:2261 1298879 RGD protein kinase binding ISS UniProtKB:Q12959 1600115 GO_REF:0000024 UniProt GO_REF:0000024 protein kinase binding ISO RGD:731903 1624291 UniProtKB:P06239 more ... RGD PMID:10779557 more ... structural constituent of postsynaptic density IEA UniProtKB:Q811D0 , ensembl:ENSMUSP000000642801600115 GO_REF:0000107 Ensembl GO_REF:0000107 structural constituent of postsynaptic density ISO RGD:10475 1624291 (MGI:MGI:4431118, PMID:20133708) RGD MGI:MGI:4431118 , PMID:20133708
Gene-Chemical Interaction Annotations
