Dlg1 (discs large MAGUK scaffold protein 1)

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Gene: Dlg1 (discs large MAGUK scaffold protein 1) Rattus norvegicus

Analyze

Symbol:

Dlg1

Name:

discs large MAGUK scaffold protein 1

RGD ID:

2505

Description:

Enables several functions, including PDZ domain binding activity; ionotropic glutamate receptor binding activity; and kinesin binding activity. Involved in several processes, including neurotransmitter receptor localization to postsynaptic specialization membrane; positive regulation of potassium ion transport; and regulation of protein localization. Located in several cellular components, including basolateral plasma membrane; lateral plasma membrane; and paranode region of axon. Is active in glutamatergic synapse and postsynaptic density, intracellular component. Biomarker of Parkinson's disease. Human ortholog(s) of this gene implicated in invasive ductal carcinoma. Orthologous to human DLG1 (discs large MAGUK scaffold protein 1); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; INTERACTS WITH 6-propyl-2-thiouracil; aflatoxin B1; ammonium chloride.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

discs large homolog 1; discs large homolog 1, scribble cell polarity complex component; discs, large homolog 1; disks large homolog 1; Dlgh1; Drosophila discs-large tumor suppressor homologue (synapse associated protein); SAP-97; SAP97; synapse-associated protein 97

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Allele / Splice:

Dlg1^{Tn(sb-T2/Bart3)2.133Mcwi}

Genetic Models:

F344-Dlg1^{Tn(sb-T2/Bart3)2.133Mcwi}

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	11	68,911,883 - 69,103,230 (-)	NCBI	mRatBN7.2
mRatBN7.2 Ensembl	11	68,911,883 - 69,102,689 (-)	Ensembl
Rnor_6.0	11	72,164,566 - 72,378,895 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	11	72,163,749 - 72,378,895 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	11	75,389,409 - 75,454,358 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Rnor_5.0	11	75,239,783 - 75,349,409 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	11	70,735,283 - 70,930,374 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	11	70,792,871 - 70,987,963 (-)	NCBI
Celera	11	68,335,260 - 68,524,109 (-)	NCBI		Celera
Cytogenetic Map	11	q22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autistic disorder (ISO)

cervix uteri carcinoma in situ (ISO)

cleft palate (ISO)

invasive ductal carcinoma (ISO)

Parkinson's disease (IEP)

schizophrenia (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

3,3',5,5'-tetrabromobisphenol A (ISO)

3,4-methylenedioxymethamphetamine (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-diaminodiphenylmethane (ISO)

5-fluorouracil (ISO)

6-propyl-2-thiouracil (EXP)

aflatoxin B1 (EXP)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

antirheumatic drug (ISO)

aristolochic acid (ISO)

Aroclor 1254 (ISO)

arsenite(3-) (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bis(2-chloroethyl) sulfide (EXP)

bis(2-ethylhexyl) phthalate (EXP)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

Brodifacoum (EXP)

Butylparaben (EXP)

cadmium dichloride (ISO)

calcidiol (EXP)

carbon nanotube (ISO)

chlorpyrifos (EXP)

cobalt dichloride (ISO)

cyclosporin A (ISO)

DDE (EXP)

decabromodiphenyl ether (ISO)

dexamethasone (ISO)

diarsenic trioxide (ISO)

diazinon (EXP)

dibutyl phthalate (EXP)

dioxygen (ISO)

dizocilpine maleate (EXP)

dorsomorphin (ISO)

doxorubicin (ISO)

elemental selenium (ISO)

enzacamene (EXP)

epoxiconazole (EXP)

ethanol (ISO)

finasteride (EXP)

fipronil (EXP)

folic acid (ISO)

formaldehyde (ISO)

geldanamycin (ISO)

gentamycin (EXP)

hydrogen peroxide (ISO)

indometacin (ISO)

irinotecan (ISO)

ivermectin (ISO)

linuron (EXP)

methapyrilene (EXP)

methyl methanesulfonate (ISO)

methylmercury chloride (ISO)

N-methyl-N'-nitro-N-nitrosoguanidine (ISO)

nicotinamide (ISO)

okadaic acid (ISO)

oxaliplatin (EXP)

oxidopamine (EXP)

p-chloromercuribenzoic acid (ISO)

paracetamol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

phorbol 13-acetate 12-myristate (ISO)

pioglitazone (ISO)

poly(I:C) (EXP)

potassium chromate (ISO)

prochloraz (EXP)

procymidone (EXP)

quercetin (ISO)

resveratrol (ISO)

SB 431542 (ISO)

selenium atom (ISO)

sodium arsenite (ISO)

sulforaphane (EXP)

sulindac (EXP)

teprenone (ISO)

tert-butyl hydroperoxide (ISO)

theophylline (ISO)

thimerosal (ISO)

topotecan (EXP)

trichostatin A (ISO)

triptonide (ISO)

troglitazone (ISO)

tungsten (ISO)

valproic acid (ISO)

vinclozolin (EXP)

vorinostat (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

actin filament organization (ISO,ISS)

actin filament polymerization (IEA,ISO)

activation of protein kinase activity (IEA,ISO)

amyloid precursor protein metabolic process (IEA,ISO)

astral microtubule organization (IEA,ISO)

bicellular tight junction assembly (IEA,ISO)

branching involved in ureteric bud morphogenesis (IEA,ISO)

cell adhesion (IEP)

cell population proliferation (ISO)

cell-cell adhesion (IBA,IEA,ISO,ISS)

chemical synaptic transmission (IBA)

cortical actin cytoskeleton organization (IEA,ISO,ISS)

cortical microtubule organization (IEA,ISO)

embryonic skeletal system morphogenesis (IEA,ISO)

endothelial cell proliferation (IEA,ISO,ISS)

establishment of centrosome localization (IEA,ISO)

establishment or maintenance of epithelial cell apical/basal polarity (IBA)

hard palate development (IEA,ISO)

immunological synapse formation (IEA,ISO)

lens development in camera-type eye (IEA,ISO)

maintenance of postsynaptic density structure (IEA)

membrane raft organization (IEA,ISO)

negative regulation of epithelial cell proliferation (IEA,ISO)

negative regulation of ERK1 and ERK2 cascade (IEA,ISO)

negative regulation of G1/S transition of mitotic cell cycle (IEA,ISO,ISS)

negative regulation of p38MAPK cascade (IEA,ISO)

negative regulation of protein kinase B signaling (IEA,ISO)

negative regulation of T cell proliferation (IEA,ISO)

negative regulation of transcription by RNA polymerase II (IEA,ISO)

neurotransmitter receptor localization to postsynaptic specialization membrane (IBA,IDA,IEA,IMP,ISO)

peristalsis (IEA,ISO)

positive regulation of actin filament polymerization (IEA,ISO)

positive regulation of cell population proliferation (IEA,ISO)

positive regulation of potassium ion transport (IEA,IMP,ISO)

positive regulation of protein localization to plasma membrane (IEA,ISO)

protein kinase B signaling (IEA,ISO)

protein localization (ISO)

protein localization to plasma membrane (IEA,ISO)

protein-containing complex localization (ISO)

receptor clustering (IBA)

receptor localization to synapse (IBA)

regulation of cell shape (IEA,ISO)

regulation of membrane potential (ISO)

regulation of myelination (IEA,ISO)

regulation of NIK/NF-kappaB signaling (ISO)

regulation of potassium ion export across plasma membrane (IEA,ISO)

regulation of potassium ion import (IEA,ISO)

regulation of protein localization (IMP)

regulation of protein localization to synapse (IEA,ISO)

regulation of ventricular cardiac muscle cell action potential (IEA,ISO)

regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization (IEA,ISO)

reproductive structure development (IEA,ISO)

smooth muscle tissue development (IEA,ISO)

T cell activation (ISO)

T cell proliferation (IEA,ISO)

tissue morphogenesis (ISO)

ureteric bud development (ISO)

Cellular Component

apical plasma membrane (IEA)

basal plasma membrane (IDA)

basement membrane (IEA,ISO)

basolateral plasma membrane (IBA,IDA,IEA,ISO,ISS)

bicellular tight junction (IEA,ISO)

cell junction (IBA,ISO)

cell projection membrane (IEA,ISO)

cell-cell junction (ISO)

cytoplasm (ISO)

cytoplasmic side of plasma membrane (IEA,ISO)

cytosol (IDA)

dendrite (IDA)

endoplasmic reticulum (IEA,ISO)

endoplasmic reticulum membrane (TAS)

glutamatergic synapse (IDA,IEA,IMP,ISO)

Golgi apparatus (IEA,ISO)

immunological synapse (IEA,ISO)

lateral loop (IEA,ISO)

lateral plasma membrane (IDA,IEA,ISO)

membrane raft (IEA,ISO)

microtubule (IEA,ISO)

microvillus (IDA)

MPP7-DLG1-LIN7 complex (IEA,ISO)

myelin sheath abaxonal region (IEA,ISO)

neuromuscular junction (IBA,IEA,ISO)

neuron projection (IBA,IDA)

neuronal cell body (IDA)

node of Ranvier (IEA,ISO)

nucleus (IEA,ISO)

paranode region of axon (IDA)

perinuclear region of cytoplasm (IEA,ISO)

plasma membrane (IDA,IEA,ISO,TAS)

postsynaptic density (IDA,IEA,ISO,TAS)

postsynaptic density membrane (IBA)

postsynaptic density, intracellular component (IDA)

postsynaptic membrane (TAS)

presynaptic membrane (IDA)

synapse (ISO)

synaptic membrane (IEA,ISO)

synaptic vesicle membrane (IDA)

T-tubule (IDA)

Molecular Function

ionotropic glutamate receptor binding (IPI)

kinesin binding (IPI)

L27 domain binding (IEA,ISO)

mitogen-activated protein kinase kinase binding (IEA,ISO)

molecular adaptor activity (IEA,ISO)

PDZ domain binding (IPI)

phosphatase binding (IEA,ISO,ISS)

potassium channel regulator activity (IEA,ISO)

protein binding (IPI,ISO)

protein C-terminus binding (IEA,IPI,ISO)

protein kinase binding (IPI,ISO,ISS)

structural constituent of postsynaptic density (IEA,ISO)

transmembrane transporter binding (IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

acebutolol pharmacodynamics pathway (ISO)

adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway (ISO)

amiodarone pharmacodynamics pathway (ISO)

amlodipine pharmacodynamics pathway (ISO)

atenolol pharmacodynamics pathway (ISO)

betaxolol pharmacodynamics pathway (ISO)

bisoprolol pharmacodynamics pathway (ISO)

bupranolol drug pathway (ISO)

bupranolol pharmacodynamics pathway (ISO)

calcium/calmodulin dependent kinase 2 signaling pathway (ISO)

carvedilol pharmacodynamics pathway (ISO)

diltiazem pharmacodynamics pathway (ISO)

disopyramide pharmacodynamics pathway (ISO)

dobutamine pharmacodynamics pathway (ISO)

E-cadherin signaling pathway (ISO)

esmolol pharmacodynamics pathway (ISO)

flecainde pharmacodynamics pathway (ISO)

fosphenytoin pharmacodynamics pathway (ISO)

ibutilide pharmacodynamics pathway (ISO)

isoprenaline pharmacodynamics pathway (ISO)

isradipine pharmacodynamics pathway (ISO)

levobunolol pharmacodynamics pathway (ISO)

lidocaine pharmacodynamics pathway (ISO)

metoprolol pharmacodynamics pathway (ISO)

mexiletine pharmacodynamics pathway (ISO)

nadolol pharmacodynamics pathway (ISO)

nebivolol pharmacodynamics pathway (ISO)

nifedipine pharmacodynamics pathway (ISO)

nimodipine pharmacodynamics pathway (ISO)

nisoldipine pharmacodynamics pathway (ISO)

nitrendipine pharmacodynamics pathway (ISO)

penbutolol pharmacodynamics pathway (ISO)

phenytoin pharmacodynamics pathway (ISO)

pindolol pharmacodynamics pathway (ISO)

procainamide pharmacodynamics pathway (ISO)

propranolol pharmacodynamics pathway (ISO)

quinidine pharmacodynamics pathway (ISO)

sotalol pharmacodynamics pathway (ISO)

T cell receptor signaling pathway (IEA)

timolol pharmacodynamics pathway (ISO)

verapamil pharmacodynamics pathway (ISO)

References

References - curated


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17.	GOA data from the GO Consortium
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Additional References at PubMed

PMID:8601796	PMID:8922391	PMID:9341123	PMID:9674605	PMID:10646847	PMID:10656683	PMID:10779557	PMID:10939335	PMID:11238884	PMID:12050163	PMID:12351654	PMID:12857860
PMID:12970345	PMID:14596909	PMID:14645510	PMID:14681019	PMID:14699157	PMID:15263016	PMID:15277200	PMID:15673434	PMID:15699074	PMID:15729360	PMID:16105026	PMID:16495462
PMID:16621792	PMID:16815335	PMID:16882004	PMID:17172448	PMID:17187070	PMID:17237226	PMID:17332497	PMID:17335044	PMID:17435047	PMID:17724087	PMID:18004877	PMID:19357261
PMID:19620977	PMID:19632332	PMID:19633205	PMID:19836928	PMID:19858198	PMID:20133708	PMID:20237282	PMID:20448149	PMID:20458337	PMID:20530486	PMID:20551903	PMID:20625331
PMID:20865734	PMID:21164104	PMID:21615688	PMID:21768261	PMID:21920314	PMID:22242544	PMID:22718765	PMID:22871113	PMID:23038739	PMID:23460828	PMID:23576434	PMID:23676497
PMID:23696820	PMID:24191021	PMID:25447080	PMID:25468996	PMID:25701814	PMID:26149358	PMID:29476059	PMID:30067285	PMID:35039052	PMID:35145085

Genomics

Comparative Map Data

Dlg1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	11	68,911,883 - 69,103,230 (-)	NCBI	mRatBN7.2
mRatBN7.2 Ensembl	11	68,911,883 - 69,102,689 (-)	Ensembl
Rnor_6.0	11	72,164,566 - 72,378,895 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	11	72,163,749 - 72,378,895 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	11	75,389,409 - 75,454,358 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Rnor_5.0	11	75,239,783 - 75,349,409 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	11	70,735,283 - 70,930,374 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	11	70,792,871 - 70,987,963 (-)	NCBI
Celera	11	68,335,260 - 68,524,109 (-)	NCBI		Celera
Cytogenetic Map	11	q22	NCBI

DLG1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	197,042,560 - 197,299,321 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	3	197,042,560 - 197,299,330 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	3	196,769,431 - 197,026,192 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	198,253,828 - 198,509,844 (-)	NCBI	NCBI36		hg18	NCBI36
Build 34	3	198,259,732 - 198,513,757	NCBI
Celera	3	195,354,807 - 195,610,760 (-)	NCBI
Cytogenetic Map	3	q29	NCBI
HuRef	3	194,068,872 - 194,324,699 (-)	NCBI		HuRef
CHM1_1	3	196,740,135 - 196,996,273 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	3	199,768,533 - 200,020,586 (-)	NCBI

Dlg1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	16	31,482,261 - 31,692,174 (+)	NCBI	GRCm39		mm39
GRCm39 Ensembl	16	31,482,261 - 31,693,947 (+)	Ensembl
GRCm38	16	31,663,443 - 31,873,356 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	16	31,663,443 - 31,875,129 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	16	31,664,125 - 31,873,432 (+)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	16	31,583,786 - 31,793,093 (+)	NCBI			mm8
Celera	16	32,162,337 - 32,367,214 (+)	NCBI		Celera
Cytogenetic Map	16	B2	NCBI
cM Map	16	22.4	NCBI

Dlg1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955420	13,068,289 - 13,273,805 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955420	13,068,289 - 13,273,805 (-)	NCBI	ChiLan1.0	ChiLan1.0

DLG1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	3	204,319,410 - 204,586,232 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	204,323,724 - 204,584,987 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	3	194,386,263 - 194,648,015 (-)	NCBI	Mhudiblu_PPA_v0		panPan3

DLG1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	33	30,016,323 - 30,253,180 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	33	30,016,600 - 30,253,547 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	33	30,039,726 - 30,276,522 (-)	NCBI
ROS_Cfam_1.0	33	30,264,744 - 30,502,044 (-)	NCBI
ROS_Cfam_1.0 Ensembl	33	30,264,748 - 30,501,362 (-)	Ensembl
UMICH_Zoey_3.1	33	30,059,072 - 30,295,858 (-)	NCBI
UNSW_CanFamBas_1.0	33	30,096,091 - 30,333,239 (-)	NCBI
UU_Cfam_GSD_1.0	33	30,717,286 - 30,954,124 (-)	NCBI

Dlg1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	143,094,725 - 143,350,067 (-)	NCBI
SpeTri2.0	NW_004936833	551,989 - 843,064 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DLG1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	132,820,870 - 133,086,843 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	132,819,931 - 133,084,880 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	142,336,324 - 142,629,113 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

DLG1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	15	89,937,900 - 90,214,976 (+)	NCBI	ChlSab1.1		chlSab2
ChlSab1.1 Ensembl	15	90,055,964 - 90,215,652 (+)	Ensembl	ChlSab1.1		chlSab2
Vero_WHO_p1.0	NW_023666041	63,711,831 - 63,988,641 (+)	NCBI	Vero_WHO_p1.0

Dlg1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624730	62,002,280 - 62,223,319 (-)	Ensembl	HetGla_female_1.0		hetGla2
HetGla 1.0	NW_004624730	62,001,547 - 62,223,098 (-)	NCBI	HetGla_female_1.0		hetGla2

Position Markers

AW530915

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	89,702,043 - 89,702,208 (+)	MAPPER	mRatBN7.2
mRatBN7.2	11	68,946,213 - 68,946,378 (-)	MAPPER	mRatBN7.2
mRatBN7.2	10	89,702,043 - 89,702,208 (-)	MAPPER	mRatBN7.2
mRatBN7.2	11	68,946,213 - 68,946,378 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	92,916,666 - 92,916,830	NCBI	Rnor6.0
Rnor_6.0	11	72,208,294 - 72,208,458	NCBI	Rnor6.0
Rnor_5.0	11	75,283,122 - 75,283,286	UniSTS	Rnor5.0
Rnor_5.0	10	92,675,244 - 92,675,408	UniSTS	Rnor5.0
RGSC_v3.4	10	94,120,433 - 94,120,597	UniSTS	RGSC3.4
RGSC_v3.4	11	70,769,193 - 70,769,357	UniSTS	RGSC3.4
Celera	11	68,368,229 - 68,368,393	UniSTS
Celera	10	88,387,767 - 88,387,931	UniSTS
Cytogenetic Map	11	q22	UniSTS

BE109290

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	11	68,953,570 - 68,953,725 (+)	MAPPER	mRatBN7.2
Rnor_6.0	11	72,215,651 - 72,215,805	NCBI	Rnor6.0
Rnor_5.0	11	75,290,479 - 75,290,633	UniSTS	Rnor5.0
RGSC_v3.4	11	70,776,550 - 70,776,704	UniSTS	RGSC3.4
Celera	11	68,375,585 - 68,375,739	UniSTS
RH 3.4 Map	11	405.0	UniSTS
Cytogenetic Map	11	q22	UniSTS

RH138276

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	11	68,961,352 - 68,961,486 (+)	MAPPER	mRatBN7.2
Rnor_6.0	11	72,223,456 - 72,223,589	NCBI	Rnor6.0
Rnor_5.0	11	75,298,284 - 75,298,417	UniSTS	Rnor5.0
RGSC_v3.4	11	70,784,355 - 70,784,488	UniSTS	RGSC3.4
Celera	11	68,382,733 - 68,382,866	UniSTS
RH 3.4 Map	11	402.7	UniSTS
Cytogenetic Map	11	q22	UniSTS

AU049047

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	11	68,959,734 - 68,959,945 (+)	MAPPER	mRatBN7.2
Rnor_6.0	11	72,221,840 - 72,222,048	NCBI	Rnor6.0
Rnor_5.0	11	75,296,668 - 75,296,876	UniSTS	Rnor5.0
RGSC_v3.4	11	70,782,739 - 70,782,947	UniSTS	RGSC3.4
Celera	11	68,381,104 - 68,381,325	UniSTS
Cytogenetic Map	11	q22	UniSTS

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1300147	Bp187	Blood pressure QTL 187	3.67		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	11	1	69446234	Rat
724554	Iddm17	Insulin dependent diabetes mellitus QTL 17		0.001	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	11	18976208	86241447	Rat
724563	Uae10	Urinary albumin excretion QTL 10	6		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	11	27672410	82846715	Rat
1300110	Stl7	Serum triglyceride level QTL 7	4.64		blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	11	29528418	82566702	Rat
2298551	Neuinf10	Neuroinflammation QTL 10	3.7		nervous system integrity trait (VT:0010566)	spinal cord beta-2 microglobulin mRNA level (CMO:0002125)	11	31239134	78851519	Rat
70180	BpQTLcluster10	Blood pressure QTL cluster 10	3.19		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	11	34918041	79918041	Rat
1300135	Rf19	Renal function QTL 19	3.38		blood creatinine amount (VT:0005328)	creatinine clearance (CMO:0000765)	11	40946188	82566702	Rat
2312566	Glom20	Glomerulus QTL 20	3.6	0.001	kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	11	44285759	82566702	Rat
1581565	Pur10	Proteinuria QTL 10		0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	11	44803318	82846466	Rat
1581572	Uae35	Urinary albumin excretion QTL 35		0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	11	44803318	82846466	Rat
4889859	Pur28	Proteinuria QTL 28	19.5	0.001	total urine protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	11	45459323	75190161	Rat
724561	Plsm4	Polydactyly-luxate syndrome (PLS) morphotypes QTL 4		0.0003	forelimb integrity trait (VT:0010562)	front foot phalanges count (CMO:0001947)	11	54457534	86241447	Rat
4889521	Gluco62	Glucose level QTL 62	2.82	0.001	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	11	55136729	82993457	Rat
7411658	Foco27	Food consumption QTL 27	16.2	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	11	56351424	86241447	Rat
631506	Bp104	Blood pressure QTL 104	2.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	11	59802794	82566545	Rat
70208	Niddm22	Non-insulin dependent diabetes mellitus QTL 22	3.61		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	11	59802794	82566553	Rat
10058954	Gmadr7	Adrenal mass QTL 7	2.49	0.0049	adrenal gland mass (VT:0010420)	both adrenal glands wet weight to body weight ratio (CMO:0002411)	11	60346590	86241447	Rat
1549848	Bvd6	Brain ventricular dilatation QTL 6	3.1	0.0001	brain ventricle morphology trait (VT:0000822)	hydrocephalus severity score (CMO:0001881)	11	66113321	82169223	Rat
634339	Niddm50	Non-insulin dependent diabetes mellitus QTL 50	3.32		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	11	66422148	86241447	Rat
1354593	Stl12	Serum triglyceride level QTL 12	3.36		blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	11	66422148	86241447	Rat

Genetic Models

This gene Dlg1 is modified in the following models/strains

F344-Dlg1^{Tn(sb-T2/Bart3)2.133Mcwi}

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	39
Count of miRNA genes:	38
Interacting mature miRNAs:	39
Transcripts:	ENSRNOT00000058885
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	41	54	38	19	38	8	10	74	35	35	11	8
Low		2	3	3		3		1			6
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001393734	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_012788	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039088001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039088002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039088003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039088004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039088005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039088006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039088007	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039088008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039088009	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039088010	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039088011	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039088012	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039088013	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039088014	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039088015	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039088016	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039088017	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039088018	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039088019	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039088020	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039088021	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039088022	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039088023	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039088024	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039088025	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005490974	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005490975	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005490976	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005490977	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473967	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ211533	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ213556	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000222	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U14950	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000058885 ⟹ ENSRNOP00000055672

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	11	68,913,345 - 69,102,689 (-)	Ensembl
Rnor_6.0 Ensembl	11	72,164,566 - 72,378,895 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000078737 ⟹ ENSRNOP00000071898

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	11	68,911,883 - 69,102,545 (-)	Ensembl
Rnor_6.0 Ensembl	11	72,163,749 - 72,378,718 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000102386 ⟹ ENSRNOP00000088710

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	11	68,911,883 - 69,102,545 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000108927 ⟹ ENSRNOP00000097997

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	11	68,913,345 - 69,029,008 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000109975 ⟹ ENSRNOP00000085582

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	11	68,911,883 - 69,030,997 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000113230 ⟹ ENSRNOP00000081862

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	11	68,913,345 - 69,030,997 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000117728 ⟹ ENSRNOP00000091905

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	11	68,913,345 - 69,102,689 (-)	Ensembl

RefSeq Acc Id:

NM_012788 ⟹ NP_036920

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	11	68,913,344 - 69,102,803 (-)	NCBI
Rnor_6.0	11	72,164,566 - 72,378,895 (-)	NCBI
Rnor_5.0	11	75,239,783 - 75,349,409 (-)	NCBI
Rnor_5.0	11	75,389,409 - 75,454,358 (-)	NCBI
RGSC_v3.4	11	70,735,283 - 70,930,374 (-)	RGD
Celera	11	68,335,260 - 68,524,109 (-)	RGD

Sequence:

show sequence

CACGAGGCGACTGGGGGCGCGGAAGGGAGGCGAGGTTCCGGGGGTGGGGCGGCCCGGAGGCGAG
CGGGCGAGCGGGGCCGCCGAGCGGCGGCGAGAGGGCAGGCGGCGGCGGCCGAGGCGGAGAGAGC
GGCGCGGGGTGCGGCCGCCGAGAGGAGCTCCTCCCCCGTCCCCTCACCCCCTCAGCTGAGCTCG
AGTCGGGGCGGGGCGGGGTACGTGGAGCGGGGCCGGGCGGGGAGCTGCTCCGAGTCTGGCCGGA
GCGCACCCGGGGCGCCCGCGTTCGCCGCTCGCGGGAACTTTGCGGCGGACGGTGTGGAGGCCGC
GGAGGGGTGCATGAGCGGCGCAGGGCGGCGCACAGAGCGGCGGCTGTCCGGTCCGGCCCCTGCT
GGAGTCGCCGCCGGAGGAGGCGAGCGAGGAGCCAGGTGTGTGTGCCTTCTTCCTGCTTCTGGAA
AAAATGCCGGTCCGGAAGCAAGATACCCAGAGAGCATTGCATCTGTTGGAAGAATATCGGTCGA
AACTAAGCCAAACCGAAGACAGACAGCTCAGGAGTTCCATAGAGCGGGTTATTAGCATATTTCA
GAGCAACCTCTTTCAGGCTTTAATAGACATTCAAGAATTTTATGAAGTGACCTTACTTGATAAT
CCAAAATGTGTGGATCATTCAAAGCAGTGTGAACCGGTCCAACCCGGGAATCCTTGGGAGAGTG
GCAGCCTTTCAAGTGCTGCTGTGACTTCAGAGAGCCTGCCCGGCGGCCTTAGCCCTCCAGTAGA
GAAATACCGGTATCAGGACGAAGAGGTGCTGCCTTCAGAGCGGATTTCCCCGCAAGTCCCAAAT
GAGGTGCTGGGTCCGGAGCTGGTTCACGTCTCGGAGAAGAGCCTGTCAGAGATTGAGAATGTCC
ACGGGTTTGTCTCTCACTCTCATATCTCACCCATAAAGCCCACAGAAGCTGTTCCTCCCTCCTC
TCCCATTGTCCCTGTGACCCCTGCCTTGCCAGTCCCTGCTGAGAGTCCTGTCGTCCTGCCCTCC
ACACCACAGGCAAATCCTCCTCCTGTCCTGGTCAACACAGACAGCTTGGAGACACCAACTTATG
TTAATGGTACTGATGCAGATTATGAATATGAGGAAATCACACTTGAAAGGGGAAATTCAGGCTT
GGGTTTCAGCATTGCAGGAGGTACAGACAACCCACACATTGGAGATGACTCAAGTATTTTCATC
ACCAAAATTATCACGGGAGGAGCAGCTGCCCAGGATGGAAGATTGCGGGTAAATGACTGTATAC
TGAGAGTAAATGAAGCAGATGTTCGTGATGTAACCCACAGCAAAGCAGTTGAAGCATTGAAAGA
AGCTGGATCGATAGTGCGATTATATGTGAAAAGGCGGAAGGCCTTCAGAAAAAATCATGAAATA
AAACTTATTAAAGGCCCTAAAGGTCTTGGGTTCAGCATTGCTGGAGGTGTTGGAAACCAGCACA
TTCCTGGGGATAACAGCATCTATGTAACCAAAATAATTGAAGGAGGTGCAGCACACAAGGACGG
CAAACTTCAGATTGGAGACAAGCTTCTAGCAGTGAACAGTGTCTGTTTAGAAGAAGTTACTCAT
GAAGAAGCAGTGACTGCCTTAAAGAATACATCTGATTTTGTTTATTTGAAAGCGGCAAAACCAA
CAAGTATGTATATAAATGATGGCTATGCACCACCCGACATCACTAATTCTTCTTCTCAGTCTGT
TGACAACCATGTTAGCCCGTCTTCATACTTGGGCCAGACTCCAGCGTCACCAGCCAGATACTCA
CCCATTTCTAAAGCAGTGCTTGGAGATGATGAGATCACTAGGGAACCTAGAAAAGTTGTTCTTC
ATCGTGGCTCAACGGGACTTGGTTTCAACATTGTGGGAGGCGAAGATGGAGAAGGGATTTTTAT
CTCTTTCATCCTTGCTGGGGGACCTGCTGACCTAAGCGGAGAGCTCAGAAAAGGAGATCGCATT
ATATCGGTAAACAGTGTTGACCTCAGAGCTGCAAGTCATGAACAAGCAGCTGCCGCATTAAAAA
ACGCAGGCCAAGCTGTCACTATTGTCGCACAGTATCGGCCTGAAGAGTACAGTCGTTTTGAAGC
TAAAATTCACGACTTGCGGGAGACGATGATGAACAGCAGTGTCAGCTCAGGGTCAGGGTCTCTC
CGAACCAGCCAAAAGCGGTCCCTCTATGTCAGAGCCCTTTTTGATTACGACAAGACTAAAGACA
GTGGCCTTCCCAGTCAAGGGTTGAACTTCAAATTCGGAGATATTCTCCATGTTATCAATGCTTC
TGATGACGAGTGGTGGCAGGCCAGACAGGTGACCCCAGATGGTGAGAGTGACGAAGTTGGAGTA
ATTCCTAGTAAACGCAGAGTTGAGAAGAAAGAACGAGCCCGATTAAAAACAGTCAAATTCAATT
CTAAAACAAGAGGAGATAAAGGGGAGATCCCTGACGACATGGGATCAAAAGGCCTGAAGCACGT
AACTTCTAATGCCAGCGATAGCGAAAGTAGTTACCATGAATATGGCTGCTCAAAAGGTGGTCAA
GAAGAATATGTTTTATCGTATGAGCCGGTGAATCAGCAAGAAGTTAATTATACCCGACCAGTCA
TCATATTAGGACCTATGAAAGACAGAGTAAATGATGACTTAATCTCAGAATTTCCTGACAAATT
TGGATCCTGTGTCCCTCATACAACTAGACCAAAGCGTGACTATGAGGTGGATGGACGAGATTAC
CATTTTGTGACTTCAAGAGAACAGATGGAGAAAGATATCCAGGAGCATAAATTCATTGAAGCTG
GCCAGTATAACAACCATCTATACGGAACGAGTGTCCAATCTGTGCGAGCAGTAGCAGAGAAGGG
CAAGCATTGTATCCTTGATGTGTCTGGAAATGCCATCAAGAGGTTGCAGATTGCACAGCTCTAT
CCAATATCTATTTTTATTAAACCCAAATCCATGGAAAATATCATGGAAATGAATAAACGCCTAA
CAGACGAACAGGCCAGAAAAACGTTTGAGAGAGCAGTGAGACTGGAGCAGGAGTTCACTGAGCA
TTTCACAGCTATTGTCCAGGGAGACACGCTGGAGGACATTTACAATCAAGTGAAGCAGATCATA
GAAGAGCAGTCTGGTCCTTACATCTGGGTCCCAGCAAAAGAAAAATTATGAAGACAGATGTTGC
TCTTTCTTTTTCCATGGTCTCATCTCTCTGCCCTGCTCTGGAGGTCTGTCTTCAGC

hide sequence

RefSeq Acc Id:

XM_039088001 ⟹ XP_038943929

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	11	68,911,883 - 69,102,311 (-)	NCBI

RefSeq Acc Id:

XM_039088002 ⟹ XP_038943930

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	11	68,911,883 - 69,102,340 (-)	NCBI

RefSeq Acc Id:

XM_039088003 ⟹ XP_038943931

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	11	68,911,883 - 69,102,311 (-)	NCBI

RefSeq Acc Id:

XM_039088004 ⟹ XP_038943932

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	11	68,911,883 - 69,102,311 (-)	NCBI

RefSeq Acc Id:

XM_039088005 ⟹ XP_038943933

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	11	68,911,883 - 69,102,311 (-)	NCBI

RefSeq Acc Id:

XM_039088006 ⟹ XP_038943934

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	11	68,911,883 - 69,102,342 (-)	NCBI

RefSeq Acc Id:

XM_039088007 ⟹ XP_038943935

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	11	68,911,883 - 69,102,311 (-)	NCBI

RefSeq Acc Id:

XM_039088008 ⟹ XP_038943936

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	11	68,911,883 - 69,102,311 (-)	NCBI

RefSeq Acc Id:

XM_039088009 ⟹ XP_038943937

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	11	68,911,883 - 69,102,311 (-)	NCBI

RefSeq Acc Id:

XM_039088010 ⟹ XP_038943938

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	11	68,911,883 - 69,102,311 (-)	NCBI

RefSeq Acc Id:

XM_039088011 ⟹ XP_038943939

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	11	68,911,883 - 69,102,311 (-)	NCBI

RefSeq Acc Id:

XM_039088012 ⟹ XP_038943940

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	11	68,911,883 - 69,102,311 (-)	NCBI

RefSeq Acc Id:

XM_039088013 ⟹ XP_038943941

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	11	68,911,883 - 69,102,311 (-)	NCBI

RefSeq Acc Id:

XM_039088014 ⟹ XP_038943942

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	11	68,911,883 - 69,102,311 (-)	NCBI

RefSeq Acc Id:

XM_039088015 ⟹ XP_038943943

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	11	68,911,883 - 69,102,311 (-)	NCBI

RefSeq Acc Id:

XM_039088016 ⟹ XP_038943944

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	11	68,911,883 - 69,102,311 (-)	NCBI

RefSeq Acc Id:

XM_039088017 ⟹ XP_038943945

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	11	68,911,883 - 69,102,518 (-)	NCBI

RefSeq Acc Id:

XM_039088018 ⟹ XP_038943946

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	11	68,911,883 - 69,103,230 (-)	NCBI

RefSeq Acc Id:

XM_039088019 ⟹ XP_038943947

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	11	68,911,883 - 69,029,619 (-)	NCBI

RefSeq Acc Id:

XM_039088020 ⟹ XP_038943948

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	11	68,911,883 - 69,076,406 (-)	NCBI

RefSeq Acc Id:

XM_039088021 ⟹ XP_038943949

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	11	68,911,883 - 69,029,616 (-)	NCBI

RefSeq Acc Id:

XM_039088022 ⟹ XP_038943950

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	11	68,911,883 - 69,029,615 (-)	NCBI

RefSeq Acc Id:

XM_039088023 ⟹ XP_038943951

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	11	68,911,883 - 69,029,613 (-)	NCBI

RefSeq Acc Id:

XM_039088024 ⟹ XP_038943952

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	11	68,911,883 - 69,029,613 (-)	NCBI

RefSeq Acc Id:

XM_039088025 ⟹ XP_038943953

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	11	68,911,883 - 69,029,610 (-)	NCBI

RefSeq Acc Id:

XR_005490974

RefSeq Status:

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	11	68,927,780 - 69,102,342 (-)	NCBI

RefSeq Acc Id:

XR_005490975

RefSeq Status:

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	11	68,928,674 - 69,102,342 (-)	NCBI

RefSeq Acc Id:

XR_005490976

RefSeq Status:

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	11	68,928,661 - 69,102,342 (-)	NCBI

RefSeq Acc Id:

XR_005490977

RefSeq Status:

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	11	68,927,291 - 69,102,344 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001380663	(Get FASTA)	NCBI Sequence Viewer
	NP_036920	(Get FASTA)	NCBI Sequence Viewer
	XP_038943929	(Get FASTA)	NCBI Sequence Viewer
	XP_038943930	(Get FASTA)	NCBI Sequence Viewer
	XP_038943931	(Get FASTA)	NCBI Sequence Viewer
	XP_038943932	(Get FASTA)	NCBI Sequence Viewer
	XP_038943933	(Get FASTA)	NCBI Sequence Viewer
	XP_038943934	(Get FASTA)	NCBI Sequence Viewer
	XP_038943935	(Get FASTA)	NCBI Sequence Viewer
	XP_038943936	(Get FASTA)	NCBI Sequence Viewer
	XP_038943937	(Get FASTA)	NCBI Sequence Viewer
	XP_038943938	(Get FASTA)	NCBI Sequence Viewer
	XP_038943939	(Get FASTA)	NCBI Sequence Viewer
	XP_038943940	(Get FASTA)	NCBI Sequence Viewer
	XP_038943941	(Get FASTA)	NCBI Sequence Viewer
	XP_038943942	(Get FASTA)	NCBI Sequence Viewer
	XP_038943943	(Get FASTA)	NCBI Sequence Viewer
	XP_038943944	(Get FASTA)	NCBI Sequence Viewer
	XP_038943945	(Get FASTA)	NCBI Sequence Viewer
	XP_038943946	(Get FASTA)	NCBI Sequence Viewer
	XP_038943947	(Get FASTA)	NCBI Sequence Viewer
	XP_038943948	(Get FASTA)	NCBI Sequence Viewer
	XP_038943949	(Get FASTA)	NCBI Sequence Viewer
	XP_038943950	(Get FASTA)	NCBI Sequence Viewer
	XP_038943951	(Get FASTA)	NCBI Sequence Viewer
	XP_038943952	(Get FASTA)	NCBI Sequence Viewer
	XP_038943953	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA79976	(Get FASTA)	NCBI Sequence Viewer
	EDM11457	(Get FASTA)	NCBI Sequence Viewer
	EDM11458	(Get FASTA)	NCBI Sequence Viewer
	EDM11459	(Get FASTA)	NCBI Sequence Viewer
	EDM11460	(Get FASTA)	NCBI Sequence Viewer
	EDM11461	(Get FASTA)	NCBI Sequence Viewer
	EDM11462	(Get FASTA)	NCBI Sequence Viewer
	Q62696	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_036920 ⟸ NM_012788

- Sequence:

show sequence

MPVRKQDTQRALHLLEEYRSKLSQTEDRQLRSSIERVISIFQSNLFQALIDIQEFYEVTLLDNP
KCVDHSKQCEPVQPGNPWESGSLSSAAVTSESLPGGLSPPVEKYRYQDEEVLPSERISPQVPNE
VLGPELVHVSEKSLSEIENVHGFVSHSHISPIKPTEAVPPSSPIVPVTPALPVPAESPVVLPST
PQANPPPVLVNTDSLETPTYVNGTDADYEYEEITLERGNSGLGFSIAGGTDNPHIGDDSSIFIT
KIITGGAAAQDGRLRVNDCILRVNEADVRDVTHSKAVEALKEAGSIVRLYVKRRKAFRKNHEIK
LIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNSVCLEEVTHE
EAVTALKNTSDFVYLKAAKPTSMYINDGYAPPDITNSSSQSVDNHVSPSSYLGQTPASPARYSP
ISKAVLGDDEITREPRKVVLHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDRII
SVNSVDLRAASHEQAAAALKNAGQAVTIVAQYRPEEYSRFEAKIHDLRETMMNSSVSSGSGSLR
TSQKRSLYVRALFDYDKTKDSGLPSQGLNFKFGDILHVINASDDEWWQARQVTPDGESDEVGVI
PSKRRVEKKERARLKTVKFNSKTRGDKGEIPDDMGSKGLKHVTSNASDSESSYHEYGCSKGGQE
EYVLSYEPVNQQEVNYTRPVIILGPMKDRVNDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYH
FVTSREQMEKDIQEHKFIEAGQYNNHLYGTSVQSVRAVAEKGKHCILDVSGNAIKRLQIAQLYP
ISIFIKPKSMENIMEMNKRLTDEQARKTFERAVRLEQEFTEHFTAIVQGDTLEDIYNQVKQIIE
EQSGPYIWVPAKEKL

hide sequence

RefSeq Acc Id:

ENSRNOP00000055672 ⟸ ENSRNOT00000058885

RefSeq Acc Id:

ENSRNOP00000071898 ⟸ ENSRNOT00000078737

RefSeq Acc Id:	XP_038943946 ⟸ XM_039088018
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038943945 ⟸ XM_039088017
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038943934 ⟸ XM_039088006
- Peptide Label:	isoform X6

RefSeq Acc Id:	XP_038943930 ⟸ XM_039088002
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038943944 ⟸ XM_039088016
- Peptide Label:	isoform X16

RefSeq Acc Id:	XP_038943943 ⟸ XM_039088015
- Peptide Label:	isoform X15

RefSeq Acc Id:	XP_038943942 ⟸ XM_039088014
- Peptide Label:	isoform X14

RefSeq Acc Id:	XP_038943941 ⟸ XM_039088013
- Peptide Label:	isoform X13

RefSeq Acc Id:	XP_038943940 ⟸ XM_039088012
- Peptide Label:	isoform X12

RefSeq Acc Id:	XP_038943938 ⟸ XM_039088010
- Peptide Label:	isoform X10

RefSeq Acc Id:	XP_038943936 ⟸ XM_039088008
- Peptide Label:	isoform X8

RefSeq Acc Id:	XP_038943939 ⟸ XM_039088011
- Peptide Label:	isoform X11

RefSeq Acc Id:	XP_038943937 ⟸ XM_039088009
- Peptide Label:	isoform X9

RefSeq Acc Id:	XP_038943935 ⟸ XM_039088007
- Peptide Label:	isoform X7

RefSeq Acc Id:	XP_038943933 ⟸ XM_039088005
- Peptide Label:	isoform X5

RefSeq Acc Id:	XP_038943932 ⟸ XM_039088004
- Peptide Label:	isoform X4

RefSeq Acc Id:	XP_038943931 ⟸ XM_039088003
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_038943929 ⟸ XM_039088001
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038943948 ⟸ XM_039088020
- Peptide Label:	isoform X18

RefSeq Acc Id:	XP_038943947 ⟸ XM_039088019
- Peptide Label:	isoform X17

RefSeq Acc Id:	XP_038943949 ⟸ XM_039088021
- Peptide Label:	isoform X19

RefSeq Acc Id:	XP_038943950 ⟸ XM_039088022
- Peptide Label:	isoform X20

RefSeq Acc Id:	XP_038943952 ⟸ XM_039088024
- Peptide Label:	isoform X22

RefSeq Acc Id:	XP_038943951 ⟸ XM_039088023
- Peptide Label:	isoform X21

RefSeq Acc Id:	XP_038943953 ⟸ XM_039088025
- Peptide Label:	isoform X23

RefSeq Acc Id:

ENSRNOP00000081862 ⟸ ENSRNOT00000113230

RefSeq Acc Id:

ENSRNOP00000088710 ⟸ ENSRNOT00000102386

RefSeq Acc Id:

ENSRNOP00000085582 ⟸ ENSRNOT00000109975

RefSeq Acc Id:

ENSRNOP00000097997 ⟸ ENSRNOT00000108927

RefSeq Acc Id:

ENSRNOP00000091905 ⟸ ENSRNOT00000117728

Protein Domains

Guanylate kinase-like L27 PDZ SH3

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q62696-F1-model_v2	AlphaFold	Q62696	1-911	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13698221

Promoter ID:

EPDNEW_R8744

Type:

single initiation site

Name:

Dlg1_1

Description:

discs large MAGUK scaffold protein 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	11	72,378,806 - 72,378,866	EPDNEW

Strain Variation

Strain Sequence Variants (MRatBN7.2)

ACI/EurMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

ACI/N (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BN-Lx/CubMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BN/NHsdMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BN/NHsdMcwi (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BN/SsN (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BUF/N (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BXH2/CubMcwi (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BXH3/CubMcwi (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

DA/OlaHsd (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Envigo
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

F344/DuCrl (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Charles River
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

F344/N (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

F344/NCrl (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Charles River
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

F344/Stm (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

FHH/EurMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

FXLE16/Stm (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

FXLE18/Stm (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

GK/FarMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

HXB10/IpcvMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

HXB2/IpcvMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

HXB20/IpcvMcwi (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

HXB31/IpcvMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

HXB4/IpcvMcwi (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LE/Stm (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEW/Crl (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Charles River
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF10A/StmMcwi (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF11/Stm (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF1A/Stm (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF1C/Stm (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF2B/Stm (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF3/Stm (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF4/Stm (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LH/MavRrrcAek (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Kwitek
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LL/MavRrrcAek (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Kwitek
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LN/MavRrrcAek (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Kwitek
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

M520/N (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

M520/NRrrcMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

MR/N (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

MWF/Hsd (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

PVG/Seac (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

SHR/OlalpcvMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

SHRSP/A3NCrl (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Charles River
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

SR/JrHsd (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Envigo
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

SS/JrHsdMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

WAG/RijCrl (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Charles River
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

WKY/N (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

WKY/NCrl (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Charles River
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

WN/N (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:2505	AgrOrtholog
BioCyc Gene	G2FUF-21064	BioCyc
Ensembl Genes	ENSRNOG00000038597	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000055672	UniProtKB/TrEMBL
	ENSRNOP00000071898	ENTREZGENE, UniProtKB/TrEMBL
	ENSRNOP00000081862	ENTREZGENE
	ENSRNOP00000085582	ENTREZGENE
	ENSRNOP00000088710	ENTREZGENE
	ENSRNOP00000091905	ENTREZGENE
	ENSRNOP00000097997	ENTREZGENE
Ensembl Transcript	ENSRNOT00000058885	UniProtKB/TrEMBL
	ENSRNOT00000078737	ENTREZGENE, UniProtKB/TrEMBL
	ENSRNOT00000102386	ENTREZGENE
	ENSRNOT00000108927	ENTREZGENE
	ENSRNOT00000109975	ENTREZGENE
	ENSRNOT00000113230	ENTREZGENE
	ENSRNOT00000117728	ENTREZGENE
Gene3D-CATH	2.30.42.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	3.40.50.300	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	DLG1-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	DLG1_PEST_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GK/Ca_channel_bsu	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Guanylate_kin-like_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Guanylate_kinase_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	L27_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	L27_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	L27_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	P-loop_NTPase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PDZ	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PDZ_assoc	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PDZ_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SH3-like_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SH3_domain	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:25252	UniProtKB/Swiss-Prot
NCBI Gene	25252	ENTREZGENE
Pfam	Guanylate_kin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	L27_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	MAGUK_N_PEST	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PDZ	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PDZ_assoc	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SH3_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Dlg1	PhenoGen
PIRSF	MAGUK_DLGH	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	GUANYLATE_KINASE_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GUANYLATE_KINASE_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	L27	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PDZ	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SH3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	GuKc	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	L27	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	MAGUK_N_PEST	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PDZ	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SH3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF101288	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF50044	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF50156	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF52540	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR	TC205414
UniProt	A0A0G2K1M2_RAT	UniProtKB/TrEMBL
	DLG1_RAT	UniProtKB/Swiss-Prot
	F1LNM0_RAT	UniProtKB/TrEMBL
	Q62696	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-02-15	Dlg1	discs, large homolog 1 (Drosophila)	Dlgh1	discs, large homolog 1 (Drosophila)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2002-11-06	Dlgh1	discs, large homolog 1 (Drosophila)	Dlg1	Drosophila discs-large tumor suppressor homologue (synapse associated protein)	Name updated	625702	APPROVED
2002-06-10	Dlg1	Drosophila discs-large tumor suppressor homologue (synapse associated protein)			Symbol and Name status set to approved	70586	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_cellular_localization	localized in presynaptic nerve termini of excitatory synapses in the hypocampus at unmyelinated axons and at sites of contact among epithelial cells	1298878
gene_cellular_localization	localized to and along bundles of unmyelinated axons at cytoplasmic surfaces of plasma membranes	1298878
gene_cellular_localization	co-localizes with both ionotropic glutamate receptors (nucleus) and such downstream signaling proteins as Ca2+/calmodulin-dependent protein kinase II (CaMKII)	1298879
gene_expression	may provide synaptic targeting for NMDA receptors	1298879
gene_homology	has high similarity to rat sap90	1298878
gene_physical_interaction	binds to the NR2A subunit of the NMDA receptor in its unphosphorylated form	1298879
gene_process	may participate in cell adhesion and function in site-specific cellular activities	1298878
gene_process	targets ionotropic glutamate receptors at postsynaptic sites	1298879
gene_product	member of membrane-associated guanylate kinase protein family	1298879
gene_regulation	phosphorylated by CaMKII via N-methyl-D-aspartic acid (NMDA) receptor activation	1298879

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)