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Gene: Dlg1 (discs large MAGUK scaffold protein 1) Rattus norvegicus
Symbol: Dlg1
Name: discs large MAGUK scaffold protein 1
RGD ID: 2505
Description: Exhibits several functions, including PDZ domain binding activity; ionotropic glutamate receptor binding activity; and kinesin binding activity. Involved in several processes, including cell adhesion; neurotransmitter receptor localization to postsynaptic specialization membrane; and positive regulation of potassium ion transport. Localizes to several cellular components, including basal plasma membrane; paranode region of axon; and postsynaptic density, intracellular component. Predicted to colocalize with ionotropic glutamate receptor complex. Biomarker of Parkinson's disease. Human ortholog(s) of this gene implicated in invasive ductal carcinoma. Orthologous to human DLG1 (discs large MAGUK scaffold protein 1); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; INTERACTS WITH 6-propyl-2-thiouracil; aflatoxin B1; ammonium chloride.
Type: protein-coding
Also known as: discs large homolog 1; discs large homolog 1, scribble cell polarity complex component; discs, large homolog 1; disks large homolog 1; Dlgh1; Drosophila discs-large tumor suppressor homologue (synapse associated protein); SAP-97; SAP97; synapse-associated protein 97
Homo sapiens (human) : DLG1 (discs large MAGUK scaffold protein 1)  HGNC  Alliance
Mus musculus (house mouse) : Dlg1 (discs large MAGUK scaffold protein 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dlg1 (discs large MAGUK scaffold protein 1)
Pan paniscus (bonobo/pygmy chimpanzee) : DLG1 (discs large MAGUK scaffold protein 1)
Canis lupus familiaris (dog) : DLG1 (discs large MAGUK scaffold protein 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dlg1 (discs large MAGUK scaffold protein 1)
Sus scrofa (pig) : DLG1 (discs large MAGUK scaffold protein 1)
Chlorocebus sabaeus (African green monkey) : DLG1 (discs large MAGUK scaffold protein 1)
Heterocephalus glaber (naked mole-rat) : Dlg1 (discs large MAGUK scaffold protein 1)
more info ...
Allele / Splice: Dlg1Tn(sb-T2/Bart3)2.133Mcwi  
Genetic Models: F344-Dlg1Tn(sb-T2/Bart3)2.133Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01172,164,566 - 72,378,895 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1172,163,749 - 72,378,895 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01175,239,783 - 75,349,409 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01175,389,409 - 75,454,358 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41170,735,283 - 70,930,374 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11170,792,871 - 70,987,963 (-)NCBI
Celera1168,335,260 - 68,524,109 (-)NCBICelera
Cytogenetic Map11q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Dlg1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2505
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-10-06
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.