Dlg1 (discs large MAGUK scaffold protein 1) - Rat Genome Database

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Gene: Dlg1 (discs large MAGUK scaffold protein 1) Rattus norvegicus
Analyze
Symbol: Dlg1
Name: discs large MAGUK scaffold protein 1
RGD ID: 2505
Description: Enables several functions, including PDZ domain binding activity; ionotropic glutamate receptor binding activity; and kinesin binding activity. Involved in several processes, including cell adhesion; neurotransmitter receptor localization to postsynaptic specialization membrane; and positive regulation of potassium ion transport. Located in several cellular components, including basolateral plasma membrane; lateral plasma membrane; and postsynaptic density, intracellular component. Is active in glutamatergic synapse. Biomarker of Parkinson's disease. Human ortholog(s) of this gene implicated in invasive ductal carcinoma. Orthologous to human DLG1 (discs large MAGUK scaffold protein 1); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; INTERACTS WITH 6-propyl-2-thiouracil; aflatoxin B1; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: discs large homolog 1; discs large homolog 1, scribble cell polarity complex component; discs, large homolog 1; disks large homolog 1; Dlgh1; Drosophila discs-large tumor suppressor homologue (synapse associated protein); SAP-97; SAP97; synapse-associated protein 97
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Dlg1Tn(sb-T2/Bart3)2.133Mcwi  
Genetic Models: F344-Dlg1Tn(sb-T2/Bart3)2.133Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21168,911,883 - 69,103,230 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1168,911,883 - 69,102,689 (-)Ensembl
Rnor_6.01172,164,566 - 72,378,895 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1172,163,749 - 72,378,895 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01175,389,409 - 75,454,358 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01175,239,783 - 75,349,409 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41170,735,283 - 70,930,374 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11170,792,871 - 70,987,963 (-)NCBI
Celera1168,335,260 - 68,524,109 (-)NCBICelera
Cytogenetic Map11q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid  (ISO)
Aroclor 1254  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP)
bisphenol F  (ISO)
Brodifacoum  (EXP)
Butylparaben  (EXP)
cadmium dichloride  (ISO)
calcidiol  (EXP)
carbon nanotube  (ISO)
chlorpyrifos  (EXP)
cobalt dichloride  (ISO)
cyclosporin A  (ISO)
DDE  (EXP)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dibutyl phthalate  (EXP)
dioxygen  (ISO)
dizocilpine maleate  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
enzacamene  (EXP)
epoxiconazole  (EXP)
ethanol  (ISO)
finasteride  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
geldanamycin  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
irinotecan  (ISO)
ivermectin  (ISO)
linuron  (EXP)
methapyrilene  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
nicotinamide  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
oxidopamine  (EXP)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pioglitazone  (ISO)
poly(I:C)  (EXP)
potassium chromate  (ISO)
prochloraz  (EXP)
procymidone  (EXP)
quercetin  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
sodium arsenite  (ISO)
sulforaphane  (EXP)
sulindac  (EXP)
teprenone  (ISO)
tert-butyl hydroperoxide  (ISO)
theophylline  (ISO)
thimerosal  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin filament organization  (IEA,ISO,ISS)
activation of protein kinase activity  (IEA,ISO)
amyloid precursor protein metabolic process  (IEA,ISO)
astral microtubule organization  (IEA,ISO)
bicellular tight junction assembly  (IEA,ISO)
branching involved in ureteric bud morphogenesis  (IEA,ISO)
cell adhesion  (IEP)
cell-cell adhesion  (IBA,IEA,ISO,ISS)
cellular protein-containing complex localization  (IEA,ISO)
chemical synaptic transmission  (IBA)
cortical actin cytoskeleton organization  (IEA,ISO,ISS)
cortical microtubule organization  (IEA,ISO)
embryonic skeletal system morphogenesis  (IEA,ISO)
endothelial cell proliferation  (IEA,ISO,ISS)
establishment of centrosome localization  (IEA,ISO)
establishment or maintenance of epithelial cell apical/basal polarity  (IBA)
hard palate development  (IEA,ISO)
immunological synapse formation  (IEA,ISO)
lens development in camera-type eye  (IEA,ISO)
maintenance of postsynaptic density structure  (IEA)
membrane raft organization  (IEA,ISO)
negative regulation of epithelial cell proliferation  (IEA,ISO)
negative regulation of ERK1 and ERK2 cascade  (IEA,ISO)
negative regulation of G1/S transition of mitotic cell cycle  (IEA,ISO,ISS)
negative regulation of p38MAPK cascade  (IEA,ISO)
negative regulation of protein kinase B signaling  (IEA,ISO)
negative regulation of T cell proliferation  (IEA,ISO)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
neurotransmitter receptor localization to postsynaptic specialization membrane  (IBA,IDA,IEA,IMP,ISO)
peristalsis  (IEA,ISO)
positive regulation of actin filament polymerization  (IEA,ISO)
positive regulation of cell population proliferation  (IEA,ISO)
positive regulation of potassium ion transport  (IEA,IMP,ISO)
positive regulation of protein localization to plasma membrane  (IEA,ISO)
protein localization  (ISO)
protein localization to plasma membrane  (IEA,ISO)
receptor clustering  (IBA)
receptor localization to synapse  (IBA)
regulation of cell shape  (IEA,ISO)
regulation of membrane potential  (ISO)
regulation of myelination  (IEA,ISO)
regulation of NIK/NF-kappaB signaling  (ISO)
regulation of potassium ion export across plasma membrane  (IEA,ISO)
regulation of potassium ion import  (IEA,ISO)
regulation of protein localization  (IMP)
regulation of protein localization to synapse  (IEA,ISO)
regulation of ventricular cardiac muscle cell action potential  (IEA,ISO)
regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization  (IEA,ISO)
reproductive structure development  (IEA,ISO)
smooth muscle tissue development  (IEA,ISO)
T cell activation  (IEA,ISO)
tissue morphogenesis  (ISO)
ureteric bud development  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway  (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
calcium/calmodulin dependent kinase 2 signaling pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
E-cadherin signaling pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
T cell receptor signaling pathway  (IEA)
timolol pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References

References - curated
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4. Brenman JE, etal., J Neurosci. 1998 Nov 1;18(21):8805-13.
5. Cai C, etal., J Biol Chem 2002 Aug 30;277(35):31484-90.
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7. Coultrap SJ and Bayer KU, Trends Neurosci. 2012 Oct;35(10):607-18. doi: 10.1016/j.tins.2012.05.003. Epub 2012 Jun 19.
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16. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
17. GOA data from the GO Consortium
18. Kim K, etal., EMBO J. 2009 Apr 22;28(8):1170-9. doi: 10.1038/emboj.2009.44. Epub 2009 Feb 19.
19. Lee SS, etal., Proc Natl Acad Sci U S A. 1997 Jun 24;94(13):6670-5.
20. Leonoudakis D, etal., J Biol Chem 2004 Apr 30;279(18):19051-63. Epub 2004 Feb 11.
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22. Leonoudakis D, etal., J Cell Sci. 2001 Mar;114(Pt 5):987-98.
23. Mantovani F and Banks L, J Biol Chem. 2003 Oct 24;278(43):42477-86. Epub 2003 Aug 5.
24. Marcello E, etal., J Neurosci. 2007 Feb 14;27(7):1682-91.
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27. Matsumoto M, etal., FEBS Lett. 2012 Nov 2;586(21):3805-12. doi: 10.1016/j.febslet.2012.09.018. Epub 2012 Sep 25.
28. MGD data from the GO Consortium
29. Milstein ML, etal., Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):E2134-43. doi: 10.1073/pnas.1109370109. Epub 2012 Apr 16.
30. Mok H, etal., J Neurosci. 2002 Jul 1;22(13):5253-8.
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32. Nash JE, etal., FASEB J. 2005 Apr;19(6):583-5. Epub 2005 Feb 9.
33. NCBI rat LocusLink and RefSeq merged data July 26, 2002
34. Noseda R, etal., PLoS Biol. 2016 Apr 12;14(4):e1002440. doi: 10.1371/journal.pbio.1002440. eCollection 2016 Apr.
35. Pipeline to import KEGG annotations from KEGG into RGD
36. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
37. Pipeline to import SMPDB annotations from SMPDB into RGD
38. RGD automated data pipeline
39. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
40. RGD automated import pipeline for gene-chemical interactions
41. Rumbaugh G, etal., J Neurosci. 2003 Jun 1;23(11):4567-76.
42. Sussman HM, etal., J Speech Hear Res. 1975 Mar;18(1):74-81.
43. Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
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Additional References at PubMed
PMID:8601796   PMID:8922391   PMID:9341123   PMID:9674605   PMID:10646847   PMID:10656683   PMID:10779557   PMID:10939335   PMID:11238884   PMID:12050163   PMID:12351654   PMID:12857860  
PMID:12970345   PMID:14596909   PMID:14645510   PMID:14681019   PMID:14699157   PMID:15263016   PMID:15277200   PMID:15673434   PMID:15699074   PMID:15729360   PMID:16105026   PMID:16495462  
PMID:16621792   PMID:16815335   PMID:16882004   PMID:17172448   PMID:17187070   PMID:17237226   PMID:17332497   PMID:17335044   PMID:17435047   PMID:17724087   PMID:18004877   PMID:19357261  
PMID:19620977   PMID:19632332   PMID:19633205   PMID:19836928   PMID:19858198   PMID:20133708   PMID:20237282   PMID:20448149   PMID:20458337   PMID:20530486   PMID:20551903   PMID:20625331  
PMID:20865734   PMID:21164104   PMID:21615688   PMID:21768261   PMID:21920314   PMID:22242544   PMID:22718765   PMID:22871113   PMID:23038739   PMID:23460828   PMID:23576434   PMID:23676497  
PMID:23696820   PMID:24191021   PMID:25447080   PMID:25468996   PMID:25701814   PMID:26149358   PMID:29476059   PMID:30067285  


Genomics

Comparative Map Data
Dlg1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21168,911,883 - 69,103,230 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1168,911,883 - 69,102,689 (-)Ensembl
Rnor_6.01172,164,566 - 72,378,895 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1172,163,749 - 72,378,895 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01175,389,409 - 75,454,358 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01175,239,783 - 75,349,409 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41170,735,283 - 70,930,374 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11170,792,871 - 70,987,963 (-)NCBI
Celera1168,335,260 - 68,524,109 (-)NCBICelera
Cytogenetic Map11q22NCBI
DLG1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl3197,042,560 - 197,299,330 (-)EnsemblGRCh38hg38GRCh38
GRCh383197,042,560 - 197,299,321 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh373196,769,431 - 197,026,192 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363198,253,828 - 198,509,844 (-)NCBINCBI36hg18NCBI36
Build 343198,259,732 - 198,513,757NCBI
Celera3195,354,807 - 195,610,760 (-)NCBI
Cytogenetic Map3q29NCBI
HuRef3194,068,872 - 194,324,699 (-)NCBIHuRef
CHM1_13196,740,135 - 196,996,273 (-)NCBICHM1_1
Dlg1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391631,482,261 - 31,692,174 (+)NCBIGRCm39mm39
GRCm39 Ensembl1631,482,261 - 31,693,947 (+)Ensembl
GRCm381631,663,443 - 31,873,356 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1631,663,443 - 31,875,129 (+)EnsemblGRCm38mm10GRCm38
MGSCv371631,664,125 - 31,873,432 (+)NCBIGRCm37mm9NCBIm37
MGSCv361631,583,786 - 31,793,093 (+)NCBImm8
Celera1632,162,337 - 32,367,214 (+)NCBICelera
Cytogenetic Map16B2NCBI
cM Map1622.4NCBI
Dlg1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542013,068,289 - 13,273,805 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542013,068,289 - 13,273,805 (-)NCBIChiLan1.0ChiLan1.0
DLG1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13204,319,410 - 204,586,232 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3204,323,724 - 204,584,987 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v03194,386,263 - 194,648,015 (-)NCBIMhudiblu_PPA_v0panPan3
DLG1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13330,016,323 - 30,253,180 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3330,016,600 - 30,253,547 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3330,039,726 - 30,276,522 (-)NCBI
ROS_Cfam_1.03330,264,744 - 30,502,044 (-)NCBI
UMICH_Zoey_3.13330,059,072 - 30,295,858 (-)NCBI
UNSW_CanFamBas_1.03330,096,091 - 30,333,239 (-)NCBI
UU_Cfam_GSD_1.03330,717,286 - 30,954,124 (-)NCBI
Dlg1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602143,094,725 - 143,350,067 (-)NCBI
SpeTri2.0NW_004936833551,989 - 843,064 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DLG1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13132,820,870 - 133,086,843 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113132,819,931 - 133,084,880 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213142,336,324 - 142,629,113 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DLG1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11589,937,900 - 90,214,976 (+)NCBI
ChlSab1.1 Ensembl1590,055,964 - 90,215,652 (+)Ensembl
Vero_WHO_p1.0NW_02366604163,711,831 - 63,988,641 (+)NCBI
Dlg1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473062,001,547 - 62,223,098 (-)NCBI

Position Markers
AW530915  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21089,702,043 - 89,702,208 (+)MAPPERmRatBN7.2
mRatBN7.21168,946,213 - 68,946,378 (-)MAPPERmRatBN7.2
mRatBN7.21089,702,043 - 89,702,208 (-)MAPPERmRatBN7.2
mRatBN7.21168,946,213 - 68,946,378 (+)MAPPERmRatBN7.2
Rnor_6.01092,916,666 - 92,916,830NCBIRnor6.0
Rnor_6.01172,208,294 - 72,208,458NCBIRnor6.0
Rnor_5.01175,283,122 - 75,283,286UniSTSRnor5.0
Rnor_5.01092,675,244 - 92,675,408UniSTSRnor5.0
RGSC_v3.41094,120,433 - 94,120,597UniSTSRGSC3.4
RGSC_v3.41170,769,193 - 70,769,357UniSTSRGSC3.4
Celera1168,368,229 - 68,368,393UniSTS
Celera1088,387,767 - 88,387,931UniSTS
Cytogenetic Map11q22UniSTS
BE109290  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21168,953,570 - 68,953,725 (+)MAPPERmRatBN7.2
Rnor_6.01172,215,651 - 72,215,805NCBIRnor6.0
Rnor_5.01175,290,479 - 75,290,633UniSTSRnor5.0
RGSC_v3.41170,776,550 - 70,776,704UniSTSRGSC3.4
Celera1168,375,585 - 68,375,739UniSTS
RH 3.4 Map11405.0UniSTS
Cytogenetic Map11q22UniSTS
RH138276  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21168,961,352 - 68,961,486 (+)MAPPERmRatBN7.2
Rnor_6.01172,223,456 - 72,223,589NCBIRnor6.0
Rnor_5.01175,298,284 - 75,298,417UniSTSRnor5.0
RGSC_v3.41170,784,355 - 70,784,488UniSTSRGSC3.4
Celera1168,382,733 - 68,382,866UniSTS
RH 3.4 Map11402.7UniSTS
Cytogenetic Map11q22UniSTS
AU049047  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21168,959,734 - 68,959,945 (+)MAPPERmRatBN7.2
Rnor_6.01172,221,840 - 72,222,048NCBIRnor6.0
Rnor_5.01175,296,668 - 75,296,876UniSTSRnor5.0
RGSC_v3.41170,782,739 - 70,782,947UniSTSRGSC3.4
Celera1168,381,104 - 68,381,325UniSTS
Cytogenetic Map11q22UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11169446234Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)113123913478851519Rat
70180BpQTLcluster10Blood pressure QTL cluster 103.19arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)113491804179918041Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)114094618882566702Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)114428575982566702Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
4889859Pur28Proteinuria QTL 2819.50.001total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)114545932375190161Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)115445753486241447Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)115513672982993457Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)115635142486241447Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)115980279482566545Rat
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)115980279482566553Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)116034659086241447Rat
1549848Bvd6Brain ventricular dilatation QTL 63.10.0001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)116611332182169223Rat
634339Niddm50Non-insulin dependent diabetes mellitus QTL 503.32blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)116642214886241447Rat
1354593Stl12Serum triglyceride level QTL 123.36blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)116642214886241447Rat


Genetic Models
This gene Dlg1 is modified in the following models/strains
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:39
Count of miRNA genes:38
Interacting mature miRNAs:39
Transcripts:ENSRNOT00000058885
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 41 54 38 19 38 8 10 74 35 35 11 8
Low 2 3 3 3 1 6
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001393734 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_012788 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088022 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088023 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088024 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088025 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005490974 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005490975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005490976 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005490977 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH473967 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211533 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213556 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000222 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U14950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000058885   ⟹   ENSRNOP00000055672
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1168,913,345 - 69,102,689 (-)Ensembl
Rnor_6.0 Ensembl1172,164,566 - 72,378,895 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000078737   ⟹   ENSRNOP00000071898
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1168,911,883 - 69,102,545 (-)Ensembl
Rnor_6.0 Ensembl1172,163,749 - 72,378,718 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000102386   ⟹   ENSRNOP00000088710
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1168,911,883 - 69,102,545 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000108927   ⟹   ENSRNOP00000097997
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1168,913,345 - 69,029,008 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000109975   ⟹   ENSRNOP00000085582
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1168,911,883 - 69,030,997 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000113230   ⟹   ENSRNOP00000081862
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1168,913,345 - 69,030,997 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000117728   ⟹   ENSRNOP00000091905
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1168,913,345 - 69,102,689 (-)Ensembl
RefSeq Acc Id: NM_012788   ⟹   NP_036920
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21168,913,344 - 69,102,803 (-)NCBI
Rnor_6.01172,164,566 - 72,378,895 (-)NCBI
Rnor_5.01175,239,783 - 75,349,409 (-)NCBI
Rnor_5.01175,389,409 - 75,454,358 (-)NCBI
RGSC_v3.41170,735,283 - 70,930,374 (-)RGD
Celera1168,335,260 - 68,524,109 (-)RGD
Sequence:
RefSeq Acc Id: XM_039088001   ⟹   XP_038943929
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21168,911,883 - 69,102,311 (-)NCBI
RefSeq Acc Id: XM_039088002   ⟹   XP_038943930
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21168,911,883 - 69,102,340 (-)NCBI
RefSeq Acc Id: XM_039088003   ⟹   XP_038943931
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21168,911,883 - 69,102,311 (-)NCBI
RefSeq Acc Id: XM_039088004   ⟹   XP_038943932
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21168,911,883 - 69,102,311 (-)NCBI
RefSeq Acc Id: XM_039088005   ⟹   XP_038943933
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21168,911,883 - 69,102,311 (-)NCBI
RefSeq Acc Id: XM_039088006   ⟹   XP_038943934
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21168,911,883 - 69,102,342 (-)NCBI
RefSeq Acc Id: XM_039088007   ⟹   XP_038943935
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21168,911,883 - 69,102,311 (-)NCBI
RefSeq Acc Id: XM_039088008   ⟹   XP_038943936
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21168,911,883 - 69,102,311 (-)NCBI
RefSeq Acc Id: XM_039088009   ⟹   XP_038943937
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21168,911,883 - 69,102,311 (-)NCBI
RefSeq Acc Id: XM_039088010   ⟹   XP_038943938
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21168,911,883 - 69,102,311 (-)NCBI
RefSeq Acc Id: XM_039088011   ⟹   XP_038943939
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21168,911,883 - 69,102,311 (-)NCBI
RefSeq Acc Id: XM_039088012   ⟹   XP_038943940
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21168,911,883 - 69,102,311 (-)NCBI
RefSeq Acc Id: XM_039088013   ⟹   XP_038943941
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21168,911,883 - 69,102,311 (-)NCBI
RefSeq Acc Id: XM_039088014   ⟹   XP_038943942
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21168,911,883 - 69,102,311 (-)NCBI
RefSeq Acc Id: XM_039088015   ⟹   XP_038943943
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21168,911,883 - 69,102,311 (-)NCBI
RefSeq Acc Id: XM_039088016   ⟹   XP_038943944
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21168,911,883 - 69,102,311 (-)NCBI
RefSeq Acc Id: XM_039088017   ⟹   XP_038943945
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21168,911,883 - 69,102,518 (-)NCBI
RefSeq Acc Id: XM_039088018   ⟹   XP_038943946
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21168,911,883 - 69,103,230 (-)NCBI
RefSeq Acc Id: XM_039088019   ⟹   XP_038943947
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21168,911,883 - 69,029,619 (-)NCBI
RefSeq Acc Id: XM_039088020   ⟹   XP_038943948
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21168,911,883 - 69,076,406 (-)NCBI
RefSeq Acc Id: XM_039088021   ⟹   XP_038943949
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21168,911,883 - 69,029,616 (-)NCBI
RefSeq Acc Id: XM_039088022   ⟹   XP_038943950
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21168,911,883 - 69,029,615 (-)NCBI
RefSeq Acc Id: XM_039088023   ⟹   XP_038943951
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21168,911,883 - 69,029,613 (-)NCBI
RefSeq Acc Id: XM_039088024   ⟹   XP_038943952
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21168,911,883 - 69,029,613 (-)NCBI
RefSeq Acc Id: XM_039088025   ⟹   XP_038943953
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21168,911,883 - 69,029,610 (-)NCBI
RefSeq Acc Id: XR_005490974
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21168,927,780 - 69,102,342 (-)NCBI
RefSeq Acc Id: XR_005490975
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21168,928,674 - 69,102,342 (-)NCBI
RefSeq Acc Id: XR_005490976
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21168,928,661 - 69,102,342 (-)NCBI
RefSeq Acc Id: XR_005490977
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21168,927,291 - 69,102,344 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001380663 (Get FASTA)   NCBI Sequence Viewer  
  NP_036920 (Get FASTA)   NCBI Sequence Viewer  
  XP_038943929 (Get FASTA)   NCBI Sequence Viewer  
  XP_038943930 (Get FASTA)   NCBI Sequence Viewer  
  XP_038943931 (Get FASTA)   NCBI Sequence Viewer  
  XP_038943932 (Get FASTA)   NCBI Sequence Viewer  
  XP_038943933 (Get FASTA)   NCBI Sequence Viewer  
  XP_038943934 (Get FASTA)   NCBI Sequence Viewer  
  XP_038943935 (Get FASTA)   NCBI Sequence Viewer  
  XP_038943936 (Get FASTA)   NCBI Sequence Viewer  
  XP_038943937 (Get FASTA)   NCBI Sequence Viewer  
  XP_038943938 (Get FASTA)   NCBI Sequence Viewer  
  XP_038943939 (Get FASTA)   NCBI Sequence Viewer  
  XP_038943940 (Get FASTA)   NCBI Sequence Viewer  
  XP_038943941 (Get FASTA)   NCBI Sequence Viewer  
  XP_038943942 (Get FASTA)   NCBI Sequence Viewer  
  XP_038943943 (Get FASTA)   NCBI Sequence Viewer  
  XP_038943944 (Get FASTA)   NCBI Sequence Viewer  
  XP_038943945 (Get FASTA)   NCBI Sequence Viewer  
  XP_038943946 (Get FASTA)   NCBI Sequence Viewer  
  XP_038943947 (Get FASTA)   NCBI Sequence Viewer  
  XP_038943948 (Get FASTA)   NCBI Sequence Viewer  
  XP_038943949 (Get FASTA)   NCBI Sequence Viewer  
  XP_038943950 (Get FASTA)   NCBI Sequence Viewer  
  XP_038943951 (Get FASTA)   NCBI Sequence Viewer  
  XP_038943952 (Get FASTA)   NCBI Sequence Viewer  
  XP_038943953 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA79976 (Get FASTA)   NCBI Sequence Viewer  
  EDM11457 (Get FASTA)   NCBI Sequence Viewer  
  EDM11458 (Get FASTA)   NCBI Sequence Viewer  
  EDM11459 (Get FASTA)   NCBI Sequence Viewer  
  EDM11460 (Get FASTA)   NCBI Sequence Viewer  
  EDM11461 (Get FASTA)   NCBI Sequence Viewer  
  EDM11462 (Get FASTA)   NCBI Sequence Viewer  
  Q62696 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_036920   ⟸   NM_012788
- Sequence:
RefSeq Acc Id: ENSRNOP00000055672   ⟸   ENSRNOT00000058885
RefSeq Acc Id: ENSRNOP00000071898   ⟸   ENSRNOT00000078737
RefSeq Acc Id: XP_038943946   ⟸   XM_039088018
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038943945   ⟸   XM_039088017
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038943934   ⟸   XM_039088006
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038943930   ⟸   XM_039088002
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038943944   ⟸   XM_039088016
- Peptide Label: isoform X16
RefSeq Acc Id: XP_038943943   ⟸   XM_039088015
- Peptide Label: isoform X15
RefSeq Acc Id: XP_038943942   ⟸   XM_039088014
- Peptide Label: isoform X14
RefSeq Acc Id: XP_038943941   ⟸   XM_039088013
- Peptide Label: isoform X13
RefSeq Acc Id: XP_038943940   ⟸   XM_039088012
- Peptide Label: isoform X12
RefSeq Acc Id: XP_038943938   ⟸   XM_039088010
- Peptide Label: isoform X10
RefSeq Acc Id: XP_038943936   ⟸   XM_039088008
- Peptide Label: isoform X8
RefSeq Acc Id: XP_038943939   ⟸   XM_039088011
- Peptide Label: isoform X11
RefSeq Acc Id: XP_038943937   ⟸   XM_039088009
- Peptide Label: isoform X9
RefSeq Acc Id: XP_038943935   ⟸   XM_039088007
- Peptide Label: isoform X7
RefSeq Acc Id: XP_038943933   ⟸   XM_039088005
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038943932   ⟸   XM_039088004
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038943931   ⟸   XM_039088003
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038943929   ⟸   XM_039088001
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038943948   ⟸   XM_039088020
- Peptide Label: isoform X18
RefSeq Acc Id: XP_038943947   ⟸   XM_039088019
- Peptide Label: isoform X17
RefSeq Acc Id: XP_038943949   ⟸   XM_039088021
- Peptide Label: isoform X19
RefSeq Acc Id: XP_038943950   ⟸   XM_039088022
- Peptide Label: isoform X20
RefSeq Acc Id: XP_038943952   ⟸   XM_039088024
- Peptide Label: isoform X22
RefSeq Acc Id: XP_038943951   ⟸   XM_039088023
- Peptide Label: isoform X21
RefSeq Acc Id: XP_038943953   ⟸   XM_039088025
- Peptide Label: isoform X23
RefSeq Acc Id: ENSRNOP00000081862   ⟸   ENSRNOT00000113230
RefSeq Acc Id: ENSRNOP00000088710   ⟸   ENSRNOT00000102386
RefSeq Acc Id: ENSRNOP00000085582   ⟸   ENSRNOT00000109975
RefSeq Acc Id: ENSRNOP00000097997   ⟸   ENSRNOT00000108927
RefSeq Acc Id: ENSRNOP00000091905   ⟸   ENSRNOT00000117728
Protein Domains
Guanylate kinase-like   L27   PDZ   SH3

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698221
Promoter ID:EPDNEW_R8744
Type:single initiation site
Name:Dlg1_1
Description:discs large MAGUK scaffold protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01172,378,806 - 72,378,866EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN-Lx/CubMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BUF/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
DA/OlaHsd (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
F344/Stm (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FXLE16/Stm (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/FarMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
HXB10/IpcvMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEXF10A/StmMcwi (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrcAek (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrcAek (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrcAek (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
M520/NRrrcMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MWF/Hsd (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/OlalpcvMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/RijCrl (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2505 AgrOrtholog
Ensembl Genes ENSRNOG00000038597 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000055672 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000071898 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000058885 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000078737 UniProtKB/TrEMBL
Gene3D-CATH 2.30.42.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro DLG1-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DLG1_PEST_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GK/Ca_channel_bsu UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Guanylate_kin-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Guanylate_kinase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  L27_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  L27_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  L27_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ_assoc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25252 UniProtKB/Swiss-Prot
NCBI Gene 25252 ENTREZGENE
Pfam Guanylate_kin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  L27_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAGUK_N_PEST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ_assoc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Dlg1 PhenoGen
PIRSF MAGUK_DLGH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE GUANYLATE_KINASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GUANYLATE_KINASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  L27 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART GuKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  L27 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAGUK_N_PEST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF101288 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50044 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50156 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC205414
UniProt A0A0G2K1M2_RAT UniProtKB/TrEMBL
  DLG1_RAT UniProtKB/Swiss-Prot
  F1LNM0_RAT UniProtKB/TrEMBL
  Q62696 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-15 Dlg1  discs, large homolog 1 (Drosophila)  Dlgh1  discs, large homolog 1 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Dlgh1  discs, large homolog 1 (Drosophila)  Dlg1  Drosophila discs-large tumor suppressor homologue (synapse associated protein)  Name updated 625702 APPROVED
2002-06-10 Dlg1  Drosophila discs-large tumor suppressor homologue (synapse associated protein)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized in presynaptic nerve termini of excitatory synapses in the hypocampus at unmyelinated axons and at sites of contact among epithelial cells 1298878
gene_cellular_localization localized to and along bundles of unmyelinated axons at cytoplasmic surfaces of plasma membranes 1298878
gene_cellular_localization co-localizes with both ionotropic glutamate receptors (nucleus) and such downstream signaling proteins as Ca2+/calmodulin-dependent protein kinase II (CaMKII) 1298879
gene_expression may provide synaptic targeting for NMDA receptors 1298879
gene_homology has high similarity to rat sap90 1298878
gene_physical_interaction binds to the NR2A subunit of the NMDA receptor in its unphosphorylated form 1298879
gene_process may participate in cell adhesion and function in site-specific cellular activities 1298878
gene_process targets ionotropic glutamate receptors at postsynaptic sites 1298879
gene_product member of membrane-associated guanylate kinase protein family 1298879
gene_regulation phosphorylated by CaMKII via N-methyl-D-aspartic acid (NMDA) receptor activation 1298879