Dlg1 (discs large MAGUK scaffold protein 1) - Rat Genome Database
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Gene: Dlg1 (discs large MAGUK scaffold protein 1) Rattus norvegicus
Analyze
Symbol: Dlg1
Name: discs large MAGUK scaffold protein 1
RGD ID: 2505
Description: Exhibits several functions, including PDZ domain binding activity; ionotropic glutamate receptor binding activity; and kinesin binding activity. Involved in several processes, including cell adhesion; neurotransmitter receptor localization to postsynaptic specialization membrane; and positive regulation of potassium ion transport. Localizes to several cellular components, including basal plasma membrane; paranode region of axon; and postsynaptic density, intracellular component. Predicted to colocalize with ionotropic glutamate receptor complex. Biomarker of Parkinson's disease. Human ortholog(s) of this gene implicated in invasive ductal carcinoma. Orthologous to human DLG1 (discs large MAGUK scaffold protein 1); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; INTERACTS WITH 6-propyl-2-thiouracil; aflatoxin B1; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: discs large homolog 1; discs large homolog 1, scribble cell polarity complex component; discs, large homolog 1; disks large homolog 1; Dlgh1; Drosophila discs-large tumor suppressor homologue (synapse associated protein); SAP-97; SAP97; synapse-associated protein 97
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Dlg1Tn(sb-T2/Bart3)2.133Mcwi  
Genetic Models: F344-Dlg1Tn(sb-T2/Bart3)2.133Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01172,164,566 - 72,378,895 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1172,163,749 - 72,378,895 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01175,239,783 - 75,349,409 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01175,389,409 - 75,454,358 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41170,735,283 - 70,930,374 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11170,792,871 - 70,987,963 (-)NCBI
Celera1168,335,260 - 68,524,109 (-)NCBICelera
Cytogenetic Map11q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
Aroclor 1254  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP)
bisphenol F  (ISO)
Brodifacoum  (EXP)
Butylparaben  (EXP)
cadmium dichloride  (ISO)
calcidiol  (EXP)
carbon nanotube  (ISO)
chlorpyrifos  (EXP)
cobalt dichloride  (ISO)
cyclosporin A  (ISO)
DDE  (EXP)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dibutyl phthalate  (EXP)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
enzacamene  (EXP)
epoxiconazole  (EXP)
ethanol  (ISO)
finasteride  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
geldanamycin  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
irinotecan  (ISO)
linuron  (EXP)
methapyrilene  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
nicotinamide  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
oxidopamine  (EXP)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pioglitazone  (ISO)
poly(I:C)  (EXP)
potassium chromate  (ISO)
prochloraz  (EXP)
procymidone  (EXP)
quercetin  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
sodium arsenite  (ISO)
sulforaphane  (EXP)
sulindac  (EXP)
teprenone  (ISO)
tert-butyl hydroperoxide  (ISO)
theophylline  (ISO)
thimerosal  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin filament organization  (IEA,ISO,ISS)
activation of protein kinase activity  (IEA,ISO)
amyloid precursor protein metabolic process  (IEA,ISO)
astral microtubule organization  (IEA,ISO)
bicellular tight junction assembly  (IEA,ISO)
branching involved in ureteric bud morphogenesis  (IEA,ISO)
cell adhesion  (IEP)
cell-cell adhesion  (IBA,IEA,ISO,ISS)
cellular protein-containing complex localization  (IEA,ISO)
chemical synaptic transmission  (IBA)
cortical actin cytoskeleton organization  (IEA,ISO,ISS)
cortical microtubule organization  (IEA,ISO)
embryonic skeletal system morphogenesis  (IEA,ISO)
endothelial cell proliferation  (IEA,ISO,ISS)
establishment of centrosome localization  (IEA,ISO)
establishment or maintenance of epithelial cell apical/basal polarity  (IBA)
hard palate development  (IEA,ISO)
immunological synapse formation  (IEA,ISO)
lens development in camera-type eye  (IEA,ISO)
maintenance of postsynaptic density structure  (IEA)
membrane raft organization  (IEA,ISO)
negative regulation of epithelial cell proliferation  (IEA,ISO)
negative regulation of ERK1 and ERK2 cascade  (IEA,ISO)
negative regulation of G1/S transition of mitotic cell cycle  (IEA,ISO,ISS)
negative regulation of p38MAPK cascade  (IEA,ISO)
negative regulation of protein kinase B signaling  (IEA,ISO)
negative regulation of T cell proliferation  (IEA,ISO)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
neurotransmitter receptor localization to postsynaptic specialization membrane  (IBA,IDA,IEA,IMP,ISO)
peristalsis  (IEA,ISO)
positive regulation of actin filament polymerization  (IEA,ISO)
positive regulation of cell population proliferation  (IEA,ISO)
positive regulation of potassium ion transport  (IEA,IMP,ISO)
positive regulation of protein localization to plasma membrane  (IEA,ISO)
protein localization  (ISO)
protein localization to plasma membrane  (IEA,ISO)
receptor clustering  (IBA)
receptor localization to synapse  (IBA)
regulation of cell shape  (IEA,ISO)
regulation of membrane potential  (ISO)
regulation of myelination  (IEA,ISO)
regulation of NIK/NF-kappaB signaling  (ISO)
regulation of potassium ion export across plasma membrane  (IEA,ISO)
regulation of potassium ion import  (IEA,ISO)
regulation of protein localization  (IMP)
regulation of protein localization to synapse  (IEA,ISO)
regulation of ventricular cardiac muscle cell action potential  (IEA,ISO)
regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization  (IEA,ISO)
reproductive structure development  (IEA,ISO)
smooth muscle tissue development  (IEA,ISO)
T cell activation  (IEA,ISO)
tissue morphogenesis  (ISO)
ureteric bud development  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway  (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
calcium/calmodulin dependent kinase 2 signaling pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
E-cadherin signaling pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
T cell receptor signaling pathway  (IEA)
timolol pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References

References - curated
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8. DeGiorgis JA, etal., Brain Cell Biol. 2006 Dec;35(4-6):239-50. Epub 2008 Apr 5.
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15. Gardoni F, etal., J Neurosci. 2006 Mar 15;26(11):2914-22.
16. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
17. GOA data from the GO Consortium
18. Kim K, etal., EMBO J. 2009 Apr 22;28(8):1170-9. doi: 10.1038/emboj.2009.44. Epub 2009 Feb 19.
19. Lee SS, etal., Proc Natl Acad Sci U S A. 1997 Jun 24;94(13):6670-5.
20. Leonoudakis D, etal., J Biol Chem 2004 Apr 30;279(18):19051-63. Epub 2004 Feb 11.
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22. Leonoudakis D, etal., J Cell Sci. 2001 Mar;114(Pt 5):987-98.
23. Mantovani F and Banks L, J Biol Chem. 2003 Oct 24;278(43):42477-86. Epub 2003 Aug 5.
24. Marcello E, etal., J Neurosci. 2007 Feb 14;27(7):1682-91.
25. Martinez-Turrillas R, etal., Biochem Biophys Res Commun. 2007 Feb 16;353(3):750-5. Epub 2006 Dec 19.
26. Matsumine A, etal., Science. 1996 May 17;272(5264):1020-3. doi: 10.1126/science.272.5264.1020.
27. Matsumoto M, etal., FEBS Lett. 2012 Nov 2;586(21):3805-12. doi: 10.1016/j.febslet.2012.09.018. Epub 2012 Sep 25.
28. MGD data from the GO Consortium
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30. Mok H, etal., J Neurosci. 2002 Jul 1;22(13):5253-8.
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33. NCBI rat LocusLink and RefSeq merged data July 26, 2002
34. Noseda R, etal., PLoS Biol. 2016 Apr 12;14(4):e1002440. doi: 10.1371/journal.pbio.1002440. eCollection 2016 Apr.
35. Pipeline to import KEGG annotations from KEGG into RGD
36. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
37. Pipeline to import SMPDB annotations from SMPDB into RGD
38. RGD automated data pipeline
39. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
40. RGD automated import pipeline for gene-chemical interactions
41. Rumbaugh G, etal., J Neurosci. 2003 Jun 1;23(11):4567-76.
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Additional References at PubMed
PMID:8601796   PMID:8922391   PMID:9341123   PMID:9674605   PMID:10646847   PMID:10656683   PMID:10779557   PMID:10939335   PMID:11238884   PMID:12050163   PMID:12351654   PMID:12857860  
PMID:12970345   PMID:14596909   PMID:14645510   PMID:14681019   PMID:14699157   PMID:15263016   PMID:15277200   PMID:15673434   PMID:15699074   PMID:15729360   PMID:16105026   PMID:16495462  
PMID:16621792   PMID:16815335   PMID:16882004   PMID:17172448   PMID:17187070   PMID:17237226   PMID:17332497   PMID:17335044   PMID:17435047   PMID:17724087   PMID:18004877   PMID:19357261  
PMID:19620977   PMID:19632332   PMID:19633205   PMID:19836928   PMID:19858198   PMID:20133708   PMID:20237282   PMID:20448149   PMID:20458337   PMID:20530486   PMID:20551903   PMID:20625331  
PMID:20865734   PMID:21164104   PMID:21615688   PMID:21768261   PMID:21920314   PMID:22242544   PMID:22718765   PMID:22871113   PMID:23038739   PMID:23460828   PMID:23576434   PMID:23676497  
PMID:23696820   PMID:24191021   PMID:25447080   PMID:25468996   PMID:25701814   PMID:26149358   PMID:29476059   PMID:30067285  


Genomics

Comparative Map Data
Dlg1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01172,164,566 - 72,378,895 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1172,163,749 - 72,378,895 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01175,239,783 - 75,349,409 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01175,389,409 - 75,454,358 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41170,735,283 - 70,930,374 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11170,792,871 - 70,987,963 (-)NCBI
Celera1168,335,260 - 68,524,109 (-)NCBICelera
Cytogenetic Map11q22NCBI
DLG1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl3197,042,560 - 197,299,330 (-)EnsemblGRCh38hg38GRCh38
GRCh383197,042,560 - 197,299,321 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh373196,769,431 - 197,026,171 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363198,253,828 - 198,509,844 (-)NCBINCBI36hg18NCBI36
Build 343198,259,732 - 198,513,757NCBI
Celera3195,354,807 - 195,610,760 (-)NCBI
Cytogenetic Map3q29NCBI
HuRef3194,068,872 - 194,324,699 (-)NCBIHuRef
CHM1_13196,740,135 - 196,996,969 (-)NCBICHM1_1
Dlg1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391631,482,261 - 31,692,174 (+)NCBIGRCm39mm39
GRCm381631,663,443 - 31,873,356 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1631,663,443 - 31,875,129 (+)EnsemblGRCm38mm10GRCm38
MGSCv371631,664,125 - 31,873,432 (+)NCBIGRCm37mm9NCBIm37
MGSCv361631,583,786 - 31,793,093 (+)NCBImm8
Celera1632,162,337 - 32,367,214 (+)NCBICelera
Cytogenetic Map16B2NCBI
cM Map1622.4NCBI
Dlg1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542013,068,289 - 13,273,805 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542013,068,289 - 13,273,805 (-)NCBIChiLan1.0ChiLan1.0
DLG1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13204,319,410 - 204,586,232 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3204,323,724 - 204,584,987 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v03194,386,263 - 194,648,015 (-)NCBIMhudiblu_PPA_v0panPan3
DLG1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl3330,016,600 - 30,253,547 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.13330,016,323 - 30,253,180 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dlg1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936833551,989 - 843,064 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DLG1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13132,820,870 - 133,086,843 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113132,819,931 - 133,084,880 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213142,336,324 - 142,629,113 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DLG1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11589,937,900 - 90,214,976 (+)NCBI
ChlSab1.1 Ensembl1590,055,964 - 90,215,652 (+)Ensembl
Dlg1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473062,001,547 - 62,223,098 (-)NCBI

Position Markers
AW530915  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01092,916,666 - 92,916,830NCBIRnor6.0
Rnor_6.01172,208,294 - 72,208,458NCBIRnor6.0
Rnor_5.01175,283,122 - 75,283,286UniSTSRnor5.0
Rnor_5.01092,675,244 - 92,675,408UniSTSRnor5.0
RGSC_v3.41170,769,193 - 70,769,357UniSTSRGSC3.4
RGSC_v3.41094,120,433 - 94,120,597UniSTSRGSC3.4
Celera1088,387,767 - 88,387,931UniSTS
Celera1168,368,229 - 68,368,393UniSTS
Cytogenetic Map11q22UniSTS
BE109290  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01172,215,651 - 72,215,805NCBIRnor6.0
Rnor_5.01175,290,479 - 75,290,633UniSTSRnor5.0
RGSC_v3.41170,776,550 - 70,776,704UniSTSRGSC3.4
Celera1168,375,585 - 68,375,739UniSTS
Cytogenetic Map11q22UniSTS
RH 3.4 Map11405.0UniSTS
RH138276  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01172,223,456 - 72,223,589NCBIRnor6.0
Rnor_5.01175,298,284 - 75,298,417UniSTSRnor5.0
RGSC_v3.41170,784,355 - 70,784,488UniSTSRGSC3.4
Celera1168,382,733 - 68,382,866UniSTS
Cytogenetic Map11q22UniSTS
RH 3.4 Map11402.7UniSTS
AU049047  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01172,221,840 - 72,222,048NCBIRnor6.0
Rnor_5.01175,296,668 - 75,296,876UniSTSRnor5.0
RGSC_v3.41170,782,739 - 70,782,947UniSTSRGSC3.4
Celera1168,381,104 - 68,381,325UniSTS
Cytogenetic Map11q22UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11172720192Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111901627290463843Rat
10755497Bp388Blood pressure QTL 3882.76arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)111947517979734728Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112831466586994795Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)113043533986714631Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)113215552082443118Rat
70180BpQTLcluster10Blood pressure QTL cluster 103.19arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)113590063480900634Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)114309033886714631Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)114658320986714631Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114726402386994547Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114726402386994547Rat
4889859Pur28Proteinuria QTL 2819.50.001total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)114790104978471527Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)115785881090463843Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)115994302390463843Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)116010984287141948Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)116265336586714475Rat
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)116265336586714483Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)116449467190463843Rat
1549848Bvd6Brain ventricular dilatation QTL 63.10.0001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)116934231986312439Rat
1354593Stl12Serum triglyceride level QTL 123.36blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)116964970890463843Rat


Genetic Models
This gene Dlg1 is modified in the following models/strains
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:39
Count of miRNA genes:38
Interacting mature miRNAs:39
Transcripts:ENSRNOT00000058885
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 41 54 38 19 38 8 10 74 35 35 11 8
Low 2 3 3 3 1 6
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_012788 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AABR07034445 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AABR07034446 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AABR07034447 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AABR07034448 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AABR07034449 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AABR07034450 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AABR07034451 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AABR07034452 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AABR07034453 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01069862 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01069863 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01069864 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01069865 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01069866 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01069867 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473967 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211533 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U14950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000058885   ⟹   ENSRNOP00000055672
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1172,164,566 - 72,378,895 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000078737   ⟹   ENSRNOP00000071898
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1172,163,749 - 72,378,718 (-)Ensembl
RefSeq Acc Id: NM_012788   ⟹   NP_036920
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01172,164,566 - 72,378,895 (-)NCBI
Rnor_5.01175,239,783 - 75,349,409 (-)NCBI
Rnor_5.01175,389,409 - 75,454,358 (-)NCBI
RGSC_v3.41170,735,283 - 70,930,374 (-)RGD
Celera1168,335,260 - 68,524,109 (-)RGD
Sequence:
Reference Sequences
RefSeq Acc Id: NP_036920   ⟸   NM_012788
- UniProtKB: Q62696 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000055672   ⟸   ENSRNOT00000058885
RefSeq Acc Id: ENSRNOP00000071898   ⟸   ENSRNOT00000078737
Protein Domains
Guanylate kinase-like   L27   PDZ   SH3

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698221
Promoter ID:EPDNEW_R8744
Type:single initiation site
Name:Dlg1_1
Description:discs large MAGUK scaffold protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01172,378,806 - 72,378,866EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2505 AgrOrtholog
Ensembl Genes ENSRNOG00000038597 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000055672 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000071898 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000058885 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000078737 UniProtKB/TrEMBL
Gene3D-CATH 2.30.42.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro DLG1-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DLG1_PEST_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GK/Ca_channel_bsu UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Guanylate_kin-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Guanylate_kinase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  L27_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  L27_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  L27_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ_assoc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25252 UniProtKB/Swiss-Prot
NCBI Gene 25252 ENTREZGENE
Pfam Guanylate_kin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  L27_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAGUK_N_PEST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ_assoc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Dlg1 PhenoGen
PIRSF MAGUK_DLGH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE GUANYLATE_KINASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GUANYLATE_KINASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  L27 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART GuKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  L27 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAGUK_N_PEST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF101288 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50044 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50156 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC205414
UniGene Rn.89331 ENTREZGENE
UniProt A0A0G2K1M2_RAT UniProtKB/TrEMBL
  DLG1_RAT UniProtKB/Swiss-Prot
  F1LNM0_RAT UniProtKB/TrEMBL
  Q62696 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-15 Dlg1  discs, large homolog 1 (Drosophila)  Dlgh1  discs, large homolog 1 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Dlgh1  discs, large homolog 1 (Drosophila)  Dlg1  Drosophila discs-large tumor suppressor homologue (synapse associated protein)  Name updated 625702 APPROVED
2002-06-10 Dlg1  Drosophila discs-large tumor suppressor homologue (synapse associated protein)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized in presynaptic nerve termini of excitatory synapses in the hypocampus at unmyelinated axons and at sites of contact among epithelial cells 1298878
gene_cellular_localization localized to and along bundles of unmyelinated axons at cytoplasmic surfaces of plasma membranes 1298878
gene_cellular_localization co-localizes with both ionotropic glutamate receptors (nucleus) and such downstream signaling proteins as Ca2+/calmodulin-dependent protein kinase II (CaMKII) 1298879
gene_expression may provide synaptic targeting for NMDA receptors 1298879
gene_homology has high similarity to rat sap90 1298878
gene_physical_interaction binds to the NR2A subunit of the NMDA receptor in its unphosphorylated form 1298879
gene_process may participate in cell adhesion and function in site-specific cellular activities 1298878
gene_process targets ionotropic glutamate receptors at postsynaptic sites 1298879
gene_product member of membrane-associated guanylate kinase protein family 1298879
gene_regulation phosphorylated by CaMKII via N-methyl-D-aspartic acid (NMDA) receptor activation 1298879