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Gene: Dlg3 (discs large MAGUK scaffold protein 3) Rattus norvegicus
Symbol: Dlg3
Name: discs large MAGUK scaffold protein 3
Description: Exhibits several functions, including PDZ domain binding activity; ionotropic glutamate receptor binding activity; and protein C-terminus binding activity. Involved in positive regulation of protein tyrosine kinase activity. Localizes to several cellular components, including the glutamatergic synapse; neuron projection; and postsynaptic density, intracellular component. Predicted to colocalize with the ionotropic glutamate receptor complex. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability. Orthologous to human DLG3 (discs large MAGUK scaffold protein 3); INTERACTS WITH (+)-schisandrin B; (RS)-amphetamine; 17beta-estradiol.
Type: protein-coding
Also known as: discs large homolog 3; discs, large homolog 3; discs, large homolog 3 (Drosophila); disks large homolog 3; Dlgh3; PSD-95/SAP90-related protein 1; SAP-102; SAP102; synapse-associated protein 102
Homo sapiens (human) : DLG3 (discs large MAGUK scaffold protein 3)  HGNC  Alliance
Mus musculus (house mouse) : Dlg3 (discs large MAGUK scaffold protein 3)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dlg3 (discs large MAGUK scaffold protein 3)
Pan paniscus (bonobo/pygmy chimpanzee) : DLG3 (discs large MAGUK scaffold protein 3)
Canis lupus familiaris (dog) : DLG3 (discs large MAGUK scaffold protein 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dlg3 (discs large MAGUK scaffold protein 3)
Sus scrofa (pig) : DLG3 (discs large MAGUK scaffold protein 3)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0X70,596,246 - 70,648,529 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0X71,468,290 - 71,520,286 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X88,777,585 - 88,828,504 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1X88,851,017 - 88,901,937 (+)NCBI
CeleraX66,218,231 - 66,268,819 (+)NCBICelera
Cytogenetic MapXq22NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Dlg3
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 68423
Created: 2001-07-11
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.