Dlg3 (discs large MAGUK scaffold protein 3) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Dlg3 (discs large MAGUK scaffold protein 3) Rattus norvegicus
Analyze
Symbol: Dlg3
Name: discs large MAGUK scaffold protein 3
RGD ID: 68423
Description: Exhibits several functions, including PDZ domain binding activity; ionotropic glutamate receptor binding activity; and protein C-terminus binding activity. A structural constituent of postsynaptic density. Involved in positive regulation of protein tyrosine kinase activity. Localizes to several cellular components, including dendritic shaft; glutamatergic synapse; and postsynaptic density, intracellular component. Predicted to colocalize with ionotropic glutamate receptor complex. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 90. Orthologous to human DLG3 (discs large MAGUK scaffold protein 3); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 4-[1-hydroxy-2-[4-(phenylmethyl)-1-piperidinyl]propyl]phenol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: discs large homolog 3; discs, large homolog 3; discs, large homolog 3 (Drosophila); disks large homolog 3; Dlgh3; PSD-95/SAP90-related protein 1; SAP-102; SAP102; synapse-associated protein 102
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X65,859,653 - 65,911,887 (+)NCBI
Rnor_6.0 EnsemblX70,596,576 - 70,648,532 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0X70,596,246 - 70,648,529 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0X71,468,290 - 71,520,286 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X88,777,585 - 88,828,504 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1X88,851,017 - 88,901,937 (+)NCBI
CeleraX66,218,231 - 66,268,819 (+)NCBICelera
Cytogenetic MapXq22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

References

References - curated
1. Chen BS, etal., J Biol Chem. 2006 Jun 16;281(24):16583-90. Epub 2006 Apr 10.
2. DeMarco SJ and Strehler EE, J Biol Chem. 2001 Jun 15;276(24):21594-600. Epub 2001 Mar 26.
3. Gardoni F, etal., J Neurosci. 2006 Mar 15;26(11):2914-22.
4. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. GOA data from the GO Consortium
6. Karnak D, etal., J Biol Chem 2002 Nov 29;277(48):46730-5. Epub 2002 Sep 25.
7. Kim K, etal., EMBO J. 2009 Apr 22;28(8):1170-9. doi: 10.1038/emboj.2009.44. Epub 2009 Feb 19.
8. Lau LF, etal., J Biol Chem. 1996 Aug 30;271(35):21622-8.
9. Lee HW, etal., J Neurosci. 2010 Apr 21;30(16):5508-18. doi: 10.1523/JNEUROSCI.4283-09.2010.
10. Leonoudakis D, etal., J Biol Chem. 2004 May 21;279(21):22331-46. Epub 2004 Mar 15.
11. Lim IA, etal., J Biol Chem. 2002 Jun 14;277(24):21697-711. Epub 2002 Apr 5.
12. MGD data from the GO Consortium
13. Muller BM, etal., Neuron. 1996 Aug;17(2):255-65.
14. NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. OMIM Disease Annotation Pipeline
16. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. RGD automated import pipeline for gene-chemical interactions
18. Rockliffe N and Gawler D, FEBS Lett. 2006 Feb 6;580(3):831-8. Epub 2006 Jan 18.
19. Sans N, etal., Nat Cell Biol. 2003 Jun;5(6):520-30.
20. Stathakis DG, etal., Genomics 1998 Apr 15;49(2):310-3.
21. Sussman HM, etal., J Speech Hear Res. 1975 Mar;18(1):74-81.
22. Takeuchi M, etal., J Biol Chem 1997 May 2;272(18):11943-51.
23. Tarpey P, etal., Am J Hum Genet 2004 Jun 7;75(2).
24. Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
25. Tobaben S, etal., J Biol Chem 2000 Nov 17;275(46):36204-10.
26. Wang CY, etal., J Neurosci. 2006 Feb 22;26(8):2174-83.
27. Wu HY, etal., J Biol Chem. 2007 Jul 13;282(28):20075-87. doi: 10.1074/jbc.M700624200. Epub 2007 May 25.
28. Yang J, etal., EMBO J. 2011 Jan 5;30(1):165-80. doi: 10.1038/emboj.2010.286. Epub 2010 Nov 30.
29. Zheng CY, etal., J Neurosci. 2010 Mar 31;30(13):4757-66. doi: 10.1523/JNEUROSCI.6108-09.2010.
Additional References at PubMed
PMID:9581761   PMID:14596909   PMID:15458844   PMID:15992371   PMID:17046693   PMID:17670980   PMID:17938206   PMID:19104036   PMID:19389623   PMID:21209193   PMID:21920314   PMID:22632720  
PMID:22664934   PMID:22871113   PMID:23486974   PMID:23946397   PMID:24509856   PMID:25429150   PMID:25555912   PMID:29574717   PMID:30053369   PMID:30067114   PMID:31682872  


Genomics

Comparative Map Data
Dlg3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X65,859,653 - 65,911,887 (+)NCBI
Rnor_6.0 EnsemblX70,596,576 - 70,648,532 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0X70,596,246 - 70,648,529 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0X71,468,290 - 71,520,286 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X88,777,585 - 88,828,504 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1X88,851,017 - 88,901,937 (+)NCBI
CeleraX66,218,231 - 66,268,819 (+)NCBICelera
Cytogenetic MapXq22NCBI
DLG3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 EnsemblX70,444,835 - 70,505,490 (+)EnsemblGRCh38hg38GRCh38
GRCh38X70,444,835 - 70,505,490 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X69,664,685 - 69,725,340 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X69,581,449 - 69,642,062 (+)NCBINCBI36hg18NCBI36
Build 34X69,447,839 - 69,505,554NCBI
CeleraX70,018,031 - 70,078,673 (+)NCBI
Cytogenetic MapXq13.1NCBI
HuRefX63,486,322 - 63,547,144 (+)NCBIHuRef
CHM1_1X69,558,605 - 69,619,214 (+)NCBICHM1_1
Dlg3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X99,811,200 - 99,862,016 (+)NCBIGRCm39mm39
GRCm39 EnsemblX99,811,328 - 99,862,016 (+)Ensembl
GRCm38X100,767,411 - 100,818,410 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX100,767,722 - 100,818,410 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X97,963,062 - 98,013,749 (+)NCBIGRCm37mm9NCBIm37
MGSCv36X96,970,466 - 97,021,127 (+)NCBImm8
CeleraX87,686,891 - 87,737,556 (+)NCBICelera
Cytogenetic MapXC3NCBI
Dlg3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554759,992,215 - 10,056,348 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554759,992,888 - 10,056,197 (+)NCBIChiLan1.0ChiLan1.0
DLG3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1X69,771,482 - 69,831,376 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX69,771,477 - 69,831,369 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0X59,712,755 - 59,773,372 (+)NCBIMhudiblu_PPA_v0panPan3
DLG3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X54,886,700 - 54,941,502 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX54,886,389 - 54,939,675 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX45,713,141 - 45,768,580 (+)NCBI
ROS_Cfam_1.0X55,853,333 - 55,908,759 (+)NCBI
UMICH_Zoey_3.1X53,822,238 - 53,877,672 (+)NCBI
UNSW_CanFamBas_1.0X55,153,323 - 55,208,774 (+)NCBI
UU_Cfam_GSD_1.0X55,080,264 - 55,135,709 (+)NCBI
Dlg3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X47,220,157 - 47,276,307 (-)NCBI
SpeTri2.0NW_004936762982,331 - 1,038,486 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DLG3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX56,472,305 - 56,527,991 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X56,471,941 - 56,531,481 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X63,666,759 - 63,724,414 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DLG3
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X60,290,280 - 60,346,954 (+)NCBI
ChlSab1.1 EnsemblX60,290,630 - 60,346,953 (+)Ensembl
Dlg3
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624903409,721 - 473,422 (+)NCBI

Position Markers
BE119338  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0X70,609,544 - 70,609,713NCBIRnor6.0
Rnor_5.0X71,481,301 - 71,481,470UniSTSRnor5.0
RGSC_v3.4X88,790,552 - 88,790,721UniSTSRGSC3.4
CeleraX66,231,196 - 66,231,365UniSTS
Cytogenetic MapXq31UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X15688119127888215Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X44320616158345622Rat
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX44557974120045269Rat
61431Cia19Collagen induced arthritis QTL 194.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X70352120127888215Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:360
Count of miRNA genes:149
Interacting mature miRNAs:161
Transcripts:ENSRNOT00000003741, ENSRNOT00000045082
Prediction methods:Miranda, Pita, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 3 2 1 2 74 20 31 11
Low 43 54 39 18 39 8 10 15 9 8
Below cutoff 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000003741   ⟹   ENSRNOP00000003741
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX70,596,577 - 70,647,298 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000045082   ⟹   ENSRNOP00000047310
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX70,596,576 - 70,648,527 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000076057
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX70,644,361 - 70,646,372 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000076079   ⟹   ENSRNOP00000067983
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX70,596,580 - 70,648,532 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000076450
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX70,596,848 - 70,648,532 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000076456   ⟹   ENSRNOP00000068233
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX70,645,270 - 70,648,532 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000076503
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX70,603,582 - 70,648,527 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000088114   ⟹   ENSRNOP00000071634
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX70,596,901 - 70,646,921 (+)Ensembl
RefSeq Acc Id: NM_031639   ⟹   NP_113827
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X65,859,947 - 65,910,655 (+)NCBI
Rnor_6.0X70,596,577 - 70,647,298 (+)NCBI
Rnor_5.0X71,468,290 - 71,520,286 (+)NCBI
RGSC_v3.4X88,777,585 - 88,828,504 (+)RGD
CeleraX66,218,231 - 66,268,819 (+)RGD
Sequence:
RefSeq Acc Id: XM_006257080   ⟹   XP_006257142
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X65,859,698 - 65,911,887 (+)NCBI
Rnor_6.0X70,596,251 - 70,648,529 (+)NCBI
Rnor_5.0X71,468,290 - 71,520,286 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006257081   ⟹   XP_006257143
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X65,859,700 - 65,911,887 (+)NCBI
Rnor_6.0X70,596,253 - 70,648,529 (+)NCBI
Rnor_5.0X71,468,290 - 71,520,286 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006257082   ⟹   XP_006257144
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X65,859,701 - 65,911,887 (+)NCBI
Rnor_6.0X70,596,246 - 70,648,529 (+)NCBI
Rnor_5.0X71,468,290 - 71,520,286 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006257083   ⟹   XP_006257145
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X65,859,703 - 65,911,887 (+)NCBI
Rnor_6.0X70,596,249 - 70,648,529 (+)NCBI
Rnor_5.0X71,468,290 - 71,520,286 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006257084   ⟹   XP_006257146
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X65,866,946 - 65,911,887 (+)NCBI
Rnor_6.0X70,603,571 - 70,648,529 (+)NCBI
Rnor_5.0X71,468,290 - 71,520,286 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006257085   ⟹   XP_006257147
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X65,869,471 - 65,911,887 (+)NCBI
Rnor_6.0X70,605,385 - 70,648,529 (+)NCBI
Rnor_5.0X71,468,290 - 71,520,286 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008773267   ⟹   XP_008771489
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X65,859,697 - 65,911,887 (+)NCBI
Rnor_6.0X70,596,249 - 70,648,529 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008773268   ⟹   XP_008771490
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X65,866,828 - 65,911,887 (+)NCBI
Rnor_6.0X70,603,436 - 70,648,529 (+)NCBI
Sequence:
RefSeq Acc Id: XR_005498052
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X65,859,653 - 65,906,469 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_113827   ⟸   NM_031639
- UniProtKB: Q62936 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006257142   ⟸   XM_006257080
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K0Y9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006257143   ⟸   XM_006257081
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_006257144   ⟸   XM_006257082
- Peptide Label: isoform X4
- UniProtKB: Q62936 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006257145   ⟸   XM_006257083
- Peptide Label: isoform X5
- UniProtKB: A0A096MJ42 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006257146   ⟸   XM_006257084
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_006257147   ⟸   XM_006257085
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: XP_008771489   ⟸   XM_008773267
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_008771490   ⟸   XM_008773268
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: ENSRNOP00000047310   ⟸   ENSRNOT00000045082
RefSeq Acc Id: ENSRNOP00000071634   ⟸   ENSRNOT00000088114
RefSeq Acc Id: ENSRNOP00000067983   ⟸   ENSRNOT00000076079
RefSeq Acc Id: ENSRNOP00000003741   ⟸   ENSRNOT00000003741
RefSeq Acc Id: ENSRNOP00000068233   ⟸   ENSRNOT00000076456
Protein Domains
Guanylate kinase-like   PDZ   SH3

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701870
Promoter ID:EPDNEW_R12392
Type:multiple initiation site
Name:Dlg3_1
Description:discs large MAGUK scaffold protein 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X70,596,588 - 70,596,648EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Damaging Variants


Assembly: Rnor_5.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
X 71468988 71468989 A G snv DOB/Oda (KyushuU), NIG-III/Hok (KyushuU)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68423 AgrOrtholog
Ensembl Genes ENSRNOG00000002767 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000003741 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000047310 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000067983 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000068233 UniProtKB/TrEMBL
  ENSRNOP00000071634 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000003741 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000045082 UniProtKB/Swiss-Prot
  ENSRNOT00000076079 UniProtKB/TrEMBL
  ENSRNOT00000076456 UniProtKB/TrEMBL
  ENSRNOT00000088114 UniProtKB/TrEMBL
Gene3D-CATH 2.30.42.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro DLG1-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DLG1_PEST_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DLG3_SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GK/Ca_channel_bsu UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Guanylate_kin-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Guanylate_kinase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ_assoc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:58948 UniProtKB/Swiss-Prot
NCBI Gene 58948 ENTREZGENE
Pfam Guanylate_kin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAGUK_N_PEST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ_assoc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Dlg3 PhenoGen
PIRSF MAGUK_DLGH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE GUANYLATE_KINASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GUANYLATE_KINASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART GuKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAGUK_N_PEST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50044 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50156 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC218155
UniProt A0A096MJ42 ENTREZGENE, UniProtKB/TrEMBL
  A0A096MJR5_RAT UniProtKB/TrEMBL
  A0A0G2K0Y9 ENTREZGENE, UniProtKB/TrEMBL
  DLG3_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary P70547 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-01 Dlg3  discs large MAGUK scaffold protein 3  Dlg3  discs large homolog 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-01-27 Dlg3  discs large homolog 3  Dlg3  discs, large homolog 3 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-18 Dlg3  discs, large homolog 3 (Drosophila)  Dlgh3  discs, large homolog 3 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Dlgh3  discs, large homolog 3 (Drosophila)       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference