Myd88 (MYD88, innate immune signal transduction adaptor) - Rat Genome Database

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Gene: Myd88 (MYD88, innate immune signal transduction adaptor) Rattus norvegicus
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Symbol: Myd88
Name: MYD88, innate immune signal transduction adaptor
RGD ID: 735043
Description: Enables Toll binding activity and interleukin-1 receptor binding activity. Involved in several processes, including JNK cascade; cell surface receptor signaling pathway; and positive regulation of smooth muscle cell proliferation. Located in postsynaptic density. Part of protein-containing complex. Biomarker of hepatocellular carcinoma. Human ortholog(s) of this gene implicated in colorectal cancer (multiple); hepatocellular carcinoma; lung cancer (multiple); lymphoma (multiple); and primary immunodeficiency disease. Orthologous to human MYD88 (MYD88 innate immune signal transduction adaptor); PARTICIPATES IN interleukin-1 signaling pathway; Toll-like receptor signaling pathway; apoptotic cell death pathway; INTERACTS WITH (+)-pilocarpine; 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrobenzenesulfonic acid.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: myeloid differentiation primary response 88; myeloid differentiation primary response gene 88; myeloid differentiation primary response protein MyD88
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.28119,074,439 - 119,078,508 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl8119,074,437 - 119,079,415 (-)Ensembl
Rnor_6.08128,022,512 - 128,027,462 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8128,022,473 - 128,026,841 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08127,229,273 - 127,234,226 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48124,299,729 - 124,303,798 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.18124,319,465 - 124,323,535 (-)NCBI
Celera8118,225,640 - 118,229,709 (-)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
anemia  (ISO)
anogenital venereal wart  (ISO)
asthma  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
Bacterial Keratitis  (ISO)
breast cancer  (ISO)
breast carcinoma  (ISO)
Brugada syndrome  (ISO)
Cachexia  (ISO)
Carcinoma, Lewis Lung  (ISO)
central nervous system lymphoma  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
chronic lymphocytic leukemia  (ISO)
Colitis-Associated Neoplasms  (ISO)
colon adenocarcinoma  (ISO)
colon cancer  (ISO)
colon carcinoma  (ISO)
Colonic Polyps  (ISO)
colorectal adenocarcinoma  (ISO)
colorectal adenoma  (ISO)
colorectal cancer  (ISO)
Colorectal Cancer 10  (ISO)
colorectal carcinoma  (ISO)
Coronavirus infectious disease  (ISS)
diarrhea  (ISO)
diffuse large B-cell lymphoma  (ISO)
Eosinophilia  (ISO)
esophageal cancer  (ISO)
Experimental Arthritis  (ISO)
Experimental Colitis  (ISO)
extrahepatic cholestasis  (ISO)
follicular lymphoma  (ISO)
gastroenteritis  (ISO)
Helicobacter Infections  (ISO)
hepatitis B  (ISO)
hepatocellular carcinoma  (IEP,ISO)
hypertension  (ISO)
Immunodeficiency 68  (ISO)
Inflammation  (ISO)
Intestinal Polyps  (ISO)
Liver Injury  (ISO)
lung adenocarcinoma  (ISO)
lung cancer  (ISO)
lung non-small cell carcinoma  (ISO)
lymphoma  (ISO)
melanoma  (ISO)
multiple myeloma  (ISO)
Myocardial Reperfusion Injury  (IDA)
Neoplasm Invasiveness  (ISO)
Neoplastic Cell Transformation  (ISO)
non-alcoholic steatohepatitis  (ISO)
non-Hodgkin lymphoma  (ISO)
Paraproteinemias  (ISO)
plasma cell neoplasm  (ISO)
pneumonia  (ISO)
pulmonary eosinophilia  (ISO)
Reperfusion Injury  (ISO)
severe acute respiratory syndrome  (ISO)
stomach cancer  (ISO)
Stomach Neoplasms  (ISO)
testicular lymphoma  (ISO)
Visceral Heterotaxy 4, Autosomal  (ISO)
Waldenstroem's macroglobulinemia  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,4-dinitrotoluene  (EXP)
2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine  (EXP)
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine  (ISO)
2-butoxyethanol  (ISO)
3-mercaptopropanoic acid  (ISO)
3-phenylprop-2-enal  (ISO)
4-hydroxy-3-[4-(2-hydroxyphenyl)phenyl]-6-oxo-7H-thieno[2,3-b]pyridine-5-carbonitrile  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-methyl-3-[[1-oxo-2-(propylamino)propyl]amino]-2-thiophenecarboxylic acid methyl ester  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (ISO)
alpha-D-galactose  (EXP,ISO)
antirheumatic drug  (ISO)
aristolochic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
artesunate  (EXP)
ATP  (ISO)
baicalin  (EXP)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
beta-D-glucan  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
boldenone  (EXP)
bortezomib  (ISO)
buspirone  (EXP)
cadmium dichloride  (ISO)
cadmium selenide  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon atom  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
casticin  (ISO)
chaetoglobosin A  (ISO)
chlorogenic acid  (EXP,ISO)
chloroquine  (ISO)
chrysin  (ISO)
cirsilineol  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
clofibric acid  (EXP)
copper(II) sulfate  (ISO)
crocin-1  (EXP)
cudratricusxanthone A  (ISO)
curcumin  (EXP,ISO)
cyclosporin A  (ISO)
D-glucose  (EXP)
DAPT  (EXP,ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
diclofenac  (ISO)
dioxygen  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elemental carbon  (ISO)
erlotinib hydrochloride  (ISO)
esculetin  (ISO)
ethanol  (EXP,ISO)
fisetin  (ISO)
flutamide  (EXP)
folic acid  (ISO)
fructose  (ISO)
galactose  (EXP,ISO)
Gastrodin  (EXP)
Genipin  (ISO)
genistein  (ISO)
genkwanin  (ISO)
gentamycin  (EXP)
Ginkgolide A  (ISO)
glucose  (EXP)
graphene oxide  (ISO)
high-density lipoprotein cholesterol  (ISO)
hydrogen peroxide  (ISO)
icosanoid  (ISO)
immunological adjuvant  (ISO)
isoprenaline  (EXP)
ivermectin  (ISO)
Kukoamine B  (ISO)
lactulose  (EXP)
lead(0)  (ISO)
lead(2+)  (ISO)
lipopolysaccharide  (EXP,ISO)
melatonin  (EXP)
metam  (ISO)
metformin  (EXP)
methamphetamine  (EXP,ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
monocrotaline  (ISO)
motexafin gadolinium  (ISO)
muramyl dipeptide  (ISO)
myrtenol  (EXP)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-[2-(diethylamino)ethyl]-2-methoxy-5-methylsulfonylbenzamide  (EXP)
N-acetyl-L-cysteine  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
Nonylphenol  (EXP)
o-anisidine  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
pentachlorophenol  (ISO)
pentobarbital  (EXP)
peptidoglycan  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pipoxolan  (ISO)
pirinixic acid  (ISO)
platycodin D  (EXP)
poly(I:C)  (ISO)
polymyxin B2  (ISO)
progesterone  (ISO)
quercetin  (ISO)
resiquimod  (ISO)
resveratrol  (ISO)
rosmarinic acid  (EXP)
rotenone  (ISO)
Salvianolic acid A  (ISO)
saxagliptin  (EXP)
scoparone  (ISO)
scopoletin  (EXP)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (EXP,ISO)
Soman  (EXP)
streptozocin  (EXP,ISO)
sulforaphane  (ISO)
sulfur dioxide  (ISO)
sunitinib  (ISO)
tamibarotene  (ISO)
temozolomide  (ISO)
tetrachloromethane  (EXP,ISO)
thalidomide  (ISO)
thymoquinone  (EXP)
titanium atom  (EXP)
titanium dioxide  (ISO)
tributylstannane  (EXP)
trichloroethene  (ISO)
trichostatin A  (ISO)
trimethyltin  (ISO)
trovafloxacin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
zearalenone  (ISO)
zinc acetate  (ISO)
zinc oxide  (ISO)
zinc protoporphyrin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
3'-UTR-mediated mRNA stabilization  (ISO)
apoptotic process  (ISO)
cell surface receptor signaling pathway  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to mechanical stimulus  (ISO)
cellular response to oxidised low-density lipoprotein particle stimulus  (ISO)
cytokine-mediated signaling pathway  (IMP)
defense response to bacterium  (ISO)
defense response to Gram-positive bacterium  (IBA,ISO,ISS)
defense response to protozoan  (ISO)
defense response to virus  (ISO,ISS)
establishment of endothelial intestinal barrier  (ISO)
I-kappaB kinase/NF-kappaB signaling  (IEA,ISO)
immunoglobulin mediated immune response  (ISO)
induced systemic resistance  (ISO)
inflammatory response  (ISO)
innate immune response  (IBA)
interleukin-1-mediated signaling pathway  (ISO)
JNK cascade  (IMP,ISO)
leukocyte activation involved in inflammatory response  (ISO)
lipopolysaccharide-mediated signaling pathway  (ISO)
MyD88-dependent toll-like receptor signaling pathway  (ISO)
neutrophil activation involved in immune response  (ISO)
neutrophil-mediated killing of bacterium  (ISO)
phagocytosis  (ISO)
positive regulation of chemokine production  (ISO)
positive regulation of cytokine production involved in inflammatory response  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of I-kappaB kinase/NF-kappaB signaling  (ISO,TAS)
positive regulation of interleukin-1 beta production  (ISO,ISS)
positive regulation of interleukin-17 production  (ISO)
positive regulation of interleukin-23 production  (ISO)
positive regulation of interleukin-6 production  (ISO)
positive regulation of interleukin-8 production  (ISO)
positive regulation of JNK cascade  (ISO)
positive regulation of lymphocyte proliferation  (ISO)
positive regulation of macrophage cytokine production  (IEA,ISO)
positive regulation of NF-kappaB transcription factor activity  (ISO)
positive regulation of NLRP3 inflammasome complex assembly  (ISO,ISS)
positive regulation of smooth muscle cell proliferation  (IMP)
positive regulation of tumor necrosis factor production  (ISO)
positive regulation of type I interferon production  (ISO)
regulation of cell population proliferation  (ISO)
regulation of chemokine (C-X-C motif) ligand 1 production  (ISO)
regulation of chemokine (C-X-C motif) ligand 2 production  (ISO)
regulation of gene expression  (ISO)
regulation of inflammatory response  (ISO)
regulation of interleukin-6 production  (ISO)
regulation of neutrophil migration  (ISO)
regulation of tumor necrosis factor production  (ISO)
response to amine  (IEP)
response to amino acid  (IEP)
response to ethanol  (IEP)
response to interleukin-1  (ISO)
response to lipopolysaccharide  (ISO)
response to molecule of fungal origin  (ISO)
response to organic cyclic compound  (IEP)
response to organonitrogen compound  (IEP)
response to peptidoglycan  (ISO)
response to virus  (ISO)
Toll signaling pathway  (IBA,IDA)
toll-like receptor 8 signaling pathway  (ISO,ISS)
type I interferon signaling pathway  (ISO)

Cellular Component

Molecular Function

References

References - curated
1. Anderson BJ, etal., Crit Care. 2019 Dec 9;23(1):400. doi: 10.1186/s13054-019-2684-2.
2. Banerjee A, etal., Infect Immun. 2014 Jan;82(1):356-63. doi: 10.1128/IAI.01344-13. Epub 2013 Oct 28.
3. Bohnert KR, etal., Mol Cell Biol. 2019 Jul 16;39(15). pii: MCB.00184-19. doi: 10.1128/MCB.00184-19. Print 2019 Aug 1.
4. Cao XX, etal., Ann Hematol. 2017 Nov;96(11):1867-1871. doi: 10.1007/s00277-017-3094-7. Epub 2017 Aug 12.
5. Chandrasekar B, etal., J Biol Chem. 2005 Jul 15;280(28):26263-77. Epub 2005 May 11.
6. Chang CW, etal., Int J Mol Sci. 2020 Jan 8;21(2). pii: ijms21020386. doi: 10.3390/ijms21020386.
7. Chen Z, etal., Am J Surg Pathol. 2020 Apr;44(4):444-455. doi: 10.1097/PAS.0000000000001386.
8. Coleman OI, etal., Gastroenterology. 2018 Nov;155(5):1539-1552.e12. doi: 10.1053/j.gastro.2018.07.028. Epub 2018 Jul 29.
9. Deng Y, etal., Genet Mol Res. 2016 Mar 4;15(1):15016826. doi: 10.4238/gmr.15016826.
10. Ding YF, etal., Front Pharmacol. 2019 Apr 24;10:389. doi: 10.3389/fphar.2019.00389. eCollection 2019.
11. Egunsola AT, etal., Cell Immunol. 2012;272(2):220-9. doi: 10.1016/j.cellimm.2011.10.008. Epub 2011 Oct 25.
12. Frick M, etal., Leuk Lymphoma. 2018 May;59(5):1260-1263. doi: 10.1080/10428194.2017.1370546. Epub 2017 Sep 3.
13. Gardoni F, etal., J Neuroinflammation. 2011 Feb 11;8(1):14.
14. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
15. Grommes C, etal., Cancer Discov. 2017 Sep;7(9):1018-1029. doi: 10.1158/2159-8290.CD-17-0613. Epub 2017 Jun 15.
16. Gschwandtner M, etal., Cytokine. 2017 Mar;91:65-73. doi: 10.1016/j.cyto.2016.12.008. Epub 2016 Dec 21.
17. Hartman ZC, etal., Cancer Res. 2010 Sep 15;70(18):7209-20. doi: 10.1158/0008-5472.CAN-10-0905. Epub 2010 Sep 7.
18. Hassan HM, etal., Am J Cancer Res. 2021 Feb 1;11(2):350-369. eCollection 2021.
19. Hazeki K, etal., Eur J Immunol 2003 Mar;33(3):740-7.
20. He M, etal., Toxicol Appl Pharmacol. 2016 Apr 1;296:61-72. doi: 10.1016/j.taap.2016.02.011. Epub 2016 Feb 13.
21. Holtorf A, etal., Oncoimmunology. 2018 Jun 11;7(8):e1466770. doi: 10.1080/2162402X.2018.1466770. eCollection 2018.
22. Hong EH, etal., Int J Cancer. 2013 Jun 15;132(12):2839-48. doi: 10.1002/ijc.27974. Epub 2012 Dec 19.
23. Hu Q, etal., J Int Med Res. 2020 May;48(5):300060520917877. doi: 10.1177/0300060520917877.
24. Jia RJ, etal., Cell Death Dis. 2014 Mar 6;5:e1103. doi: 10.1038/cddis.2014.71.
25. Jin C, etal., Cell. 2019 Feb 21;176(5):998-1013.e16. doi: 10.1016/j.cell.2018.12.040. Epub 2019 Jan 31.
26. Kajino-Sakamoto R, etal., Oncogene. 2021 Jan;40(2):408-420. doi: 10.1038/s41388-020-01541-3. Epub 2020 Nov 12.
27. Kennedy CL, etal., Oncogene. 2014 May 8;33(19):2540-6. doi: 10.1038/onc.2013.205. Epub 2013 Jun 3.
28. Kinowaki K, etal., Pathol Int. 2017 May;67(5):256-263. doi: 10.1111/pin.12529. Epub 2017 Apr 3.
29. Klimosch SN, etal., Cancer Res. 2013 Dec 15;73(24):7232-42. doi: 10.1158/0008-5472.CAN-13-1746. Epub 2013 Oct 23.
30. Koliaraki V, etal., Cell Rep. 2019 Jan 15;26(3):536-545.e4. doi: 10.1016/j.celrep.2018.12.072.
31. Kumar H, etal., Int Rev Immunol. 2011 Feb;30(1):16-34.
32. Li C, etal., Cardiovasc Res 2004 Feb 15;61(3):538-47.
33. Li JA, etal., Inflamm Res. 2014 Jul;63(7):549-56. doi: 10.1007/s00011-014-0724-6. Epub 2014 Mar 9.
34. Li WL, etal., Gene. 2014 Aug 10;546(2):263-70. doi: 10.1016/j.gene.2014.05.070. Epub 2014 Jun 2.
35. Liu J, etal., Hepatol Res. 2019 Oct;49(10):1182-1194. doi: 10.1111/hepr.13359. Epub 2019 May 9.
36. Lozano-Pope I, etal., BMC Cancer. 2017 Feb 15;17(1):133. doi: 10.1186/s12885-017-3114-y.
37. Maeda Y, etal., Cancer Prev Res (Phila). 2016 Mar;9(3):253-63. doi: 10.1158/1940-6207.CAPR-15-0315. Epub 2016 Feb 17.
38. MGD data from the GO Consortium
39. Milanski M, etal., J Neurosci. 2009 Jan 14;29(2):359-70.
40. Mohs A, etal., Carcinogenesis. 2020 Apr 22;41(2):171-181. doi: 10.1093/carcin/bgy173.
41. Natividad A, etal., BMC Med Genet. 2009 Dec 16;10:138. doi: 10.1186/1471-2350-10-138.
42. Naugler WE, etal., Science. 2007 Jul 6;317(5834):121-4. doi: 10.1126/science.1140485.
43. Oliva J, etal., Exp Mol Pathol. 2011 Jun;90(3):239-43. doi: 10.1016/j.yexmp.2011.01.005. Epub 2011 Jan 25.
44. OMIM Disease Annotation Pipeline
45. Pipeline to import KEGG annotations from KEGG into RGD
46. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
47. Pollicino T, etal., Virology. 2013 Sep;444(1-2):317-28. doi: 10.1016/j.virol.2013.06.028. Epub 2013 Jul 23.
48. Rakoff-Nahoum S and Medzhitov R, Science. 2007 Jul 6;317(5834):124-7. doi: 10.1126/science.1140488.
49. RGD automated data pipeline
50. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
51. RGD automated import pipeline for gene-chemical interactions
52. Rhee SH, etal., Gastroenterology. 2008 Aug;135(2):518-28. doi: 10.1053/j.gastro.2008.04.022. Epub 2008 Apr 23.
53. Rosenzweig HL, etal., Arthritis Rheum. 2010 Apr;62(4):1051-9. doi: 10.1002/art.27335.
54. Royse KE, etal., Int J Mol Epidemiol Genet. 2017 Apr 15;8(2):8-18. eCollection 2017.
55. Salcedo R, etal., J Exp Med. 2010 Aug 2;207(8):1625-36. doi: 10.1084/jem.20100199. Epub 2010 Jul 12.
56. Scheeren FA, etal., Nat Cell Biol. 2014 Dec;16(12):1238-48. doi: 10.1038/ncb3058. Epub 2014 Nov 2.
57. Schiechl G, etal., J Clin Invest. 2011 May;121(5):1692-708. doi: 10.1172/JCI42540. Epub 2011 Apr 25.
58. Shi YJ, etal., Mol Med Rep. 2013 Aug;8(2):480-6. doi: 10.3892/mmr.2013.1511. Epub 2013 Jun 6.
59. Soltany-Rezaee-Rad M, etal., Gastroenterol Res Pract. 2014;2014:185035. doi: 10.1155/2014/185035. Epub 2014 Jan 8.
60. Song J, etal., Cancer Lett. 2018 Oct 1;433:65-75. doi: 10.1016/j.canlet.2018.06.036. Epub 2018 Jun 28.
61. Sun Y, etal., Infect Immun. 2006 Sep;74(9):5325-32.
62. Verstrepen L, etal., Cell Mol Life Sci. 2008 Oct;65(19):2964-78.
63. Wang EL, etal., Br J Cancer. 2010 Mar 2;102(5):908-15. doi: 10.1038/sj.bjc.6605558. Epub 2010 Feb 9.
64. Weber A, etal., Sci Signal. 2010 Jan 19;3(105):cm1. doi: 10.1126/scisignal.3105cm1.
65. Xiang F, etal., Tumour Biol. 2016 May;37(5):6017-25. doi: 10.1007/s13277-015-4436-5. Epub 2015 Nov 23.
66. Xie L, etal., J Natl Cancer Inst. 2015 Dec 28;108(4). pii: djv364. doi: 10.1093/jnci/djv364. Print 2016 Apr.
67. Xin G, etal., Exp Biol Med (Maywood). 2015 Oct;240(10):1279-86. doi: 10.1177/1535370215570189. Epub 2015 Mar 18.
68. Xu L, etal., Biotechnol Lett. 2020 Jul;42(7):1113-1121. doi: 10.1007/s10529-020-02815-2. Epub 2020 Mar 5.
69. Xu X, etal., Cell Death Dis. 2017 Oct 12;8(10):e3124. doi: 10.1038/cddis.2017.519.
70. Yamada S, etal., Leuk Lymphoma. 2015 Jul;56(7):2141-5. doi: 10.3109/10428194.2014.979413. Epub 2015 Jan 14.
71. Yuan C, etal., Biochem Biophys Res Commun. 2015 Aug 14;464(1):249-55. doi: 10.1016/j.bbrc.2015.06.132. Epub 2015 Jun 23.
72. Zhang C, etal., Br J Pharmacol. 2020 Jul;177(14):3240-3257. doi: 10.1111/bph.15046. Epub 2020 Apr 12.
73. Zhang L, etal., Oncol Rep. 2019 Nov;42(5):1843-1855. doi: 10.3892/or.2019.7278. Epub 2019 Aug 14.
74. Zhou R, etal., Invest Ophthalmol Vis Sci. 2012 Oct 25;53(11):7382-8. doi: 10.1167/iovs.12-10238.
75. Zhou SX, etal., Asian Pac J Cancer Prev. 2012;13(6):2807-12. doi: 10.7314/apjcp.2012.13.6.2807.
76. Zhu G, etal., Int J Mol Med. 2020 Jan;45(1):131-140. doi: 10.3892/ijmm.2019.4390. Epub 2019 Oct 31.
77. Šutić M, etal., Transl Lung Cancer Res. 2019 Dec;8(6):1000-1015. doi: 10.21037/tlcr.2019.12.08.
Additional References at PubMed
PMID:10607756   PMID:10854325   PMID:11067888   PMID:11544529   PMID:12034707   PMID:12477932   PMID:12719478   PMID:12761501   PMID:12855817   PMID:12872135   PMID:14764662   PMID:14993594  
PMID:15294994   PMID:15800576   PMID:16199478   PMID:16259957   PMID:16751103   PMID:16954392   PMID:17258210   PMID:17475835   PMID:17635956   PMID:17660297   PMID:18203139   PMID:18589162  
PMID:19265123   PMID:19281832   PMID:19326394   PMID:19342961   PMID:19509286   PMID:19593445   PMID:20021788   PMID:20037584   PMID:20219467   PMID:21376021   PMID:21516116   PMID:21530945  
PMID:21543208   PMID:21988832   PMID:22155109   PMID:22155231   PMID:23141143   PMID:23633945   PMID:23684713   PMID:24111943   PMID:24429329   PMID:24582748   PMID:24842692   PMID:25084278  
PMID:25169970   PMID:25416956   PMID:25652858   PMID:25695672   PMID:25738964   PMID:25800037   PMID:25810567   PMID:25848864   PMID:25910212   PMID:26119193   PMID:26363072   PMID:26585410  
PMID:26684858   PMID:26895894   PMID:27057550   PMID:27107012   PMID:27107073   PMID:27107801   PMID:27193049   PMID:27716366   PMID:28161820   PMID:29115455   PMID:29150630   PMID:29304519  
PMID:29359143   PMID:29524303   PMID:29892012   PMID:29940584   PMID:30107238   PMID:30143913   PMID:30883606   PMID:31177708   PMID:31432123   PMID:31939007   PMID:32084554   PMID:32214070  
PMID:32240615   PMID:33236160   PMID:33383282   PMID:33744886   PMID:34260072   PMID:34369678   PMID:34719837  


Genomics

Comparative Map Data
Myd88
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.28119,074,439 - 119,078,508 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl8119,074,437 - 119,079,415 (-)Ensembl
Rnor_6.08128,022,512 - 128,027,462 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8128,022,473 - 128,026,841 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08127,229,273 - 127,234,226 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48124,299,729 - 124,303,798 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.18124,319,465 - 124,323,535 (-)NCBI
Celera8118,225,640 - 118,229,709 (-)NCBICelera
Cytogenetic Map8q32NCBI
MYD88
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38338,138,661 - 38,143,022 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl338,138,478 - 38,143,022 (+)EnsemblGRCh38hg38GRCh38
GRCh37338,180,152 - 38,184,513 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36338,155,009 - 38,159,517 (+)NCBINCBI36hg18NCBI36
Build 34338,155,156 - 38,159,514NCBI
Celera338,115,770 - 38,120,314 (+)NCBI
Cytogenetic Map3p22.2NCBI
HuRef338,220,931 - 38,225,475 (+)NCBIHuRef
CHM1_1338,131,949 - 38,136,493 (+)NCBICHM1_1
Myd88
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399119,165,000 - 119,169,084 (-)NCBIGRCm39mm39
GRCm39 Ensembl9119,165,000 - 119,170,477 (-)Ensembl
GRCm389119,335,934 - 119,340,018 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9119,335,934 - 119,341,411 (-)EnsemblGRCm38mm10GRCm38
MGSCv379119,245,106 - 119,249,158 (-)NCBIGRCm37mm9NCBIm37
MGSCv369119,184,686 - 119,188,738 (-)NCBImm8
Celera9119,805,118 - 119,809,170 (-)NCBICelera
Cytogenetic Map9F3NCBI
cM Map971.33NCBI
Myd88
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542725,553,589 - 25,559,138 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542725,553,589 - 25,557,654 (+)NCBIChiLan1.0ChiLan1.0
MYD88
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1338,319,024 - 38,323,572 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl338,319,024 - 38,323,572 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0338,036,565 - 38,041,014 (+)NCBIMhudiblu_PPA_v0panPan3
MYD88
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1237,901,578 - 7,905,274 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl237,901,250 - 7,904,534 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha237,943,535 - 7,947,227 (+)NCBI
ROS_Cfam_1.0238,191,155 - 8,194,847 (+)NCBI
ROS_Cfam_1.0 Ensembl238,191,134 - 8,194,847 (+)Ensembl
UMICH_Zoey_3.1238,005,061 - 8,008,753 (+)NCBI
UNSW_CanFamBas_1.0238,146,176 - 8,149,868 (+)NCBI
UU_Cfam_GSD_1.0238,138,449 - 8,142,140 (+)NCBI
Myd88
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118194,532,893 - 194,537,794 (-)NCBI
SpeTri2.0NW_00493647327,672,237 - 27,676,339 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MYD88
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1322,964,071 - 22,983,109 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11322,976,951 - 22,979,568 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21325,181,100 - 25,183,718 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MYD88
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1151,276,804 - 1,281,811 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl151,276,798 - 1,281,166 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366606310,006,548 - 10,011,071 (-)NCBIVero_WHO_p1.0
Myd88
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247312,677,259 - 2,681,408 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
RH132399  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28119,074,623 - 119,074,819 (+)MAPPERmRatBN7.2
Rnor_6.08128,022,697 - 128,022,892NCBIRnor6.0
Rnor_5.08127,229,458 - 127,229,653UniSTSRnor5.0
RGSC_v3.48124,299,914 - 124,300,109UniSTSRGSC3.4
Celera8118,225,825 - 118,226,020UniSTS
RH 3.4 Map81285.09UniSTS
Cytogenetic Map8q32UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)846531639119088624Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)846531639119088624Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)846531639119088624Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088624Rat
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)861290298119084929Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)876468691121468691Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)882460758122812818Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)893535351123900184Rat
1358893Bp263Blood pressure QTL 2635.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
1358903Bp252Blood pressure QTL 25270.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
738014Anxrr15Anxiety related response QTL 153.60.005locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)895718998123900184Rat
2300182Bmd56Bone mineral density QTL 565.4femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)895718998123900184Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8100149864120994388Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:712
Count of miRNA genes:293
Interacting mature miRNAs:363
Transcripts:ENSRNOT00000018341
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 44 28 19 28 25 19 11
Low 43 13 13 13 8 11 74 10 22 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000018341   ⟹   ENSRNOP00000018341
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8119,074,439 - 119,078,508 (-)Ensembl
Rnor_6.0 Ensembl8128,022,473 - 128,026,841 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000096753   ⟹   ENSRNOP00000081836
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8119,074,442 - 119,079,415 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000111747   ⟹   ENSRNOP00000088914
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8119,074,439 - 119,078,508 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000112994   ⟹   ENSRNOP00000079057
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8119,074,437 - 119,078,508 (-)Ensembl
RefSeq Acc Id: NM_198130   ⟹   NP_937763
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.28119,074,439 - 119,078,508 (-)NCBI
Rnor_6.08128,022,512 - 128,026,581 (-)NCBI
Rnor_5.08127,229,273 - 127,234,226 (-)NCBI
RGSC_v3.48124,299,729 - 124,303,798 (-)RGD
Celera8118,225,640 - 118,229,709 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_937763 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH97266 (Get FASTA)   NCBI Sequence Viewer  
  AAO91937 (Get FASTA)   NCBI Sequence Viewer  
  EDL76917 (Get FASTA)   NCBI Sequence Viewer  
  Q6Y1S1 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_937763   ⟸   NM_198130
- Sequence:
RefSeq Acc Id: ENSRNOP00000018341   ⟸   ENSRNOT00000018341
RefSeq Acc Id: ENSRNOP00000079057   ⟸   ENSRNOT00000112994
RefSeq Acc Id: ENSRNOP00000081836   ⟸   ENSRNOT00000096753
RefSeq Acc Id: ENSRNOP00000088914   ⟸   ENSRNOT00000111747
Protein Domains
Death   TIR

Protein Structures
Name Modeller Protein Id AA Range Protein Structure Video
AF-Q6Y1S1-F1-model_v2 AlphaFold Q6Y1S1 1-296 view protein structure  

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696369
Promoter ID:EPDNEW_R6894
Type:initiation region
Name:Myd88_1
Description:myeloid differentiation primary response 88
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08128,026,563 - 128,026,623EPDNEW

Strain Variation

Strain Sequence Variants (MRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:735043 AgrOrtholog
BioCyc Gene G2FUF-28791 BioCyc
Ensembl Genes ENSRNOG00000013634 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000018341 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000018341 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.533.10 UniProtKB/Swiss-Prot
  3.40.50.10140 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7459961 IMAGE-MGC_LOAD
InterPro DEATH-like_dom_sf UniProtKB/Swiss-Prot
  Death_domain UniProtKB/Swiss-Prot
  MyD88_Death UniProtKB/Swiss-Prot
  Myelin_different_resp_MyD88 UniProtKB/Swiss-Prot
  TIR_dom UniProtKB/Swiss-Prot
  Toll_tir_struct_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:301059 UniProtKB/Swiss-Prot
MGC_CLONE MGC:114236 IMAGE-MGC_LOAD
NCBI Gene 301059 ENTREZGENE
PANTHER PTHR15079 UniProtKB/Swiss-Prot
Pfam Death UniProtKB/Swiss-Prot
  TIR UniProtKB/Swiss-Prot
PhenoGen Myd88 PhenoGen
PIRSF MyD88 UniProtKB/Swiss-Prot
PROSITE DEATH_DOMAIN UniProtKB/Swiss-Prot
  TIR UniProtKB/Swiss-Prot
SMART DEATH UniProtKB/Swiss-Prot
  TIR UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47986 UniProtKB/Swiss-Prot
  SSF52200 UniProtKB/Swiss-Prot
UniProt MYD88_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q4QRC0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-07-20 Myd88  MYD88, innate immune signal transduction adaptor  Myd88  myeloid differentiation primary response 88  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-11-21 Myd88  myeloid differentiation primary response 88  Myd88  myeloid differentiation primary response gene 88  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-08 Myd88  myeloid differentiation primary response gene 88      Symbol and Name status set to approved 1299863 APPROVED