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Gene: Myd88 (MYD88, innate immune signal transduction adaptor) Rattus norvegicus
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Symbol: Myd88
Name: MYD88, innate immune signal transduction adaptor
RGD ID: 735043
Description: Exhibits Toll binding activity and interleukin-1 receptor binding activity. Involved in JNK cascade; cell surface receptor signaling pathway; and positive regulation of smooth muscle cell proliferation. Localizes to postsynaptic density and protein-containing complex. Human ortholog(s) of this gene implicated in Waldenstroem's macroglobulinemia and primary immunodeficiency disease. Orthologous to human MYD88 (MYD88 innate immune signal transduction adaptor); PARTICIPATES IN interleukin-1 signaling pathway; Toll-like receptor signaling pathway; apoptotic cell death pathway; INTERACTS WITH (+)-pilocarpine; 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrobenzenesulfonic acid.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: myeloid differentiation primary response 88; myeloid differentiation primary response gene 88; myeloid differentiation primary response protein MyD88
Orthologs:
Homo sapiens (human) : MYD88 (MYD88 innate immune signal transduction adaptor)  HGNC  Alliance
Mus musculus (house mouse) : Myd88 (myeloid differentiation primary response gene 88)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Myd88 (MYD88 innate immune signal transduction adaptor)
Pan paniscus (bonobo/pygmy chimpanzee) : MYD88 (MYD88 innate immune signal transduction adaptor)
Canis lupus familiaris (dog) : MYD88 (MYD88 innate immune signal transduction adaptor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Myd88 (MYD88 innate immune signal transduction adaptor)
Sus scrofa (pig) : MYD88 (MYD88 innate immune signal transduction adaptor)
Chlorocebus sabaeus (African green monkey) : MYD88 (MYD88 innate immune signal transduction adaptor)
Heterocephalus glaber (naked mole-rat) : Myd88 (MYD88 innate immune signal transduction adaptor)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.08128,022,512 - 128,027,462 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8128,022,473 - 128,026,841 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08127,229,273 - 127,234,226 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48124,299,729 - 124,303,798 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.18124,319,465 - 124,323,535 (-)NCBI
Celera8118,225,640 - 118,229,709 (-)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
 
More on Myd88
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 735043
Created: 2004-02-05
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.