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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2892
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il1r1
Name: interleukin 1 receptor type 1
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il1r1increases expressionEXP 6480464CTDLipopolysaccharides results in increased expression of IL1R1 mRNAPMID:13679239
Il1r1increases expressionISOIL1R1 (Homo sapiens)6480464CTDLipopolysaccharides results in increased expression of IL1R1 mRNAPMID:21045076 PMID:21135123 PMID:35811015
Il1r1increases expressionISOIl1r1 (Mus musculus)6480464CTDLipopolysaccharides results in increased expression of IL1R1 mRNAPMID:15371095 PMID:25843059
Il1r1multiple interactionsISOIL1R1 (Homo sapiens)6480464CTD[S-(1,2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of IL1R1 mRNA; HNRNPD protein inhibits the reaction [Lipopolysaccharides results in increased expression of IL1R1 mRNA]PMID:21135123 PMID:35811015
Il1r1multiple interactionsISOIl1r1 (Mus musculus)6480464CTD3,4-dihydroxybenzohydroxamic acid inhibits the reaction [Lipopolysaccharides results in increased expression of IL1R1 mRNA]; IL1R1 protein affects the reaction [[Lipopolysaccharides co-treated with [Aluminum Hydroxide co-treated with Magnesium Hydroxide]] results in increased cleavage of and results in increased secretion of IL1B protein]; IL1R1 protein affects the reaction [[Lipopolysaccharides co-treated with Alum Compounds] results in increased cleavage of and results in increased secretion of IL1B protein]; IL1R1 protein affects the susceptibility to [Lipopolysaccharides co-treated with deoxynivalenol]PMID:12773775 PMID:18604214 PMID:25843059
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