Mettl21c (methyltransferase 21C, AARS1 lysine) - Rat Genome Database

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Gene: Mettl21c (methyltransferase 21C, AARS1 lysine) Rattus norvegicus
Analyze
Symbol: Mettl21c
Name: methyltransferase 21C, AARS1 lysine (Ensembl:methyltransferase like 21C)
RGD ID: 1561425
Description: Predicted to enable heat shock protein binding activity and protein-lysine N-methyltransferase activity. Predicted to be involved in peptidyl-lysine trimethylation. Predicted to act upstream of or within cellular response to hormone stimulus; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; and skeletal muscle tissue development. Predicted to be located in nucleus. Predicted to be part of protein-containing complex. Predicted to be active in cytosol. Orthologous to human METTL21C (methyltransferase 21C, AARS1 lysine); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; decabromodiphenyl ether.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: hypothetical protein LOC301378; LOC301378; methyltransferase like 21C; methyltransferase-like protein 21C; protein-lysine methyltransferase METTL21C; RGD1561425; similar to RIKEN cDNA 4832428D23 gene
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2946,130,451 - 46,145,128 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl946,134,001 - 46,145,112 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx954,649,455 - 54,660,563 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0959,772,255 - 59,783,363 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0958,052,492 - 58,063,600 (-)NCBIRnor_WKY
Rnor_6.0950,750,971 - 50,762,082 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl950,750,971 - 50,762,082 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0950,415,610 - 50,426,721 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4943,072,035 - 43,083,147 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera943,846,552 - 43,857,665 (-)NCBICelera
Cytogenetic Map9q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:22948820   PMID:23349634   PMID:24677265  


Genomics

Comparative Map Data
Mettl21c
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2946,130,451 - 46,145,128 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl946,134,001 - 46,145,112 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx954,649,455 - 54,660,563 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0959,772,255 - 59,783,363 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0958,052,492 - 58,063,600 (-)NCBIRnor_WKY
Rnor_6.0950,750,971 - 50,762,082 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl950,750,971 - 50,762,082 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0950,415,610 - 50,426,721 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4943,072,035 - 43,083,147 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera943,846,552 - 43,857,665 (-)NCBICelera
Cytogenetic Map9q22NCBI
METTL21C
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3813102,685,747 - 102,704,300 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl13102,685,747 - 102,695,044 (-)EnsemblGRCh38hg38GRCh38
GRCh3713103,338,097 - 103,347,394 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3613102,136,098 - 102,144,855 (-)NCBINCBI36Build 36hg18NCBI36
Celera1384,180,440 - 84,189,196 (-)NCBICelera
Cytogenetic Map13q33.1NCBI
HuRef1383,930,631 - 83,939,404 (-)NCBIHuRef
CHM1_113103,307,550 - 103,316,292 (-)NCBICHM1_1
T2T-CHM13v2.013101,901,727 - 101,913,115 (-)NCBIT2T-CHM13v2.0
Mettl21c
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39144,048,559 - 44,081,745 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl144,048,568 - 44,059,194 (-)EnsemblGRCm39 Ensembl
GRCm38144,009,399 - 44,042,620 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl144,009,408 - 44,020,034 (-)EnsemblGRCm38mm10GRCm38
MGSCv37144,066,253 - 44,076,851 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36143,953,954 - 43,964,552 (-)NCBIMGSCv36mm8
Celera144,352,461 - 44,363,059 (-)NCBICelera
Cytogenetic Map1C1.1NCBI
Mettl21c
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554048,447,359 - 8,460,847 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554048,447,359 - 8,460,853 (+)NCBIChiLan1.0ChiLan1.0
METTL21C
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.113102,981,536 - 102,990,282 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl13102,981,536 - 102,990,336 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01383,845,572 - 83,855,215 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
METTL21C
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12252,181,222 - 52,194,859 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2252,182,115 - 52,190,163 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2251,961,007 - 51,972,053 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02252,632,209 - 52,643,253 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2252,633,037 - 52,641,528 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12252,281,430 - 52,292,469 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02252,297,679 - 52,308,687 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02252,338,746 - 52,349,804 (-)NCBIUU_Cfam_GSD_1.0
Mettl21c
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945187,587,069 - 187,600,029 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364728,354,807 - 8,365,399 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049364728,355,075 - 8,366,229 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
METTL21C
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1171,008,846 - 71,020,730 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11171,008,854 - 71,021,640 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21178,325,626 - 78,335,286 (-)NCBISscrofa10.2Sscrofa10.2susScr3
METTL21C
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1381,240,899 - 81,251,111 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl381,241,412 - 81,250,502 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604637,778,090 - 37,787,841 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mettl21c
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247938,774,561 - 8,780,792 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247938,772,999 - 8,782,049 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mettl21c
44 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:36
Count of miRNA genes:28
Interacting mature miRNAs:34
Transcripts:ENSRNOT00000015492
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9125408446254084Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9125408446254084Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9510982650109826Rat
11353947Bp392Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)9728325252283252Rat
9589133Insul26Insulin level QTL 2617.960.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)9895256053952560Rat
7411609Foco16Food consumption QTL 1625.60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9895256053952560Rat
631680Cm11Cardiac mass QTL 113.10.00089heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)92043051965430519Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92207116986369743Rat
631643Bp120Blood pressure QTL 12030.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)92207120067071200Rat
1598823Memor16Memory QTL 161.9exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)92213332249968732Rat
7207805Bmd88Bone mineral density QTL 884femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)92375402458157242Rat
1300180Bw14Body weight QTL 143.776body mass (VT:0001259)body weight (CMO:0000012)92375402461381613Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)92375414483851531Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)92526804479271759Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)92746863972468639Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)93253550577535505Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)93253550577535505Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)93696235977814038Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)93696235992058970Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat
6903941Pur31Proteinuria QTL 310.036urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)94019418885194188Rat
11353949Bp393Blood pressure QTL 393arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94019418885194188Rat
61352Bp34Blood pressure QTL 345arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94249534379271511Rat
10058949Gmadr5Adrenal mass QTL 520.014adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)94279151387976209Rat
11353951Bp394Blood pressure QTL 394arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94464992189649921Rat
12879506Pur33Proteinuria QTL 33urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)94464992189649921Rat
11353957Bmd92Bone mineral density QTL 920.01tibia mineral mass (VT:1000283)volumetric bone mineral density (CMO:0001553)94611419991114199Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 8 11 8
Low 30 18 3 15 3 9 6 8 8
Below cutoff 2 11 7 6 4 6 9 4 14 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000015492   ⟹   ENSRNOP00000015490
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl946,134,001 - 46,145,112 (-)Ensembl
Rnor_6.0 Ensembl950,750,971 - 50,762,082 (-)Ensembl
RefSeq Acc Id: NM_001106908   ⟹   NP_001100378
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2946,134,001 - 46,145,112 (-)NCBI
Rnor_6.0950,750,971 - 50,762,082 (-)NCBI
Rnor_5.0950,415,610 - 50,426,721 (-)NCBI
RGSC_v3.4943,072,035 - 43,083,147 (-)RGD
Celera943,846,552 - 43,857,665 (-)RGD
Sequence:
RefSeq Acc Id: XM_017596347   ⟹   XP_017451836
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2946,130,455 - 46,143,119 (-)NCBI
Rnor_6.0950,751,191 - 50,760,038 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039083264   ⟹   XP_038939192
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2946,130,451 - 46,136,497 (-)NCBI
RefSeq Acc Id: XM_039083266   ⟹   XP_038939194
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2946,134,512 - 46,145,128 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001100378 (Get FASTA)   NCBI Sequence Viewer  
  XP_017451836 (Get FASTA)   NCBI Sequence Viewer  
  XP_038939192 (Get FASTA)   NCBI Sequence Viewer  
  XP_038939194 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL99140 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001100378   ⟸   NM_001106908
- UniProtKB: D3ZJG1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017451836   ⟸   XM_017596347
- Peptide Label: isoform X2
- UniProtKB: D3ZJG1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000015490   ⟸   ENSRNOT00000015492
RefSeq Acc Id: XP_038939192   ⟸   XM_039083264
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038939194   ⟸   XM_039083266
- Peptide Label: isoform X3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZJG1-F1-model_v2 AlphaFold D3ZJG1 1-248 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696643
Promoter ID:EPDNEW_R7167
Type:single initiation site
Name:Mettl21c_1
Description:methyltransferase like 21C
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0950,762,009 - 50,762,069EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1561425 AgrOrtholog
BioCyc Gene G2FUF-27658 BioCyc
Ensembl Genes ENSRNOG00000011591 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000015490 ENTREZGENE
  ENSRNOP00000015490.5 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000015492 ENTREZGENE
  ENSRNOT00000015492.6 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.150 UniProtKB/TrEMBL
InterPro Methyltransferase-16_put UniProtKB/TrEMBL
  SAM-dependent_MTases-like UniProtKB/TrEMBL
KEGG Report rno:301378 UniProtKB/TrEMBL
NCBI Gene 301378 ENTREZGENE
PANTHER PTHR14614 UniProtKB/TrEMBL
Pfam Methyltransf_16 UniProtKB/TrEMBL
PhenoGen Mettl21c PhenoGen
Superfamily-SCOP SSF53335 UniProtKB/TrEMBL
UniProt D3ZJG1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-17 Mettl21c  methyltransferase 21C, AARS1 lysine  Mettl21c  methyltransferase like 21C  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-05-25 Mettl21c  methyltransferase like 21C  RGD1561425  similar to RIKEN cDNA 4832428D23 gene  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1561425  similar to RIKEN cDNA 4832428D23 gene   RGD1561425_predicted  similar to RIKEN cDNA 4832428D23 gene (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1561425_predicted  similar to RIKEN cDNA 4832428D23 gene (predicted)  LOC301378  similar to RIKEN cDNA 4832428D23 gene  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC301378  similar to RIKEN cDNA 4832428D23 gene      Symbol and Name status set to provisional 70820 PROVISIONAL