Cps1 (carbamoyl-phosphate synthase 1) - Rat Genome Database

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Gene: Cps1 (carbamoyl-phosphate synthase 1) Rattus norvegicus
Symbol: Cps1
Name: carbamoyl-phosphate synthase 1
RGD ID: 2395
Description: Enables several functions, including anion binding activity; calcium ion binding activity; and carbamoyl-phosphate synthase (ammonia) activity. Involved in several processes, including cellular response to cAMP; cellular response to oleic acid; and response to peptide hormone. Located in mitochondrial inner membrane. Part of protein-containing complex. Biomarker of fatty liver disease; hypertension; and obesity. Human ortholog(s) of this gene implicated in carbamoyl phosphate synthetase I deficiency disease; persistent fetal circulation syndrome; and vascular disease. Orthologous to human CPS1 (carbamoyl-phosphate synthase 1); PARTICIPATES IN urea cycle pathway; 2-hydroxyglutaric aciduria pathway; AGAT deficiency pathway; INTERACTS WITH (+)-schisandrin B; 1,3-dinitrobenzene; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: carbamoyl-phosphate synthase [ammonia], mitochondrial; carbamoyl-phosphate synthetase 1; carbamoyl-phosphate synthetase 1, mitochondrial; carbamoyl-phosphate synthetase I; carbamyl phosphate synthetase I; carbamyl-phosphate synthetase; Carboamyl-phosphate synthetase 1; cps; cps-1; CPSase I
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2968,614,153 - 68,737,037 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl968,614,153 - 68,737,033 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx977,103,116 - 77,225,425 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0982,232,050 - 82,354,355 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0980,638,581 - 80,759,682 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0974,113,437 - 74,236,274 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl974,124,016 - 74,236,274 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0973,072,857 - 73,183,868 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4965,907,211 - 66,017,942 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1966,054,192 - 66,164,924 (+)NCBI
Celera966,092,717 - 66,214,118 (+)NCBICelera
Cytogenetic Map9q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrabromodibenzodioxine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-acetamidofluorene  (EXP)
3-chloropropane-1,2-diol  (EXP)
acetamide  (EXP)
acrolein  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bexarotene  (EXP)
bisphenol A  (EXP,ISO)
bosentan  (ISO)
buta-1,3-diene  (ISO)
butanal  (ISO)
cadmium dichloride  (EXP)
captan  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP,ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
cyclosporin A  (ISO)
dexamethasone  (EXP,ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP,ISO)
entinostat  (ISO)
ethanol  (EXP)
etoposide  (ISO)
flucloxacillin  (ISO)
flutamide  (EXP)
folpet  (ISO)
formaldehyde  (ISO)
glafenine  (EXP)
hydrogen peroxide  (ISO)
inulin  (ISO)
iodide salt  (EXP)
isoprenaline  (ISO)
ivermectin  (ISO)
Licochalcone B  (ISO)
methapyrilene  (EXP)
methotrexate  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
mitomycin C  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
N-nitrosomorpholine  (EXP)
N-Nitrosopyrrolidine  (ISO)
nefazodone  (EXP)
nimesulide  (EXP)
nitric oxide  (ISO)
nitrofen  (EXP)
nitroprusside  (ISO)
O-methyleugenol  (ISO)
ochratoxin A  (ISO)
ozone  (ISO)
paracetamol  (ISO)
perfluorododecanoic acid  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (EXP,ISO)
pirinixic acid  (EXP,ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
quercetin  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP,ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tauroursodeoxycholic acid  (EXP)
temozolomide  (ISO)
tetrachloromethane  (EXP,ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
trichloroethene  (EXP)
Triptolide  (ISO)
triptonide  (ISO)
troglitazone  (EXP,ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc dichloride  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component


References - curated
# Reference Title Reference Citation
1. Decreased urea synthesis in cafeteria-diet-induced obesity in the rat. Barber T, etal., Biochem J. 1985 Sep 15;230(3):675-81.
2. Import of carbamylphosphate synthetase and ornithine transcarbamylase into mitochondria of rat liver: detection of aggregates of enzyme in cytoplasm and mitochondria using immunoelectron microscopy with the protein A-gold method. Brands R and Hoogenraad N, Aust J Exp Biol Med Sci. 1986 Apr;64 ( Pt 2):165-73.
3. The interaction of cardiolipin with rat liver carbamoyl phosphate synthetase I. Brandt MA and Powers-Lee SG, Arch Biochem Biophys. 1991 Oct;290(1):14-20.
4. Significant Down-Regulation of Urea Cycle Generates Clinically Relevant Proteomic Signature in Hepatocellular Carcinoma Patients with Macrovascular Invasion. Cao Y, etal., J Proteome Res. 2019 May 3;18(5):2032-2044. doi: 10.1021/acs.jproteome.8b00921. Epub 2019 Mar 29.
5. Regulation of mitochondrial carbamoyl-phosphate synthetase 1 activity by active site fatty acylation. Corvi MM, etal., J Biol Chem. 2001 Dec 7;276(49):45704-12. Epub 2001 Sep 27.
6. Reciprocal regulation of glutamine synthetase and carbamoylphosphate synthetase levels in rat liver. de Groot CJ, etal., Biochim Biophys Acta. 1987 Apr 29;908(3):231-40.
7. Arginine-metabolizing enzymes in the developing rat small intestine. De Jonge WJ, etal., Pediatr Res. 1998 Apr;43(4 Pt 1):442-51.
8. Development of the ornithine cycle in rat liver: zonation of a metabolic pathway. Dingemanse MA, etal., Hepatology. 1996 Aug;24(2):407-11.
9. Calcium binding to polypeptides of rat liver and Zajdela hepatoma mitochondrial inner membranes. Evtodienko YV, etal., FEBS Lett. 1998 Feb 13;423(1):45-8.
10. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
11. S 35171 exerts protective effects in spontaneously hypertensive stroke-prone rats by preserving mitochondrial function. Gelosa P, etal., Eur J Pharmacol. 2009 Feb 14;604(1-3):117-24. Epub 2008 Dec 24.
12. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
13. Arginine synthesis by hepatomas in vitro. II. Isolation and characterization of Morris hepatoma variants unable to convert ornithine to arginine, and modulation of urea-cycle enzymes by dexamethasone and cyclic-AMP. Goss SJ J Cell Sci. 1984 Jun;68:305-19.
14. Effects of growth hormone on steroid-induced increase in ability of urea synthesis and urea enzyme mRNA levels. Grofte T, etal., Am J Physiol. 1998 Jul;275(1 Pt 1):E79-86.
15. Carbamyl phosphate synthetase I deficiency. One base substitution in an exon of the CPS I gene causes a 9-basepair deletion due to aberrant splicing. Hoshide R, etal., J Clin Invest. 1993 May;91(5):1884-7.
16. Effect of dimethylnitrosamine upon carbamoyl phosphate and ornithine utilization in rat liver. Karsai T, etal., Anticancer Res. 1985 Jul-Aug;5(4):441-4.
17. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
18. Conditional disruption of hepatic carbamoyl phosphate synthetase 1 in mice results in hyperammonemia without orotic aciduria and can be corrected by liver-directed gene therapy. Khoja S, etal., Mol Genet Metab. 2018 Apr 12. pii: S1096-7192(18)30059-3. doi: 10.1016/j.ymgme.2018.04.001.
19. Proteomic analysis of rat liver peroxisome: presence of peroxisome-specific isozyme of Lon protease. Kikuchi M, etal., J Biol Chem. 2004 Jan 2;279(1):421-8. Epub 2003 Oct 15.
20. Rat liver 10-formyltetrahydrofolate dehydrogenase, carbamoyl phosphate synthetase 1 and betaine homocysteine S-methytransferase were co-purified on Kunitz-type soybean trypsin inhibitor-coupled sepharose CL-4B. Kim HS, etal., J Biochem Mol Biol. 2007 Jul 31;40(4):604-9.
21. Mixture of N-carbamoyl-L-glutamate plus L-arginine can protect rats with liver cirrhosis from acute ammonia intoxication. Kim WH, etal., J Hepatol. 2001 Dec;35(6):719-25.
22. Alterations in renal and hepatic nitrogen metabolism in rats during HCl ingestion. Lardner AL and O'Donovan DJ, Metabolism. 1998 Feb;47(2):163-7.
23. Required allosteric effector site for N-acetylglutamate on carbamoyl-phosphate synthetase I. McCudden CR and Powers-Lee SG, J Biol Chem. 1996 Jul 26;271(30):18285-94.
24. Diet- and hormone-induced reversal of the carbamoylphosphate synthetase mRNA gradient in the rat liver lobulus. Moorman AF, etal., FEBS Lett. 1990 Dec 10;276(1-2):9-13.
25. [Ammonia metabolism of liver of the fetus induced experimental IUGR in rats--in respect of the enzymes in pyrimidin biosynthesis and urea cycle system] Nagasaki T Nippon Sanka Fujinka Gakkai Zasshi. 1985 Jan;37(1):24-30.
26. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
27. Cirrhosis and endotoxin decrease urea synthesis in rats. Nielsen SS, etal., Hepatol Res. 2007 Jul;37(7):540-7.
28. Timing and sequence of differentiation of embryonic rat hepatocytes along the biliary epithelial lineage. Notenboom RG, etal., Hepatology. 2003 Sep;38(3):683-91.
29. Characterization and derivation of the gene coding for mitochondrial carbamyl phosphate synthetase I of rat. Nyunoya H, etal., J Biol Chem 1985 Aug 5;260(16):9346-56.
30. Purification and expression of a processing protease on beta-alanine-oxoglutarate aminotransferase from rat liver mitochondria. Ohyama T, etal., FEBS Lett. 2004 Aug 13;572(1-3):251-5.
31. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
32. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
33. Enzyme-linked immunosorbent assay of carbamoylphosphate synthetase I: plasma enzyme in rat experimental hepatitis and its clearance. Ozaki M, etal., Enzyme Protein. 1994-1995;48(4):213-21.
34. Neonatal pulmonary hypertension--urea-cycle intermediates, nitric oxide production, and carbamoyl-phosphate synthetase function. Pearson DL, etal., N Engl J Med. 2001 Jun 14;344(24):1832-8.
35. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
36. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
37. The interaction of rat liver carbamoyl phosphate synthetase and ornithine transcarbamoylase with inner mitochondrial membranes. Powers-Lee SG, etal., J Biol Chem. 1987 Nov 15;262(32):15683-8.
38. Mitochondrial dysfunction precedes insulin resistance and hepatic steatosis and contributes to the natural history of non-alcoholic fatty liver disease in an obese rodent model. Rector RS, etal., J Hepatol. 2010 May;52(5):727-36. Epub 2010 Mar 4.
39. GOA pipeline RGD automated data pipeline
40. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
41. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
42. Regulation of ammonia-metabolizing enzymes expression in the liver of obese rats: differences between genetic and nutritional obesities. Roig R, etal., Int J Obes Relat Metab Disord. 1997 Aug;21(8):681-5.
43. Development of alimentary zinc deficiency in growing rats is retarded at low dietary protein levels. Roth HP J Nutr. 2003 Jul;133(7):2294-301.
44. Long-term culture and differentiation of rat embryonic stem cell-like cells into neuronal, glial, endothelial, and hepatic lineages. Ruhnke M, etal., Stem Cells. 2003;21(4):428-36.
45. Rat liver and intestinal mucosa differ in the developmental pattern and hormonal regulation of carbamoyl-phosphate synthetase I and ornithine carbamoyl transferase gene expression. Ryall JC, etal., Eur J Biochem. 1986 May 2;156(3):453-8.
46. cyclicAMP and glucocorticoid responsiveness of the rat carbamoylphosphate synthetase gene requires the interplay of upstream regulatory units. Schoneveld OJ, etal., Biochimie. 2007 May;89(5):574-80. Epub 2007 Feb 20.
47. Relationship between carbamoyl-phosphate synthetase genotype and systemic vascular function. Summar ML, etal., Hypertension. 2004 Feb;43(2):186-91. Epub 2004 Jan 12.
48. Toward the identification of liver toxicity markers: a proteome study in human cell culture and rats. Thome-Kromer B, etal., Proteomics. 2003 Oct;3(10):1835-62.
49. Long-chain fatty acids suppress the induction of urea cycle enzyme genes by glucocorticoid action. Tomomura M, etal., FEBS Lett. 1996 Dec 16;399(3):310-2.
50. Messenger RNA profiles in liver injury and stress: a comparison of lethal and nonlethal rat models. Tygstrup N, etal., Biochem Biophys Res Commun 2002 Jan 11;290(1):518-25.
51. Expression of messenger RNA for liver functions following 70% and 90% hepatectomy. Tygstrup N, etal., J Hepatol. 1996 Jul;25(1):72-8.
52. Coordinate induction of the urea cycle enzymes by glucagon and dexamethasone is accomplished by three different mechanisms. Ulbright C and Snodgrass PJ, Arch Biochem Biophys. 1993 Mar;301(2):237-43.
53. Exocrine pancreas trans-differentiation to hepatocytes--a physiological response to elevated glucocorticoid in vivo. Wallace K, etal., J Steroid Biochem Mol Biol. 2009 Aug;116(1-2):76-85. Epub 2009 May 13.
54. Urea cycle gene expression is suppressed by PFOA treatment in rats. Walters MW and Wallace KB, Toxicol Lett. 2010 Aug 1;197(1):46-50. Epub 2010 May 7.
55. Cloning of cDNA coding for carbamyl phosphate synthetase I and changes in levels of CPS1 mRNA during hepatocarcinogenesis. Wu SJ, etal., Sci Sin B. 1988 Feb;31(2):197-203.
Additional References at PubMed
PMID:6200105   PMID:6249820   PMID:7416778   PMID:9711878   PMID:9862865   PMID:15897806   PMID:17140418   PMID:18063578   PMID:20031578   PMID:21120950   PMID:22402285   PMID:25684186  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2968,614,153 - 68,737,037 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl968,614,153 - 68,737,033 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx977,103,116 - 77,225,425 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0982,232,050 - 82,354,355 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0980,638,581 - 80,759,682 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0974,113,437 - 74,236,274 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl974,124,016 - 74,236,274 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0973,072,857 - 73,183,868 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4965,907,211 - 66,017,942 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1966,054,192 - 66,164,924 (+)NCBI
Celera966,092,717 - 66,214,118 (+)NCBICelera
Cytogenetic Map9q32NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh382210,477,685 - 210,679,107 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2210,477,682 - 210,679,107 (+)EnsemblGRCh38hg38GRCh38
GRCh372211,342,409 - 211,543,831 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362211,129,583 - 211,252,076 (+)NCBINCBI36Build 36hg18NCBI36
Build 342211,246,843 - 211,369,335NCBI
Celera2205,110,438 - 205,311,714 (+)NCBICelera
Cytogenetic Map2q34NCBI
HuRef2203,188,451 - 203,390,097 (+)NCBIHuRef
CHM1_12211,348,531 - 211,549,854 (+)NCBICHM1_1
T2T-CHM13v2.02210,958,482 - 211,159,839 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39167,151,294 - 67,270,426 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl167,162,185 - 67,270,418 (+)EnsemblGRCm39 Ensembl
GRCm38167,122,426 - 67,231,267 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl167,123,026 - 67,231,259 (+)EnsemblGRCm38mm10GRCm38
MGSCv37167,169,640 - 67,277,022 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36167,056,235 - 67,164,475 (+)NCBIMGSCv36mm8
Celera167,649,362 - 67,756,702 (+)NCBICelera
Cytogenetic Map1C3NCBI
cM Map133.75NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554574,844,152 - 4,961,246 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554574,848,116 - 4,961,384 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan12B113,116,036 - 113,318,192 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B97,735,486 - 97,936,623 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B216,136,857 - 216,337,728 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B216,136,857 - 216,337,728 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.13718,308,164 - 18,428,487 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3718,143,986 - 18,427,697 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3719,188,984 - 19,309,290 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03718,246,433 - 18,366,577 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3718,082,221 - 18,366,572 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13718,198,783 - 18,319,066 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03718,161,084 - 18,281,176 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03718,175,864 - 18,296,018 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024405303166,764,670 - 166,886,826 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365865,739,337 - 5,850,312 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365865,739,038 - 5,850,317 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl15113,150,157 - 113,339,078 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115113,210,038 - 113,339,086 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215125,183,128 - 125,279,098 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11096,267,890 - 96,392,393 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1096,267,889 - 96,392,206 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040102,979,677 - 103,099,178 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046247655,528,112 - 5,651,415 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247655,527,029 - 5,652,343 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Cps1
706 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:52
Count of miRNA genes:50
Interacting mature miRNAs:52
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92207116986369743Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)92375414483851531Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)92526804479271759Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)92746863972468639Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)93253550577535505Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)93253550577535505Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)93696235977814038Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)93696235992058970Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat
6903941Pur31Proteinuria QTL 310.036urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)94019418885194188Rat
11353949Bp393Blood pressure QTL 393arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94019418885194188Rat
61352Bp34Blood pressure QTL 345arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94249534379271511Rat
10058949Gmadr5Adrenal mass QTL 520.014adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)94279151387976209Rat
11353951Bp394Blood pressure QTL 394arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94464992189649921Rat
12879506Pur33Proteinuria QTL 33urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)94464992189649921Rat
11353957Bmd92Bone mineral density QTL 920.01tibia mineral mass (VT:1000283)volumetric bone mineral density (CMO:0001553)94611419991114199Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94859825193598251Rat
1598849Memor17Memory QTL 172.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)94996854671098346Rat
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)95584784177026453Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)95662771378595166Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)95662771378595166Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)95662771378595166Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)956771635101771635Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)958163035100929646Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)961381434104821652Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)96207227596470995Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)96207227596470995Rat
61385Edpm9Estrogen-dependent pituitary mass QTL 93.430.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)963869687108869687Rat
731171Glom6Glomerulus QTL 62.80.0003kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)964573531109573531Rat


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 19 19 19
Medium 2 14 12 12 2 2
Low 4 23 10 15 10 8 8 33 27 14 6 8
Below cutoff 1 24 1 2 1 33 8 21 1


RefSeq Acc Id: ENSRNOT00000019023   ⟹   ENSRNOP00000019021
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl968,614,153 - 68,737,033 (+)Ensembl
Rnor_6.0 Ensembl974,124,016 - 74,236,274 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000076059
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl974,232,497 - 74,235,700 (+)Ensembl
RefSeq Acc Id: NM_017072   ⟹   NP_058768
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
mRatBN7.2968,614,153 - 68,736,131 (+)NCBI
Rnor_6.0974,113,437 - 74,235,368 (+)NCBI
Rnor_5.0973,072,857 - 73,183,868 (-)NCBI
RGSC_v3.4965,907,211 - 66,017,942 (+)RGD
Celera966,092,717 - 66,214,118 (+)NCBI
RefSeq Acc Id: XM_017596592   ⟹   XP_017452081
Rat AssemblyChrPosition (strand)Source
mRatBN7.2968,624,729 - 68,737,037 (+)NCBI
Rnor_6.0974,123,994 - 74,236,274 (+)NCBI
RefSeq Acc Id: NP_058768   ⟸   NM_017072
- Peptide Label: precursor
- UniProtKB: P07756 (UniProtKB/Swiss-Prot),   A6KFE3 (UniProtKB/TrEMBL),   A6KFE6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017452081   ⟸   XM_017596592
- Peptide Label: isoform X1
- UniProtKB: P07756 (UniProtKB/Swiss-Prot),   A6KFE3 (UniProtKB/TrEMBL),   A6KFE6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000019021   ⟸   ENSRNOT00000019023
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P07756-F1-model_v2 AlphaFold P07756 1-1500 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13696729
Promoter ID:EPDNEW_R7254
Type:multiple initiation site
Description:carbamoyl-phosphate synthase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.0974,124,017 - 74,124,077EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2395 AgrOrtholog
BioCyc Gene G2FUF-27280 BioCyc
BioCyc Pathway CITRULLINE-DEG-PWY [L-citrulline degradation] BioCyc
  PWY-4984 [urea cycle] BioCyc
Ensembl Genes ENSRNOG00000013704 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000019023 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.1030.10 UniProtKB/Swiss-Prot
  3.30.1490.20 UniProtKB/Swiss-Prot UniProtKB/Swiss-Prot UniProtKB/Swiss-Prot, UniProtKB/TrEMBL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL UniProtKB/Swiss-Prot
  ATP-grasp fold, A domain UniProtKB/TrEMBL
  ATP-grasp fold, B domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Carbamoyl-phosphate synthase small subunit, N-terminal domain UniProtKB/TrEMBL
  Carbamoyl-phosphate synthetase, large subunit oligomerisation domain UniProtKB/TrEMBL
  Methylglyoxal synthase-like domain UniProtKB/TrEMBL
InterPro ATP-grasp UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATP_grasp_subdomain_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CarbamoylP_synth_lsu UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CarbamoylP_synth_lsu_oligo UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CarbamoylP_synth_lsu_oligo_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CarbamoylP_synth_ssu UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CarbamoylP_synth_ssu_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CarbP_synth_ssu_N_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CbamoylP_synth_lsu-like_ATP-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CbamoylP_synth_lsu_CPSase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Class_I_gatase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CPSase_GATase1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GATASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MGS-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MGS-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PreATP-grasp_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:497840 UniProtKB/Swiss-Prot
Pfam CPSase_L_D2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CPSase_L_D3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CPSase_sm_chain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GATase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MGS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cps1 PhenoGen
  CPSGATASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CPSASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CPSASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GATASE_TYPE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MGS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000013704 RatGTEx
SMART CPSase_L_D3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CPSase_sm_chain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MGS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Carbamoyl phosphate synthetase, large subunit connection domain UniProtKB/TrEMBL
  Carbamoyl phosphate synthetase, small subunit N-terminal domain UniProtKB/TrEMBL
  Class I glutamine amidotransferase-like UniProtKB/TrEMBL
  Glutathione synthetase ATP-binding domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Methylglyoxal synthase-like UniProtKB/TrEMBL
  PreATP-grasp domain UniProtKB/TrEMBL
  SSF48108 UniProtKB/Swiss-Prot
  SSF52021 UniProtKB/Swiss-Prot
  SSF52317 UniProtKB/Swiss-Prot
  SSF52335 UniProtKB/Swiss-Prot
  SSF52440 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-25 Cps1  carbamoyl-phosphate synthase 1  Cps1  carbamoyl-phosphate synthetase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-11-05 Cps1  carbamoyl-phosphate synthetase 1  Cps1  carbamoyl-phosphate synthetase 1, mitochondrial  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Cps1  carbamoyl-phosphate synthetase 1, mitochondrial  Cps1  carbamoyl-phosphate synthetase 1  Name updated 1299863 APPROVED
2004-09-10 Cps1  carbamoyl-phosphate synthetase 1, mitochondrial    carbamoyl-phosphate synthetase 1  Name updated 1299863 APPROVED
2002-06-10 Cps1  Carboamyl-phosphate synthetase 1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression maybe induced in response to some types liver damage 70249
gene_protein 1,500 amino acids; 164.5 kDa 728256