Gene: Cps1 (carbamoyl-phosphate synthase 1) Rattus norvegicus
Analyze
Symbol:
Cps1
Name:
carbamoyl-phosphate synthase 1
Description:
Exhibits several functions, including anion binding activity; calcium ion binding activity; and carbamoyl-phosphate synthase (ammonia) activity. Predicted to contribute to carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity. Involved in several processes, including cellular response to cAMP; cellular response to oleic acid; and response to peptide hormone. Localizes to the mitochondrial inner membrane and protein-containing complex. Biomarker of fatty liver disease; hypertension; and obesity. Human ortholog(s) of this gene implicated in carbamoyl phosphate synthetase I deficiency disease; persistent fetal circulation syndrome; and vascular disease. Orthologous to human CPS1 (carbamoyl-phosphate synthase 1); PARTICIPATES IN urea cycle pathway; 2-hydroxyglutaric aciduria pathway; AGAT deficiency pathway; INTERACTS WITH (+)-schisandrin B; 1,3-dinitrobenzene; 2,3,7,8-tetrachlorodibenzodioxine.
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
carbamoyl-phosphate synthase [ammonia], mitochondrial; carbamoyl-phosphate synthetase 1; carbamoyl-phosphate synthetase 1, mitochondrial; carbamoyl-phosphate synthetase I; carbamyl phosphate synthetase I; carbamyl-phosphate synthetase; Carboamyl-phosphate synthetase 1; cps; cps-1; CPSase I
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
CPS1 (carbamoyl-phosphate synthase 1) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):
Cps1 (carbamoyl-phosphate synthetase 1) HGNC
Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Cps1 (carbamoyl-phosphate synthase 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
CPS1 (carbamoyl-phosphate synthase 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
CPS1 (carbamoyl-phosphate synthase 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Cps1 (carbamoyl-phosphate synthase 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
CPS1 (carbamoyl-phosphate synthase 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):
CPS1 (carbamoyl-phosphate synthase 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Cps1 (carbamoyl-phosphate synthase 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Other homologs 2
Homo sapiens (human):
CAD (carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase) HGNC
OrthoMCL
Alliance orthologs 3
Mus musculus (house mouse):
Cps1 (carbamoyl-phosphate synthetase 1)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Homo sapiens (human):
CPS1 (carbamoyl-phosphate synthase 1)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Danio rerio (zebrafish):
cps1 (carbamoyl-phosphate synthase 1, mitochondrial)
Alliance
DIOPT (Ensembl Compara, OMA, OrthoFinder, PANTHER, TreeFam)
Saccharomyces cerevisiae (baker's yeast):
CPA2
Alliance
DIOPT (Ensembl Compara, OMA, PANTHER, TreeFam)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 9 74,113,437 - 74,236,274 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 9 74,124,016 - 74,236,274 (+) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 9 73,072,857 - 73,183,868 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 9 65,907,211 - 66,017,942 (+) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 9 66,054,192 - 66,164,924 (+) NCBI Celera 9 66,092,717 - 66,214,118 (+) NCBI Celera Cytogenetic Map 9 q32 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - ClinVar
carbamoyl phosphate synthetase I deficiency disease ISO RGD:70833 8554872 ClinVar Annotator: match by term: Congenital hyperammonemia, type I ClinVar PMID:12655559 more ... carbamoyl phosphate synthetase I deficiency disease ISO RGD:70833 8554872 ClinVar Annotator: match by term: Congenital hyperammonemia, type I ClinVar PMID:19167850 more ... carbamoyl phosphate synthetase I deficiency disease ISO RGD:70833 8554872 ClinVar Annotator: match by term: Congenital hyperammonemia, type I ClinVar PMID:16737834 more ... carbamoyl phosphate synthetase I deficiency disease ISO RGD:70833 8554872 ClinVar Annotator: match by term: Congenital hyperammonemia, type I ClinVar PMID:16737834 more ... carbamoyl phosphate synthetase I deficiency disease ISO RGD:70833 8554872 ClinVar Annotator: match by term: Congenital hyperammonemia, type I ClinVar PMID:15617192 more ... carbamoyl phosphate synthetase I deficiency disease ISO RGD:70833 8554872 ClinVar Annotator: match by term: Congenital hyperammonemia, type I ClinVar PMID:15617192 more ... carbamoyl phosphate synthetase I deficiency disease ISO RGD:70833 8554872 ClinVar Annotator: match by term: Congenital hyperammonemia, type I ClinVar PMID:17310273 more ... carbamoyl phosphate synthetase I deficiency disease ISO RGD:70833 8554872 ClinVar Annotator: match by term: Congenital hyperammonemia, type I ClinVar PMID:20855223 , PMID:28492532 carbamoyl phosphate synthetase I deficiency disease ISO RGD:70833 8554872 ClinVar Annotator: match by term: Congenital hyperammonemia, type I ClinVar PMID:21120950 more ... carbamoyl phosphate synthetase I deficiency disease ISO RGD:70833 8554872 ClinVar Annotator: match by term: Congenital hyperammonemia, type I ClinVar PMID:12655559 , PMID:19793055 carbamoyl phosphate synthetase I deficiency disease ISO RGD:70833 8554872 ClinVar Annotator: match by term: Congenital hyperammonemia, type I ClinVar PMID:12655559 more ... carbamoyl phosphate synthetase I deficiency disease ISO RGD:70833 8554872 ClinVar Annotator: match by term: Congenital hyperammonemia, type I ClinVar PMID:28444906 carbamoyl phosphate synthetase I deficiency disease ISO RGD:70833 8554872 ClinVar Annotator: match by term: Congenital hyperammonemia, type I ClinVar PMID:20800523 carbamoyl phosphate synthetase I deficiency disease ISO RGD:70833 8554872 ClinVar Annotator: match by term: Congenital hyperammonemia, type I ClinVar PMID:20578160 , PMID:9686343 carbamoyl phosphate synthetase I deficiency disease ISO RGD:70833 8554872 ClinVar Annotator: match by term: Congenital hyperammonemia, type I ClinVar PMID:15876373 more ... carbamoyl phosphate synthetase I deficiency disease ISO RGD:70833 8554872 ClinVar Annotator: match by term: Congenital hyperammonemia, type I ClinVar PMID:19309799 , PMID:21120950 carbamoyl phosphate synthetase I deficiency disease ISO RGD:70833 8554872 ClinVar Annotator: match by term: Congenital hyperammonemia, type I ClinVar PMID:26440671 carbamoyl phosphate synthetase I deficiency disease ISO RGD:70833 8554872 ClinVar Annotator: match by term: Congenital hyperammonemia, type I ClinVar PMID:21120950 more ... carbamoyl phosphate synthetase I deficiency disease ISO RGD:70833 8554872 ClinVar Annotator: match by term: Congenital hyperammonemia, type I ClinVar PMID:21120950 , PMID:24813853 carbamoyl phosphate synthetase I deficiency disease ISO RGD:70833 8554872 ClinVar Annotator: match by term: Congenital hyperammonemia, type I ClinVar PMID:16737834 , PMID:27290639 carbamoyl phosphate synthetase I deficiency disease ISO RGD:70833 8554872 ClinVar Annotator: match by term: Congenital hyperammonemia, type I ClinVar PMID:21120950 , PMID:22173106 carbamoyl phosphate synthetase I deficiency disease ISO RGD:70833 8554872 ClinVar Annotator: match by term: Congenital hyperammonemia, type I ClinVar PMID:27150549 carbamoyl phosphate synthetase I deficiency disease ISO RGD:70833 8554872 ClinVar Annotator: match by term: Congenital hyperammonemia, type I ClinVar PMID:16737834 more ... carbamoyl phosphate synthetase I deficiency disease ISO RGD:70833 8554872 ClinVar Annotator: match by term: Congenital hyperammonemia, type I ClinVar PMID:12955727 more ... carbamoyl phosphate synthetase I deficiency disease ISO RGD:70833 8554872 ClinVar Annotator: match by term: Congenital hyperammonemia, type I ClinVar PMID:21120950 more ... carbamoyl phosphate synthetase I deficiency disease ISO RGD:70833 8554872 ClinVar Annotator: match by term: Congenital hyperammonemia, type I ClinVar PMID:15050969 more ... carbamoyl phosphate synthetase I deficiency disease ISO RGD:70833 8554872 ClinVar Annotator: match by term: Congenital hyperammonemia, type I ClinVar PMID:22575620 , PMID:24813853 carbamoyl phosphate synthetase I deficiency disease ISO RGD:70833 8554872 ClinVar Annotator: match by term: Congenital hyperammonemia, type I ClinVar PMID:12655559 carbamoyl phosphate synthetase I deficiency disease ISO RGD:70833 8554872 ClinVar Annotator: match by term: Congenital hyperammonemia, type I ClinVar PMID:24813853 carbamoyl phosphate synthetase I deficiency disease ISO RGD:70833 8554872 ClinVar Annotator: match by term: Congenital hyperammonemia, type I ClinVar PMID:21120950 , PMID:28492532 carbamoyl phosphate synthetase I deficiency disease ISO RGD:70833 8554872 ClinVar Annotator: match by term: Congenital hyperammonemia, type I ClinVar PMID:21120950 more ... carbamoyl phosphate synthetase I deficiency disease ISO RGD:70833 8554872 ClinVar Annotator: match by term: Congenital hyperammonemia, type I ClinVar PMID:21120950 carbamoyl phosphate synthetase I deficiency disease ISO RGD:70833 8554872 ClinVar Annotator: match by term: Congenital hyperammonemia, type I ClinVar PMID:16737834 , PMID:28492532 carbamoyl phosphate synthetase I deficiency disease ISO RGD:70833 8554872 ClinVar Annotator: match by term: Congenital hyperammonemia, type I ClinVar PMID:21120950 more ... carbamoyl phosphate synthetase I deficiency disease ISO RGD:70833 8554872 ClinVar Annotator: match by term: Congenital hyperammonemia, type I ClinVar PMID:16737834 carbamoyl phosphate synthetase I deficiency disease ISO RGD:70833 8554872 ClinVar Annotator: match by term: Congenital hyperammonemia, type I ClinVar PMID:18666241 , PMID:25741868 carbamoyl phosphate synthetase I deficiency disease ISO RGD:70833 8554872 ClinVar Annotator: match by term: CPS I DEFICIENCY ClinVar PMID:18414213 carbamoyl phosphate synthetase I deficiency disease ISO RGD:70833 8554872 ClinVar Annotator: match by OMIM:237300 ClinVar carbamoyl phosphate synthetase I deficiency disease ISO RGD:70833 8554872 ClinVar Annotator: match by term: CPS I DEFICIENCY ClinVar PMID:25741868 carbamoyl phosphate synthetase I deficiency disease ISO RGD:70833 8554872 ClinVar Annotator: match by term: Congenital hyperammonemia, type I ClinVar PMID:28526534 carbamoyl phosphate synthetase I deficiency disease ISO RGD:70833 8554872 ClinVar Annotator: match by OMIM:237300 ClinVar PMID:8486760 carbamoyl phosphate synthetase I deficiency disease ISO RGD:70833 8554872 ClinVar Annotator: match by OMIM:237300 ClinVar PMID:19793055 carbamoyl phosphate synthetase I deficiency disease ISO RGD:70833 8554872 ClinVar Annotator: match by term: Congenital hyperammonemia, type I ClinVar PMID:22173106 , PMID:25741868 carbamoyl phosphate synthetase I deficiency disease ISO RGD:70833 8554872 ClinVar Annotator: match by OMIM:237300 ClinVar PMID:17310273 carbamoyl phosphate synthetase I deficiency disease ISO RGD:70833 8554872 ClinVar Annotator: match by OMIM:237300 ClinVar PMID:11474210 carbamoyl phosphate synthetase I deficiency disease ISO RGD:70833 8554872 ClinVar Annotator: match by OMIM:237300 ClinVar PMID:9711878 carbamoyl phosphate synthetase I deficiency disease ISO RGD:70833 8554872 ClinVar Annotator: match by term: CPS I DEFICIENCY ClinVar PMID:28492532 carbamoyl phosphate synthetase I deficiency disease ISO RGD:70833 8554872 ClinVar Annotator: match by term: CPS I DEFICIENCY ClinVar PMID:25741868 , PMID:28492532 lung cancer ISO RGD:70833 8554872 ClinVar Annotator: match by term: Lung cancer ClinVar Neonatal Pulmonary Hypertension ISO RGD:70833 8554872 ClinVar Annotator: match by term: Pulmonary hypertension, neonatal, susceptibility to ClinVar PMID:11407344 more ... Neurodevelopmental Disorders ISO RGD:70833 8554872 ClinVar Annotator: match by term: Neurodevelopmental disorder ClinVar PMID:25741868 trichorhinophalangeal syndrome type I ISO RGD:70833 8554872 ClinVar Annotator: match by term: Trichorhinophalangeal dysplasia type I ClinVar PMID:25741868 Veno-Occlusive Disease ISO RGD:70833 8554872 ClinVar Annotator: match by term: Venoocclusive disease after bone marrow transplantation, susceptibility to ClinVar PMID:11407344 more ...
Imported Annotations - CTD
carbamoyl phosphate synthetase I deficiency disease ISO RGD:70833 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:8486760 , PMID:17310273 Chemical and Drug Induced Liver Injury ISO RGD:70833 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:25231249 Coma ISO RGD:70833 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:8438805 Endotoxemia ISO RGD:70833 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:16741687 Experimental Liver Cirrhosis ISO RGD:70833 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:15650968 Hyperammonemia ISO RGD:70833 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:8486760 , PMID:17310273 Neonatal Pulmonary Hypertension ISO RGD:70833 11554173 CTD Direct Evidence: marker/mechanism CTD persistent fetal circulation syndrome ISO RGD:70833 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:11407344 pre-malignant neoplasm ISO RGD:70833 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:21472284 Imported Annotations - OMIM
carbamoyl phosphate synthetase I deficiency disease ISO RGD:70833 7240710 OMIM Neonatal Pulmonary Hypertension susceptibility ISO RGD:70833 7240710 OMIM
(+)-schisandrin B multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of CPS1 mRNA] CTD PMID:31150632 1,3-dinitrobenzene decreases expression EXP 6480464 3-dinitrobenzene results in decreased expression of CPS1 protein CTD PMID:24140754 17beta-estradiol decreases expression ISO RGD:70833 6480464 Estradiol results in decreased expression of CPS1 mRNA CTD PMID:20106945 2,3,7,8-tetrabromodibenzodioxine increases expression ISO RGD:10389 6480464 2 more ... CTD PMID:27604104 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:10389 6480464 [Tetrachlorodibenzodioxin binds to AHR protein] which results in decreased expression of CPS1 mRNA CTD PMID:16214954 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:70833 6480464 Tetrachlorodibenzodioxin results in decreased expression of CPS1 mRNA CTD PMID:20106945 , PMID:26159488 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:70833 6480464 [Endosulfan co-treated with Tetrachlorodibenzodioxin] results in decreased expression of CPS1 mRNA CTD PMID:26159488 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of CPS1 mRNA CTD PMID:21215274 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:10389 6480464 Tetrachlorodibenzodioxin results in decreased expression of CPS1 mRNA CTD PMID:19770486 2,4-dinitrotoluene affects expression EXP 6480464 2, 4-dinitrotoluene affects the expression of CPS1 mRNA CTD PMID:21346803 2,6-dinitrotoluene affects expression EXP 6480464 2, 6-dinitrotoluene affects the expression of CPS1 mRNA CTD PMID:21346803 2-acetamidofluorene multiple interactions EXP 6480464 [2-Acetylaminofluorene co-treated with Carbon Tetrachloride] affects the expression of CPS1 protein CTD PMID:11813887 3-chloropropane-1,2-diol affects expression EXP 6480464 alpha-Chlorohydrin analog affects the expression of CPS1 protein CTD PMID:26597043 3-chloropropane-1,2-diol decreases expression EXP 6480464 alpha-Chlorohydrin results in decreased expression of CPS1 protein CTD PMID:26597043 aflatoxin B1 affects expression ISO RGD:70833 6480464 Aflatoxin B1 affects the expression of CPS1 protein CTD PMID:20106945 aflatoxin B1 increases methylation ISO RGD:70833 6480464 Aflatoxin B1 results in increased methylation of CPS1 intron CTD PMID:30157460 aflatoxin B1 decreases methylation ISO RGD:70833 6480464 Aflatoxin B1 results in decreased methylation of CPS1 gene CTD PMID:27153756 aflatoxin B1 decreases expression ISO RGD:70833 6480464 Aflatoxin B1 results in decreased expression of CPS1 mRNA CTD PMID:27153756 all-trans-retinoic acid decreases expression ISO RGD:70833 6480464 Tretinoin results in decreased expression of CPS1 mRNA CTD PMID:21934132 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of CPS1 mRNA CTD PMID:16483693 atrazine affects methylation EXP 6480464 Atrazine affects the methylation of CPS1 gene CTD PMID:28931070 benzo[a]pyrene decreases expression ISO RGD:10389 6480464 Benzo(a)pyrene results in decreased expression of CPS1 mRNA, Benzo(a)pyrene results in decreased expression of CPS1 protein CTD PMID:19770486 , PMID:29145655 benzo[a]pyrene decreases expression ISO RGD:70833 6480464 Benzo(a)pyrene results in decreased expression of CPS1 mRNA CTD PMID:16269432 more ... benzo[a]pyrene diol epoxide I decreases expression ISO RGD:70833 6480464 7 more ... CTD PMID:26238291 bexarotene decreases expression EXP 6480464 bexarotene results in decreased expression of CPS1 mRNA CTD PMID:16648578 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of CPS1 mRNA CTD PMID:25181051 , PMID:30816183 bisphenol A increases expression ISO RGD:10389 6480464 bisphenol A results in increased expression of CPS1 mRNA CTD PMID:30245210 bisphenol A increases methylation EXP 6480464 bisphenol A results in increased methylation of CPS1 gene CTD PMID:28505145 bosentan decreases expression ISO RGD:70833 6480464 Bosentan results in decreased expression of CPS1 mRNA, Bosentan results in decreased expression of CPS1 protein CTD PMID:29761207 buta-1,3-diene decreases expression ISO RGD:10389 6480464 1, 3-butadiene results in decreased expression of CPS1 mRNA CTD PMID:29038090 butanal decreases expression ISO RGD:70833 6480464 butyraldehyde results in decreased expression of CPS1 mRNA CTD PMID:26079696 cadmium dichloride affects expression EXP 6480464 Cadmium Chloride affects the expression of CPS1 mRNA CTD PMID:22110744 carbon nanotube decreases expression ISO RGD:10389 6480464 Nanotubes, Carbon results in decreased expression of CPS1 mRNA CTD PMID:25620056 cisplatin multiple interactions ISO RGD:70833 6480464 [Cisplatin co-treated with jinfukang] results in decreased expression of CPS1 mRNA CTD PMID:27392435 cisplatin decreases expression ISO RGD:70833 6480464 Cisplatin results in decreased expression of CPS1 mRNA CTD PMID:27392435 clofibrate decreases expression ISO RGD:10389 6480464 Clofibrate results in decreased expression of CPS1 mRNA CTD PMID:17585979 clofibrate multiple interactions ISO RGD:10389 6480464 [Clofibrate co-treated with Acetaminophen] affects the expression of CPS1 mRNA, PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of CPS1 mRNA] CTD PMID:17585979 cobalt dichloride decreases expression ISO RGD:70833 6480464 cobaltous chloride results in decreased expression of CPS1 mRNA CTD PMID:19376846 cobalt dichloride decreases expression EXP 6480464 cobaltous chloride results in decreased expression of CPS1 mRNA CTD PMID:24386269 copper(II) sulfate decreases expression ISO RGD:70833 6480464 Copper Sulfate results in decreased expression of CPS1 mRNA CTD PMID:19549813 cyclosporin A decreases expression ISO RGD:70833 6480464 Cyclosporine results in decreased expression of CPS1 mRNA CTD PMID:20106945 , PMID:25562108 dexamethasone increases expression ISO RGD:10389 6480464 Dexamethasone results in increased expression of CPS1 protein CTD PMID:12198645 dexamethasone increases expression EXP 6480464 Dexamethasone results in increased expression of CPS1 mRNA CTD PMID:15965953 dioxygen decreases expression ISO RGD:70833 6480464 Oxygen deficiency results in decreased expression of CPS1 mRNA CTD PMID:24236059 doxorubicin decreases expression ISO RGD:70833 6480464 Doxorubicin results in decreased expression of CPS1 mRNA CTD PMID:29803840 endosulfan multiple interactions ISO RGD:70833 6480464 [Endosulfan co-treated with Tetrachlorodibenzodioxin] results in decreased expression of CPS1 mRNA CTD PMID:26159488 endosulfan decreases expression EXP 6480464 Endosulfan results in decreased expression of CPS1 mRNA CTD PMID:29391264 endosulfan decreases expression ISO RGD:70833 6480464 Endosulfan results in decreased expression of CPS1 mRNA CTD PMID:26159488 entinostat increases expression ISO RGD:70833 6480464 entinostat results in increased expression of CPS1 mRNA CTD PMID:27188386 ethanol decreases expression EXP 6480464 Ethanol results in decreased expression of CPS1 protein CTD PMID:23200777 etoposide affects response to substance ISO RGD:70833 6480464 CPS1 protein affects the susceptibility to Etoposide CTD PMID:16217747 flutamide decreases expression EXP 6480464 Flutamide results in decreased expression of CPS1 mRNA CTD PMID:24793618 formaldehyde decreases expression ISO RGD:70833 6480464 Formaldehyde results in decreased expression of CPS1 mRNA CTD PMID:23649840 glafenine decreases expression EXP 6480464 Glafenine results in decreased expression of CPS1 mRNA CTD PMID:24136188 hydrogen peroxide affects expression ISO RGD:70833 6480464 Hydrogen Peroxide affects the expression of CPS1 mRNA CTD PMID:20044591 isoprenaline increases expression ISO RGD:10389 6480464 Isoproterenol results in increased expression of CPS1 mRNA CTD PMID:21335049 methapyrilene decreases expression EXP 6480464 Methapyrilene results in decreased expression of CPS1 mRNA CTD PMID:30467583 methotrexate affects response to substance ISO RGD:70833 6480464 CPS1 protein affects the susceptibility to Methotrexate CTD PMID:16217747 methyl methanesulfonate decreases expression ISO RGD:70833 6480464 Methyl Methanesulfonate results in decreased expression of CPS1 mRNA CTD PMID:23649840 methylmercury chloride decreases expression ISO RGD:70833 6480464 methylmercuric chloride results in decreased expression of CPS1 mRNA CTD PMID:23179753 mitomycin C affects response to substance ISO RGD:70833 6480464 CPS1 protein affects the susceptibility to Mitomycin CTD PMID:16217747 N-nitrosodiethylamine multiple interactions EXP 6480464 [Phenobarbital co-treated with Diethylnitrosamine] results in decreased expression of CPS1 protein CTD PMID:20935162 N-nitrosodiethylamine multiple interactions ISO RGD:10389 6480464 [Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of CPS1 mRNA CTD PMID:24535843 N-nitrosodimethylamine decreases expression EXP 6480464 Dimethylnitrosamine results in decreased expression of CPS1 protein CTD PMID:2864015 N-nitrosomorpholine affects expression EXP 6480464 N-nitrosomorpholine affects the expression of CPS1 protein CTD PMID:19716841 nefazodone decreases expression EXP 6480464 nefazodone results in decreased expression of CPS1 mRNA CTD PMID:24136188 nimesulide decreases expression EXP 6480464 nimesulide results in decreased expression of CPS1 mRNA CTD PMID:24136188 nitric oxide affects abundance ISO RGD:70833 6480464 CPS1 gene SNP affects the abundance of Nitric Oxide metabolite CTD PMID:14718356 nitroprusside affects response to substance ISO RGD:70833 6480464 CPS1 gene SNP affects the susceptibility to Nitroprusside CTD PMID:14718356 ochratoxin A increases expression ISO RGD:70833 6480464 ochratoxin A results in increased expression of CPS1 protein CTD PMID:26861962 paracetamol multiple interactions ISO RGD:10389 6480464 [Clofibrate co-treated with Acetaminophen] affects the expression of CPS1 mRNA more ... CTD PMID:17585979 , PMID:25499718 paracetamol decreases expression ISO RGD:70833 6480464 Acetaminophen results in decreased expression of CPS1 mRNA CTD PMID:25704631 paracetamol affects expression ISO RGD:10389 6480464 Acetaminophen affects the expression of CPS1 mRNA CTD PMID:17562736 perfluorododecanoic acid decreases expression EXP 6480464 perfluorododecanoic acid results in decreased expression of CPS1 mRNA, perfluorododecanoic acid results in decreased expression of CPS1 protein CTD PMID:26168851 perfluorododecanoic acid multiple interactions EXP 6480464 PPARA mRNA inhibits the reaction [perfluorododecanoic acid results in decreased expression of CPS1 mRNA] CTD PMID:26168851 perfluorooctane-1-sulfonic acid decreases expression ISO RGD:70833 6480464 perfluorooctane sulfonic acid results in decreased expression of CPS1 mRNA CTD PMID:21723365 perfluorooctane-1-sulfonic acid decreases expression EXP 6480464 perfluorooctane sulfonic acid results in decreased expression of CPS1 mRNA CTD PMID:21723365 perfluorooctanoic acid affects expression ISO RGD:10389 6480464 perfluorooctanoic acid affects the expression of CPS1 mRNA CTD PMID:18281256 perfluorooctanoic acid decreases expression ISO RGD:70833 6480464 perfluorooctanoic acid results in decreased expression of CPS1 mRNA CTD PMID:21723365 , PMID:27153767 perfluorooctanoic acid increases expression ISO RGD:70833 6480464 perfluorooctanoic acid results in increased expression of CPS1 protein CTD PMID:26879310 perfluorooctanoic acid decreases expression EXP 6480464 perfluorooctanoic acid results in decreased expression of CPS1 mRNA, perfluorooctanoic acid results in decreased expression of CPS1 protein CTD PMID:20452409 , PMID:21723365 phenobarbital multiple interactions EXP 6480464 [Phenobarbital co-treated with Diethylnitrosamine] results in decreased expression of CPS1 protein CTD PMID:20935162 phenobarbital affects expression ISO RGD:70833 6480464 Phenobarbital affects the expression of CPS1 mRNA CTD PMID:19159669 phenobarbital multiple interactions ISO RGD:10389 6480464 [Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of CPS1 mRNA CTD PMID:24535843 pirinixic acid decreases expression ISO RGD:10389 6480464 pirinixic acid results in decreased expression of CPS1 mRNA, pirinixic acid results in decreased expression of CPS1 protein CTD PMID:15226431 , PMID:23811191 pirinixic acid decreases expression EXP 6480464 pirinixic acid results in decreased expression of CPS1 mRNA CTD PMID:17164430 , PMID:19162173 potassium dichromate increases expression ISO RGD:10389 6480464 Potassium Dichromate results in increased expression of CPS1 mRNA CTD PMID:23608068 pregnenolone 16alpha-carbonitrile decreases expression EXP 6480464 Pregnenolone Carbonitrile results in decreased expression of CPS1 mRNA CTD PMID:19162173 quercetin increases expression ISO RGD:70833 6480464 Quercetin results in increased expression of CPS1 protein CTD PMID:19207037 sodium arsenate decreases expression ISO RGD:10389 6480464 sodium arsenate results in decreased expression of CPS1 mRNA CTD PMID:21795629 sodium dichromate affects expression EXP 6480464 sodium bichromate affects the expression of CPS1 mRNA CTD PMID:22110744 sunitinib decreases expression ISO RGD:70833 6480464 Sunitinib results in decreased expression of CPS1 mRNA CTD PMID:31533062 tauroursodeoxycholic acid decreases expression EXP 6480464 tauroursodeoxycholic acid results in decreased expression of CPS1 mRNA CTD PMID:15885361 tetrachloromethane multiple interactions EXP 6480464 [2-Acetylaminofluorene co-treated with Carbon Tetrachloride] affects the expression of CPS1 protein, schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of CPS1 mRNA] CTD PMID:11813887 , PMID:31150632 tetrachloromethane decreases expression EXP 6480464 Carbon Tetrachloride results in decreased expression of CPS1 mRNA CTD PMID:31150632 tetrachloromethane decreases expression ISO RGD:10389 6480464 Carbon Tetrachloride results in decreased expression of CPS1 mRNA CTD PMID:26639393 tetrachloromethane increases expression ISO RGD:10389 6480464 Carbon Tetrachloride results in increased expression of CPS1 mRNA, Carbon Tetrachloride results in increased expression of CPS1 protein CTD PMID:15650968 , PMID:17109383 thimerosal decreases expression ISO RGD:70833 6480464 Thimerosal results in decreased expression of CPS1 mRNA CTD PMID:27188386 troglitazone decreases expression ISO RGD:10389 6480464 troglitazone results in decreased expression of CPS1 protein CTD PMID:18495193 troglitazone decreases expression EXP 6480464 troglitazone results in decreased expression of CPS1 protein CTD PMID:21315101 troglitazone increases expression ISO RGD:10389 6480464 troglitazone results in increased expression of CPS1 protein CTD PMID:18495193 valdecoxib decreases expression EXP 6480464 valdecoxib results in decreased expression of CPS1 mRNA CTD PMID:24136188 valproic acid affects response to substance ISO RGD:70833 6480464 CPS1 protein affects the susceptibility to Valproic Acid CTD PMID:1414247 , PMID:2974563 valproic acid decreases expression ISO RGD:70833 6480464 Valproic Acid results in decreased expression of CPS1 mRNA CTD PMID:29501571 valproic acid decreases methylation ISO RGD:70833 6480464 Valproic Acid results in decreased methylation of CPS1 gene CTD PMID:29501571 valproic acid increases expression ISO RGD:70833 6480464 Valproic Acid results in increased expression of CPS1 mRNA CTD PMID:23179753 , PMID:27188386 valproic acid affects expression ISO RGD:70833 6480464 Valproic Acid affects the expression of CPS1 mRNA CTD PMID:25979313 valproic acid affects expression ISO RGD:10389 6480464 Valproic Acid affects the expression of CPS1 mRNA CTD PMID:17963808 vorinostat increases expression ISO RGD:70833 6480464 vorinostat results in increased expression of CPS1 mRNA CTD PMID:27188386 zinc atom increases expression ISO RGD:70833 6480464 Zinc results in increased expression of CPS1 mRNA CTD PMID:16870260 zinc dichloride increases expression ISO RGD:70833 6480464 zinc chloride results in increased expression of CPS1 mRNA CTD PMID:16870260 zinc(0) increases expression ISO RGD:70833 6480464 Zinc results in increased expression of CPS1 mRNA CTD PMID:16870260
Gene-Chemical Interaction Annotations
