Il1rl2 (interleukin 1 receptor-like 2)

Gene: Il1rl2 (interleukin 1 receptor-like 2) Rattus norvegicus

Analyze

Symbol:

Il1rl2

Name:

interleukin 1 receptor-like 2

RGD ID:

621782

Description:

Predicted to enable NAD+ nucleosidase activity; NAD+ nucleotidase, cyclic ADP-ribose generating; and interleukin-1 receptor activity. Predicted to be involved in regulation of inflammatory response. Predicted to act upstream of or within positive regulation of T cell differentiation and positive regulation of interleukin-6 production. Predicted to be located in membrane. Orthologous to human IL1RL2 (interleukin 1 receptor like 2); INTERACTS WITH alpha-Zearalanol; ammonium chloride; bisphenol A.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

IL-1Rrp2; IL-36 receptor; IL1R-rp2; interleukin-1 receptor-like 2; interleukin-1 receptor-related protein 2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Allele / Splice:

Il1rl2^{tm1(Myh6-cre)Mhzh}

Genetic Models:

SD-Il1rl2^{tm1(Myh6-cre)Mhzh}

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	50,087,271 - 50,134,225 (+)	NCBI		GRCr8
mRatBN7.2	9	42,591,658 - 42,639,351 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	42,591,934 - 42,636,667 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	9	51,094,273 - 51,139,209 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	56,216,970 - 56,261,896 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	54,492,602 - 54,537,352 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	47,044,870 - 47,093,679 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	47,047,832 - 47,095,831 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	9	46,733,619 - 46,778,352 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	9	39,492,187 - 39,537,792 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	9	39,493,600 - 39,539,206 (+)	NCBI
Celera	9	40,337,394 - 40,381,411 (+)	NCBI		Celera
Cytogenetic Map	9	q22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

aortic dissection (ISO)

Myocardial Reperfusion Injury (IMP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

2-palmitoylglycerol (ISO)

3,4-methylenedioxymethamphetamine (ISO)

4,4'-sulfonyldiphenol (ISO)

alpha-Zearalanol (EXP)

ammonium chloride (EXP)

aristolochic acid A (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

CGP 52608 (ISO)

choline (ISO)

dioxygen (EXP)

elemental selenium (ISO)

endosulfan (EXP)

epoxiconazole (ISO)

ethanol (ISO)

folic acid (ISO)

FR900359 (ISO)

fulvestrant (ISO)

L-methionine (ISO)

lead diacetate (ISO)

microcystin-LR (ISO)

monosodium L-glutamate (ISO)

ozone (ISO)

paracetamol (EXP)

perfluorohexanesulfonic acid (ISO)

perfluorooctanoic acid (EXP)

potassium dichromate (ISO)

selenium atom (ISO)

silver atom (ISO)

silver(0) (ISO)

sodium arsenite (ISO)

tetrachloromethane (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cytokine-mediated signaling pathway (IEA)

positive regulation of interleukin-6 production (IEA,ISO)

positive regulation of T cell differentiation (IEA,ISO)

regulation of inflammatory response (IBA,IEA,ISO)

Cellular Component

membrane (IEA)

Molecular Function

hydrolase activity (IEA)

interleukin-1 receptor activity (IEA)

NAD+ nucleosidase activity (IEA)

NAD+ nucleotidase, cyclic ADP-ribose generating (IEA)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal circulating chemokine level (IMP)

abnormal circulating myoglobin level (IMP)

abnormal nitric oxide homeostasis (IMP)

decreased cardiomyocyte apoptosis (IMP)

decreased circulating lactate dehydrogenase level (IMP)

decreased circulating troponin level (IMP)

decreased circulating tumor necrosis factor level (IMP)

decreased interleukin-1 beta secretion (IMP)

decreased macrophage cell number (IMP)

increased cardiac muscle contractility (IMP)

increased left ventricle systolic pressure (IMP)

oxidative stress (IMP)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Cloning of a cDNA encoding a novel interleukin-1 receptor related protein (IL 1R-rp2).	Lovenberg TW, etal., J Neuroimmunol 1996 Nov;70(2):113-22.
3.	Deficiency of Interleukin-36 Receptor Protected Cardiomyocytes from Ischemia-Reperfusion Injury in Cardiopulmonary Bypass.	Luo C, etal., Med Sci Monit. 2020 Feb 12;26:e918933. doi: 10.12659/MSM.918933.
4.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
5.	GOA pipeline	RGD automated data pipeline
6.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:21860022	PMID:22968459	PMID:23064362

Genomics

Comparative Map Data

Il1rl2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	50,087,271 - 50,134,225 (+)	NCBI		GRCr8
mRatBN7.2	9	42,591,658 - 42,639,351 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	42,591,934 - 42,636,667 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	9	51,094,273 - 51,139,209 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	56,216,970 - 56,261,896 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	54,492,602 - 54,537,352 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	47,044,870 - 47,093,679 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	47,047,832 - 47,095,831 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	9	46,733,619 - 46,778,352 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	9	39,492,187 - 39,537,792 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	9	39,493,600 - 39,539,206 (+)	NCBI
Celera	9	40,337,394 - 40,381,411 (+)	NCBI		Celera
Cytogenetic Map	9	q22	NCBI

IL1RL2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	102,186,973 - 102,243,086 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	102,187,006 - 102,240,002 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	102,803,433 - 102,856,462 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	102,169,865 - 102,222,243 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	102,261,950 - 102,314,329	NCBI
Celera	2	97,004,649 - 97,057,020 (+)	NCBI		Celera
Cytogenetic Map	2	q12.1	NCBI
HuRef	2	96,567,290 - 96,619,802 (+)	NCBI		HuRef
CHM1_1	2	102,807,775 - 102,860,073 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	102,645,259 - 102,701,349 (+)	NCBI		T2T-CHM13v2.0

Il1rl2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	40,363,697 - 40,406,722 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	40,363,770 - 40,406,722 (+)	Ensembl		GRCm39 Ensembl
GRCm38	1	40,324,589 - 40,367,555 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	40,324,610 - 40,367,562 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	40,381,472 - 40,422,316 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	1	40,269,173 - 40,310,017 (+)	NCBI		MGSCv36	mm8
Celera	1	40,135,784 - 40,176,671 (+)	NCBI		Celera
Cytogenetic Map	1	B	NCBI
cM Map	1	18.96	NCBI

Il1rl2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955470	7,704,134 - 7,742,064 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955470	7,703,369 - 7,742,058 (+)	NCBI	ChiLan1.0	ChiLan1.0

IL1RL2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	12	25,995,088 - 26,049,489 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2A	25,997,849 - 26,051,650 (-)	NCBI		NHGRI_mPanPan1
PanPan1.1	2A	103,237,107 - 103,289,427 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2A	103,237,996 - 103,289,414 (+)	Ensembl	panpan1.1		panPan2

IL1RL2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	10	40,776,670 - 40,817,263 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	10	40,778,590 - 40,816,044 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	10	40,698,936 - 40,742,868 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	10	41,639,600 - 41,683,546 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	10	41,645,070 - 41,682,534 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	10	41,353,871 - 41,397,328 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	10	41,635,603 - 41,679,766 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	10	41,827,554 - 41,871,492 (-)	NCBI		UU_Cfam_GSD_1.0

Il1rl2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024406292	90,201,299 - 90,240,726 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936713	893,769 - 930,889 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936713	893,020 - 932,406 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

IL1RL2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	51,966,691 - 52,011,479 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	51,978,857 - 52,011,607 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	54,382,183 - 54,396,574 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

IL1RL2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	14	5,862,140 - 5,912,789 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	14	5,863,727 - 5,915,370 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666041	173,542,157 - 173,595,405 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Il1rl2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624749	6,749,007 - 6,779,753 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624749	6,747,131 - 6,781,908 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Il1rl2
297 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	249
Count of miRNA genes:	186
Interacting mature miRNAs:	209
Transcripts:	ENSRNOT00000019880
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
7411571	Bw138	Body weight QTL 138	14.3	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	9	32535505	77535505	Rat
1300180	Bw14	Body weight QTL 14	3.776		body mass (VT:0001259)	body weight (CMO:0000012)	9	23754024	61381613	Rat
631680	Cm11	Cardiac mass QTL 11	3.1	0.00089	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	9	20430519	65430519	Rat
70218	Cm28	Cardiac mass QTL 28	8.3	0.0001	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	9	25268044	79271759	Rat
724544	Uae9	Urinary albumin excretion QTL 9	4.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	9	25268044	114175309	Rat
1354650	Despr5	Despair related QTL 5	4.01	0.0017	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	9	1254084	46254084	Rat
7207805	Bmd88	Bone mineral density QTL 88	4		femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	9	23754024	58157242	Rat
631643	Bp120	Blood pressure QTL 120	3	0.004	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	22071200	67071200	Rat
731164	Uae25	Urinary albumin excretion QTL 25	3.5	0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	9	25661188	100929786	Rat
9589133	Insul26	Insulin level QTL 26	17.96	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	9	8952560	53952560	Rat
631211	Bw4	Body weight QTL4	5.31		retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	9	5109826	50109826	Rat
2303559	Gluco54	Glucose level QTL 54	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	9	1254084	46254084	Rat
7411609	Foco16	Food consumption QTL 16	25.6	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	9	8952560	53952560	Rat
8662828	Vetf6	Vascular elastic tissue fragility QTL 6	3.9		artery integrity trait (VT:0010639)	patent ductus arteriosus score (CMO:0002566)	9	36962359	92058970	Rat
61352	Bp34	Blood pressure QTL 34	5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	42495343	79271511	Rat
1598834	Memor11	Memory QTL 11	2.5		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	9	36962359	77814038	Rat
70186	Niddm26	Non-insulin dependent diabetes mellitus QTL 26	3.87		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	9	22071169	86369743	Rat
7207814	Bmd91	Bone mineral density QTL 91	3.5		femur size trait (VT:1000369)	femoral neck cross-sectional area (CMO:0001697)	9	23754144	83851531	Rat
6903941	Pur31	Proteinuria QTL 31		0.036	urine total protein amount (VT:0000032)	urine protein excretion rate (CMO:0000759)	9	40194188	85194188	Rat
1641911	Alcrsp13	Alcohol response QTL 13			response to alcohol trait (VT:0010489)	brain neurotensin receptor 1 density (CMO:0002068)	9	1	43718459	Rat
2290450	Scl57	Serum cholesterol level QTL 57	4.15		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	9	36962359	95410867	Rat
11353949	Bp393	Blood pressure QTL 393			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	40194188	85194188	Rat
61425	Cia15	Collagen induced arthritis QTL 15	4.6		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	9	5109826	42921101	Rat
10054125	Srcrt7	Stress Responsive Cort QTL 7	3.33	0.0011	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	9	1	87073594	Rat
1600365	Mcs20	Mammary carcinoma susceptibility QTL 20	3		mammary gland integrity trait (VT:0010552)	mammary tumor growth rate (CMO:0000344)	9	13533770	42791750	Rat
11353947	Bp392	Blood pressure QTL 392			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	7283252	52283252	Rat
1331757	Cdexp1	CD45RC expression in CD8 T cells QTL 1	4.3		CD8-positive T cell quantity (VT:0008077)	blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)	9	1024537	67509080	Rat
7411656	Foco26	Food consumption QTL 26	9.8	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	9	32535505	77535505	Rat
1298088	Edpm11	Estrogen-dependent pituitary mass QTL 11	2.5		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	9	1	43718459	Rat
1598823	Memor16	Memory QTL 16	1.9		exploratory behavior trait (VT:0010471)	difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)	9	22133322	49968732	Rat
1641894	Alcrsp12	Alcohol response QTL 12			response to alcohol trait (VT:0010489)	brain neurotensin receptor 1 density (CMO:0002068)	9	27468639	72468639	Rat

Genetic Models

This gene Il1rl2 is modified in the following models/strains:

SD-Il1rl2^{tm1(Myh6-cre)Mhzh}

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium
Low	2	12	12	4	19	4			32	14	31	11
Below cutoff	1	28	36	34		34	5	7	42	20	10		5

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_133575	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017596258	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017596259	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017596260	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473965	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000009	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U49066	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000019880 ⟹ ENSRNOP00000019880

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	9	42,591,934 - 42,636,667 (+)	Ensembl
Rnor_6.0 Ensembl	9	47,047,832 - 47,095,831 (+)	Ensembl

RefSeq Acc Id:

NM_133575 ⟹ NP_598259

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	50,087,552 - 50,132,302 (+)	NCBI
mRatBN7.2	9	42,591,934 - 42,636,667 (+)	NCBI
Rnor_6.0	9	47,048,915 - 47,093,679 (+)	NCBI
Rnor_5.0	9	46,733,619 - 46,778,352 (+)	NCBI
RGSC_v3.4	9	39,492,187 - 39,537,792 (+)	RGD
Celera	9	40,337,394 - 40,381,411 (+)	RGD

Sequence:

show sequence

CCGGCTGGCCTAGGATCAGGCAAGAAAAGGCTGAACGCCTTTCTAAGGACGGACTCTTTCTGTA
CAGCTCCACTTGGGGAAGCCCGAAATGGGGATGCCACCCTTGCTCTTCTGTTGGGTGTCTTTCG
TGCTTCCACTTTTTGTGGCAGCAGGTAACTGTACTGATGTCTATATGCACCATGAGATGATTTC
AGAGGGCCAGCCTTTCCCCTTCAACTGCACATACCCTCCAGTAACAAACGGGGCAGTGAATCTG
ACATGGCATAGAACACCCAGTAAGAGCCCAATCTCCATCAACAGACACGTTAGAATTCACCAGG
ACCAGTCCTGGATTTTGTTTCTTCCGTTGGCATTGGAGGACTCAGGCATCTATCAATGTGTTAT
AAAGGATGCCCACAGCTGTTACCGAATAGCTATAAACCTAACCGTTTTTAGAAAACACTGGTGC
GACTCTTCCAACGAAGAGAGTTCCATAAATTCCTCAGATGAGTACCAGCAATGGTTACCCATAG
GAAAATCGGGCAGTCTGACGTGCCATCTCTACTTCCCAGAGAGCTGTGTTTTGGATTCAATAAA
GTGGTATAAGGGTTGTGAAGAGATTAAAGTGAGCAAGAAGTTTTGCCCTACAGGAACAAAGCTT
CTTGTTAACAACATCGACGTGGAGGATAGTGGGAGCTATGCATGCTCAGCCAGACTGACACACT
TGGGGAGAATCTTCACGGTTAGAAACTACATTGCTGTGAATACCAAGGAAGTTGGGTCTGGAGG
AAGGATCCCTAACATCACGTATCCAAAAAACAACTCCATTGAAGTTCAACTTGGCTCCACCCTC
ATTGTGGACTGCAATATAACAGACACGAAGGAGAATACGAACCTCAGATGCTGGCGAGTTAACA
ACACCCTGGTGGACGATTACTACAACGACTTCAAACGCATCCAGGAAGGAATCGAAACCAATCT
GTCTCTGAGGAATCACATTCTGTACACAGTGAACATAACATTCTTAGAAGTGAAAATGGAGGAC
TACGGCCATCCTTTCACATGCCACGCTGCGGTGTCCGCAGCCTACATCATTCTGAAACGCCCAG
CTCCAGACTTCCGGGCTTACCTCATAGGAGGTCTCATGGCTTTCCTACTTCTGGCCGTGTCCAT
TCTGTACATCTACAACACCTTTAAGGTCGACATCGTGCTTTGGTATAGGAGTACCTTCCACACT
GCCCAGGCTCCAGATGACGAGAAGCTGTATGATGCCTATGTCTTATACCCCAAGTACCCAAGAG
AAAGCCAGGGCCATGATGTGGACACACTGGTGTTGAAGATCTTGCCCGAGGTGCTGGAGAAACA
GTGTGGATATAAGTTATTCATATTTGGCAGGGATGAATTCCCTGGACAAGCTGTGGCCAGCGTC
ATTGATGAAAACATTAAGCTGTGTAGGAGGCTGATGGTCCTCGTGGCACCAGAGACATCCAGCT
TCAGCTTTCTGAAGAACTTGACTGAAGAACAAATCGCTGTCTACAATGCCCTCGTCCAGGACGG
CATGAAGGTCATTCTGATTGAACTGGAGAGAGTCAAGGACTACAGCACCATGCCCGAGTCCATT
CAGTACATCCGACAGAAGCACGGGGCCATCCAGTGGGATGGGGACTTCACAGAGCAGGCACAGT
GCGCCAAGACGAAATTCTGGAAGAAAGTGAGATATCATATGCCACCCAGGAGGTACCCGGCATC
TCCCCCCGTCCAGCTGCTAGGACACACACCCCGCATACCAGGCTAGTGCAGTGCCACCGCCACG
GGGCTCATAACTCCTTAAGAGCGGTTAGTGTGTGGTGGCTCGCACTACAACCTCTCTGGATCAT
CTACCCCCGTAGCTTGCTCTTTTGTGCTTGTGAGCGACCTCGTCCTTAGCCACGTCATATTTTG
ATTTTTTGTTTGTTTTGTTTGTTTGTTGTATGCTTTTAGTCATAGCTGATTCGTACTACTCCTG
TTTGCTTCATGGTTCCTGAATCCCAGAGACTCCCTGAGCATGGGTGGCTATCATGTTGGG

hide sequence

RefSeq Acc Id:

XM_017596259 ⟹ XP_017451748

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	50,087,271 - 50,134,225 (+)	NCBI
mRatBN7.2	9	42,591,658 - 42,639,351 (+)	NCBI
Rnor_6.0	9	47,048,447 - 47,093,600 (+)	NCBI

Sequence:

show sequence

TCAAGGGACAGTGCCCGGACAGACACCTATCCATCTTAACTTTGTGAACTTGGGACAGCTAGTC
AGACTGGCCCTGTGGTTGTTTAGAAAGTCTTACAGTTTCTAATCCACAAAGACCACCAGGAAGG
CCCACTTAGAAGCTGCTGGTCTGATGGCATTTGCTATCTCTGCACTTCCTAGTGCCCAGTGGGG
TTTCCCGTGTCTCTGGGGCAGGAAGACAGGTCCGGGCTAGCATCGCTTTATGGCAAGTTTAAAC
TGCAGCATTCAACCTGTCGGGAGTCCGCTTTACTGAAGATCTAGAGGGTTAATCCTAAACCATG
TGGAATGGCTTCCACATCTGGAATAGTCCATATTAGGGCAATGCTGGGCATGTTAAGAACCGCT
CAAACAGTGCTTGGAAAGAAATGATAATTTTTTTTAGCGATGATCTGGGGCATATTTAAGCCGA
CATTCCTGCTAGATGAACGTGCTGGCCTAGGATCAGGCAAGAAAAGGCTGAACGCCTTTCTAAG
GACGGACTCTTTCTGTACAGCTCCACTTGGGGAAGGTGAGTCTGCCCCGCCCGTGGCGGAGAGG
CGATGCCCAGGCTGCTGAATCCGGTCCCTGGCGTGGTTCCAGCTCTGCTCTAGGAGACCCGGCG
CTCTGAGACCTCATAGACAGCCCGAAATGGGGATGCCACCCTTGCTCTTCTGTTGGGTGTCTTT
CGTGCTTCCACTTTTTGTGGCAGCAGGTAACTGTACTGATGTCTATATGCACCATGAGATGATT
TCAGAGGGCCAGCCTTTCCCCTTCAACTGCACATACCCTCCAGTAACAAACGGGGCAGTGAATC
TGACATGGCATAGAACACCCAGTAAGAGCCCAATCTCCATCAACAGACACGTTAGAATTCACCA
GGACCAGTCCTGGATTTTGTTTCTTCCGTTGGCATTGGAGGACTCAGGCATCTATCAATGTGTT
ATAAAGGATGCCCACAGCTGTTACCGAATAGCTATAAACCTAACCGTTTTTAGAAAACACTGGT
GCGACTCTTCCAACGAAGAGAGTTCCATAAATTCCTCAGATGAGTACCAGCAATGGTTACCCAT
AGGAAAATCGGGCAGTCTGACGTGCCATCTCTACTTCCCAGAGAGCTGTGTTTTGGATTCAATA
AAGTGGTATAAGGGTTGTGAAGAGATTAAAGTGAGCAAGAAGTTTTGCCCTACAGGAACAAAGC
TTCTTGTTAACAACATCGACGTGGAGGATAGTGGGAGCTATGCATGCTCAGCCAGACTGACACA
CTTGGGGAGAATCTTCACGGTTAGAAACTACATTGCTGTGAATACCAAGGAAGTTGGGTCTGGA
GGAAGGATCCCTAACATCACGTATCCAAAAAACAACTCCATTGAAGTTCAACTTGGCTCCACCC
TCATTGTGGACTGCAATATAACAGACACGAAGGAGAATACGAACCTCAGATGCTGGCGAGTTAA
CAACACCCTGGTGGACGATTACTACAACGACTCCAAACGCATCCAGGAAGGAATCGAAACCAAT
CTGTCTCTGAGGAATCACATTCTGTACACAGTGAACATAACATTCTTAGAAGTGAAAATGGAGG
ACTACGGCCATCCTTTCACATGCCACGCTGGCGTGTCCGCAGCCTACATCATTCTGAAACGCCC
AGCTCCAGACTTCCGGGCTTACCTCATAGGAGGTCTCATGGCTTTCCTACTTCTGGCCGTGTCC
ATTCTGTACATCTACAACACCTTTAAGGTCGACATCGTGCTTTGGTATAGGAGTACCTTCCACA
CTGCCCAGGCTCCAGATGACGAGAAGCTGTATGATGCCTATGTCTTATACCCCAAGTACCCAAG
AGAAAGCCAGGGCCATGATGTGGACACACTGGTGTTGAAGATCTTGCCCGAGGTGCTGGAGAAA
CAGTGTGGATATAAGTTATTCATATTTGGCAGGGATGAATTCCCTGGACAAGCTGTGGCCAGCG
TCATTGATGAAAACATTAAGCTGTGTAGGAGGCTGATGGTCCTCGTGGCACCAGAGACATCCAG
CTTCAGCTTTCTGAAGAACTTGACTGAAGAACAAATCGCTGTCTACAATGCCCTCGTCCAGGAC
GGCATGAAGGTCATTCTGATTGAACTGGAGAGAGTCAAGGACTACAGCACCATGCCCGAGTCCA
TTCAGTACATCCGACAGAAGCACGGGGCCATCCAGTGGGATGGGGACTTCACAGAGCAGGCACA
GTGCGCCAAGACGAAATTCTGGAAGAAAGTGAGATATCATATGCCACCCAGGAGGTACCCGGCA
TCTCCCCCCGTCCAGCTGCTAGGACACACACCCCGCATACCAGGCTAGTGCAGTGCCACCGCCA
CGGGGCTCATAACTCCTTAAGAGCGGTTAGTGTGTGGTGGCTCGCACTACAACCTCTCTGGATC
ATCTACCCCCGTAGCTTGCTCTTTTGTGCTTGTGAGCGACCTCGTCCTTAGCCACGTCATATTT
TGATTTTTTGTTTGTTTTGTTTGTTTGTTGTATGCTTTTAGTCATAGCT

hide sequence

Protein Sequences


Protein RefSeqs	NP_598259	(Get FASTA)	NCBI Sequence Viewer
	XP_017451748	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAB53238	(Get FASTA)	NCBI Sequence Viewer
	EDL99176	(Get FASTA)	NCBI Sequence Viewer
	EDL99177	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000019880.1
GenBank Protein	Q62929	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_598259 ⟸ NM_133575
- Peptide Label:	precursor
- UniProtKB:	Q62929 (UniProtKB/Swiss-Prot), G3V7W4 (UniProtKB/TrEMBL), A6INN3 (UniProtKB/TrEMBL)
- Sequence:	show sequence MGMPPLLFCWVSFVLPLFVAAGNCTDVYMHHEMISEGQPFPFNCTYPPVTNGAVNLTWHRTPSK SPISINRHVRIHQDQSWILFLPLALEDSGIYQCVIKDAHSCYRIAINLTVFRKHWCDSSNEESS INSSDEYQQWLPIGKSGSLTCHLYFPESCVLDSIKWYKGCEEIKVSKKFCPTGTKLLVNNIDVE DSGSYACSARLTHLGRIFTVRNYIAVNTKEVGSGGRIPNITYPKNNSIEVQLGSTLIVDCNITD TKENTNLRCWRVNNTLVDDYYNDFKRIQEGIETNLSLRNHILYTVNITFLEVKMEDYGHPFTCH AAVSAAYIILKRPAPDFRAYLIGGLMAFLLLAVSILYIYNTFKVDIVLWYRSTFHTAQAPDDEK LYDAYVLYPKYPRESQGHDVDTLVLKILPEVLEKQCGYKLFIFGRDEFPGQAVASVIDENIKLC RRLMVLVAPETSSFSFLKNLTEEQIAVYNALVQDGMKVILIELERVKDYSTMPESIQYIRQKHG AIQWDGDFTEQAQCAKTKFWKKVRYHMPPRRYPASPPVQLLGHTPRIPG hide sequence

RefSeq Acc Id:	XP_017451748 ⟸ XM_017596259
- Peptide Label:	isoform X1
- UniProtKB:	Q62929 (UniProtKB/Swiss-Prot), G3V7W4 (UniProtKB/TrEMBL), A6INN3 (UniProtKB/TrEMBL)
- Sequence:	show sequence MGMPPLLFCWVSFVLPLFVAAGNCTDVYMHHEMISEGQPFPFNCTYPPVTNGAVNLTWHRTPSK SPISINRHVRIHQDQSWILFLPLALEDSGIYQCVIKDAHSCYRIAINLTVFRKHWCDSSNEESS INSSDEYQQWLPIGKSGSLTCHLYFPESCVLDSIKWYKGCEEIKVSKKFCPTGTKLLVNNIDVE DSGSYACSARLTHLGRIFTVRNYIAVNTKEVGSGGRIPNITYPKNNSIEVQLGSTLIVDCNITD TKENTNLRCWRVNNTLVDDYYNDSKRIQEGIETNLSLRNHILYTVNITFLEVKMEDYGHPFTCH AGVSAAYIILKRPAPDFRAYLIGGLMAFLLLAVSILYIYNTFKVDIVLWYRSTFHTAQAPDDEK LYDAYVLYPKYPRESQGHDVDTLVLKILPEVLEKQCGYKLFIFGRDEFPGQAVASVIDENIKLC RRLMVLVAPETSSFSFLKNLTEEQIAVYNALVQDGMKVILIELERVKDYSTMPESIQYIRQKHG AIQWDGDFTEQAQCAKTKFWKKVRYHMPPRRYPASPPVQLLGHTPRIPG hide sequence

Ensembl Acc Id:

ENSRNOP00000019880 ⟸ ENSRNOT00000019880

Protein Domains

Ig-like Ig-like C2-type TIR

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q62929-F1-model_v2	AlphaFold	Q62929	1-561	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:621782	AgrOrtholog
BioCyc Gene	G2FUF-27724	BioCyc
Ensembl Genes	ENSRNOG00000014683	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000019880.4	UniProtKB/TrEMBL
Gene3D-CATH	2.60.40.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	3.40.50.10140	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	Ig-like_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ig-like_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ig-like_fold	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ig_sub	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ig_sub2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	IL-1_rcpt_fam	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	IL-1_rcpt_I/II-typ	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TIR_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Toll_tir_struct_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:171106	UniProtKB/Swiss-Prot
NCBI Gene	171106	ENTREZGENE
PANTHER	INTERLEUKIN-1 RECEPTOR-LIKE 2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR11890	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Ig_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TIR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Il1rl2	PhenoGen
PRINTS	INTRLKN1R12F	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	INTRLKN1R1F	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	IG_LIKE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TIR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000014683	RatGTEx
SMART	IGc2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SM00409	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TIR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF48726	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF52200	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A6INN3	ENTREZGENE, UniProtKB/TrEMBL
	G3V7W4	ENTREZGENE, UniProtKB/TrEMBL
	ILRL2_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2004-09-10	Il1rl2	interleukin 1 receptor-like 2			Symbol and Name status set to approved	1299863	APPROVED
2002-08-07	Il1rl2	interleukin 1 receptor-like 2			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_expression	expressed in lung and epididymis with lower levels of expression detected in the testis and cerebral cortex	729063
gene_function	did not bind either [125I]-recombinant human IL 1 alpha or [125I]-recombinant human IL 1 beta with high affinity	729063

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar

Mammalian Phenotype