IL1RL2 (interleukin 1 receptor like 2) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: IL1RL2 (interleukin 1 receptor like 2) Homo sapiens
Analyze
Symbol: IL1RL2
Name: interleukin 1 receptor like 2
RGD ID: 1353187
HGNC Page HGNC:5999
Description: Predicted to enable interleukin-1 receptor activity. Predicted to be involved in regulation of inflammatory response. Predicted to act upstream of or within positive regulation of T cell differentiation and positive regulation of interleukin-6 production. Predicted to be located in plasma membrane. Predicted to be integral component of plasma membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: IL-1 receptor-related protein 2; IL-1Rrp2; IL-36 receptor; IL-36R; IL1R-rp2; IL1RRP2; interleukin 1 receptor-like 2; interleukin-1 receptor-like 2; interleukin-1 receptor-related protein 2
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382102,186,973 - 102,243,086 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2102,187,006 - 102,240,002 (+)EnsemblGRCh38hg38GRCh38
GRCh372102,803,433 - 102,856,462 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362102,169,865 - 102,222,243 (+)NCBINCBI36hg18NCBI36
Build 342102,261,950 - 102,314,329NCBI
Celera297,004,649 - 97,057,020 (+)NCBI
Cytogenetic Map2q12.1NCBI
HuRef296,567,290 - 96,619,802 (+)NCBIHuRef
CHM1_12102,807,775 - 102,860,073 (+)NCBICHM1_1
T2T-CHM13v2.02102,645,259 - 102,698,266 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. Cloning of a cDNA encoding a novel interleukin-1 receptor related protein (IL 1R-rp2). Lovenberg TW, etal., J Neuroimmunol 1996 Nov;70(2):113-22.
3. Deficiency of Interleukin-36 Receptor Protected Cardiomyocytes from Ischemia-Reperfusion Injury in Cardiopulmonary Bypass. Luo C, etal., Med Sci Monit. 2020 Feb 12;26:e918933. doi: 10.12659/MSM.918933.
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1833184   PMID:8332913   PMID:9325300   PMID:10191101   PMID:10882729   PMID:11466363   PMID:12477932   PMID:16546408   PMID:19074885   PMID:19180518   PMID:19684156   PMID:19773279  
PMID:20190752   PMID:20237496   PMID:20353565   PMID:20800603   PMID:20959797   PMID:21860022   PMID:21873635   PMID:22144259   PMID:22315422   PMID:23128233   PMID:23817569   PMID:23966867  
PMID:23999434   PMID:25902739   PMID:26269592   PMID:26813344   PMID:27269181   PMID:27307043   PMID:27673278   PMID:27853811   PMID:28514442   PMID:29176319   PMID:29987050   PMID:33034926  
PMID:33961781   PMID:35171706  


Genomics

Comparative Map Data
IL1RL2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382102,186,973 - 102,243,086 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2102,187,006 - 102,240,002 (+)EnsemblGRCh38hg38GRCh38
GRCh372102,803,433 - 102,856,462 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362102,169,865 - 102,222,243 (+)NCBINCBI36hg18NCBI36
Build 342102,261,950 - 102,314,329NCBI
Celera297,004,649 - 97,057,020 (+)NCBI
Cytogenetic Map2q12.1NCBI
HuRef296,567,290 - 96,619,802 (+)NCBIHuRef
CHM1_12102,807,775 - 102,860,073 (+)NCBICHM1_1
T2T-CHM13v2.02102,645,259 - 102,698,266 (+)NCBI
Il1rl2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39140,363,697 - 40,406,722 (+)NCBIGRCm39mm39
GRCm39 Ensembl140,363,770 - 40,406,722 (+)Ensembl
GRCm38140,324,589 - 40,367,555 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl140,324,610 - 40,367,562 (+)EnsemblGRCm38mm10GRCm38
MGSCv37140,381,472 - 40,422,316 (+)NCBIGRCm37mm9NCBIm37
MGSCv36140,269,173 - 40,310,017 (+)NCBImm8
Celera140,135,784 - 40,176,671 (+)NCBICelera
Cytogenetic Map1BNCBI
Il1rl2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2942,591,658 - 42,639,351 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl942,591,934 - 42,636,667 (+)Ensembl
Rnor_6.0947,044,870 - 47,093,679 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl947,047,832 - 47,095,831 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0946,733,619 - 46,778,352 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4939,492,187 - 39,537,792 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1939,493,600 - 39,539,206 (+)NCBI
Celera940,337,394 - 40,381,411 (+)NCBICelera
Cytogenetic Map9q22NCBI
Il1rl2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554707,704,134 - 7,742,064 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554707,703,369 - 7,742,058 (+)NCBIChiLan1.0ChiLan1.0
IL1RL2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12A103,237,107 - 103,289,427 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A103,237,996 - 103,289,414 (+)Ensemblpanpan1.1panPan2
IL1RL2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11040,776,670 - 40,817,263 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1040,778,590 - 40,816,044 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1040,698,936 - 40,742,868 (-)NCBI
ROS_Cfam_1.01041,639,600 - 41,683,546 (-)NCBI
ROS_Cfam_1.0 Ensembl1041,645,070 - 41,682,534 (-)Ensembl
UMICH_Zoey_3.11041,353,871 - 41,397,328 (-)NCBI
UNSW_CanFamBas_1.01041,635,603 - 41,679,766 (-)NCBI
UU_Cfam_GSD_1.01041,827,554 - 41,871,492 (-)NCBI
Il1rl2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629290,201,299 - 90,240,726 (-)NCBI
SpeTri2.0NW_004936713893,020 - 932,406 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL1RL2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl351,966,691 - 52,011,479 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1351,978,857 - 52,011,607 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2354,382,183 - 54,396,574 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IL1RL2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1145,862,140 - 5,912,789 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl145,863,727 - 5,915,370 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666041173,542,157 - 173,595,405 (+)NCBIVero_WHO_p1.0
Il1rl2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247496,749,007 - 6,779,753 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046247496,747,131 - 6,781,908 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
RH120754  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372102,851,970 - 102,852,313UniSTSGRCh37
Build 362102,218,402 - 102,218,745RGDNCBI36
Celera297,053,179 - 97,053,522RGD
Cytogenetic Map2q12UniSTS
HuRef296,615,961 - 96,616,304UniSTS
TNG Radiation Hybrid Map260805.0UniSTS
STS-U49065  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372102,855,691 - 102,855,806UniSTSGRCh37
Build 362102,222,123 - 102,222,238RGDNCBI36
Celera297,056,900 - 97,057,015RGD
Cytogenetic Map2q12UniSTS
HuRef296,619,682 - 96,619,797UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:933
Count of miRNA genes:497
Interacting mature miRNAs:550
Transcripts:ENST00000264257, ENST00000421464, ENST00000441515, ENST00000481806, ENST00000539491
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 14 102 13 10 937 1 28 96 105 5 2 501
Low 1133 858 1472 552 198 396 1219 377 1427 332 888 1266 165 931 589 1
Below cutoff 1224 2042 129 40 1179 41 1978 1760 2134 33 427 137 1 271 1676

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001351446 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001351447 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001351448 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001351449 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001351450 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_003854 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006712820 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006712822 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011512091 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011512092 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011512093 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011512094 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011512096 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017005174 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017005175 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017005176 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017005177 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017005180 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047446164 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047446165 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047446166 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_007083520 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_007083521 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_923053 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC007248 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC007271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF284434 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK315334 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC107064 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA448166 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471127 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068276 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ131903 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U49065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000264257   ⟹   ENSP00000264257
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2102,187,023 - 102,240,002 (+)Ensembl
RefSeq Acc Id: ENST00000421464   ⟹   ENSP00000387611
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2102,187,314 - 102,201,582 (+)Ensembl
RefSeq Acc Id: ENST00000441515   ⟹   ENSP00000413348
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2102,187,015 - 102,239,351 (+)Ensembl
RefSeq Acc Id: ENST00000481806
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2102,187,006 - 102,239,338 (+)Ensembl
RefSeq Acc Id: NM_001351446   ⟹   NP_001338375
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382102,187,314 - 102,240,002 (+)NCBI
T2T-CHM13v2.02102,645,600 - 102,698,266 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001351447   ⟹   NP_001338376
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382102,186,973 - 102,240,002 (+)NCBI
T2T-CHM13v2.02102,645,259 - 102,698,266 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001351448   ⟹   NP_001338377
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382102,186,973 - 102,240,002 (+)NCBI
T2T-CHM13v2.02102,645,259 - 102,698,266 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001351449   ⟹   NP_001338378
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382102,187,023 - 102,240,002 (+)NCBI
T2T-CHM13v2.02102,645,309 - 102,698,266 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001351450   ⟹   NP_001338379
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382102,187,023 - 102,240,002 (+)NCBI
T2T-CHM13v2.02102,645,309 - 102,698,266 (+)NCBI
Sequence:
RefSeq Acc Id: NM_003854   ⟹   NP_003845
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382102,187,023 - 102,240,002 (+)NCBI
GRCh372102,803,433 - 102,856,462 (+)NCBI
Build 362102,169,865 - 102,222,243 (+)NCBI Archive
Celera297,004,649 - 97,057,020 (+)RGD
HuRef296,567,290 - 96,619,802 (+)ENTREZGENE
CHM1_12102,807,775 - 102,860,073 (+)NCBI
T2T-CHM13v2.02102,645,309 - 102,698,266 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006712822   ⟹   XP_006712885
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382102,189,176 - 102,240,002 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011512091   ⟹   XP_011510393
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382102,187,023 - 102,240,002 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011512092   ⟹   XP_011510394
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382102,187,023 - 102,239,283 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011512093   ⟹   XP_011510395
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382102,187,023 - 102,240,002 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011512094   ⟹   XP_011510396
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382102,187,314 - 102,240,002 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011512096   ⟹   XP_011510398
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382102,187,023 - 102,240,002 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017005174   ⟹   XP_016860663
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382102,187,023 - 102,243,086 (+)NCBI
Sequence:
RefSeq Acc Id: XM_047446164   ⟹   XP_047302120
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382102,187,314 - 102,240,002 (+)NCBI
RefSeq Acc Id: XM_047446165   ⟹   XP_047302121
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382102,187,023 - 102,240,002 (+)NCBI
RefSeq Acc Id: XM_047446166   ⟹   XP_047302122
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382102,189,233 - 102,240,002 (+)NCBI
RefSeq Acc Id: XR_007083520
RefSeq Status:
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382102,187,023 - 102,222,578 (+)NCBI
RefSeq Acc Id: XR_007083521
RefSeq Status:
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382102,187,023 - 102,225,952 (+)NCBI
RefSeq Acc Id: XR_923053
RefSeq Status:
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382102,187,023 - 102,225,984 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_003845   ⟸   NM_003854
- Peptide Label: isoform a precursor
- UniProtKB: Q587I8 (UniProtKB/Swiss-Prot),   Q9HB29 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006712885   ⟸   XM_006712822
- Peptide Label: isoform X8
- Sequence:
RefSeq Acc Id: XP_011510394   ⟸   XM_011512092
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_011510398   ⟸   XM_011512096
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: XP_011510393   ⟸   XM_011512091
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_011510395   ⟸   XM_011512093
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_011510396   ⟸   XM_011512094
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_016860663   ⟸   XM_017005174
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: NP_001338378   ⟸   NM_001351449
- Peptide Label: isoform d
- Sequence:
RefSeq Acc Id: NP_001338379   ⟸   NM_001351450
- Peptide Label: isoform d
- Sequence:
RefSeq Acc Id: NP_001338376   ⟸   NM_001351447
- Peptide Label: isoform b
- Sequence:
RefSeq Acc Id: NP_001338377   ⟸   NM_001351448
- Peptide Label: isoform c
- Sequence:
RefSeq Acc Id: NP_001338375   ⟸   NM_001351446
- Peptide Label: isoform a precursor
- UniProtKB: Q587I8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000413348   ⟸   ENST00000441515
RefSeq Acc Id: ENSP00000387611   ⟸   ENST00000421464
RefSeq Acc Id: ENSP00000264257   ⟸   ENST00000264257
RefSeq Acc Id: XP_047302121   ⟸   XM_047446165
- Peptide Label: isoform X6
RefSeq Acc Id: XP_047302120   ⟸   XM_047446164
- Peptide Label: isoform X1
RefSeq Acc Id: XP_047302122   ⟸   XM_047446166
- Peptide Label: isoform X9
Protein Domains
Ig-like   Ig-like C2-type   TIR

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9HB29-F1-model_v2 AlphaFold Q9HB29 1-575 view protein structure

Promoters
RGD ID:6797638
Promoter ID:HG_KWN:34197
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell
Transcripts:OTTHUMT00000253290,   OTTHUMT00000331184,   OTTHUMT00000331185,   UC002TBT.1
Position:
Human AssemblyChrPosition (strand)Source
Build 362102,169,476 - 102,169,976 (+)MPROMDB
RGD ID:6861204
Promoter ID:EPDNEW_H3767
Type:initiation region
Name:IL1RL2_1
Description:interleukin 1 receptor like 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh382102,186,988 - 102,187,048EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 2q11.2-12.3(chr2:100378510-108472871)x3 copy number gain See cases [RCV000050836] Chr2:100378510..108472871 [GRCh38]
Chr2:100994972..109089327 [GRCh37]
Chr2:100361404..108455759 [NCBI36]
Chr2:2q11.2-12.3
pathogenic
GRCh38/hg38 2q11.1-12.1(chr2:94817406-103252396)x3 copy number gain See cases [RCV000052946] Chr2:94817406..103252396 [GRCh38]
Chr2:95618109..103868854 [GRCh37]
Chr2:94846878..103235286 [NCBI36]
Chr2:2q11.1-12.1
pathogenic
GRCh38/hg38 2q11.2-13(chr2:97672522-110211318)x3 copy number gain See cases [RCV000052947] Chr2:97672522..110211318 [GRCh38]
Chr2:98288985..110968895 [GRCh37]
Chr2:97655417..110326184 [NCBI36]
Chr2:2q11.2-13
pathogenic
GRCh38/hg38 2p11.2-q11.2(chr2:91443218-102334856)x3 copy number gain See cases [RCV000052945] Chr2:91443218..102334856 [GRCh38]
Chr2:91617683..102951316 [GRCh37]
Chr2:90981410..102317748 [NCBI36]
Chr2:2p11.2-q11.2
pathogenic
NM_003854.2(IL1RL2):c.133C>T (p.Pro45Ser) single nucleotide variant Malignant melanoma [RCV000064985] Chr2:102189150 [GRCh38]
Chr2:102805610 [GRCh37]
Chr2:102172042 [NCBI36]
Chr2:2q12.1
not provided
NM_003854.2(IL1RL2):c.733C>T (p.Leu245=) single nucleotide variant Malignant melanoma [RCV000064986] Chr2:102218961 [GRCh38]
Chr2:102835421 [GRCh37]
Chr2:102201853 [NCBI36]
Chr2:2q12.1
not provided
NM_003854.2(IL1RL2):c.938C>T (p.Pro313Leu) single nucleotide variant Malignant melanoma [RCV000064987] Chr2:102219964 [GRCh38]
Chr2:102836424 [GRCh37]
Chr2:102202856 [NCBI36]
Chr2:2q12.1
not provided
GRCh38/hg38 2q11.2-12.2(chr2:102084275-106085903)x1 copy number loss See cases [RCV000134974] Chr2:102084275..106085903 [GRCh38]
Chr2:102700735..106702359 [GRCh37]
Chr2:102067167..106068791 [NCBI36]
Chr2:2q11.2-12.2
likely pathogenic
GRCh38/hg38 2q11.2-13(chr2:101710825-110791418)x3 copy number gain See cases [RCV000138645] Chr2:101710825..110791418 [GRCh38]
Chr2:102327287..111548995 [GRCh37]
Chr2:101693719..111265466 [NCBI36]
Chr2:2q11.2-13
pathogenic
GRCh38/hg38 2q11.1-13(chr2:94678532-110602409)x3 copy number gain See cases [RCV000141075] Chr2:94678532..110602409 [GRCh38]
Chr2:95344257..111359986 [GRCh37]
Chr2:94707984..111076455 [NCBI36]
Chr2:2q11.1-13
pathogenic
GRCh38/hg38 2q11.2-12.2(chr2:100478285-106498909)x3 copy number gain See cases [RCV000141445] Chr2:100478285..106498909 [GRCh38]
Chr2:101094747..107115365 [GRCh37]
Chr2:100461179..106481797 [NCBI36]
Chr2:2q11.2-12.2
uncertain significance
GRCh38/hg38 2q11.2-12.2(chr2:101234070-105679157)x1 copy number loss See cases [RCV000142969] Chr2:101234070..105679157 [GRCh38]
Chr2:101850532..106295614 [GRCh37]
Chr2:101216964..105662046 [NCBI36]
Chr2:2q11.2-12.2
pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:14238-243048760)x3 copy number gain not provided [RCV000752802] Chr2:14238..243048760 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
GRCh37/hg19 2q11.1-12.3(chr2:95529039-108518266) copy number gain See cases [RCV000449270] Chr2:95529039..108518266 [GRCh37]
Chr2:2q11.1-12.3
pathogenic
GRCh37/hg19 2q11.1-13(chr2:95327499-111370025)x4 copy number gain See cases [RCV000446842] Chr2:95327499..111370025 [GRCh37]
Chr2:2q11.1-13
pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:12771-242783384) copy number gain See cases [RCV000512056] Chr2:12771..242783384 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
GRCh37/hg19 2q11.1-12.2(chr2:95518497-107186127) copy number gain See cases [RCV000511158] Chr2:95518497..107186127 [GRCh37]
Chr2:2q11.1-12.2
uncertain significance
GRCh37/hg19 2p25.3-q37.3(chr2:12771-242783384)x3 copy number gain See cases [RCV000511212] Chr2:12771..242783384 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
Single allele deletion not provided [RCV000714264] Chr2:40608411..146900718 [GRCh37]
Chr2:2p22.1-q22.3
likely pathogenic
GRCh37/hg19 2q11.1-13(chr2:96353030-114045463)x3 copy number gain not provided [RCV000682168] Chr2:96353030..114045463 [GRCh37]
Chr2:2q11.1-13
pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:15672-243101834)x3 copy number gain not provided [RCV000752804] Chr2:15672..243101834 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
NM_003854.4(IL1RL2):c.710T>C (p.Ile237Thr) single nucleotide variant not provided [RCV000969441] Chr2:102212160 [GRCh38]
Chr2:102828620 [GRCh37]
Chr2:2q12.1
benign
NM_003854.4(IL1RL2):c.1665C>T (p.Cys555=) single nucleotide variant not provided [RCV000880062] Chr2:102235264 [GRCh38]
Chr2:102851724 [GRCh37]
Chr2:2q12.1
likely benign
NM_003854.4(IL1RL2):c.1054G>A (p.Val352Ile) single nucleotide variant not provided [RCV000968545] Chr2:102225960 [GRCh38]
Chr2:102842420 [GRCh37]
Chr2:2q12.1
benign
GRCh37/hg19 2q11.2-12.1(chr2:102248064-103361749)x3 copy number gain not provided [RCV000848462] Chr2:102248064..103361749 [GRCh37]
Chr2:2q11.2-12.1
uncertain significance
NM_003854.4(IL1RL2):c.-12-281C>A single nucleotide variant Ascending aortic dissection [RCV001543147] Chr2:102187575 [GRCh38]
Chr2:102804035 [GRCh37]
Chr2:2q12.1
association
NM_003854.4(IL1RL2):c.1678+1065T>C single nucleotide variant Ascending aortic dissection [RCV001543153] Chr2:102236342 [GRCh38]
Chr2:102852802 [GRCh37]
Chr2:2q12.1
association
NM_003854.4(IL1RL2):c.1611G>T (p.Pro537=) single nucleotide variant not provided [RCV000912305] Chr2:102235210 [GRCh38]
Chr2:102851670 [GRCh37]
Chr2:2q12.1
likely benign
GRCh37/hg19 2q11.2-12.2(chr2:101699537-106383710)x1 copy number loss not provided [RCV001827686] Chr2:101699537..106383710 [GRCh37]
Chr2:2q11.2-12.2
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:5999 AgrOrtholog
COSMIC IL1RL2 COSMIC
Ensembl Genes ENSG00000115598 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000264257 ENTREZGENE
  ENSP00000264257.2 UniProtKB/Swiss-Prot
  ENSP00000387611.1 UniProtKB/TrEMBL
  ENSP00000413348 ENTREZGENE
  ENSP00000413348.2 UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000264257 ENTREZGENE
  ENST00000264257.7 UniProtKB/Swiss-Prot
  ENST00000421464.1 UniProtKB/TrEMBL
  ENST00000441515 ENTREZGENE
  ENST00000441515.3 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.10140 UniProtKB/Swiss-Prot
GTEx ENSG00000115598 GTEx
HGNC ID HGNC:5999 ENTREZGENE
Human Proteome Map IL1RL2 Human Proteome Map
InterPro Ig-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_6 UniProtKB/Swiss-Prot
  Ig_sub UniProtKB/Swiss-Prot
  IL-1_rcpt_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-1_rcpt_I-typ UniProtKB/Swiss-Prot
  IL-1_rcpt_I/II-typ UniProtKB/Swiss-Prot
  IL-1RAcP-like_ig UniProtKB/TrEMBL
  TIR_dom UniProtKB/Swiss-Prot
  Toll_tir_struct_dom_sf UniProtKB/Swiss-Prot
KEGG Report hsa:8808 UniProtKB/Swiss-Prot
NCBI Gene 8808 ENTREZGENE
OMIM 604512 OMIM
PANTHER PTHR11890 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ig_2 UniProtKB/Swiss-Prot
  Ig_6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIR UniProtKB/Swiss-Prot
PharmGKB PA29815 PharmGKB
PRINTS INTRLEUKN1R1 UniProtKB/Swiss-Prot
  INTRLKN1R12F UniProtKB/Swiss-Prot
PROSITE IG_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIR UniProtKB/Swiss-Prot
SMART SM00409 UniProtKB/Swiss-Prot
  TIR UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52200 UniProtKB/Swiss-Prot
UniProt C9K0I8_HUMAN UniProtKB/TrEMBL
  ILRL2_HUMAN UniProtKB/Swiss-Prot
  Q587I8 ENTREZGENE
  Q9HB29 ENTREZGENE
UniProt Secondary A4FU63 UniProtKB/Swiss-Prot
  Q13525 UniProtKB/Swiss-Prot
  Q45H74 UniProtKB/Swiss-Prot
  Q53TU8 UniProtKB/Swiss-Prot
  Q587I8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-19 IL1RL2  interleukin 1 receptor like 2    interleukin 1 receptor-like 2  Symbol and/or name change 5135510 APPROVED
2011-09-01 IL1RL2  interleukin 1 receptor-like 2  IL1RL2  interleukin 1 receptor-like 2  Symbol and/or name change 5135510 APPROVED