RGD Reference Report - Increased Th17 functions are accompanied by Tregs activities in lupoid leishmaniasis. - Rat Genome Database

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Increased Th17 functions are accompanied by Tregs activities in lupoid leishmaniasis.

Authors: Nabavi, N S  Pezeshkpoor, F  Valizadeh, N  Ahmadi Ghezeldasht, S  Rezaee, S A 
Citation: Nabavi NS, etal., Parasite Immunol. 2018 Jan;40(1). doi: 10.1111/pim.12507. Epub 2017 Dec 17.
RGD ID: 38455981
Pubmed: PMID:29205403   (View Abstract at PubMed)
DOI: DOI:10.1111/pim.12507   (Journal Full-text)

The immunopathogenesis of lupoid leishmaniasis is challenging. Although an appropriate immune response is critical for controlling these parasites, inappropriate inflammatory reactions can also promote increased pathology. The role of immune modulatory effect of the main transcription factors and cytokines of T regulatory and Th17 cells in pathogenesis of leishmaniasis chronicity was investigated in this study. The gene expression of interleukin-10 (IL-10), transforming growth factor-β (TGF-β1), forkhead box P3 (Foxp3), interleukin-17(IL-17A) and retinoic acid-related orphan receptor gamma t (ROrC) was assessed in peripheral blood mononuclear cells of eighty blood samples from cutaneous leishmaniasis (CL) patients with usual lesions (n = 31), lupoid lesions (n = 29) and healthy volunteers (n = 20). Quantitative relative real-time PCR (qRT-PCR) was performed using the Taqman and Sybergreen methods for expression of target genes. Expression of Foxp3 (P = .013), IL-10 (P < .001) and IL-17A (P < .001) was significantly higher in lupoid patient compare to the nonlupoid group. Expression of Foxp3 (P < .001), IL-10 (P < .001) and IL-17A (P = .033) was significantly more in nonlupoid subjects than in healthy volunteers, except for RORγt. These findings suggest that Foxp3+ cells, IL-10 and IL-17 play important roles in the immunopathogenesis of CL and that these roles differ depending on the causal leishmania species and different body compartments.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
cutaneous leishmaniasis  IEP 38455981; 38455981; 38455981mRNA:increased expression:Peripheral blood mononuclear cell:RGD 
cutaneous leishmaniasis  ISOFOXP3 (Homo sapiens)38455981; 38455981mRNA:increased expression:Peripheral blood mononuclear cell:RGD 
cutaneous leishmaniasis  ISOIL10 (Homo sapiens)38455981; 38455981mRNA:increased expression:Peripheral blood mononuclear cell:RGD 
cutaneous leishmaniasis  ISOIL17A (Homo sapiens)38455981; 38455981mRNA:increased expression:Peripheral blood mononuclear cell:RGD 

Objects Annotated

Genes (Rattus norvegicus)
Foxp3  (forkhead box P3)
Il10  (interleukin 10)
Il17a  (interleukin 17A)

Genes (Mus musculus)
Foxp3  (forkhead box P3)
Il10  (interleukin 10)
Il17a  (interleukin 17A)

Genes (Homo sapiens)
FOXP3  (forkhead box P3)
IL10  (interleukin 10)
IL17A  (interleukin 17A)


Additional Information