Il17a (interleukin 17A) - Rat Genome Database

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Gene: Il17a (interleukin 17A) Heterocephalus glaber
Analyze
Symbol: Il17a
Name: interleukin 17A
RGD ID: 18929497
Description: ENCODES a protein that exhibits protein heterodimerization activity (ortholog); protein homodimerization activity (ortholog); INVOLVED IN cellular response to glucocorticoid stimulus (ortholog); cellular response to interleukin-1 (ortholog); defense response to fungus (ortholog); PARTICIPATES IN interleukin-23 signaling pathway; interleukin-27 signaling pathway; ASSOCIATED WITH acne (ortholog); Acute Lung Injury (ortholog); acute myocardial infarction (ortholog); FOUND IN external side of plasma membrane (ortholog); extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: interleukin-17A
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248553,911,349 - 3,913,136 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248553,911,349 - 3,914,214 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acne  (ISO)
Acute Lung Injury  (ISO)
acute myocardial infarction  (ISO)
acute necrotizing pancreatitis  (ISO)
Acute Otitis Media  (ISO)
acute promyelocytic leukemia  (ISO)
allergic disease  (ISO)
allergic rhinitis  (ISO)
Animal Toxoplasmosis  (ISO)
ankylosing spondylitis  (ISO)
anti-basement membrane glomerulonephritis  (ISO)
Arterial Thrombosis  (ISO)
asthma  (ISO)
atherosclerosis  (ISO)
atopic dermatitis  (ISO)
autoimmune disease  (ISO)
autoimmune thyroiditis  (ISO)
Bacteremia  (ISO)
bacterial pneumonia  (ISO)
Behcet's disease  (ISO)
brain ischemia  (ISO)
Breast Neoplasms  (ISO)
Bronchial Hyperreactivity  (ISO)
bronchiolitis  (ISO)
bronchiolitis obliterans  (ISO)
cardiovascular system disease  (ISO)
central nervous system disease  (ISO)
cerebrovascular disease  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Chemically-Induced Disorders  (ISO)
chlamydia  (ISO)
chronic obstructive pulmonary disease  (ISO)
Chronic Rhinosinusitis  (ISO)
colitis  (ISO)
congestive heart failure  (ISO)
corneal neovascularization  (ISO)
COVID-19  (ISO)
Cryopyrin-Associated Periodic Syndromes  (ISO)
cutaneous leishmaniasis  (ISO)
cutaneous lupus erythematosus  (ISO)
cystic fibrosis  (ISO)
Delayed Hypersensitivity  (ISO)
Discoid Lupus Erythematosus  (ISO)
Drug Eruptions  (ISO)
Emphysema  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Neuritis  (ISO)
Experimental Autoimmune Uveitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
extrinsic allergic alveolitis  (ISO)
graft-versus-host disease  (ISO)
Gram-Negative Bacterial Infections  (ISO)
Graves' disease  (ISO)
histoplasmosis  (ISO)
Human Influenza  (ISO)
Hyperalgesia  (ISO)
hypertension  (ISO)
Ige Responsiveness, Atopic  (ISO)
ileitis  (ISO)
Inflammation  (ISO)
invasive aspergillosis  (ISO)
kidney disease  (ISO)
leprosy  (ISO)
lipoid nephrosis  (ISO)
lupus nephritis  (ISO)
lymphoproliferative syndrome  (ISO)
macular degeneration  (ISO)
MPTP Poisoning  (ISO)
multiple sclerosis  (ISO)
Mycobacterium avium complex disease  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
myocarditis  (ISO)
Nasal Polyps  (ISO)
Necrosis  (ISO)
Ocular Toxoplasmosis  (ISO)
otitis media  (ISO)
Perennial Allergic Rhinitis  (ISO)
periapical periodontitis  (ISO)
periodontal disease  (ISO)
plague  (ISO)
pleurisy  (ISO)
Pneumococcal Infections  (ISO)
Pneumococcal Pneumonia  (ISO)
pneumonia  (ISO)
psoriasis  (ISO)
psoriatic arthritis  (ISO)
pulmonary edema  (ISO)
pulmonary fibrosis  (ISO)
Respiratory Sounds  (ISO)
respiratory syncytial virus infectious disease  (ISO)
rheumatoid arthritis  (ISO)
rhinitis  (ISO)
Rhinosinusitis  (ISO)
Sepsis  (ISO)
silicosis  (ISO)
Sjogren's syndrome  (ISO)
Spondylarthritis  (ISO)
Staphylococcal Skin Infections  (ISO)
Streptococcal Infections  (ISO)
systemic lupus erythematosus  (ISO)
systemic scleroderma  (ISO)
temporal arteritis  (ISO)
trachoma  (ISO)
Transplant Rejection  (ISO)
tularemia  (ISO)
uveitis  (ISO)
Viral Bronchiolitis  (ISO)
Viral Myocarditis  (ISO)
vitiligo  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to glucocorticoid stimulus  (ISO)
cellular response to interleukin-1  (ISO)
defense response to fungus  (ISO)
defense response to Gram-negative bacterium  (ISO)
defense response to Gram-positive bacterium  (ISO)
fibroblast activation  (ISO)
gene expression  (ISO)
granulocyte migration  (ISO)
inflammatory response  (IEA)
interleukin-17-mediated signaling pathway  (ISO)
interleukin-17A-mediated signaling pathway  (ISO)
intestinal epithelial structure maintenance  (ISO)
keratinocyte differentiation  (ISO)
keratinocyte proliferation  (ISO)
negative regulation of inflammatory response to wounding  (ISO)
Notch signaling pathway  (ISO)
positive regulation of antimicrobial peptide production  (ISO)
positive regulation of bicellular tight junction assembly  (ISO)
positive regulation of cellular process  (ISO)
positive regulation of chemokine (C-X-C motif) ligand 1 production  (ISO)
positive regulation of cytokine production involved in inflammatory response  (ISO)
positive regulation of interleukin-1 beta production  (ISO)
positive regulation of interleukin-12 production  (ISO)
positive regulation of interleukin-16 production  (ISO)
positive regulation of interleukin-23 production  (ISO)
positive regulation of interleukin-6 production  (ISO)
positive regulation of osteoclast differentiation  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of tumor necrosis factor production  (ISO)
response to amino acid  (ISO)
response to wounding  (ISO)
signal transduction  (IEA)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
Il17a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248553,911,349 - 3,913,136 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248553,911,349 - 3,914,214 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
IL17A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38652,186,375 - 52,190,638 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl652,186,375 - 52,190,638 (+)EnsemblGRCh38hg38GRCh38
GRCh37652,051,173 - 52,055,436 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36652,159,144 - 52,163,395 (+)NCBINCBI36Build 36hg18NCBI36
Build 34652,159,143 - 52,163,395NCBI
Celera653,712,308 - 53,716,559 (+)NCBICelera
Cytogenetic Map6p12.2NCBI
HuRef651,882,254 - 51,886,505 (+)NCBIHuRef
CHM1_1652,053,438 - 52,057,689 (+)NCBICHM1_1
T2T-CHM13v2.0652,025,075 - 52,029,336 (+)NCBIT2T-CHM13v2.0
Il17a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39120,801,129 - 20,804,720 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl120,801,129 - 20,804,720 (+)EnsemblGRCm39 Ensembl
GRCm38120,730,905 - 20,734,496 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl120,730,905 - 20,734,496 (+)EnsemblGRCm38mm10GRCm38
MGSCv37120,720,986 - 20,724,577 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36120,716,056 - 20,719,647 (+)NCBIMGSCv36mm8
Celera120,604,456 - 20,608,046 (+)NCBICelera
Cytogenetic Map1A4NCBI
cM Map16.45NCBI
Il17a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8930,640,844 - 30,644,331 (+)NCBIGRCr8
mRatBN7.2923,144,402 - 23,147,889 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl923,144,402 - 23,147,889 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx931,641,574 - 31,645,060 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0936,762,293 - 36,765,779 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0935,077,566 - 35,081,052 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0926,841,299 - 26,844,786 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl926,841,299 - 26,844,786 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0925,696,865 - 25,700,352 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4919,454,979 - 19,458,467 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1919,453,469 - 19,455,797 (+)NCBI
Celera920,720,899 - 20,724,386 (+)NCBICelera
Cytogenetic Map9q13NCBI
Il17a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554115,896,702 - 5,900,962 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554115,896,435 - 5,899,911 (-)NCBIChiLan1.0ChiLan1.0
IL17A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2566,651,896 - 66,656,165 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1662,528,730 - 62,532,997 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0651,736,269 - 51,740,538 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1653,004,820 - 53,009,074 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl653,004,820 - 53,009,074 (+)Ensemblpanpan1.1panPan2
IL17A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11219,854,129 - 19,862,521 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1219,854,129 - 19,862,513 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1219,751,596 - 19,759,988 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01220,353,311 - 20,361,254 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11219,859,850 - 19,868,228 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01219,962,726 - 19,971,118 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01220,100,900 - 20,109,292 (+)NCBIUU_Cfam_GSD_1.0
Il17a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494655,335,194 - 55,338,342 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364768,621,860 - 8,625,008 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364768,621,860 - 8,625,008 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL17A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl746,013,584 - 46,017,153 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1746,013,584 - 46,017,161 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2752,463,736 - 52,467,313 (+)NCBISscrofa10.2Sscrofa10.2susScr3
IL17A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11720,314,082 - 20,319,917 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1720,315,773 - 20,318,785 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604452,087,244 - 52,091,712 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000020712   ⟹   ENSHGLP00000020510
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248553,911,349 - 3,913,136 (-)Ensembl
RefSeq Acc Id: XM_004869041   ⟹   XP_004869098
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248553,911,349 - 3,914,214 (-)NCBI
RefSeq Acc Id: XM_021247777   ⟹   XP_021103436
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248553,911,349 - 3,914,214 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004869098 (Get FASTA)   NCBI Sequence Viewer  
  XP_021103436 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_004869098   ⟸   XM_004869041
- Peptide Label: isoform X2
- UniProtKB: G5BC81 (UniProtKB/TrEMBL),   A0AAX6Q9G1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021103436   ⟸   XM_021247777
- Peptide Label: isoform X1
- UniProtKB: G5BC81 (UniProtKB/TrEMBL),   A0AAX6S1S2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000020510   ⟸   ENSHGLT00000020712


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000014659 Ensembl
Gene3D-CATH Cystine-knot cytokines UniProtKB/TrEMBL
InterPro Cystine-knot_cytokine UniProtKB/TrEMBL
  IL-17_chr UniProtKB/TrEMBL
  IL-17_fam UniProtKB/TrEMBL
NCBI Gene Il17a ENTREZGENE
Pfam IL17 UniProtKB/TrEMBL
PRINTS INTRLEUKIN17 UniProtKB/TrEMBL
Superfamily-SCOP Cystine-knot cytokines UniProtKB/TrEMBL
UniProt A0AAX6Q9G1 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6S1S2 ENTREZGENE, UniProtKB/TrEMBL
  G5BC81 ENTREZGENE, UniProtKB/TrEMBL