RGD Reference Report - Sequential IL-23 and IL-17 and increased Mmp8 and Mmp14 expression characterize the progression of an experimental model of periodontal disease in type 1 diabetes. - Rat Genome Database

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Sequential IL-23 and IL-17 and increased Mmp8 and Mmp14 expression characterize the progression of an experimental model of periodontal disease in type 1 diabetes.

Authors: Silva, JA  Ferrucci, DL  Peroni, LA  Abrahao, PG  Salamene, AF  Rossa-Junior, C  Carvalho, HF  Stach-Machado, DR 
Citation: Silva JA, etal., J Cell Physiol. 2012 Jun;227(6):2441-50. doi: 10.1002/jcp.22979.
RGD ID: 9068940
Pubmed: PMID:21826658   (View Abstract at PubMed)
DOI: DOI:10.1002/jcp.22979   (Journal Full-text)

Molecular mechanisms responsible for periodontal disease (PD) and its worsening in type 1 Diabetes Mellitus (DM1) remain unknown. Cytokine profile and expression levels of collagenases, Mmp14, and tissue inhibitors were determined, as were the numbers of neutrophils and macrophages in combined streptozotocin-induced DM1 and ligature-induced PD models. Increased IL-23 (80-fold) and Mmp8 expression (25-fold) was found in DM1. Ligature resulted in an IL-1beta/IL-6 profile, increased expression of Mmp8, Mmp13, and Mmp14 (but not Mmp1), and transient expression of Timp1 and Reck in non-diabetics. PD in DM1 involved IL-1beta (but not IL-6) and IL-23/IL-17, reduced IL-6 and IL-10, sustained Mmp8 and Mmp14, increased Mmp13 and reduced Reck expression in association with 20-fold higher counts of neutrophils and macrophages. IL-23 and Mmp8 expression are hallmarks of DM1. In association with the IL-1/IL-6 (Th1) response in PD, one found a secondary IL-17 (Th17) pathway in non-diabetic rats. Low IL-6/TNF-alpha suggest that the Th1 response was compromised in DM1, while IL-17 indicates a prevalence of the Th17 pathway, resulting in high neutrophil recruitment. Mmp8, Mmp13, and Mmp14 expression seems important in the tissue destruction during PD in DM1. PD-associated IL-1/IL-6 (Th1), IL-10, and Reck expression are associated with the acute-to-chronic inflammation transition, which is lost in DM1. In conclusion, IL-23/IL-17 are associated with the PD progression in DM1.




  
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Original Reference(s)
IL17AHumanExperimental Diabetes Mellitus  ISOIl17a (Rattus norvegicus)protein:increased expression:gingiva (rat)RGD 
Il17aRatExperimental Diabetes Mellitus  IEP protein:increased expression:gingiva (rat)RGD 
Il17aMouseExperimental Diabetes Mellitus  ISOIl17a (Rattus norvegicus)protein:increased expression:gingiva (rat)RGD 
IL17AHumanperiodontal disease  ISOIl17a (Rattus norvegicus)protein:increased expression:gingiva (rat)RGD 
Il17aRatperiodontal disease  IEP protein:increased expression:gingiva (rat)RGD 
Il17aMouseperiodontal disease  ISOIl17a (Rattus norvegicus)protein:increased expression:gingiva (rat)RGD 


Genes (Rattus norvegicus)
Il17a  (interleukin 17A)

Genes (Mus musculus)
Il17a  (interleukin 17A)

Genes (Homo sapiens)
IL17A  (interleukin 17A)