IL17A (interleukin 17A) - Rat Genome Database
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Gene: IL17A (interleukin 17A) Sus scrofa
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Symbol: IL17A
Name: interleukin 17A
RGD ID: 14115550
Description: ENCODES a protein that exhibits cytokine activity (inferred); protein heterodimerization activity (inferred); protein homodimerization activity (inferred); INVOLVED IN cellular response to glucocorticoid stimulus (ortholog); positive regulation of necrotic cell death (ortholog); response to amino acid (ortholog); PARTICIPATES IN interleukin-23 signaling pathway; interleukin-27 signaling pathway; ASSOCIATED WITH acne (ortholog); Acute Lung Injury (ortholog); Acute Necrotizing Pancreatitis (ortholog); FOUND IN cytoplasm (ortholog); INTERACTS WITH deoxynivalenol; fumonisin B1; lipopolysaccharide
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: IL-17; IL-17A; IL17; interleukin-17; interleukin-17A
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl746,013,584 - 46,017,153 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1746,013,584 - 46,017,161 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2752,463,736 - 52,467,313 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acne  (ISO)
Acute Lung Injury  (ISO)
Acute Necrotizing Pancreatitis  (ISO)
Acute Otitis Media  (ISO)
acute promyelocytic leukemia  (ISO)
allergic disease  (ISO)
allergic rhinitis  (ISO)
Animal Toxoplasmosis  (ISO)
ankylosing spondylitis  (ISO)
anti-basement membrane glomerulonephritis  (ISO)
Arterial Thrombosis  (ISO)
asthma  (ISO)
atherosclerosis  (ISO)
atopic dermatitis  (ISO)
autoimmune disease  (ISO)
autoimmune thyroiditis  (ISO)
Bacteremia  (ISO)
bacterial pneumonia  (ISO)
Behcet's disease  (ISO)
brain ischemia  (ISO)
Breast Neoplasms  (ISO)
Bronchial Hyperreactivity  (ISO)
bronchiolitis  (ISO)
bronchiolitis obliterans  (ISO)
cardiovascular system disease  (ISO)
central nervous system disease  (ISO)
cerebrovascular disease  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
chlamydia  (ISO)
chronic obstructive pulmonary disease  (ISO)
Chronic Rhinosinusitis  (ISO)
colitis  (ISO)
congestive heart failure  (ISO)
corneal neovascularization  (ISO)
COVID-19  (ISO)
Cryopyrin-Associated Periodic Syndromes  (ISO)
cutaneous leishmaniasis  (ISO)
cutaneous lupus erythematosus  (ISO)
cystic fibrosis  (ISO)
Delayed Hypersensitivity  (ISO)
Discoid Lupus Erythematosus  (ISO)
Drug Eruptions  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Neuritis  (ISO)
Experimental Autoimmune Uveitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
extrinsic allergic alveolitis  (ISO)
Graft vs Host Disease  (ISO)
Gram-Negative Bacterial Infections  (ISO)
Graves' disease  (ISO)
histoplasmosis  (ISO)
Human Influenza  (ISO)
Hyperalgesia  (ISO)
Ige Responsiveness, Atopic  (ISO)
ileitis  (ISO)
Inflammation  (ISO)
invasive aspergillosis  (ISO)
leprosy  (ISO)
lipoid nephrosis  (ISO)
lupus nephritis  (ISO)
lymphoproliferative syndrome  (ISO)
macular degeneration  (ISO)
MPTP Poisoning  (ISO)
multiple sclerosis  (ISO)
Mycobacterium avium complex disease  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
myocarditis  (ISO)
Nasal Polyps  (ISO)
Necrosis  (ISO)
Ocular Toxoplasmosis  (ISO)
otitis media  (ISO)
Perennial Allergic Rhinitis  (ISO)
periapical periodontitis  (ISO)
periodontal disease  (ISO)
plague  (ISO)
pleurisy  (ISO)
Pneumococcal Infections  (ISO)
Pneumococcal Pneumonia  (ISO)
pneumonia  (ISO)
psoriasis  (ISO)
psoriatic arthritis  (ISO)
pulmonary edema  (ISO)
pulmonary fibrosis  (ISO)
Respiratory Sounds  (ISO)
respiratory syncytial virus infectious disease  (ISO)
rheumatoid arthritis  (ISO)
rhinitis  (ISO)
Rhinosinusitis  (ISO)
Sepsis  (ISO)
silicosis  (ISO)
Sjogren's syndrome  (ISO)
Spondylarthritis  (ISO)
Staphylococcal Skin Infections  (ISO)
Streptococcal Infections  (ISO)
systemic lupus erythematosus  (ISO)
systemic scleroderma  (ISO)
temporal arteritis  (ISO)
trachoma  (ISO)
Transplant Rejection  (ISO)
tularemia  (ISO)
uveitis  (ISO)
Viral Bronchiolitis  (ISO)
Viral Myocarditis  (ISO)
vitiligo  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:15450131   PMID:21955445   PMID:22321808   PMID:23365350   PMID:25040151   PMID:31614911  


Genomics

Comparative Map Data
IL17A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl746,013,584 - 46,017,153 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1746,013,584 - 46,017,161 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2752,463,736 - 52,467,313 (+)NCBISscrofa10.2Sscrofa10.2susScr3
IL17A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl652,186,375 - 52,190,638 (+)EnsemblGRCh38hg38GRCh38
GRCh38652,186,375 - 52,190,638 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37652,051,185 - 52,055,436 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36652,159,144 - 52,163,395 (+)NCBINCBI36hg18NCBI36
Build 34652,159,143 - 52,163,395NCBI
Celera653,712,308 - 53,716,559 (+)NCBI
Cytogenetic Map6p12.2NCBI
HuRef651,882,254 - 51,886,505 (+)NCBIHuRef
CHM1_1652,053,438 - 52,057,689 (+)NCBICHM1_1
Il17a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39120,801,129 - 20,804,720 (+)NCBIGRCm39mm39
GRCm38120,730,905 - 20,734,496 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl120,730,905 - 20,734,496 (+)EnsemblGRCm38mm10GRCm38
MGSCv37120,720,986 - 20,724,577 (+)NCBIGRCm37mm9NCBIm37
MGSCv36120,716,056 - 20,719,647 (+)NCBImm8
Celera120,604,456 - 20,608,046 (+)NCBICelera
Cytogenetic Map1A4NCBI
Il17a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0926,841,299 - 26,844,786 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl926,841,299 - 26,844,786 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0925,696,865 - 25,700,352 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4919,454,979 - 19,458,467 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1919,453,469 - 19,455,797 (+)NCBI
Celera920,720,899 - 20,724,386 (+)NCBICelera
Cytogenetic Map9q13NCBI
Il17a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554115,896,702 - 5,900,962 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554115,896,435 - 5,899,911 (-)NCBIChiLan1.0ChiLan1.0
IL17A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1653,004,820 - 53,009,074 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl653,004,820 - 53,009,074 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0651,736,269 - 51,740,538 (+)NCBIMhudiblu_PPA_v0panPan3
IL17A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1219,854,129 - 19,862,513 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11219,854,129 - 19,862,521 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Il17a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049364768,621,860 - 8,625,008 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL17A
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11720,314,082 - 20,319,917 (-)NCBI
ChlSab1.1 Ensembl1720,315,773 - 20,318,785 (-)Ensembl
Il17a
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248553,911,349 - 3,914,214 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system hemolymphoid system respiratory system
High
Medium
Low 1 1
Below cutoff 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000001954   ⟹   ENSSSCP00000001905
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl746,013,584 - 46,017,153 (+)Ensembl
RefSeq Acc Id: NM_001005729   ⟹   NP_001005729
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1746,013,584 - 46,017,161 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001005729 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ACI16545 (Get FASTA)   NCBI Sequence Viewer  
  AHB64322 (Get FASTA)   NCBI Sequence Viewer  
  BAD52431 (Get FASTA)   NCBI Sequence Viewer  
  Q60I29 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001005729   ⟸   NM_001005729
- Peptide Label: precursor
- UniProtKB: Q60I29 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSSSCP00000001905   ⟸   ENSSSCT00000001954


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000001748 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070009259 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000001905 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00070014910 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000001954 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00070017967 UniProtKB/TrEMBL
Gene3D-CATH 2.10.90.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cystine-knot_cytokine UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-17_chr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-17_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:449530 UniProtKB/Swiss-Prot
NCBI Gene IL17A ENTREZGENE
Pfam IL17 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS INTRLEUKIN17 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57501 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Ssc.42770 ENTREZGENE
UniProt A0A4X1TJ00_PIG UniProtKB/TrEMBL
  B6E279_PIG UniProtKB/TrEMBL
  IL17_PIG UniProtKB/Swiss-Prot, ENTREZGENE