IL17A (interleukin 17A) - Rat Genome Database

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Gene: IL17A (interleukin 17A) Canis lupus familiaris
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Symbol: IL17A
Name: interleukin 17A
RGD ID: 12171461
Description: ENCODES a protein that exhibits cytokine activity (inferred); protein heterodimerization activity (inferred); protein homodimerization activity (inferred); INVOLVED IN cellular response to glucocorticoid stimulus (ortholog); cellular response to interleukin-1 (ortholog); positive regulation of cytokine production involved in inflammatory response (ortholog); PARTICIPATES IN interleukin-23 signaling pathway; interleukin-27 signaling pathway; ASSOCIATED WITH acne (ortholog); Acute Lung Injury (ortholog); acute necrotizing pancreatitis (ortholog); FOUND IN cytoplasm (ortholog); extracellular space (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: interleukin-17A
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11219,854,129 - 19,862,521 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1219,854,129 - 19,862,513 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1219,751,596 - 19,759,988 (+)NCBI
ROS_Cfam_1.01220,353,311 - 20,361,254 (+)NCBI
UMICH_Zoey_3.11219,859,850 - 19,868,228 (+)NCBI
UNSW_CanFamBas_1.01219,962,726 - 19,971,118 (+)NCBI
UU_Cfam_GSD_1.01220,100,900 - 20,109,292 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acne  (ISO)
Acute Lung Injury  (ISO)
acute necrotizing pancreatitis  (ISO)
Acute Otitis Media  (ISO)
acute promyelocytic leukemia  (ISO)
allergic disease  (ISO)
allergic rhinitis  (ISO)
Animal Toxoplasmosis  (ISO)
ankylosing spondylitis  (ISO)
anti-basement membrane glomerulonephritis  (ISO)
Arterial Thrombosis  (ISO)
asthma  (ISO)
atherosclerosis  (ISO)
atopic dermatitis  (ISO)
autoimmune disease  (ISO)
autoimmune thyroiditis  (ISO)
Bacteremia  (ISO)
bacterial pneumonia  (ISO)
Behcet's disease  (ISO)
brain ischemia  (ISO)
Breast Neoplasms  (ISO)
Bronchial Hyperreactivity  (ISO)
bronchiolitis  (ISO)
bronchiolitis obliterans  (ISO)
cardiovascular system disease  (ISO)
central nervous system disease  (ISO)
cerebrovascular disease  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
chlamydia  (ISO)
chronic obstructive pulmonary disease  (ISO)
Chronic Rhinosinusitis  (ISO)
colitis  (ISO)
congestive heart failure  (ISO)
corneal neovascularization  (ISO)
COVID-19  (ISO)
Cryopyrin-Associated Periodic Syndromes  (ISO)
cutaneous leishmaniasis  (ISO)
cutaneous lupus erythematosus  (ISO)
cystic fibrosis  (ISO)
Delayed Hypersensitivity  (ISO)
Discoid Lupus Erythematosus  (ISO)
Drug Eruptions  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Neuritis  (ISO)
Experimental Autoimmune Uveitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
extrinsic allergic alveolitis  (ISO)
Graft vs Host Disease  (ISO)
Gram-Negative Bacterial Infections  (ISO)
Graves' disease  (ISO)
histoplasmosis  (ISO)
Human Influenza  (ISO)
Hyperalgesia  (ISO)
Ige Responsiveness, Atopic  (ISO)
ileitis  (ISO)
Inflammation  (ISO)
invasive aspergillosis  (ISO)
leprosy  (ISO)
lipoid nephrosis  (ISO)
lupus nephritis  (ISO)
lymphoproliferative syndrome  (ISO)
macular degeneration  (ISO)
MPTP Poisoning  (ISO)
multiple sclerosis  (ISO)
Mycobacterium avium complex disease  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
myocarditis  (ISO)
Nasal Polyps  (ISO)
Necrosis  (ISO)
Ocular Toxoplasmosis  (ISO)
otitis media  (ISO)
Perennial Allergic Rhinitis  (ISO)
periapical periodontitis  (ISO)
periodontal disease  (ISO)
plague  (ISO)
pleurisy  (ISO)
Pneumococcal Infections  (ISO)
Pneumococcal Pneumonia  (ISO)
pneumonia  (ISO)
psoriasis  (ISO)
psoriatic arthritis  (ISO)
pulmonary edema  (ISO)
pulmonary fibrosis  (ISO)
Respiratory Sounds  (ISO)
respiratory syncytial virus infectious disease  (ISO)
rheumatoid arthritis  (ISO)
rhinitis  (ISO)
Rhinosinusitis  (ISO)
Sepsis  (ISO)
silicosis  (ISO)
Sjogren's syndrome  (ISO)
Spondylarthritis  (ISO)
Staphylococcal Skin Infections  (ISO)
Streptococcal Infections  (ISO)
systemic lupus erythematosus  (ISO)
systemic scleroderma  (ISO)
temporal arteritis  (ISO)
trachoma  (ISO)
Transplant Rejection  (ISO)
tularemia  (ISO)
uveitis  (ISO)
Viral Bronchiolitis  (ISO)
Viral Myocarditis  (ISO)
vitiligo  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:26590047  


Genomics

Comparative Map Data
IL17A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11219,854,129 - 19,862,521 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1219,854,129 - 19,862,513 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1219,751,596 - 19,759,988 (+)NCBI
ROS_Cfam_1.01220,353,311 - 20,361,254 (+)NCBI
UMICH_Zoey_3.11219,859,850 - 19,868,228 (+)NCBI
UNSW_CanFamBas_1.01219,962,726 - 19,971,118 (+)NCBI
UU_Cfam_GSD_1.01220,100,900 - 20,109,292 (+)NCBI
IL17A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38652,186,375 - 52,190,638 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl652,186,375 - 52,190,638 (+)EnsemblGRCh38hg38GRCh38
GRCh37652,051,173 - 52,055,436 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36652,159,144 - 52,163,395 (+)NCBINCBI36hg18NCBI36
Build 34652,159,143 - 52,163,395NCBI
Celera653,712,308 - 53,716,559 (+)NCBI
Cytogenetic Map6p12.2NCBI
HuRef651,882,254 - 51,886,505 (+)NCBIHuRef
CHM1_1652,053,438 - 52,057,689 (+)NCBICHM1_1
T2T-CHM13v2.0652,025,075 - 52,029,336 (+)NCBI
Il17a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39120,801,129 - 20,804,720 (+)NCBIGRCm39mm39
GRCm39 Ensembl120,801,129 - 20,804,720 (+)Ensembl
GRCm38120,730,905 - 20,734,496 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl120,730,905 - 20,734,496 (+)EnsemblGRCm38mm10GRCm38
MGSCv37120,720,986 - 20,724,577 (+)NCBIGRCm37mm9NCBIm37
MGSCv36120,716,056 - 20,719,647 (+)NCBImm8
Celera120,604,456 - 20,608,046 (+)NCBICelera
Cytogenetic Map1A4NCBI
Il17a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2923,144,402 - 23,147,889 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl923,144,402 - 23,147,889 (+)Ensembl
Rnor_6.0926,841,299 - 26,844,786 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl926,841,299 - 26,844,786 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0925,696,865 - 25,700,352 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4919,454,979 - 19,458,467 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1919,453,469 - 19,455,797 (+)NCBI
Celera920,720,899 - 20,724,386 (+)NCBICelera
Cytogenetic Map9q13NCBI
Il17a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554115,896,702 - 5,900,962 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554115,896,435 - 5,899,911 (-)NCBIChiLan1.0ChiLan1.0
IL17A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1653,004,820 - 53,009,074 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl653,004,820 - 53,009,074 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0651,736,269 - 51,740,538 (+)NCBIMhudiblu_PPA_v0panPan3
Il17a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494655,335,194 - 55,338,342 (+)NCBI
SpeTri2.0NW_0049364768,621,860 - 8,625,008 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL17A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl746,013,584 - 46,017,153 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1746,013,584 - 46,017,161 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2752,463,736 - 52,467,313 (+)NCBISscrofa10.2Sscrofa10.2susScr3
IL17A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11720,314,082 - 20,319,917 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1720,315,773 - 20,318,785 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604452,087,244 - 52,091,712 (+)NCBIVero_WHO_p1.0
Il17a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248553,911,349 - 3,913,136 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046248553,911,349 - 3,914,214 (-)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system endocrine system hemolymphoid system integumental system nervous system reproductive system respiratory system
High
Medium
Low
Below cutoff 3 7 3 1 1 5 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000049325   ⟹   ENSCAFP00000037538
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1219,854,129 - 19,862,513 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000060422   ⟹   ENSCAFP00000044804
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1219,859,808 - 19,862,513 (+)Ensembl
RefSeq Acc Id: NM_001165878   ⟹   NP_001159350
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11219,854,129 - 19,862,521 (+)NCBI
Dog10K_Boxer_Tasha1219,751,596 - 19,759,988 (+)NCBI
ROS_Cfam_1.01220,353,311 - 20,361,254 (+)NCBI
UMICH_Zoey_3.11219,859,850 - 19,868,228 (+)NCBI
UNSW_CanFamBas_1.01219,962,726 - 19,971,118 (+)NCBI
UU_Cfam_GSD_1.01220,100,900 - 20,109,292 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001159350 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAH89243 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001159350   ⟸   NM_001165878
- Peptide Label: precursor
- UniProtKB: C6L8D7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000037538   ⟸   ENSCAFT00000049325
RefSeq Acc Id: ENSCAFP00000044804   ⟸   ENSCAFT00000060422


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000028874 Ensembl
  ENSCAFG00040005812 UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00040009446 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00040010896 UniProtKB/TrEMBL
Gene3D-CATH 2.10.90.10 UniProtKB/TrEMBL
InterPro Cystine-knot_cytokine UniProtKB/TrEMBL
  IL-17_chr UniProtKB/TrEMBL
  IL-17_fam UniProtKB/TrEMBL
KEGG Report cfa:481837 UniProtKB/TrEMBL
NCBI Gene IL17A ENTREZGENE
Pfam IL17 UniProtKB/TrEMBL
PRINTS INTRLEUKIN17 UniProtKB/TrEMBL
Superfamily-SCOP SSF57501 UniProtKB/TrEMBL
UniProt A0A8C0QCB7_CANLF UniProtKB/TrEMBL
  C6L8D7 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:41942 ENTREZGENE