RGD Reference Report - Expression of Th-17 and RORgammat mRNA in Behcet's Disease. - Rat Genome Database

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Expression of Th-17 and RORgammat mRNA in Behcet's Disease.

Authors: Hamzaoui, K  Bouali, E  Ghorbel, I  Khanfir, M  Houman, H  Hamzaoui, A 
Citation: Hamzaoui K, etal., Med Sci Monit. 2011 Apr;17(4):CR227-34.
RGD ID: 8698672
Pubmed: PMID:21455110   (View Abstract at PubMed)
PMCID: PMC3539514   (View Article at PubMed Central)

BACKGROUND: To investigate plasma IL-17 level and the expression of Th17 cell transcription factor RORgammat in the pathogenesis of Behcet's Disease (BD). MATERIAL/METHODS: Blood samples were collected from 73 patients with BD (45 patients were in active stage), 20 systemic lupus erythematosus (SLE) and 12 multiple sclerosis patients (MS). Twelve patients with BD were investigated both in their active and remission stages. Samples were processed to detect IL-17A level in plasma by enzyme-linked immunosorbent assay (ELISA). Related gene expression was assessed by real-time reverse transcription polymerase chain reaction. Function of Th17 cells in active BD patients with erythema nodosum (EN)-like eruption was studied in relation to human umbilical vein endothelial cells (HUVECs). RESULTS: We demonstrated the presence of Th17 cells and RORgammat among the peripheral blood mononuclear cells (PBMC). The percentage of circulating Th17 cells and the ability to produce interleukin-17A (IL-17A) were increased in samples derived from patients with active BD, MS and SLE patients. We observed that IL-17A from patients with active BD could induce adhesion molecule messenger RNA expression in HUVECs. CONCLUSIONS: RORgammat determined Th17 cell might be involved with increased IL-17A in BD. Our results indicate that IL-17 contributes to the active proinflammatory pattern that is characteristic of inflammatory diseases and patients with active BD.




  
Object Symbol
Species
Term
Qualifier
Evidence
With
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Source
Original Reference(s)
IL17AHumanBehcet's disease  IEP protein:increased expression:plasma (human)RGD 
Il17aRatBehcet's disease  ISOIL17A (Homo sapiens)protein:increased expression:plasma (human)RGD 
Il17aMouseBehcet's disease  ISOIL17A (Homo sapiens)protein:increased expression:plasma (human)RGD 
IL17AHumanmultiple sclerosis  IEP protein:increased expression:plasma (human)RGD 
Il17aRatmultiple sclerosis  ISOIL17A (Homo sapiens)protein:increased expression:plasma (human)RGD 
Il17aMousemultiple sclerosis  ISOIL17A (Homo sapiens)protein:increased expression:plasma (human)RGD 


Genes (Rattus norvegicus)
Il17a  (interleukin 17A)

Genes (Mus musculus)
Il17a  (interleukin 17A)

Genes (Homo sapiens)
IL17A  (interleukin 17A)