Tab2 (TGF-beta activated kinase 1/MAP3K7 binding protein 2) - Rat Genome Database

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Gene: Tab2 (TGF-beta activated kinase 1/MAP3K7 binding protein 2) Mus musculus
Analyze
Symbol: Tab2
Name: TGF-beta activated kinase 1/MAP3K7 binding protein 2
RGD ID: 1319912
MGI Page MGI
Description: Predicted to enable K63-linked polyubiquitin modification-dependent protein binding activity; molecular adaptor activity; and zinc ion binding activity. Predicted to be involved in several processes, including non-canonical NF-kappaB signal transduction; positive regulation of canonical NF-kappaB signal transduction; and response to bacterium. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in cardiomyopathy; congenital heart disease; and ovary epithelial cancer. Orthologous to human TAB2 (TGF-beta activated kinase 1 (MAP3K7) binding protein 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1110030N06Rik; A530078N03Rik; Map3k; Map3k7ip2; mitogen activated protein kinase kinase kinase 7 interacting protein 2; mitogen-activated protein kinase kinase kinase 7 interacting protein 2; mitogen-activated protein kinase kinase kinase 7-interacting protein 2; mKIAA0733; TAB-2; Tak1 binding protein 2; TAK1-binding protein 2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2; TGF-beta-activated kinase 1-binding protein 2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Gm19074   Gm4917  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39107,781,412 - 7,832,039 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl107,781,417 - 7,831,994 (-)EnsemblGRCm39 Ensembl
GRCm38107,905,648 - 7,956,255 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl107,905,653 - 7,956,230 (-)EnsemblGRCm38mm10GRCm38
MGSCv37107,625,446 - 7,675,921 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36107,596,328 - 7,615,052 (-)NCBIMGSCv36mm8
Celera107,785,153 - 7,804,378 (-)NCBICelera
Cytogenetic Map10A1NCBI
cM Map102.56NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (ISO)
cytosol  (TAS)
endosome  (IEA)
lysosome  (IEA)
membrane  (IEA)
nucleoplasm  (TAS)
nucleus  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. TLR-signaling networks: an integration of adaptor molecules, kinases, and cross-talk. Brown J, etal., J Dent Res. 2011 Apr;90(4):417-27. Epub 2010 Oct 12.
2. Protein molecular modeling techniques investigating novel TAB2 variant R347X causing cardiomyopathy and congenital heart defects in multigenerational family. Caulfield TR, etal., Mol Genet Genomic Med. 2018 Apr 26. doi: 10.1002/mgg3.401.
3. 6q25.1 (TAB2) microdeletion syndrome: Congenital heart defects and cardiomyopathy. Cheng A, etal., Am J Med Genet A. 2017 Jul;173(7):1848-1857. doi: 10.1002/ajmg.a.38254. Epub 2017 May 2.
4. Circular RNA WHSC1 exerts oncogenic properties by regulating miR-7/TAB2 in lung cancer. Guan S, etal., J Cell Mol Med. 2021 Oct;25(20):9784-9795. doi: 10.1111/jcmm.16925. Epub 2021 Sep 22.
5. Associations between TAB2 Gene Polymorphisms and Epithelial Ovarian Cancer in a Chinese Population. Huang X, etal., Dis Markers. 2019 Aug 14;2019:8012979. doi: 10.1155/2019/8012979. eCollection 2019.
6. The ubiquitin E3 ligase TRAF6 exacerbates pathological cardiac hypertrophy via TAK1-dependent signalling. Ji YX, etal., Nat Commun. 2016 Jun 1;7:11267. doi: 10.1038/ncomms11267.
7. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
8. microRNA-149-5p mediates the PM2.5-induced inflammatory response by targeting TAB2 via MAPK and NF-κB signaling pathways in vivo and in vitro. Li Q, etal., Cell Biol Toxicol. 2021 Jul 31. pii: 10.1007/s10565-021-09638-5. doi: 10.1007/s10565-021-09638-5.
9. Expanding role of ubiquitination in NF-kappaB signaling. Liu S and Chen ZJ, Cell Res. 2011 Jan;21(1):6-21. Epub 2010 Dec 7.
10. MGDs mouse GO annotations MGD data from the GO Consortium
11. MGD IEA MGD IEA
12. TAK1 kinase signaling regulates embryonic angiogenesis by modulating endothelial cell survival and migration. Morioka S, etal., Blood. 2012 Nov 1;120(18):3846-57. doi: 10.1182/blood-2012-03-416198. Epub 2012 Sep 12.
13. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
14. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
15. Identification of 2 novel genes developmentally regulated in the mouse aorta-gonad-mesonephros region. Orelio C and Dzierzak E, Blood 2003 Mar 15;101(6):2246-9. Epub 2002 Nov 14.
16. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
17. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
18. Mouse MP Annotation Import Pipeline RGD automated import pipeline
19. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. In vivo therapeutic success of MicroRNA-155 antagomir in a mouse model of pulmonary fibrosis induced by bleomycin. Sun X, etal., Korean J Intern Med. 2021 Mar;36(Suppl 1):S160-S169. doi: 10.3904/kjim.2019.098. Epub 2020 Jun 9.
22. Haploinsufficiency of TAB2 causes congenital heart defects in humans. Thienpont B, etal., Am J Hum Genet. 2010 Jun 11;86(6):839-49. doi: 10.1016/j.ajhg.2010.04.011. Epub 2010 May 20.
23. TLR-4, IL-1R and TNF-R signaling to NF-kappaB: variations on a common theme. Verstrepen L, etal., Cell Mol Life Sci. 2008 Oct;65(19):2964-78.
24. Interleukin-1 (IL-1) pathway. Weber A, etal., Sci Signal. 2010 Jan 19;3(105):cm1. doi: 10.1126/scisignal.3105cm1.
25. Assigning pathogenicity for TAB2 variants using a novel scalable functional assay and expanding TAB2 disease spectrum. Xu W, etal.
26. TAB2 deficiency induces dilated cardiomyopathy by promoting RIPK1-dependent apoptosis and necroptosis. Yin H, etal., J Clin Invest. 2022 Feb 15;132(4). pii: 152297. doi: 10.1172/JCI152297.
27. The microRNA miR-23b suppresses IL-17-associated autoimmune inflammation by targeting TAB2, TAB3 and IKK-α. Zhu S, etal., Nat Med. 2012 Jul;18(7):1077-86. doi: 10.1038/nm.2815.
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11544199   PMID:12150997   PMID:12465718   PMID:12477932   PMID:12556483   PMID:12627171   PMID:14610273  
PMID:14681479   PMID:15489334   PMID:15582152   PMID:15782199   PMID:15836773   PMID:16141072   PMID:16141073   PMID:16260493   PMID:16602821   PMID:17158449   PMID:17384642   PMID:17406806  
PMID:18345001   PMID:18682563   PMID:18799693   PMID:18805969   PMID:19026643   PMID:19136967   PMID:19136968   PMID:19150425   PMID:19556242   PMID:19843958   PMID:19927120   PMID:19955178  
PMID:20194509   PMID:21267068   PMID:21873635   PMID:22167179   PMID:22331902   PMID:23226465   PMID:23449975   PMID:23509369   PMID:24270572   PMID:24498425   PMID:24535827   PMID:24736749  
PMID:25828701   PMID:26299341   PMID:26474655   PMID:26764384   PMID:27153994   PMID:27695001   PMID:28190767   PMID:30144578   PMID:30196744   PMID:31127032   PMID:31494298   PMID:32823238  
PMID:33184450   PMID:33378226   PMID:35217833   PMID:36681779   PMID:37116711  


Genomics

Comparative Map Data
Tab2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39107,781,412 - 7,832,039 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl107,781,417 - 7,831,994 (-)EnsemblGRCm39 Ensembl
GRCm38107,905,648 - 7,956,255 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl107,905,653 - 7,956,230 (-)EnsemblGRCm38mm10GRCm38
MGSCv37107,625,446 - 7,675,921 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36107,596,328 - 7,615,052 (-)NCBIMGSCv36mm8
Celera107,785,153 - 7,804,378 (-)NCBICelera
Cytogenetic Map10A1NCBI
cM Map102.56NCBI
TAB2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386149,217,926 - 149,411,607 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6149,218,641 - 149,411,613 (+)EnsemblGRCh38hg38GRCh38
GRCh376149,539,062 - 149,732,743 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366149,680,756 - 149,774,440 (+)NCBINCBI36Build 36hg18NCBI36
Build 346149,680,755 - 149,774,440NCBI
Celera6150,374,542 - 150,467,843 (+)NCBICelera
Cytogenetic Map6q25.1NCBI
HuRef6147,206,396 - 147,299,504 (+)NCBIHuRef
CHM1_16149,904,215 - 149,997,498 (+)NCBICHM1_1
T2T-CHM13v2.06150,417,736 - 150,611,453 (+)NCBIT2T-CHM13v2.0
Tab2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr814,195,400 - 4,245,485 (-)NCBIGRCr8
mRatBN7.212,375,026 - 2,425,115 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl12,375,490 - 2,424,756 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx12,024,841 - 2,074,950 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.018,025,244 - 8,075,354 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.012,306,955 - 2,357,065 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.011,999,574 - 2,017,574 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl11,999,596 - 2,073,896 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013,695,737 - 3,770,496 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.412,568,536 - 2,617,742 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.112,568,544 - 2,617,742 (-)NCBI
Celera1924,327 - 972,936 (-)NCBICelera
Cytogenetic Map1p13NCBI
Tab2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543911,826,469 - 11,903,103 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543911,826,469 - 11,903,103 (-)NCBIChiLan1.0ChiLan1.0
TAB2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25169,345,036 - 169,438,035 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16167,238,691 - 167,331,654 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06147,138,553 - 147,231,559 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16151,868,513 - 151,936,841 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6151,868,513 - 151,936,841 (+)Ensemblpanpan1.1panPan2
TAB2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1140,125,842 - 40,216,455 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl140,149,569 - 40,215,385 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha140,963,295 - 41,053,932 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0140,305,492 - 40,396,387 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl140,326,467 - 40,396,378 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1140,182,019 - 40,272,887 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0140,047,126 - 40,137,980 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0140,387,856 - 40,478,641 (+)NCBIUU_Cfam_GSD_1.0
Tab2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946135,120,261 - 135,169,883 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364892,372,216 - 2,424,515 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364892,371,953 - 2,421,882 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TAB2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl116,533,285 - 16,611,884 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1116,533,364 - 16,611,879 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2118,852,316 - 18,930,145 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TAB2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11322,234,736 - 22,312,985 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1322,234,012 - 22,282,562 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040198,258,272 - 198,349,280 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tab2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247858,690,039 - 8,747,160 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tab2
1898 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1158
Count of miRNA genes:635
Interacting mature miRNAs:758
Transcripts:ENSMUST00000130322, ENSMUST00000142007, ENSMUST00000143848, ENSMUST00000146444, ENSMUST00000147938
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11532725Sluc44b_msusceptibility to lung cancer 44b (mouse)10126289265Mouse
11532724Sluc44c_msusceptibility to lung cancer 44c (mouse)10126289265Mouse
11532723Sluc44d_msusceptibility to lung cancer 44d (mouse)10126289265Mouse
11532722Sluc44e_msusceptibility to lung cancer 44e (mouse)10126289265Mouse
11532721Sluc44_msusceptibility to lung cancer 44 (mouse)10126289265Mouse
11532720Sluc44a_msusceptibility to lung cancer 44a (mouse)10126289265Mouse
11532718Sluc44f_msusceptibility to lung cancer 44f (mouse)10126289265Mouse
11532717Sluc44g_msusceptibility to lung cancer 44g (mouse)10126289265Mouse
11533917Mts2_mmammary tumor susceptibility 2 (mouse)10126289265Mouse
1300759Geot_mgeotaxia (mouse)Not determined10126289265Mouse
1300881Sluc29_msusceptibility to lung cancer 29 (mouse)Not determined10126289265Mouse
12879494Facq1_mfear acquisition QTL 1 (mouse)10131279130Mouse
15039341Nmrs28_mNAFLD-associated magnetic resonance shift 28 (mouse)1035100134351001Mouse
1357813Ath20_matherosclerosis 20 (mouse)Not determined10328318537283334Mouse
1300790Pgia6_mproteoglycan induced arthritis 6 (mouse)Not determined10381017137810295Mouse
1300997Eae15_msusceptibility to experimental allergic encephalomyelitis 15 (mouse)Not determined10440815438408276Mouse
13208561Wght8_mweight 8 (mouse)10495000043875996Mouse
1302092Ath11_matherosclerosis 11 (mouse)Not determined10615194558693521Mouse

Markers in Region
Map3k7ip2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38107,906,324 - 7,907,307UniSTSGRCm38
MGSCv37107,626,122 - 7,627,105UniSTSGRCm37
Celera107,785,829 - 7,786,812UniSTS
Cytogenetic Map10A1UniSTS
cM Map10 UniSTS
D10Mit181  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38107,922,001 - 7,922,149UniSTSGRCm38
MGSCv37107,641,799 - 7,641,947UniSTSGRCm37
Celera107,801,505 - 7,801,653UniSTS
Cytogenetic Map10A1UniSTS
cM Map102.0UniSTS
Whitehead Genetic100.0UniSTS
Whitehead/MRC_RH10114.24UniSTS
Whitehead_YAC10 UniSTS
STS-T59224  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38107,919,439 - 7,919,626UniSTSGRCm38
MGSCv37107,639,237 - 7,639,424UniSTSGRCm37
Celera107,798,943 - 7,799,130UniSTS
Cytogenetic Map10A1UniSTS
Map3k7ip2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map10A1UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001359534 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_138667 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011243203 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011243204 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030245247 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036155973 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036155974 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036155975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036155976 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036155977 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB093262 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC092856 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK003993 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK031864 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK041067 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK086230 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK089164 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK147830 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK190119 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK207065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK217747 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW492243 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY093701 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC004072 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC004813 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF468714 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG078791 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY429748 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466562 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK391470 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CN532534 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSMUST00000130322   ⟹   ENSMUSP00000122559
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl107,795,104 - 7,800,024 (-)Ensembl
GRCm38.p6 Ensembl107,919,340 - 7,924,260 (-)Ensembl
RefSeq Acc Id: ENSMUST00000142007
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl107,783,203 - 7,787,250 (-)Ensembl
GRCm38.p6 Ensembl107,907,439 - 7,911,486 (-)Ensembl
RefSeq Acc Id: ENSMUST00000143848
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl107,783,093 - 7,786,264 (-)Ensembl
GRCm38.p6 Ensembl107,907,329 - 7,910,500 (-)Ensembl
RefSeq Acc Id: ENSMUST00000146444   ⟹   ENSMUSP00000121266
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl107,781,417 - 7,831,994 (-)Ensembl
GRCm38.p6 Ensembl107,905,653 - 7,956,230 (-)Ensembl
RefSeq Acc Id: ENSMUST00000147938   ⟹   ENSMUSP00000119515
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl107,787,256 - 7,831,657 (-)Ensembl
GRCm38.p6 Ensembl107,911,492 - 7,955,893 (-)Ensembl
RefSeq Acc Id: NM_001359534   ⟹   NP_001346463
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39107,781,417 - 7,828,829 (-)NCBI
GRCm38107,905,653 - 7,953,065 (-)NCBI
Sequence:
RefSeq Acc Id: NM_138667   ⟹   NP_619608
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39107,781,412 - 7,831,887 (-)NCBI
GRCm38107,905,648 - 7,956,123 (-)NCBI
MGSCv37107,625,446 - 7,675,921 (-)RGD
Celera107,785,153 - 7,804,378 (-)RGD
cM Map10 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_011243203   ⟹   XP_011241505
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39107,781,417 - 7,832,004 (-)NCBI
GRCm38107,905,653 - 7,956,225 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011243204   ⟹   XP_011241506
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39107,781,417 - 7,832,039 (-)NCBI
GRCm38107,905,653 - 7,956,255 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030245247   ⟹   XP_030101107
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39107,781,417 - 7,831,298 (-)NCBI
GRCm38107,905,653 - 7,955,420 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036155973   ⟹   XP_036011866
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39107,781,417 - 7,808,972 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036155974   ⟹   XP_036011867
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39107,781,501 - 7,832,004 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036155975   ⟹   XP_036011868
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39107,793,397 - 7,832,004 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036155976   ⟹   XP_036011869
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39107,789,703 - 7,832,004 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036155977   ⟹   XP_036011870
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39107,789,703 - 7,832,004 (-)NCBI
Sequence:
RefSeq Acc Id: NP_619608   ⟸   NM_138667
- UniProtKB: Q8CHD3 (UniProtKB/Swiss-Prot),   Q8BTP4 (UniProtKB/Swiss-Prot),   Q3UGP1 (UniProtKB/Swiss-Prot),   Q99KP4 (UniProtKB/Swiss-Prot),   Q99K90 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011241506   ⟸   XM_011243204
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_011241505   ⟸   XM_011243203
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_030101107   ⟸   XM_030245247
- Peptide Label: isoform X1
RefSeq Acc Id: NP_001346463   ⟸   NM_001359534
- UniProtKB: Q99K90 (UniProtKB/Swiss-Prot),   Q8CHD3 (UniProtKB/Swiss-Prot),   Q8BTP4 (UniProtKB/Swiss-Prot),   Q3UGP1 (UniProtKB/Swiss-Prot),   Q99KP4 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: ENSMUSP00000122559   ⟸   ENSMUST00000130322
RefSeq Acc Id: ENSMUSP00000119515   ⟸   ENSMUST00000147938
RefSeq Acc Id: ENSMUSP00000121266   ⟸   ENSMUST00000146444
RefSeq Acc Id: XP_036011866   ⟸   XM_036155973
- Peptide Label: isoform X1
RefSeq Acc Id: XP_036011867   ⟸   XM_036155974
- Peptide Label: isoform X2
- UniProtKB: Q99K90 (UniProtKB/Swiss-Prot),   Q8CHD3 (UniProtKB/Swiss-Prot),   Q8BTP4 (UniProtKB/Swiss-Prot),   Q3UGP1 (UniProtKB/Swiss-Prot),   Q99KP4 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_036011870   ⟸   XM_036155977
- Peptide Label: isoform X4
- UniProtKB: D3Z216 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_036011869   ⟸   XM_036155976
- Peptide Label: isoform X3
- UniProtKB: D3Z216 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_036011868   ⟸   XM_036155975
- Peptide Label: isoform X3
- UniProtKB: D3Z216 (UniProtKB/TrEMBL)
Protein Domains
CUE

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q99K90-F1-model_v2 AlphaFold Q99K90 1-693 view protein structure

Promoters
RGD ID:6819569
Promoter ID:MM_KWN:3497
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Spleen
Transcripts:OTTMUST00000086383
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36107,630,406 - 7,630,906 (-)MPROMDB
RGD ID:6819568
Promoter ID:MM_KWN:3498
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain
Transcripts:OTTMUST00000086382
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36107,631,261 - 7,632,102 (-)MPROMDB
RGD ID:6819571
Promoter ID:MM_KWN:3499
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour
Transcripts:OTTMUST00000086384,   UC007EIR.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36107,643,226 - 7,645,362 (-)MPROMDB
RGD ID:8671468
Promoter ID:EPDNEW_M13765
Type:initiation region
Name:Tab2_1
Description:Mus musculus TGF-beta activated kinase 1/MAP3K7 binding protein2 , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38107,956,132 - 7,956,192EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1915902 AgrOrtholog
Ensembl Genes ENSMUSG00000015755 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000130322.2 UniProtKB/TrEMBL
  ENSMUST00000146444 ENTREZGENE
  ENSMUST00000146444.8 UniProtKB/Swiss-Prot
  ENSMUST00000147938.2 UniProtKB/TrEMBL
Gene3D-CATH DNA helicase RuvA subunit, C-terminal domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Zn-finger domain of Sec23/24 UniProtKB/Swiss-Prot
InterPro CUE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TAB2/3_CUE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RanBP2 UniProtKB/Swiss-Prot
  Znf_RanBP2_sf UniProtKB/Swiss-Prot
KEGG Report mmu:68652 UniProtKB/Swiss-Prot
MGD MGI:1915902 ENTREZGENE
NCBI Gene 68652 ENTREZGENE
PANTHER TGF-BETA-ACTIVATED KINASE 1 AND MAP3K7-BINDING PROTEIN 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF-BETA-ACTIVATED KINASE 1 AND MAP3K7-BINDING PROTEIN TAB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam CUE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tab2 PhenoGen
PROSITE CUE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_RANBP2_1 UniProtKB/Swiss-Prot
  ZF_RANBP2_2 UniProtKB/Swiss-Prot
SMART CUE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZnF_RBZ UniProtKB/Swiss-Prot
Superfamily-SCOP SSF90209 UniProtKB/Swiss-Prot
UniProt D3Z216 ENTREZGENE, UniProtKB/TrEMBL
  D3Z564_MOUSE UniProtKB/TrEMBL
  Q3UGP1 ENTREZGENE
  Q8BTP4 ENTREZGENE
  Q8CHD3 ENTREZGENE
  Q99K90 ENTREZGENE
  Q99KP4 ENTREZGENE
  TAB2_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q3UGP1 UniProtKB/Swiss-Prot
  Q8BTP4 UniProtKB/Swiss-Prot
  Q8CHD3 UniProtKB/Swiss-Prot
  Q99KP4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-07-27 Tab2  TGF-beta activated kinase 1/MAP3K7 binding protein 2  Map3k7ip2  mitogen-activated protein kinase kinase kinase 7 interacting protein 2  Symbol and/or name change 5135510 APPROVED