Mir146a (microRNA 146a) - Rat Genome Database

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Gene: Mir146a (microRNA 146a) Rattus norvegicus
Analyze
Symbol: Mir146a
Name: microRNA 146a
RGD ID: 2325382
Description: Predicted to enable mRNA 3'-UTR binding activity and mRNA base-pairing post-transcriptional repressor activity. Involved in response to Gram-positive bacterium. Predicted to be located in extracellular exosome and synapse. Predicted to be part of RISC complex. Biomarker of streptococcal meningitis. Human ortholog(s) of this gene implicated in atrophic gastritis; carcinoma (multiple); coronary artery disease; fatal familial insomnia; and type 1 diabetes mellitus. Orthologous to human MIR146A (microRNA 146a); INTERACTS WITH aflatoxin B1; arsenite(3-); atrazine.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: microRNA mir-146a; rno-mir-146a
RGD Orthologs
Human
Mouse
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81028,349,996 - 28,350,090 (-)NCBIGRCr8GRCr8GRCr8
mRatBN7.21027,848,516 - 27,848,610 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1027,848,516 - 27,848,610 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1032,609,206 - 32,609,300 (-)NCBIUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0101,147,600 - 1,147,694 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01027,581,111 - 27,581,205 (-)NCBIUTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1031,308,786 - 31,308,880 (-)NCBI
Lyon_Normotensive1031,956,770 - 31,956,864 (-)NCBI
Lyon_Hypertensive1033,652,083 - 33,652,177 (-)NCBI
F344_StmMcwi1033,600,097 - 33,600,191 (-)NCBI
Rnor_6.01028,962,476 - 28,962,570 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1028,962,476 - 28,962,570 (-)EnsemblRnor_6.0 Ensemblrn6Rnor6.0
Rnor_5.01028,806,739 - 28,806,833 (-)NCBIRnor_5.0Rnor_5.0rn5
Celera1027,342,093 - 27,342,187 (-)NCBICelera
Cytogenetic Map10q21NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,3-benzothiazole-2-thiol  (ISO)
17beta-estradiol  (ISO)
aflatoxin B1  (EXP)
alcohol  (ISO)
aldehydo-D-glucose  (ISO)
alpha-hexylcinnamaldehyde  (ISO)
aluminium sulfate (anhydrous)  (ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (ISO)
atorvastatin calcium  (ISO)
atrazine  (EXP)
azoxystrobin  (EXP)
Bandrowski's base  (ISO)
benzene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (ISO)
bleomycin A2  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cannabidiol  (ISO)
captopril  (EXP)
carbon atom  (ISO)
catechol  (ISO)
chlorpyrifos  (EXP)
cisplatin  (EXP,ISO)
curcumin  (ISO)
D-glucose  (ISO)
decabromodiphenyl ether  (ISO)
Deoxycorticosterone acetate  (EXP)
diarsenic trioxide  (ISO)
elemental carbon  (ISO)
enalapril  (ISO)
eugenol  (ISO)
folic acid  (ISO)
furan  (EXP)
glucose  (ISO)
glyburide  (EXP)
glyphosate  (EXP)
GSK-J4  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
imidacloprid  (EXP)
ionomycin  (ISO)
iron(2+) sulfate (anhydrous)  (ISO)
lead(0)  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (ISO)
LY294002  (ISO)
mechlorethamine  (ISO)
metformin  (EXP)
morphine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nitrogen dioxide  (ISO)
ochratoxin A  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
progesterone  (ISO)
propofol  (EXP)
pyrrolidine dithiocarbamate  (ISO)
quartz  (EXP)
resveratrol  (ISO)
rotenone  (EXP,ISO)
silicon dioxide  (ISO)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
stanozolol  (EXP)
streptozocin  (EXP)
tacrolimus hydrate  (ISO)
telmisartan  (EXP,ISO)
thiabendazole  (EXP)
titanium dioxide  (ISO)
tributyl phosphate  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
tropisetron  (EXP)
urethane  (ISO)
zearalenone  (ISO)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
canonical NF-kappaB signal transduction  (ISO)
cellular response to amyloid-beta  (ISO)
cellular response to cytokine stimulus  (ISO)
cellular response to decreased oxygen levels  (ISO)
cellular response to estrogen stimulus  (ISO)
cellular response to glucose stimulus  (ISO)
cellular response to hypoxia  (ISO)
cellular response to leukemia inhibitory factor  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to oxidised low-density lipoprotein particle stimulus  (ISO)
cellular response to virus  (ISO)
innate immune response  (ISO)
interleukin-1-mediated signaling pathway  (ISO)
miRNA-mediated gene silencing by inhibition of translation  (ISO)
miRNA-mediated gene silencing by mRNA destabilization  (ISO)
miRNA-mediated post-transcriptional gene silencing  (ISO)
myeloid cell differentiation  (ISO)
negative regulation of angiogenesis  (ISO)
negative regulation of apoptotic signaling pathway  (ISO)
negative regulation of canonical NF-kappaB signal transduction  (ISO)
negative regulation of cell adhesion molecule production  (ISO)
negative regulation of cell migration involved in sprouting angiogenesis  (ISO)
negative regulation of chemokine (C-X-C motif) ligand 2 production  (ISO)
negative regulation of cholesterol storage  (ISO)
negative regulation of cytokine production involved in inflammatory response  (ISO)
negative regulation of endothelial cell proliferation  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of glial cell proliferation  (ISO)
negative regulation of inflammatory response  (ISO)
negative regulation of interleukin-6 production  (ISO)
negative regulation of interleukin-6-mediated signaling pathway  (ISO)
negative regulation of interleukin-8 production  (ISO)
negative regulation of intracellular signal transduction  (ISO)
negative regulation of leukocyte adhesion to vascular endothelial cell  (ISO)
negative regulation of matrix metallopeptidase secretion  (ISO)
negative regulation of membrane permeability  (ISO)
negative regulation of monocyte extravasation  (ISO)
negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
negative regulation of receptor signaling pathway via JAK-STAT  (ISO)
negative regulation of SMAD protein signal transduction  (ISO)
negative regulation of vascular endothelial growth factor production  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis  (ISO)
positive regulation of cell migration involved in sprouting angiogenesis  (ISO)
positive regulation of fibroblast growth factor receptor signaling pathway  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of vascular associated smooth muscle cell migration  (ISO)
positive regulation of vascular associated smooth muscle cell proliferation  (ISO)
regulation of gene expression  (ISO)
regulation of stem cell differentiation  (ISO)
regulation of toll-like receptor signaling pathway  (ISO)
response to Gram-positive bacterium  (IEP)
response to ischemia  (IEP)
response to oxygen levels  (ISO)
sensory perception of sound  (ISO)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Up-regulation of circulating miRNA146a correlates with viral load via IRAK1 and TRAF6 in hepatitis C virus-infected patients. Abdel Motaleb FI, etal., Virus Res. 2017 Jun 15;238:24-28. doi: 10.1016/j.virusres.2017.05.026. Epub 2017 Jun 3.
2. MicroRNA-146a-deficient mice develop immune complex glomerulonephritis. Amrouche L, etal., Sci Rep. 2019 Oct 30;9(1):15597. doi: 10.1038/s41598-019-51985-1.
3. Polymorphisms in genes encoding miR-155 and miR-146a are associated with protection to type 1 diabetes mellitus. Assmann TS, etal., Acta Diabetol. 2017 May;54(5):433-441. doi: 10.1007/s00592-016-0961-y. Epub 2017 Jan 19.
4. Hepatitis C Virus-Induced Upregulation of MicroRNA miR-146a-5p in Hepatocytes Promotes Viral Infection and Deregulates Metabolic Pathways Associated with Liver Disease Pathogenesis. Bandiera S, etal., J Virol. 2016 Jun 24;90(14):6387-6400. doi: 10.1128/JVI.00619-16. Print 2016 Jul 15.
5. MiRNA-Related Polymorphisms in miR-146a and TCF21 Are Associated with Increased Susceptibility to Coronary Artery Disease in an Iranian Population. Bastami M, etal., Genet Test Mol Biomarkers. 2016 May;20(5):241-8. doi: 10.1089/gtmb.2015.0253. Epub 2016 Feb 24.
6. Anti-Inflammatory Role of MicroRNA-146a in the Pathogenesis of Diabetic Nephropathy. Bhatt K, etal., J Am Soc Nephrol. 2016 Aug;27(8):2277-88. doi: 10.1681/ASN.2015010111. Epub 2015 Dec 8.
7. Serum Exosomal miRNAs for Grading Hepatic Fibrosis Due to Schistosomiasis. Cai P, etal., Int J Mol Sci. 2020 May 18;21(10). pii: ijms21103560. doi: 10.3390/ijms21103560.
8. miR-146a and miR-155 delineate a MicroRNA fingerprint associated with Toxoplasma persistence in the host brain. Cannella D, etal., Cell Rep. 2014 Mar 13;6(5):928-37. doi: 10.1016/j.celrep.2014.02.002. Epub 2014 Feb 27.
9. miR-146a G>C polymorphisms and risk of hepatocellular carcinoma in a Chinese population. Cong N, etal., Tumour Biol. 2014 Jun;35(6):5669-73. doi: 10.1007/s13277-014-1750-2. Epub 2014 Mar 11.
10. MicroRNA-146a Deficiency Protects against Listeria monocytogenes Infection by Modulating the Gut Microbiota. Du CT, etal., Int J Mol Sci. 2018 Mar 26;19(4). pii: ijms19040993. doi: 10.3390/ijms19040993.
11. Exosome-mediated miR-146a transfer suppresses type I interferon response and facilitates EV71 infection. Fu Y, etal., PLoS Pathog. 2017 Sep 14;13(9):e1006611. doi: 10.1371/journal.ppat.1006611. eCollection 2017 Sep.
12. The associations of two SNPs in miRNA-146a and one SNP in ZBTB38-RASA2 with the disease susceptibility and the clinical features of the Chinese patients of sCJD and FFI. Gao C, etal., Prion. 2018 Jan 2;12(1):34-41. doi: 10.1080/19336896.2017.1405885. Epub 2018 Jan 2.
13. Attenuation of Cardiac Dysfunction in Polymicrobial Sepsis by MicroRNA-146a Is Mediated via Targeting of IRAK1 and TRAF6 Expression. Gao M, etal., J Immunol. 2015 Jul 15;195(2):672-82. doi: 10.4049/jimmunol.1403155. Epub 2015 Jun 5.
14. Systemic Treatment with a miR-146a Mimic Suppresses Endotoxin Sensitivity and Partially Protects Mice from the Progression of Acute Graft-versus-Host Disease. Gartner JG, etal., Scand J Immunol. 2017 Nov;86(5):368-376. doi: 10.1111/sji.12597. Epub 2017 Sep 29.
15. NOD2-nitric oxide-responsive microRNA-146a activates Sonic hedgehog signaling to orchestrate inflammatory responses in murine model of inflammatory bowel disease. Ghorpade DS, etal., J Biol Chem. 2013 Nov 15;288(46):33037-48. doi: 10.1074/jbc.M113.492496. Epub 2013 Oct 3.
16. Micro RNA-320 as a novel potential biomarker in renal ischemia reperfusion. Güçlü A, etal., Ren Fail. 2016 Oct;38(9):1468-1475. doi: 10.1080/0886022X.2016.1227915. Epub 2016 Oct 19.
17. MicroR-146 blocks the activation of M1 macrophage by targeting signal transducer and activator of transcription 1 in hepatic schistosomiasis. He X, etal., EBioMedicine. 2016 Nov;13:339-347. doi: 10.1016/j.ebiom.2016.10.024. Epub 2016 Oct 19.
18. Activation of nuclear factor kappa B in the hepatic stellate cells of mice with schistosomiasis japonica. He X, etal., PLoS One. 2014 Aug 12;9(8):e104323. doi: 10.1371/journal.pone.0104323. eCollection 2014.
19. Combined effect of miR-146a rs2910164 G/C polymorphism and Toll-like receptor 4 +3725 G/C polymorphism on the risk of severe gastric atrophy in Japanese. Hishida A, etal., Dig Dis Sci. 2011 Apr;56(4):1131-7. doi: 10.1007/s10620-010-1376-1. Epub 2010 Aug 19.
20. Inhibition of miR-146a prevents enterovirus-induced death by restoring the production of type I interferon. Ho BC, etal., Nat Commun. 2014;5:3344. doi: 10.1038/ncomms4344.
21. Hepatitis B virus inhibits intrinsic RIG-I and RIG-G immune signaling via inducing miR146a. Hou Z, etal., Sci Rep. 2016 May 23;6:26150. doi: 10.1038/srep26150.
22. Circulating MicroRNAs in Extracellular Vesicles as Potential Biomarkers of Alcohol-Induced Neuroinflammation in Adolescence: Gender Differences. Ibáñez F, etal., Int J Mol Sci. 2020 Sep 14;21(18):6730. doi: 10.3390/ijms21186730.
23. Acute meningitis in rats is associated with decreased levels of miR132 and miR146a. Jagoo M, etal., Cent Eur J Immunol. 2014;39(3):316-22. doi: 10.5114/ceji.2014.45941. Epub 2014 Oct 14.
24. Association of a single-nucleotide polymorphism within the miR-146a gene with susceptibility for acute-on-chronic hepatitis B liver failure. Jiang H, etal., Immunogenetics. 2013 Apr;65(4):257-63. doi: 10.1007/s00251-012-0675-4. Epub 2013 Jan 6.
25. LncRNA MALAT1 mediates proliferation of LPS treated-articular chondrocytes by targeting the miR-146a-PI3K/Akt/mTOR axis. Li H, etal., Life Sci. 2020 Aug 1;254:116801. doi: 10.1016/j.lfs.2019.116801. Epub 2019 Aug 28.
26. Upregulation of microRNA-146a by hepatitis B virus X protein contributes to hepatitis development by downregulating complement factor H. Li JF, etal., mBio. 2015 Mar 24;6(2). pii: mBio.02459-14. doi: 10.1128/mBio.02459-14.
27. microRNA-146a promotes mycobacterial survival in macrophages through suppressing nitric oxide production. Li M, etal., Sci Rep. 2016 Mar 30;6:23351. doi: 10.1038/srep23351.
28. MicroRNA‑146a inhibits the inflammatory responses induced by interleukin‑17A during the infection of Helicobacter pylori. Li N, etal., Mol Med Rep. 2019 Feb;19(2):1388-1395. doi: 10.3892/mmr.2018.9725. Epub 2018 Dec 5.
29. Baicalin inhibits influenza virus A replication via activation of type I IFN signaling by reducing miR‑146a. Li R and Wang L, Mol Med Rep. 2019 Dec;20(6):5041-5049. doi: 10.3892/mmr.2019.10743. Epub 2019 Oct 15.
30. MiR-146a-5p inhibits cell proliferation and cell cycle progression in NSCLC cell lines by targeting CCND1 and CCND2. Li YL, etal., Oncotarget. 2016 Sep 13;7(37):59287-59298. doi: 10.18632/oncotarget.11040.
31. MicroRNA-146a provides feedback regulation of lyme arthritis but not carditis during infection with Borrelia burgdorferi. Lochhead RB, etal., PLoS Pathog. 2014 Jun 26;10(6):e1004212. doi: 10.1371/journal.ppat.1004212. eCollection 2014 Jun.
32. Transcriptomics identified a critical role for Th2 cell-intrinsic miR-155 in mediating allergy and antihelminth immunity. Okoye IS, etal., Proc Natl Acad Sci U S A. 2014 Jul 29;111(30):E3081-90. doi: 10.1073/pnas.1406322111. Epub 2014 Jul 14.
33. Dysregulated Serum MiRNA Profile and Promising Biomarkers in Dengue-infected Patients. Ouyang X, etal., Int J Med Sci. 2016 Feb 18;13(3):195-205. doi: 10.7150/ijms.13996. eCollection 2016.
34. Rg6, a rare ginsenoside, inhibits systemic inflammation through the induction of interleukin-10 and microRNA-146a. Paik S, etal., Sci Rep. 2019 Mar 13;9(1):4342. doi: 10.1038/s41598-019-40690-8.
35. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
36. MicroRNA 146a (miR-146a) is over-expressed during prion disease and modulates the innate immune response and the microglial activation state. Saba R, etal., PLoS One. 2012;7(2):e30832. doi: 10.1371/journal.pone.0030832. Epub 2012 Feb 17.
37. MicroRNA-146a controls functional plasticity in γδ T cells by targeting NOD1. Schmolka N, etal., Sci Immunol. 2018 May 4;3(23). pii: 3/23/eaao1392. doi: 10.1126/sciimmunol.aao1392.
38. MiRNA-146a polymorphism increases the odds of malaria in pregnancy. van Loon W, etal., Malar J. 2019 Jan 14;18(1):7. doi: 10.1186/s12936-019-2643-z.
39. [Expression characteristics of microRNA in mice with schistosomiasis and praziquantel treatment]. Wang CY, etal., Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi. 2014 Apr;26(2):165-8, 174.
40. MicroRNA-146a feedback suppresses T cell immune function by targeting Stat1 in patients with chronic hepatitis B. Wang S, etal., J Immunol. 2013 Jul 1;191(1):293-301. doi: 10.4049/jimmunol.1202100. Epub 2013 May 22.
41. MicroRNA-146a enhances Helicobacter pylori induced cell apoptosis in human gastric cancer epithelial cells. Wu K, etal., Asian Pac J Cancer Prev. 2014;15(14):5583-6. doi: 10.7314/apjcp.2014.15.14.5583.
42. A functional polymorphism in the miR-146a gene is associated with the risk for hepatocellular carcinoma. Xu T, etal., Carcinogenesis. 2008 Nov;29(11):2126-31. doi: 10.1093/carcin/bgn195. Epub 2008 Aug 18.
43. MicroRNA-146a regulates the transformation from liver fibrosis to cirrhosis in patients with hepatitis B via interleukin-6. Yang Z, etal., Exp Ther Med. 2019 Jun;17(6):4670-4676. doi: 10.3892/etm.2019.7490. Epub 2019 Apr 16.
44. Downregulation of miR-146a inhibits influenza A virus replication by enhancing the type I interferon response in vitro and in vivo. Zhang F, etal., Biomed Pharmacother. 2019 Mar;111:740-750. doi: 10.1016/j.biopha.2018.12.103. Epub 2019 Jan 3.
45. Involvement of TLR2-MyD88 in abnormal expression of miR-146a in peripheral blood monocytes of patients with chronic hepatitis C. Zhang WJ, etal., J Huazhong Univ Sci Technolog Med Sci. 2015 Apr;35(2):219-224. doi: 10.1007/s11596-015-1414-5. Epub 2015 Apr 16.
46. Association between miR-146aG>C and miR-196a2C>T polymorphisms and the risk of hepatocellular carcinoma in a Chinese population. Zhou B, etal., Tumour Biol. 2014 Aug;35(8):7775-80. doi: 10.1007/s13277-014-2020-z. Epub 2014 May 10.
47. Inflammation-Related MicroRNAs Are Associated with Plaque Stability Calculated by IVUS in Coronary Heart Disease Patients. Zhu GF, etal., J Interv Cardiol. 2019 Dec 1;2019:9723129. doi: 10.1155/2019/9723129. eCollection 2019.
48. The microRNA miR-23b suppresses IL-17-associated autoimmune inflammation by targeting TAB2, TAB3 and IKK-α. Zhu S, etal., Nat Med. 2012 Jul;18(7):1077-86. doi: 10.1038/nm.2815.
49. PECULIARITIES OF MIR-146A AND MIR-155 EXPRESSION IN PATIENTS WITH ALLERGOPATHY IN COMBINATION WITH CHRONIC EPSTEIN-BARR VIRUS INFECTION IN LATENT AND ACTIVE PHASES. Zubchenko S, etal., Georgian Med News. 2019 May;(290):69-73.
Additional References at PubMed
PMID:15345052   PMID:16381832   PMID:16766679   PMID:17604727   PMID:18723672   PMID:18791161   PMID:19147652   PMID:20214679   PMID:20403161   PMID:20439489   PMID:20495188   PMID:21109779  
PMID:21247879   PMID:22507670   PMID:22685718   PMID:22897173   PMID:23498784   PMID:23646144   PMID:23784108   PMID:24057185   PMID:24824805   PMID:24828499   PMID:24867582   PMID:25156638  
PMID:25567745   PMID:26239160   PMID:26782520   PMID:26782583   PMID:26925748   PMID:27167084   PMID:27830143   PMID:27889748   PMID:27999792   PMID:28205638   PMID:28474544   PMID:28739486  
PMID:28771774   PMID:28901447   PMID:29144992   PMID:29187582   PMID:29590637   PMID:29649906   PMID:29762840   PMID:30521085   PMID:30711634   PMID:30915760   PMID:31210336   PMID:31763669  
PMID:31773674   PMID:31796120   PMID:32090627   PMID:32131713   PMID:32821084   PMID:32934245   PMID:33185125   PMID:33247202   PMID:33434756   PMID:33655338   PMID:34028667   PMID:34104112  
PMID:34260048   PMID:34612146   PMID:34768001   PMID:35113000   PMID:35241728   PMID:35477552   PMID:35799283   PMID:35985935   PMID:36493861   PMID:36561887   PMID:36598302   PMID:36896948  
PMID:38309291   PMID:38720358   PMID:39125620  


Genomics

Comparative Map Data
Mir146a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81028,349,996 - 28,350,090 (-)NCBIGRCr8GRCr8GRCr8
mRatBN7.21027,848,516 - 27,848,610 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1027,848,516 - 27,848,610 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1032,609,206 - 32,609,300 (-)NCBIUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0101,147,600 - 1,147,694 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01027,581,111 - 27,581,205 (-)NCBIUTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1031,308,786 - 31,308,880 (-)NCBI
Lyon_Normotensive1031,956,770 - 31,956,864 (-)NCBI
Lyon_Hypertensive1033,652,083 - 33,652,177 (-)NCBI
F344_StmMcwi1033,600,097 - 33,600,191 (-)NCBI
Rnor_6.01028,962,476 - 28,962,570 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1028,962,476 - 28,962,570 (-)EnsemblRnor_6.0 Ensemblrn6Rnor6.0
Rnor_5.01028,806,739 - 28,806,833 (-)NCBIRnor_5.0Rnor_5.0rn5
Celera1027,342,093 - 27,342,187 (-)NCBICelera
Cytogenetic Map10q21NCBI
MIR146A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385160,485,352 - 160,485,450 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5160,485,352 - 160,485,450 (+)EnsemblGRCh38.p14 Ensemblhg38GRCh38
GRCh375159,912,359 - 159,912,457 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365159,844,936 - 159,845,034 (+)NCBIBuild 36Build 36hg18NCBI36
Celera5155,944,832 - 155,944,930 (+)NCBICelera
Cytogenetic Map5q33.3NCBI
HuRef5155,005,782 - 155,005,880 (+)NCBIHuRef
CHM1_15159,345,261 - 159,345,359 (+)NCBICHM1_1
T2T-CHM13v2.05161,013,850 - 161,013,948 (+)NCBIT2T-CHM13v2.0
Mir146
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391143,265,224 - 43,265,288 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1143,265,224 - 43,265,288 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381143,374,397 - 43,374,461 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1143,374,397 - 43,374,461 (-)EnsemblGRCm38.p6 Ensemblmm10GRCm38
MGSCv371143,187,899 - 43,187,963 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
Celera1148,002,809 - 48,002,873 (-)NCBICelera
Cytogenetic Map11A5NCBI
cM Map1125.68NCBI

miRNA Target Status (No longer updated)

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Snap25rno-miR-146a-5pMirtarbaseexternal_infoWestern blotNon-Functional MTI18381601
Smad4rno-miR-146a-5pMirtarbaseexternal_infoqRT-PCR//Western blotFunctional MTI22735812
Klf4rno-miR-146a-5pMirtarbaseexternal_infoReporter assay;Western blot;OtherFunctional MTI21109779

Predicted Targets
Summary Value
Count of predictions:8398
Count of gene targets:5211
Count of transcripts:5589
Interacting mature miRNAs:rno-miR-146a-3p, rno-miR-146a-5p
Prediction methods:Microtar, Miranda, Pita, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101577675460776754Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)102744378772443787Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10589381150893811Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10589381150893811Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)101465354159653541Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101553301273695498Rat
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)102466212373695339Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10687714251877142Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102702353561843633Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135730538Rat
7387235Uae41Urinary albumin excretion QTL 415.260.1874urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)10130004247Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)101993920764939207Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)101803578263035782Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1092219745922197Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)10210370847103708Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10589381150893811Rat
2298495Eae23Experimental allergic encephalomyelitis QTL 2316.93nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)101617552561175525Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101866841963668419Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)102011061465110614Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138832698Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102183375861843633Rat
631531Iresp2Immunoglobin response QTL26.3blood immunoglobulin E amount (VT:0002492)serum immunoglobulin E level (CMO:0002101)102342212132490778Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
631660Hcar1Hepatocarcinoma resistance QTL 13.40.0001liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)10666111835509383Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101803578263035782Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102744378772443787Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)102744378772443787Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)102011061465110614Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
5 4 4 15 13 26 36 11 21 11 84 48 11 7 23 17 25 9 9

Sequence

Nucleotide Sequences
RefSeq Transcripts NR_031892 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000053589
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1027,848,516 - 27,848,610 (-)Ensembl
Rnor_6.0 Ensembl1028,962,476 - 28,962,570 (-)Ensembl
RefSeq Acc Id: NR_031892
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81028,349,996 - 28,350,090 (-)NCBI
mRatBN7.21027,848,516 - 27,848,610 (-)NCBI
Dahl_SR_JrHsd1031,308,786 - 31,308,880 (-)NCBI
Lyon_Normotensive1031,956,770 - 31,956,864 (-)NCBI
Lyon_Hypertensive1033,652,083 - 33,652,177 (-)NCBI
F344_StmMcwi1033,600,097 - 33,600,191 (-)NCBI
Rnor_6.01028,962,476 - 28,962,570 (-)NCBI
Rnor_5.01028,806,739 - 28,806,833 (-)NCBI
Celera1027,342,093 - 27,342,187 (-)NCBI
Sequence:
Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2325382 AgrOrtholog
BioCyc Gene G2FUF-25456 BioCyc
Ensembl Genes ENSRNOG00000035466 Ensembl
miRBase MI0000919 ENTREZGENE
NCBI Gene 100314241 ENTREZGENE
PhenoGen Mir146a PhenoGen
RatGTEx ENSRNOG00000035466 RatGTEx
RNAcentral URS000050B527 RNACentral
  URS000075BB1C RNACentral
  URS000075BEC6 RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-08-14 Mir146a  microRNA 146a  Mir146a  microRNA mir-146a  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-06-02 Mir146a  microRNA mir-146a      Symbol and Name status set to provisional 70820 PROVISIONAL