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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2325382
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mir146a
Name: microRNA 146a
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mir146adecreases expression ISOMIR146A (Homo sapiens)152177908RGDLPS decreases expression of MIR146A mRNA in chondrocytes from RA patients 
Mir146aincreases expressionISOMIR146A (Homo sapiens)6480464CTDLipopolysaccharides results in increased expression of MIR146A; Lipopolysaccharides results in increased expression of MIR146A mRNAPMID:24863965 PMID:32392329 PMID:35781746
Mir146aincreases expressionISOMir146 (Mus musculus)6480464CTDLipopolysaccharides results in increased expression of MIR146 mRNAPMID:25890327
Mir146amultiple interactionsISOMIR146A (Homo sapiens)6480464CTD3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Lipopolysaccharides results in increased expression of MIR146A mRNA]; MIR146A mRNA affects the reaction [Lipopolysaccharides results in increased expression of CD74A protein]; MIR146A mRNA affects the reaction [Lipopolysaccharides results in increased expression of CD86 protein]; MYD88 affects the reaction [Lipopolysaccharides results in increased expression of MIR146A mRNA]PMID:24863965 PMID:35781746
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