RGD Reference Report - miR-146a and miR-155 delineate a MicroRNA fingerprint associated with Toxoplasma persistence in the host brain. - Rat Genome Database

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miR-146a and miR-155 delineate a MicroRNA fingerprint associated with Toxoplasma persistence in the host brain.

Authors: Cannella, Dominique  Brenier-Pinchart, Marie-Pierre  Braun, Laurence  van Rooyen, Jason M  Bougdour, Alexandre  Bastien, Olivier  Behnke, Michael S  Curt, Rose-Laurence  Curt, Aurélie  Saeij, Jeroen P J  Sibley, L David  Pelloux, Hervé  Hakimi, Mohamed-Ali 
Citation: Cannella D, etal., Cell Rep. 2014 Mar 13;6(5):928-37. doi: 10.1016/j.celrep.2014.02.002. Epub 2014 Feb 27.
RGD ID: 126925172
Pubmed: (View Article at PubMed) PMID:24582962
DOI: Full-text: DOI:10.1016/j.celrep.2014.02.002

microRNAs were recently found to be regulators of the host response to infection by apicomplexan parasites. In this study, we identified two immunomodulatory microRNAs, miR-146a and miR-155, that were coinduced in the brains of mice challenged with Toxoplasma in a strain-specific manner. These microRNAs define a characteristic fingerprint for infection by type II strains, which are the most prevalent cause of human toxoplasmosis in Europe and North America. Using forward genetics, we showed that strain-specific differences in miR-146a modulation were in part mediated by the rhoptry kinase, ROP16. Remarkably, we found that miR-146a deficiency led to better control of parasite burden in the gut and most likely of early parasite dissemination in the brain tissue, resulting in the long-term survival of mice.



Disease Annotations    

Objects Annotated

Genes (Rattus norvegicus)
Mir146a  (microRNA 146a)

Genes (Mus musculus)
Mir146  (microRNA 146)

Genes (Homo sapiens)
MIR146A  (microRNA 146a)


Additional Information