Gene: Snap25 (synaptosome associated protein 25) Rattus norvegicus
Analyze
Symbol:
Snap25
Name:
synaptosome associated protein 25
Description:
Exhibits several functions, including calcium-dependent protein binding activity; ion channel binding activity; and syntaxin-1 binding activity. Involved in several processes, including SNARE complex assembly; regulation of nervous system development; and signal release. Localizes to several cellular components, including presynaptic membrane; synaptobrevin 2-SNAP-25-syntaxin-1a complex; and synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex. Predicted to colocalize with BLOC-1 complex and vesicle. Human ortholog(s) of this gene implicated in Down syndrome and congenital myasthenic syndrome 18. Orthologous to human SNAP25 (synaptosome associated protein 25); PARTICIPATES IN insulin secretion pathway; INTERACTS WITH 1,3-dinitrobenzene; 2,2',4,4'-Tetrabromodiphenyl ether; 3,3',5,5'-tetrabromobisphenol A.
Type:
protein-coding
RefSeq Status:
REVIEWED
Also known as:
MGC105414; SNAP-25; SNAP-25a; SNAP-25B; SUP; super protein; Synaptosomal-accosiated protein, 25 kDa; synaptosomal-associated 25 kDa protein; synaptosomal-associated protein; synaptosomal-associated protein 25; Synaptosomal-associated protein 25 kDa; synaptosomal-associated protein, 25 kDa
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
SNAP25 (synaptosome associated protein 25) HGNC
Ensembl, HomoloGene, Inparanoid, NCBI, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):
Snap25 (synaptosomal-associated protein 25) HGNC
Treefam, OrthoMCL, NCBI, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Snap25 (synaptosome associated protein 25) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
SNAP25 (synaptosome associated protein 25) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
SNAP25 (synaptosome associated protein 25) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Snap25 (synaptosome associated protein 25) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
SNAP25 (synaptosome associated protein 25) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):
SNAP25 (synaptosome associated protein 25) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Snap25 (synaptosome associated protein 25) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Homo sapiens (human):
SNAP25 (synaptosome associated protein 25)
Alliance
DIOPT (PANTHER|HGNC|Ensembl Compara|OMA|PhylomeDB|OrthoFinder|InParanoid|OrthoInspector|Hieranoid)
Mus musculus (house mouse):
Snap25 (synaptosomal-associated protein 25)
Alliance
DIOPT (PANTHER|Ensembl Compara|OMA|PhylomeDB|OrthoFinder|InParanoid|OrthoInspector|Hieranoid)
Danio rerio (zebrafish):
snap25b (synaptosome associated protein 25b)
Alliance
DIOPT (OMA|PANTHER|OrthoFinder|Ensembl Compara)
Danio rerio (zebrafish):
snap25a (synaptosome associated protein 25a)
Alliance
DIOPT (PANTHER|Ensembl Compara|OMA|PhylomeDB|OrthoFinder|InParanoid|OrthoInspector|Hieranoid)
Caenorhabditis elegans (roundworm):
ric-4
Alliance
DIOPT (PANTHER|Ensembl Compara|OMA|PhylomeDB|OrthoFinder|InParanoid|OrthoInspector|Hieranoid)
Drosophila melanogaster (fruit fly):
Snap24
Alliance
DIOPT (PANTHER|Ensembl Compara|OMA|PhylomeDB|OrthoFinder|InParanoid|OrthoInspector|Hieranoid)
Drosophila melanogaster (fruit fly):
Snap25
Alliance
DIOPT (PANTHER|Ensembl Compara|OMA|PhylomeDB|OrthoFinder|InParanoid|OrthoInspector|Hieranoid)
Saccharomyces cerevisiae (baker's yeast):
SEC9
Alliance
DIOPT (PANTHER|OrthoFinder|Ensembl Compara)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information:
Annotation category: suggests misassembly; Annotation category: partial on reference assembly
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 3 129,697,408 - 129,788,417 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 3 129,599,353 - 129,788,400 (+) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 3 136,182,051 - 136,269,422 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 3 124,806,637 - 124,894,653 (+) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 3 124,712,177 - 124,800,221 (+) NCBI Celera 3 122,761,455 - 122,842,679 (+) NCBI Celera Cytogenetic Map 3 q36 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - ClinVar
Alagille syndrome ISO RGD:734151 8554872 ClinVar Annotator: match by term: Alagille syndrome 1 ClinVar PMID:10213047 more ... congenital myasthenic syndrome 18 ISO RGD:734151 8554872 ClinVar Annotator: match by term: Myasthenic syndrome, congenital, 18 ClinVar PMID:25741868 congenital myasthenic syndrome 18 ISO RGD:734151 8554872 ClinVar Annotator: match by term: Myasthenic syndrome, congenital, 18 ClinVar congenital myasthenic syndrome 18 ISO RGD:734151 8554872 ClinVar Annotator: match by term: Myasthenic syndrome, congenital, 18 ClinVar PMID:26467025 , PMID:28492532 congenital myasthenic syndrome 18 ISO RGD:734151 8554872 ClinVar Annotator: match by term: Myasthenic syndrome, congenital, 18 ClinVar PMID:25381298 congenital myasthenic syndrome 18 ISO RGD:734151 8554872 ClinVar Annotator: match by term: Myasthenic syndrome, congenital, 18 ClinVar PMID:28492532 epilepsy ISO RGD:734151 8554872 ClinVar Annotator: match by term: Seizures ClinVar PMID:26467025 , PMID:28492532 epilepsy ISO RGD:734151 8554872 ClinVar Annotator: match by term: Seizures ClinVar PMID:28492532 epilepsy ISO RGD:734151 8554872 ClinVar Annotator: match by term: Seizures ClinVar focal epilepsy ISO RGD:734151 8554872 ClinVar Annotator: match by term: Focal epilepsy ClinVar visual epilepsy ISO RGD:734151 8554872 ClinVar Annotator: match by term: Seizures ClinVar PMID:28492532 visual epilepsy ISO RGD:734151 8554872 ClinVar Annotator: match by term: Seizures ClinVar PMID:26467025 , PMID:28492532 visual epilepsy ISO RGD:734151 8554872 ClinVar Annotator: match by term: Seizures ClinVar
Imported Annotations - CTD
bipolar disorder ISO RGD:734151 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:14708030 congenital myasthenic syndrome ISO RGD:734151 11554173 CTD Direct Evidence: marker/mechanism CTD Diabetes Mellitus, Experimental ISO RGD:734151 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:16123366 epilepsy ISO RGD:734151 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:29942082 mental depression ISO RGD:734151 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:14708030 Neurodevelopmental Disorders ISO RGD:734151 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:29942082 Neuromuscular Manifestations ISO RGD:734151 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:17023870 psychotic disorder ISO RGD:734151 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:14708030 Tics ISO RGD:734151 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:17023870 type 2 diabetes mellitus ISO RGD:734151 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:16123366 Imported Annotations - MGI
attention deficit hyperactivity disorder ISS RGD:734152 13592920 OMIM:143465 more ... MouseDO obesity ISS RGD:734152 13592920 OMIM:601665 MouseDO schizophrenia ISS RGD:734152 13592920 OMIM:181500 MouseDO Imported Annotations - OMIM
congenital myasthenic syndrome 18 ISO RGD:734151 7240710 OMIM
1,3-dinitrobenzene increases oxidation EXP 6480464 3-dinitrobenzene results in increased oxidation of SNAP25 protein CTD PMID:25716674 2,2',4,4'-Tetrabromodiphenyl ether decreases expression EXP 6480464 2 more ... CTD PMID:21394737 2,2,2-tetramine increases expression ISO RGD:734152 6480464 Trientine results in increased expression of SNAP25 protein CTD PMID:23541064 2-methylcholine affects expression ISO RGD:734151 6480464 beta-methylcholine affects the expression of SNAP25 mRNA CTD PMID:21179406 3,3',5,5'-tetrabromobisphenol A increases expression EXP 6480464 tetrabromobisphenol A results in increased expression of SNAP25 mRNA, tetrabromobisphenol A results in increased expression of SNAP25 protein CTD PMID:27693314 6-propyl-2-thiouracil decreases expression EXP 6480464 Propylthiouracil results in decreased expression of SNAP25 mRNA CTD PMID:24780913 8-(4-chlorophenylthio)-cAMP multiple interactions EXP 6480464 N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [8-((4-chlorophenyl)thio)cyclic-3', 5'-AMP affects the splicing of SNAP25 exon] CTD PMID:22684629 8-(4-chlorophenylthio)-cAMP affects splicing EXP 6480464 8-((4-chlorophenyl)thio)cyclic-3', 5'-AMP affects the splicing of SNAP25 exon CTD PMID:22684629 aldehydo-D-glucose decreases expression EXP 6480464 Glucose results in decreased expression of SNAP25 protein CTD PMID:23776493 all-trans-retinoic acid multiple interactions ISO RGD:734151 6480464 Tretinoin promotes the reaction [ZMYND8 protein binds to SNAP25 gene] more ... CTD PMID:26655721 all-trans-retinoic acid increases expression ISO RGD:734151 6480464 Tretinoin results in increased expression of SNAP25 mRNA CTD PMID:21934132 , PMID:26655721 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of SNAP25 mRNA CTD PMID:16483693 ammonium chloride decreases expression EXP 6480464 Ammonium Chloride results in decreased expression of SNAP25 protein CTD PMID:16483693 arsenite(3-) decreases degradation EXP 6480464 arsenite results in decreased degradation of SNAP25 protein CTD PMID:18597805 atrazine decreases expression ISO RGD:734151 6480464 Atrazine results in decreased expression of SNAP25 mRNA CTD PMID:22378314 belinostat increases expression ISO RGD:734151 6480464 belinostat results in increased expression of SNAP25 mRNA CTD PMID:26272509 belinostat multiple interactions ISO RGD:734151 6480464 [NOG protein co-treated with belinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SNAP25 mRNA CTD PMID:27188386 benzo[a]pyrene increases expression EXP 6480464 Benzo(a)pyrene results in increased expression of SNAP25 mRNA, Benzo(a)pyrene results in increased expression of SNAP25 protein CTD PMID:21839799 , PMID:28412278 benzo[a]pyrene increases expression ISO RGD:734151 6480464 Benzo(a)pyrene results in increased expression of SNAP25 mRNA, Benzo(a)pyrene results in increased expression of SNAP25 protein CTD PMID:28412278 benzo[a]pyrene multiple interactions ISO RGD:734151 6480464 SNAP25 protein affects the reaction [Benzo(a)pyrene results in decreased expression of GRIA1 mRNA] more ... CTD PMID:28412278 bicalutamide increases expression ISO RGD:734151 6480464 bicalutamide results in increased expression of SNAP25 mRNA CTD PMID:15790403 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of SNAP25 mRNA CTD PMID:22946080 more ... bisphenol A affects expression ISO RGD:734152 6480464 bisphenol A affects the expression of SNAP25 mRNA CTD PMID:29161229 Botulinum toxin type A multiple interactions EXP 6480464 [Botulinum Toxins, Type A co-treated with botulinum toxin type E] results in increased cleavage of SNAP25 protein CTD PMID:10978741 Botulinum toxin type A increases cleavage ISO RGD:734151 6480464 Botulinum Toxins, Type A results in increased cleavage of SNAP25 protein CTD PMID:22223483 , PMID:26615023 Botulinum toxin type A multiple interactions ISO RGD:734152 6480464 Botulinum Toxins, Type A results in increased cleavage of and results in decreased expression of SNAP25 protein more ... CTD PMID:11181932 Botulinum toxin type A increases cleavage EXP 6480464 Botulinum Toxins, Type A results in increased cleavage of SNAP25 protein CTD PMID:10978741 more ... Botulinum toxin type A increases cleavage ISO RGD:734152 6480464 Botulinum Toxins, Type A results in increased cleavage of SNAP25 protein CTD PMID:26615023 C60 fullerene decreases expression EXP 6480464 fullerene C60 results in decreased expression of SNAP25 mRNA CTD PMID:19167457 carbon nanotube decreases expression ISO RGD:734151 6480464 Nanotubes, Carbon results in decreased expression of SNAP25 mRNA CTD PMID:23634900 cisplatin decreases expression EXP 6480464 Cisplatin results in decreased expression of SNAP25 mRNA CTD PMID:23558232 cisplatin multiple interactions ISO RGD:734151 6480464 [Cisplatin co-treated with jinfukang] results in decreased expression of SNAP25 mRNA CTD PMID:27392435 cisplatin decreases expression ISO RGD:734151 6480464 Cisplatin results in decreased expression of SNAP25 mRNA CTD PMID:27392435 cisplatin multiple interactions EXP 6480464 trichostatin A inhibits the reaction [Cisplatin results in decreased expression of SNAP25 mRNA] CTD PMID:23558232 clozapine increases expression EXP 6480464 Clozapine results in increased expression of SNAP25 mRNA CTD PMID:15860345 clozapine affects response to substance ISO RGD:734151 6480464 SNAP25 gene SNP affects the susceptibility to Clozapine CTD PMID:15823421 cobalt dichloride decreases expression ISO RGD:734151 6480464 cobaltous chloride results in decreased expression of SNAP25 mRNA CTD PMID:19376846 Colforsin dapropate hydrochloride affects splicing EXP 6480464 Colforsin affects the splicing of SNAP25 exon CTD PMID:22684629 Colforsin dapropate hydrochloride multiple interactions EXP 6480464 Colforsin promotes the reaction [HNRNPK protein binds to SNAP25 exon] more ... CTD PMID:22684629 crocidolite asbestos decreases expression ISO RGD:734151 6480464 Asbestos, Crocidolite results in decreased expression of SNAP25 mRNA CTD PMID:18687144 , PMID:23634900 cyclosporin A decreases expression ISO RGD:734151 6480464 Cyclosporine results in decreased expression of SNAP25 mRNA CTD PMID:27989131 cypermethrin decreases expression EXP 6480464 cypermethrin results in decreased expression of SNAP25 protein CTD PMID:21561882 cypermethrin multiple interactions EXP 6480464 Minocycline inhibits the reaction [cypermethrin results in decreased expression of SNAP25 protein] CTD PMID:21561882 D-glucose decreases expression EXP 6480464 Glucose results in decreased expression of SNAP25 protein CTD PMID:23776493 DDE multiple interactions EXP 6480464 Dichlorodiphenyl Dichloroethylene inhibits the reaction [Dietary Fats results in increased expression of SNAP25 mRNA] CTD PMID:28572628 decabromodiphenyl ether decreases expression EXP 6480464 decabromobiphenyl ether results in decreased expression of SNAP25 mRNA, decabromobiphenyl ether results in decreased expression of SNAP25 protein CTD PMID:28104350 dichlorine multiple interactions EXP 6480464 [Ozone co-treated with Chlorine] results in increased expression of SNAP25 mRNA CTD PMID:18636392 dorsomorphin multiple interactions ISO RGD:734151 6480464 [NOG protein co-treated with belinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 doxorubicin increases expression ISO RGD:734151 6480464 Doxorubicin results in increased expression of SNAP25 mRNA CTD PMID:30031762 elemental selenium multiple interactions ISO RGD:734151 6480464 [Selenium co-treated with Vitamin E] results in decreased expression of SNAP25 mRNA CTD PMID:19244175 elemental selenium decreases expression ISO RGD:734151 6480464 Selenium results in decreased expression of SNAP25 mRNA CTD PMID:19244175 ethanol decreases expression EXP 6480464 Ethanol results in decreased expression of SNAP25 mRNA CTD PMID:20655511 ethanol multiple interactions EXP 6480464 N-methyl-N-(6-methoxy-1-phenyl-1 more ... CTD PMID:20655511 fisetin multiple interactions ISO RGD:734152 6480464 fisetin inhibits the reaction [Lead results in decreased expression of SNAP25 protein] CTD PMID:31539617 flavonoids increases expression EXP 6480464 Flavonoids results in increased expression of SNAP25 mRNA CTD PMID:18035473 glucose decreases expression EXP 6480464 Glucose results in decreased expression of SNAP25 protein CTD PMID:23776493 haloperidol affects response to substance ISO RGD:734151 6480464 SNAP25 gene SNP affects the susceptibility to Haloperidol CTD PMID:15823421 haloperidol affects expression EXP 6480464 Haloperidol affects the expression of SNAP25 mRNA CTD PMID:15860345 heroin decreases expression ISO RGD:734151 6480464 Heroin results in decreased expression of SNAP25 mRNA CTD PMID:16710320 hydrazines decreases expression ISO RGD:734152 6480464 Hydrazines results in decreased expression of SNAP25 mRNA CTD PMID:21647536 hydrogen peroxide affects expression ISO RGD:734151 6480464 Hydrogen Peroxide affects the expression of SNAP25 protein CTD PMID:21179406 lead diacetate decreases expression ISO RGD:734152 6480464 lead acetate results in decreased expression of SNAP25 mRNA, lead acetate results in decreased expression of SNAP25 protein CTD PMID:21126476 lead diacetate decreases expression EXP 6480464 lead acetate results in decreased expression of SNAP25 mRNA, lead acetate results in decreased expression of SNAP25 protein CTD PMID:27492863 , PMID:27984133 lead(0) affects splicing ISO RGD:734151 6480464 Lead affects the splicing of SNAP25 mRNA CTD PMID:28903495 lead(0) decreases expression ISO RGD:734152 6480464 Lead results in decreased expression of SNAP25 protein CTD PMID:31539617 lead(0) multiple interactions ISO RGD:734152 6480464 fisetin inhibits the reaction [Lead results in decreased expression of SNAP25 protein] CTD PMID:31539617 lead(2+) multiple interactions ISO RGD:734152 6480464 fisetin inhibits the reaction [Lead results in decreased expression of SNAP25 protein] CTD PMID:31539617 lead(2+) decreases expression ISO RGD:734152 6480464 Lead results in decreased expression of SNAP25 protein CTD PMID:31539617 lead(2+) affects splicing ISO RGD:734151 6480464 Lead affects the splicing of SNAP25 mRNA CTD PMID:28903495 lipopolysaccharide affects expression ISO RGD:734151 6480464 Lipopolysaccharides affects the expression of SNAP25 mRNA CTD PMID:28070326 lipopolysaccharide multiple interactions ISO RGD:734151 6480464 Plant Extracts affects the reaction [Lipopolysaccharides affects the expression of SNAP25 mRNA] CTD PMID:28070326 methylamine multiple interactions ISO RGD:734152 6480464 methylamine inhibits the reaction [Botulinum Toxins, Type A results in increased cleavage of SNAP25 protein] CTD PMID:11181932 methylmercury chloride increases expression ISO RGD:734151 6480464 methylmercuric chloride results in increased expression of SNAP25 mRNA CTD PMID:28001369 methylphenidate affects response to substance ISO RGD:734151 6480464 SNAP25 gene polymorphism affects the susceptibility to Methylphenidate CTD PMID:17023870 methylseleninic acid increases expression ISO RGD:734151 6480464 methylselenic acid results in increased expression of SNAP25 mRNA CTD PMID:18548127 minocycline multiple interactions EXP 6480464 Minocycline inhibits the reaction [cypermethrin results in decreased expression of SNAP25 protein] CTD PMID:21561882 N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine multiple interactions ISO RGD:734152 6480464 N more ... CTD PMID:11181932 N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide multiple interactions EXP 6480464 N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [8-((4-chlorophenyl)thio)cyclic-3' more ... CTD PMID:22684629 Nonylphenol decreases expression EXP 6480464 nonylphenol results in decreased expression of SNAP25 mRNA CTD PMID:22946080 olanzapine affects response to substance ISO RGD:734151 6480464 SNAP25 gene SNP affects the susceptibility to olanzapine CTD PMID:15823421 ozone multiple interactions EXP 6480464 [Ozone co-treated with Chlorine] results in increased expression of SNAP25 mRNA CTD PMID:18636392 panobinostat multiple interactions ISO RGD:734151 6480464 [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SNAP25 mRNA CTD PMID:27188386 panobinostat increases expression ISO RGD:734151 6480464 panobinostat results in increased expression of SNAP25 mRNA CTD PMID:26272509 phenobarbital decreases expression EXP 6480464 Phenobarbital results in decreased expression of SNAP25 mRNA CTD PMID:19162173 phenylmercury acetate multiple interactions ISO RGD:734151 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SNAP25 mRNA CTD PMID:27188386 potassium chloride affects splicing EXP 6480464 Potassium Chloride affects the splicing of SNAP25 exon CTD PMID:22684629 potassium dichromate decreases expression ISO RGD:734152 6480464 Potassium Dichromate results in decreased expression of SNAP25 mRNA CTD PMID:23608068 pravastatin multiple interactions ISO RGD:734152 6480464 [LDLR gene mutant form results in increased susceptibility to Pravastatin] which results in decreased expression of SNAP25 protein CTD PMID:26875785 propofol multiple interactions EXP 6480464 SNAP25 protein affects the reaction [Propofol affects the localization of STX1A protein] CTD PMID:29320738 risperidone affects response to substance ISO RGD:734151 6480464 SNAP25 gene SNP affects the susceptibility to Risperidone CTD PMID:15823421 SB 431542 multiple interactions ISO RGD:734151 6480464 [NOG protein co-treated with belinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 selenium atom multiple interactions ISO RGD:734151 6480464 [Selenium co-treated with Vitamin E] results in decreased expression of SNAP25 mRNA CTD PMID:19244175 selenium atom decreases expression ISO RGD:734151 6480464 Selenium results in decreased expression of SNAP25 mRNA CTD PMID:19244175 silver atom decreases expression EXP 6480464 Silver analog results in decreased expression of SNAP25 mRNA, Silver results in decreased expression of SNAP25 mRNA CTD PMID:27693314 silver atom increases expression EXP 6480464 Silver analog results in increased expression of SNAP25 protein CTD PMID:27693314 silver(0) decreases expression EXP 6480464 Silver analog results in decreased expression of SNAP25 mRNA, Silver results in decreased expression of SNAP25 mRNA CTD PMID:27693314 silver(0) increases expression EXP 6480464 Silver analog results in increased expression of SNAP25 protein CTD PMID:27693314 sodium arsenite increases expression ISO RGD:734151 6480464 sodium arsenite results in increased expression of SNAP25 mRNA CTD PMID:25879800 sulforaphane decreases expression ISO RGD:734151 6480464 sulforafan results in decreased expression of SNAP25 mRNA CTD PMID:31838189 sunitinib decreases expression ISO RGD:734151 6480464 Sunitinib results in decreased expression of SNAP25 mRNA CTD PMID:31533062 testosterone multiple interactions ISO RGD:734151 6480464 [FSHB protein co-treated with Testosterone] results in increased expression of SNAP25 mRNA CTD PMID:18535249 thalidomide increases expression EXP 6480464 Thalidomide results in increased expression of SNAP25 mRNA, Thalidomide results in increased expression of SNAP25 protein CTD PMID:27693314 thimerosal decreases expression EXP 6480464 Thimerosal results in decreased expression of SNAP25 protein CTD PMID:27693314 trichostatin A multiple interactions EXP 6480464 trichostatin A inhibits the reaction [Cisplatin results in decreased expression of SNAP25 mRNA] CTD PMID:23558232 trichostatin A multiple interactions ISO RGD:734151 6480464 [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SNAP25 mRNA CTD PMID:27188386 trichostatin A increases expression ISO RGD:734151 6480464 trichostatin A results in increased expression of SNAP25 mRNA CTD PMID:24935251 , PMID:26272509 tunicamycin decreases expression ISO RGD:734151 6480464 Tunicamycin results in decreased expression of SNAP25 mRNA CTD PMID:22378314 valproic acid affects expression ISO RGD:734152 6480464 Valproic Acid affects the expression of SNAP25 mRNA CTD PMID:17963808 valproic acid affects splicing EXP 6480464 Valproic Acid affects the splicing of SNAP25 mRNA CTD PMID:29427782 valproic acid increases expression ISO RGD:734151 6480464 Valproic Acid results in increased expression of SNAP25 mRNA CTD PMID:23179753 more ... valproic acid multiple interactions ISO RGD:734151 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SNAP25 mRNA CTD PMID:27188386 valproic acid decreases expression EXP 6480464 Valproic Acid results in decreased expression of SNAP25 mRNA, Valproic Acid results in decreased expression of SNAP25 protein CTD PMID:27693314 valproic acid affects expression ISO RGD:734151 6480464 Valproic Acid affects the expression of SNAP25 mRNA CTD PMID:25979313 valproic acid increases expression ISO RGD:734152 6480464 Valproic Acid results in increased expression of SNAP25 mRNA CTD PMID:21427059 vitamin E multiple interactions ISO RGD:734151 6480464 [Selenium co-treated with Vitamin E] results in decreased expression of SNAP25 mRNA CTD PMID:19244175 vorinostat increases expression ISO RGD:734151 6480464 vorinostat results in increased expression of SNAP25 mRNA CTD PMID:26272509 vorinostat multiple interactions ISO RGD:734151 6480464 [NOG protein co-treated with Vorinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SNAP25 mRNA CTD PMID:27188386 zinc atom multiple interactions ISO RGD:734152 6480464 Zinc affects the reaction [Botulinum Toxins, Type A results in increased cleavage of SNAP25 protein] CTD PMID:11181932 zinc atom multiple interactions ISO RGD:734151 6480464 [PCI 5002 co-treated with Zinc] results in decreased expression of SNAP25 mRNA CTD PMID:18593933 zinc(0) multiple interactions ISO RGD:734152 6480464 Zinc affects the reaction [Botulinum Toxins, Type A results in increased cleavage of SNAP25 protein] CTD PMID:11181932 zinc(0) multiple interactions ISO RGD:734151 6480464 [PCI 5002 co-treated with Zinc] results in decreased expression of SNAP25 mRNA CTD PMID:18593933 zoledronic acid increases expression ISO RGD:734151 6480464 zoledronic acid results in increased expression of SNAP25 mRNA CTD PMID:24714768
Biological Process associative learning ISO RGD:734152 1624291 MGI:MGI:2180178 (MGI:MGI:5615897 , PMID:23064108) RGD MGI:MGI:5615897 , PMID:23064108 associative learning IEA UniProtKB:P60879 , ensembl:ENSMUSP000000287271600115 GO_REF:0000107 Ensembl GO_REF:0000107 axonogenesis IEP 1581079 RGD calcium ion-regulated exocytosis of neurotransmitter IDA 1581082 RGD endosomal transport IDA 1581071 RGD exocytic insertion of neurotransmitter receptor to postsynaptic membrane ISO RGD:734152 1624291 (MGI:MGI:5494785, PMID:23395379) RGD MGI:MGI:5494785 , PMID:23395379 exocytic insertion of neurotransmitter receptor to postsynaptic membrane IEA UniProtKB:P60879 , ensembl:ENSMUSP000000287271600115 GO_REF:0000107 Ensembl GO_REF:0000107 exocytosis TAS 730202 RGD exocytosis IBA MGI:MGI:109356 more ... 13792537 PMID:21873635 GO_Central growth hormone secretion IEP 1581083 RGD locomotory behavior ISO RGD:734152 1624291 MGI:MGI:2180178 (MGI:MGI:5615897 , PMID:23064108) RGD MGI:MGI:5615897 , PMID:23064108 locomotory behavior IEA UniProtKB:P60879 , ensembl:ENSMUSP000000287271600115 GO_REF:0000107 Ensembl GO_REF:0000107 long-term memory IMP 1581067 RGD long-term synaptic potentiation ISO RGD:734152 1624291 (MGI:MGI:5494785, PMID:23395379) RGD MGI:MGI:5494785 , PMID:23395379 long-term synaptic potentiation IEA UniProtKB:P60879 , ensembl:ENSMUSP000000287271600115 GO_REF:0000107 Ensembl GO_REF:0000107 neuron differentiation IEP 11570515 RGD neurotransmitter receptor internalization ISO RGD:734152 1624291 (MGI:MGI:4411959, PMID:19679075) RGD MGI:MGI:4411959 , PMID:19679075 neurotransmitter receptor internalization IEA UniProtKB:P60879 , ensembl:ENSMUSP000000287271600115 GO_REF:0000107 Ensembl GO_REF:0000107 neurotransmitter secretion ISO RGD:734152 1624291 MGI:MGI:2180178 (MGI:MGI:2156357 , PMID:11753414) RGD MGI:MGI:2156357 , PMID:11753414 positive regulation of hormone secretion IMP 1581080 RGD positive regulation of insulin secretion IEP 1581081 RGD positive regulation of synaptic plasticity ISO RGD:734152 1624291 MGI:MGI:3821974 (MGI:MGI:3510510 , PMID:15470145) RGD MGI:MGI:3510510 , PMID:15470145 potassium ion transmembrane transport IEA GO:0005249 1600115 GO_REF:0000108 GOC GO_REF:0000108 regulation of establishment of protein localization ISO RGD:734152 1624291 (MGI:MGI:5494785, PMID:23395379) RGD MGI:MGI:5494785 , PMID:23395379 regulation of establishment of protein localization IEA UniProtKB:P60879 , ensembl:ENSMUSP000000287271600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of neuron projection development IMP 8553247 PMID:21986494 ParkinsonsUK-UCL regulation of neuron projection development IEA UniProtKB:P60879 , ensembl:ENSMUSP000000287271600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of neuron projection development ISO RGD:734152 1624291 UniProtKB:Q03343 (MGI:MGI:5298138 , PMID:21986494) RGD MGI:MGI:5298138 , PMID:21986494 regulation of synapse assembly IEP 1581079 RGD short-term synaptic potentiation ISO RGD:734152 1624291 MGI:MGI:3821974 (MGI:MGI:3510510 , PMID:15470145) RGD MGI:MGI:3510510 , PMID:15470145 sleep IDA 1581074 RGD SNARE complex assembly IMP 12793053 PMID:9671503 CAFA SNARE complex assembly IMP 12793015 PMID:12680753 CAFA synaptic vesicle exocytosis EXP 13702457 PMID:8103915 SynGO synaptic vesicle exocytosis ISO RGD:734152 1624291 (MGI:MGI:6189328, PMID:17728451) RGD MGI:MGI:6189328 , PMID:17728451 synaptic vesicle exocytosis IDA 13702457 PMID:8103915 SynGO synaptic vesicle fusion to presynaptic active zone membrane IBA FB:FBgn0011288 , PANTHER:PTN000447754 13792537 PMID:21873635 GO_Central synaptic vesicle priming IBA FB:FBgn0011288 , PANTHER:PTN000447754 13792537 PMID:21873635 GO_Central vesicle fusion IBA FB:FBgn0011288 more ... 13792537 PMID:21873635 GO_Central Cellular Component actin cytoskeleton IDA 1299445 RGD anchored component of presynaptic membrane IDA 729999 PMID:7698978 SynGO axon IDA 8553882 PMID:10712642 MGI axon IEA UniProtKB:P60879 , ensembl:ENSMUSP000000287271600115 GO_REF:0000107 Ensembl GO_REF:0000107 axon ISO RGD:734152 1624291 (MGI:MGI:5795818 more ... RGD MGI:MGI:5795818 more ... axonal growth cone IDA 8553882 PMID:10712642 MGI BLOC-1 complex colocalizes_with ISO RGD:734151 1624291 (PMID:19546860) RGD PMID:19546860 BLOC-1 complex colocalizes_with ISS UniProtKB:Q17QQ3 1600115 GO_REF:0000024 UniProt GO_REF:0000024 BLOC-1 complex colocalizes_with ISS UniProtKB:P60880 1600115 GO_REF:0000024 UniProt GO_REF:0000024 BLOC-1 complex IEA UniProtKB:P60880 , ensembl:ENSP000002549761600115 GO_REF:0000107 Ensembl GO_REF:0000107 cytoplasm IDA 1581063 RGD cytoplasm ISO RGD:734151 1624291 (PMID:24327345) RGD PMID:24327345 cytoplasm ISO RGD:734152 1624291 (MGI:MGI:5442504, PMID:19546860) RGD MGI:MGI:5442504 , PMID:19546860 cytoskeleton ISO RGD:734151 1624291 (PMID:24327345) RGD PMID:24327345 cytoskeleton IEA UniProtKB:P60880 , ensembl:ENSP000002549761600115 GO_REF:0000107 Ensembl GO_REF:0000107 cytosol IDA 4892571 cytosolic fraction RGD endosome IDA 1581071 RGD extrinsic component of cytoplasmic side of plasma membrane ISO RGD:734152 1624291 (MGI:MGI:5819336, PMID:23821748) RGD MGI:MGI:5819336 , PMID:23821748 extrinsic component of cytoplasmic side of plasma membrane IEA UniProtKB:P60879 , ensembl:ENSMUSP000000287271600115 GO_REF:0000107 Ensembl GO_REF:0000107 filopodium IDA 1299445 RGD glutamatergic synapse IDA 13702457 PMID:8103915 SynGO glutamatergic synapse ISO RGD:734152 1624291 (MGI:MGI:6189328, PMID:17728451) RGD MGI:MGI:6189328 , PMID:17728451 glutamatergic synapse IEA UniProtKB:P60879 , ensembl:ENSMUSP000000287271600115 GO_REF:0000107 Ensembl GO_REF:0000107 glutamatergic synapse EXP 13702457 PMID:8103915 SynGO growth cone IDA 8553500 PMID:16598260 HGNC intracellular organelle IDA 4892571 RGD lamellipodium IDA 1299445 RGD membrane ISO RGD:734152 1624291 (MGI:MGI:5442504, PMID:19546860) RGD MGI:MGI:5442504 , PMID:19546860 membrane ISS UniProtKB:P60879 1600115 GO_REF:0000024 UniProt GO_REF:0000024 membrane raft IDA 1581078 RGD neuron projection IDA 1299445 RGD neuron projection IDA 8553247 PMID:21986494 ParkinsonsUK-UCL neuron projection IDA 8553500 PMID:16598260 HGNC neuron projection ISO RGD:734152 1624291 (MGI:MGI:3041026, PMID:14622145) RGD MGI:MGI:3041026 , PMID:14622145 neuronal cell body IDA 1299445 RGD perinuclear region of cytoplasm ISO RGD:734152 1624291 (MGI:MGI:3814962, PMID:18827011) RGD MGI:MGI:3814962 , PMID:18827011 perinuclear region of cytoplasm IEA UniProtKB:P60879 , ensembl:ENSMUSP000000287271600115 GO_REF:0000107 Ensembl GO_REF:0000107 photoreceptor inner segment IEA UniProtKB-SubCell:SL-0457 1600115 GO_REF:0000044 UniProt GO_REF:0000044 plasma membrane IDA 8553247 PMID:21986494 ParkinsonsUK-UCL plasma membrane IBA MGI:MGI:109356 more ... 13792537 PMID:21873635 GO_Central postsynapse ISO RGD:734152 1624291 (MGI:MGI:4411959, PMID:19679075) RGD MGI:MGI:4411959 , PMID:19679075 postsynapse IEA UniProtKB:P60879 , ensembl:ENSMUSP000000287271600115 GO_REF:0000107 Ensembl GO_REF:0000107 presynaptic active zone membrane IDA 12050117 PMID:11068331 SynGO presynaptic membrane ISO RGD:734152 1624291 (MGI:MGI:5606111, PMID:24680688) RGD MGI:MGI:5606111 , PMID:24680688 presynaptic membrane IEA UniProtKB:P60879 , ensembl:ENSMUSP000000287271600115 GO_REF:0000107 Ensembl GO_REF:0000107 SNARE complex IDA 1581734 RGD SNARE complex ISO RGD:734151 1624291 (PMID:12130530), (PMID:12730201), (PMID:19546860) RGD PMID:12130530 more ... SNARE complex IBA FB:FBgn0011288 more ... 13792537 PMID:21873635 GO_Central SNARE complex IDA 8553762 PMID:23949442 ParkinsonsUK-UCL SNARE complex IDA 8553500 PMID:16598260 HGNC somatodendritic compartment ISO RGD:734152 1624291 (MGI:MGI:5795818, PMID:21576241) RGD MGI:MGI:5795818 , PMID:21576241 somatodendritic compartment IEA UniProtKB:P60879 , ensembl:ENSMUSP000000287271600115 GO_REF:0000107 Ensembl GO_REF:0000107 synapse ISO RGD:734152 1624291 (MGI:MGI:3690211, PMID:10712642) RGD MGI:MGI:3690211 , PMID:10712642 synaptic vesicle ISO RGD:734152 1624291 (MGI:MGI:5606111, PMID:24680688) RGD MGI:MGI:5606111 , PMID:24680688 synaptic vesicle IEA UniProtKB:P60879 , ensembl:ENSMUSP000000287271600115 GO_REF:0000107 Ensembl GO_REF:0000107 synaptobrevin 2-SNAP-25-syntaxin-1a complex IDA 7205652 RGD synaptobrevin 2-SNAP-25-syntaxin-1a complex IMP 12793053 PMID:9671503 CAFA synaptobrevin 2-SNAP-25-syntaxin-1a complex IMP 12793015 PMID:12680753 CAFA synaptobrevin 2-SNAP-25-syntaxin-1a complex IDA 70701 PMID:7553862 MGI synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex IDA 70701 PMID:7553862 MGI synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex IBA MGI:MGI:98331 more ... 13792537 PMID:21873635 GO_Central synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex ISO RGD:734152 1624291 (MGI:MGI:4879076, PMID:21040848) RGD MGI:MGI:4879076 , PMID:21040848 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex IDA 7205655 RGD terminal bouton HDA 10047219 PMID:24876496 ParkinsonsUK-UCL trans-Golgi network ISO RGD:734152 1624291 (MGI:MGI:3814962, PMID:18827011) RGD MGI:MGI:3814962 , PMID:18827011 trans-Golgi network IEA UniProtKB:P60879 , ensembl:ENSMUSP000000287271600115 GO_REF:0000107 Ensembl GO_REF:0000107 vesicle colocalizes_with ISO RGD:734151 1624291 (PMID:15459722) RGD PMID:15459722 voltage-gated potassium channel complex IDA 1581072 RGD voltage-gated potassium channel complex colocalizes_with IDA 10047372 PMID:19077057 UniProt Molecular Function calcium-dependent protein binding IPI UniProtKB:P21707 10047386 PMID:12526776 ParkinsonsUK-UCL ion channel binding IPI UniProtKB:P15387 10047372 PMID:19077057 UniProt myosin binding IPI RGD:3143 1581734 RGD protein binding IPI RGD:708439 1299445 RGD protein binding ISO RGD:734151 1624291 UniProtKB:O00555 more ... RGD PMID:11438518 more ... protein binding ISO RGD:734152 1624291 PR:O35526 more ... RGD MGI:MGI:3663229 more ... protein binding IPI UniProtKB:G3V7P1 9850097 PMID:12070131 UniProt protein binding IPI UniProtKB:P63045 13432338 PMID:25814585 IntAct protein binding IPI UniProtKB:P63045 13432305 PMID:19571812 IntAct protein binding IPI UniProtKB:P32851 13432305 PMID:19571812 IntAct protein binding IPI UniProtKB:P32851 13432279 PMID:18275821 IntAct protein binding IPI UniProtKB:P32851 13432323 PMID:26389740 IntAct protein binding IPI UniProtKB:P32851 13432275 PMID:21193638 IntAct protein binding IPI UniProtKB:P21707 13432278 PMID:20173763 IntAct protein binding IPI UniProtKB:P32851 13432311 PMID:25581794 IntAct protein binding IPI UniProtKB:P32851 13432342 PMID:22307055 IntAct protein binding IPI UniProtKB:P32851 11573385 PMID:26876096 IntAct protein binding IPI UniProtKB:P32851 , UniProtKB:P50232 11535104 PMID:20688915 ParkinsonsUK-UCL protein binding IPI UniProtKB:P47709 8553578 PMID:16763567 IntAct protein binding IPI UniProtKB:Q9QXY2 1299445 PMID:10625663 IntAct protein binding IPI UniProtKB:P63044 13702278 PMID:19196426 UniProt protein binding IPI UniProtKB:P85969 633462 PMID:11931741 UniProt protein binding IPI UniProtKB:P54921 633462 PMID:11931741 UniProt protein binding IPI UniProtKB:P32851 8553871 PMID:18337752 IntAct protein binding IPI UniProtKB:P32851 8554124 PMID:17717530 IntAct protein binding IPI UniProtKB:Q08849 8553500 PMID:16598260 HGNC protein binding IPI UniProtKB:Q9ES66 8553339 PMID:15471947 BHF-UCL protein binding IPI UniProtKB:P32851 8554158 PMID:15316007 IntAct protein binding IPI UniProtKB:P32851 8554115 PMID:12496247 IntAct protein binding IPI UniProtKB:P32851 8553514 PMID:9759724 IntAct protein binding IPI UniProtKB:P32851 8553846 PMID:20489724 IntAct protein binding IPI UniProtKB:P32851 8553696 PMID:18822290 IntAct protein binding IPI UniProtKB:Q9CWU2 11344937 PMID:26198635 UniProt protein binding IPI UniProtKB:Q80TN5 11344937 PMID:26198635 UniProt protein binding IPI RGD:69225 632855 RGD protein binding IPI RGD:2935 69862 RGD protein binding IPI RGD:731818 68912 RGD protein binding IPI RGD:733780 1581076 RGD protein domain specific binding IPI RGD:621540 633988 BBC domain RGD protein N-terminus binding IPI RGD:2954 1581072 RGD SNAP receptor activity TAS 730202 RGD SNAP receptor activity IBA FB:FBgn0011288 more ... 13792537 PMID:21873635 GO_Central SNARE binding IDA 730202 RGD SNARE binding ISO RGD:734152 1624291 (MGI:MGI:2384381, PMID:12145198) RGD MGI:MGI:2384381 , PMID:12145198 SNARE binding IPI UniProtKB:P32851 , UniProtKB:P63045 12793053 PMID:9671503 CAFA SNARE binding IPI UniProtKB:P32851 12793053 PMID:9671503 CAFA SNARE binding IPI UniProtKB:P32851 , UniProtKB:P63045 12793015 PMID:12680753 CAFA SNARE binding IDA 70701 PMID:7553862 MGI SNARE binding IPI RGD:61880 4892592 RGD syntaxin binding IBA MGI:MGI:98331 more ... 13792537 PMID:21873635 GO_Central syntaxin-1 binding IPI RGD:69430 1581734 RGD syntaxin-1 binding IEA InterPro:IPR039077 1600115 GO_REF:0000002 InterPro GO_REF:0000002 syntaxin-1 binding IBA MGI:MGI:98331 more ... 13792537 PMID:21873635 GO_Central syntaxin-1 binding IDA 70701 PMID:7553862 MGI syntaxin-1 binding ISO RGD:734151 1624291 UniProtKB:Q16623 (PMID:12730201) RGD PMID:12730201 syntaxin-1 binding ISO RGD:734152 1624291 (MGI:MGI:3803800, PMID:18703708) RGD MGI:MGI:3803800 , PMID:18703708 syntaxin-1 binding IDA 730202 RGD voltage-gated potassium channel activity IDA 1581072 RGD voltage-gated potassium channel activity IEA InterPro:IPR039077 1600115 GO_REF:0000002 InterPro GO_REF:0000002
Gene-Chemical Interaction Annotations
