Mir128-1 (microRNA 128-1) - Rat Genome Database

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Gene: Mir128-1 (microRNA 128-1) Rattus norvegicus
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Symbol: Mir128-1
Name: microRNA 128-1
RGD ID: 2325574
Description: Predicted to enable mRNA 3'-UTR binding activity and mRNA base-pairing translational repressor activity. Predicted to be involved in several processes, including negative regulation of brown fat cell differentiation; negative regulation of lipoprotein transport; and negative regulation of macromolecule biosynthetic process. Predicted to act upstream of or within long-term synaptic potentiation; negative regulation of gene expression; and ossification. Orthologous to human MIR128-1 (microRNA 128-1); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2-methoxyethanol; atrazine.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: rno-mir-128-1
RGD Orthologs
Human
Mouse
Dog
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81342,251,884 - 42,251,965 (+)NCBIGRCr8
mRatBN7.21339,699,449 - 39,699,530 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1339,699,449 - 39,699,530 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1342,293,068 - 42,293,149 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01343,581,190 - 43,581,271 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01340,835,456 - 40,835,537 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01344,916,534 - 44,916,615 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1344,916,534 - 44,916,615 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01350,001,706 - 50,001,787 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1340,073,464 - 40,073,545 (+)NCBICelera
Cytogenetic Map13q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15345052   PMID:16381832   PMID:17604727   PMID:20403161   PMID:20937378   PMID:24307102   PMID:25751060   PMID:25858512   PMID:27621052   PMID:28114268   PMID:29278451   PMID:30701536  
PMID:31173166   PMID:31985779   PMID:32278027   PMID:32828305   PMID:33373887   PMID:34296305   PMID:34554376   PMID:34592882   PMID:37934513  


Genomics

Comparative Map Data
Mir128-1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81342,251,884 - 42,251,965 (+)NCBIGRCr8
mRatBN7.21339,699,449 - 39,699,530 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1339,699,449 - 39,699,530 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1342,293,068 - 42,293,149 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01343,581,190 - 43,581,271 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01340,835,456 - 40,835,537 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01344,916,534 - 44,916,615 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1344,916,534 - 44,916,615 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01350,001,706 - 50,001,787 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1340,073,464 - 40,073,545 (+)NCBICelera
Cytogenetic Map13q13NCBI
MIR128-1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382135,665,397 - 135,665,478 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2135,665,397 - 135,665,478 (+)EnsemblGRCh38hg38GRCh38
GRCh372136,422,967 - 136,423,048 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362136,139,436 - 136,139,517 (+)NCBINCBI36Build 36hg18NCBI36
Celera2130,133,728 - 130,133,809 (+)NCBICelera
Cytogenetic Map2q21.3NCBI
HuRef2128,415,938 - 128,416,019 (+)NCBIHuRef
CHM1_12136,427,877 - 136,427,958 (+)NCBICHM1_1
T2T-CHM13v2.02136,105,929 - 136,106,010 (+)NCBIT2T-CHM13v2.0
Mir128-1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391128,130,098 - 128,130,167 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1128,130,098 - 128,130,167 (+)EnsemblGRCm39 Ensembl
GRCm381128,202,361 - 128,202,430 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1128,202,361 - 128,202,430 (+)EnsemblGRCm38mm10GRCm38
MGSCv371130,098,938 - 130,099,007 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera1130,829,788 - 130,829,857 (+)NCBICelera
Cytogenetic Map1E3NCBI
cM Map155.8NCBI
MIR128-1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11938,435,956 - 38,436,011 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1938,679,708 - 38,679,763 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01939,881,919 - 39,881,974 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11938,524,004 - 38,524,059 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01938,687,099 - 38,687,154 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01939,920,158 - 39,920,213 (+)NCBIUU_Cfam_GSD_1.0
MIR128-1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1516,273,551 - 16,273,659 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11516,273,557 - 16,273,638 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21518,661,614 - 18,661,695 (-)NCBISscrofa10.2Sscrofa10.2susScr3

miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Snap25rno-miR-128-3pMirtarbaseexternal_infoImmunocytochemistry//Luciferase reporter assay//MiFunctional MTI18381601

Predicted Targets
Summary Value
Count of predictions:14561
Count of gene targets:8852
Count of transcripts:9688
Interacting mature miRNAs:rno-miR-128-1-5p, rno-miR-128-3p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9589141Insul28Insulin level QTL 2810.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)13931346554313465Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132230187567301875Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133741558480753406Rat
1300163Cardf1Cardiac cell morphology QTL 14.18aorta morphology trait (VT:0000272)artery lesion measurement (CMO:0000975)131192944945417941Rat
2317040Aia21Adjuvant induced arthritis QTL 212.75joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
631645Bp121Blood pressure QTL 1213.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131491565559915655Rat
2317046Aia8Adjuvant induced arthritis QTL 83.9700000286102295joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
2303030Bp327Blood pressure QTL 327arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133039535141184251Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
61339Bp24Blood pressure QTL 240.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13599466844807491Rat
70170Eae14Experimental allergic encephalomyelitis QTL 140.0024nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)132320344868203448Rat
1331784Bp222Blood pressure QTL 2222.944arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131769443653050594Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133453521879535218Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)133843340883433408Rat
2302275Gluco37Glucose level QTL 373.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)131192944946193066Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
1558644Cm45Cardiac mass QTL 453.60.002heart mass (VT:0007028)heart wet weight (CMO:0000069)132369296968692969Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133228447177284471Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
2301962Cm72Cardiac mass QTL 724.12heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)133124133158363171Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
2292232Pur16Proteinuria QTL 1617.2urine total protein amount (VT:0000032)urine protein level (CMO:0000591)133615572341961389Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133726209282262092Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133741558482415584Rat
6893338Cm76Cardiac mass QTL 7600.99heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)132369296968692969Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
9589164Gluco66Glucose level QTL 666.670.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)131515872260158722Rat
738036Lnnr4Liver neoplastic nodule remodeling QTL 43.64liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)13142356786Rat
7411662Foco29Food consumption QTL 2920.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)13931346554313465Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
1 8 10 46 25 27 9 19 9 66 37 38 11 12 18

Sequence

Nucleotide Sequences
RefSeq Transcripts NR_031873 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000053657
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1339,699,449 - 39,699,530 (+)Ensembl
Rnor_6.0 Ensembl1344,916,534 - 44,916,615 (+)Ensembl
RefSeq Acc Id: NR_031873
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81342,251,884 - 42,251,965 (+)NCBI
mRatBN7.21339,699,449 - 39,699,530 (+)NCBI
Rnor_6.01344,916,534 - 44,916,615 (+)NCBI
Rnor_5.01350,001,706 - 50,001,787 (+)NCBI
Celera1340,073,464 - 40,073,545 (+)NCBI
Sequence:
Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2325574 AgrOrtholog
BioCyc Gene G2FUF-18414 BioCyc
Ensembl Genes ENSRNOG00000035534 Ensembl
miRBase MI0000900 ENTREZGENE
NCBI Gene 100314026 ENTREZGENE
PhenoGen Mir128-1 PhenoGen
RatGTEx ENSRNOG00000035534 RatGTEx
RNAcentral URS000024A59E RNACentral
  URS00002D9CBA RNACentral
  URS00005DD85B RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-04-09 Mir128-1  microRNA 128-1  Mir128-1  microRNA mir-128-1  Name updated 61478 APPROVED
2010-06-02 Mir128-1  microRNA mir-128-1      Symbol and Name status set to provisional 70820 PROVISIONAL