RGD Reference Report - Developmental expression of SNAP-25 protein in the rat striatum and cerebral cortex. - Rat Genome Database

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Developmental expression of SNAP-25 protein in the rat striatum and cerebral cortex.

Authors: Sidor-Kaczmarek, J  Labuda, C  Litwinowicz, B  Spodnik, JH  Kowianski, P  Dziewiatkowski, J  Morys, J 
Citation: Sidor-Kaczmarek J, etal., Folia Morphol (Warsz). 2004 Aug;63(3):285-8.
RGD ID: 1581079
Pubmed: PMID:15478103   (View Abstract at PubMed)

The developmental changes of 25-kDa synaptosomal-associated protein (SNAP-25) expression in the rat striatum and cerebral cortex were examined using Western- blotting and densitometric scanning of immunoblots. Analysis of the striatum extracts from postnatal day 0 (P0) to postnatal day 120 (P120) demonstrated that SNAP-25 is poorly expressed until P14. From this point the expression level gradually increases to reach a maximum on P60 and then decreases. The pattern of SNAP-25 expression in the rat cerebral cortex is different. Two peaks are observed, the first on P10 and the second on P60, after which the expression level decreases. These results appear to confirm the role of SNAP-25 protein in axon outgrowth and synaptogenesis in the nervous system.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
axonogenesis  IEP 1581079 RGD 
regulation of synapse assembly  IEP 1581079 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Snap25  (synaptosome associated protein 25)


Additional Information