RGD Reference Report - The Kv2.1 channels mediate neuronal apoptosis induced by excitotoxicity. - Rat Genome Database

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The Kv2.1 channels mediate neuronal apoptosis induced by excitotoxicity.

Authors: Yao, H  Zhou, K  Yan, D  Li, M  Wang, Y 
Citation: Yao H, etal., J Neurochem. 2009 Feb;108(4):909-19. doi: 10.1111/j.1471-4159.2008.05834.x. Epub 2008 Dec 10.
RGD ID: 10047372
Pubmed: PMID:19077057   (View Abstract at PubMed)
DOI: DOI:10.1111/j.1471-4159.2008.05834.x   (Journal Full-text)

Chronic loss of intracellular K(+) can induce neuronal apoptosis in pathological conditions. However, the mechanism by which the K(+) channels are regulated in this process remains largely unknown. Here, we report that the increased membrane expression of Kv2.1 proteins in cortical neurons deprived of serum, a condition known to induce K(+) loss, promotes neuronal apoptosis. The increase in I(K) current density and apoptosis in the neurons deprived of serum were inhibited by a dominant negative form of Kv2.1 and MK801, an antagonist to NMDA receptors. The membrane level of Kv2.1 and its interaction with SNAP25 were increased, whereas the Kv2.1 phosphorylation was inhibited in the neurons deprived of serum. Botulinum neurotoxin, an agent known to prevent formation of soluble N-ethylmaleimide-sensitive factor attachment protein receptor complex, suppressed the increase in I(K) current density. Together, these results suggest that NMDA receptor-dependent Kv2.1 membrane translocation is regulated by a soluble N-ethylmaleimide-sensitive factor attachment protein receptor-dependent vesicular trafficking mechanism and is responsible for neuronal cell death induced by chronic loss of K(+).

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

Cellular Component
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
dendrite located_inIDA 10047372PMID:19077057UniProt 
neuronal cell body membrane located_inIDA 10047372PMID:19077057UniProt 
voltage-gated potassium channel complex part_ofIDA 10047372PMID:19077057UniProt 
voltage-gated potassium channel complex located_inIDA 10047372; 10047372; 10047372PMID:19077057UniProt 

Molecular Function

Objects Annotated

Genes (Rattus norvegicus)
Kcnb1  (potassium voltage-gated channel subfamily B member 1)
Snap25  (synaptosome associated protein 25)
Stx1a  (syntaxin 1A)
Vamp2  (vesicle-associated membrane protein 2)


Additional Information