RGD Reference Report - Omega-3 and omega-6 fatty acids stimulate cell membrane expansion by acting on syntaxin 3. - Rat Genome Database

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Omega-3 and omega-6 fatty acids stimulate cell membrane expansion by acting on syntaxin 3.

Authors: Darios, F  Davletov, B 
Citation: Darios F and Davletov B, Nature. 2006 Apr 6;440(7085):813-7.
RGD ID: 8553500
Pubmed: PMID:16598260   (View Abstract at PubMed)
DOI: DOI:10.1038/nature04598   (Journal Full-text)

Growth of neurite processes from the cell body is the critical step in neuronal development and involves a large increase in cell membrane surface area. Arachidonic-acid-releasing phospholipases are highly enriched in nerve growth cones and have previously been implicated in neurite outgrowth. Cell membrane expansion is achieved through the fusion of transport organelles with the plasma membrane; however, the identity of the molecular target of arachidonic acid has remained elusive. Here we show that syntaxin 3 (STX3), a plasma membrane protein, has an important role in the growth of neurites, and also serves as a direct target for omega-6 arachidonic acid. By using syntaxin 3 in a screening assay, we determined that the dietary omega-3 linolenic and docosahexaenoic acids can efficiently substitute for arachidonic acid in activating syntaxin 3. Our findings provide a molecular basis for the previously established action of omega-3 and omega-6 polyunsaturated fatty acids in membrane expansion at the growth cones, and represent the first identification of a single effector molecule for these essential nutrients.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
neuron projection development involved_inIDA 8553500PMID:16598260HGNC-UCL 

Cellular Component
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
growth cone located_inIDA 8553500; 8553500PMID:16598260HGNC-UCL 
neuron projection located_inIDA 8553500; 8553500PMID:16598260HGNC-UCL 
plasma membrane located_inTAS 8553500PMID:16598260HGNC-UCL 
SNARE complex part_ofIDA 8553500; 8553500; 8553500PMID:16598260HGNC-UCL 

Molecular Function
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
arachidonic acid binding enablesIDA 8553500PMID:16598260HGNC-UCL 
protein binding enablesIPIUniProtKB:Q088498553500PMID:16598260IntAct 
protein binding enablesIPIUniProtKB:P608818553500PMID:16598260IntAct 

Objects Annotated

Genes (Rattus norvegicus)
Snap25  (synaptosome associated protein 25)
Stx3  (syntaxin 3)
Ykt6  (YKT6 v-SNARE homolog)

Additional Information