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Gene: Myo5a (myosin VA) Rattus norvegicus
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Symbol: Myo5a
Name: myosin VA
Description: Exhibits several functions, including ATP binding activity; ATP-dependent protein binding activity; and syntaxin-1 binding activity. Involved in several processes, including cytoskeleton-dependent intracellular transport; positive regulation of protein localization to plasma membrane; and positive regulation of vascular associated smooth muscle cell migration. Localizes to several cellular components, including the Schaffer collateral - CA1 synapse; actin cytoskeleton; and cytoplasmic vesicle. Predicted to colocalize with several cellular components, including the endosome; peroxisome; and polymeric cytoskeletal fiber. Human ortholog(s) of this gene implicated in Griscelli syndrome type 1. Orthologous to human MYO5A (myosin VA); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: D; dilute myosin heavy chain, non-muscle; Dilute-opisthotonus; Dop; Myh12; myosin 5a; myosin-Va; unconventional myosin-Va
Orthologs:
Homo sapiens (human) : MYO5A (myosin VA)  HGNC  Alliance
Mus musculus (house mouse) : Myo5a (myosin VA)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Myo5a (myosin VA)
Pan paniscus (bonobo/pygmy chimpanzee) : MYO5A (myosin VA)
Canis lupus familiaris (dog) : MYO5A (myosin VA)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Myo5a (myosin VA)
Sus scrofa (pig) : MYO5A (myosin VA)
Chlorocebus sabaeus (green monkey) : MYO5A (myosin VA)
Heterocephalus glaber (naked mole-rat) : Myo5a (myosin VA)
more info ...
Is Marker For: Strains:   DOP/Nem  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: suggests misassembly; Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0882,038,966 - 82,156,507 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl882,037,977 - 82,156,617 (+)Ensembl
Rnor_5.0881,641,953 - 81,759,995 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4879,909,224 - 80,027,290 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1879,928,282 - 80,046,341 (+)NCBI
Celera875,604,281 - 75,764,672 (+)NCBICelera
Cytogenetic Map8q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Myo5a
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3143
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-11-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.