Snap25 (synaptosomal-associated protein 25) - Rat Genome Database

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Gene: Snap25 (synaptosomal-associated protein 25) Mus musculus
Analyze
Symbol: Snap25
Name: synaptosomal-associated protein 25
RGD ID: 734152
MGI Page MGI
Description: Enables SNAP receptor activity and syntaxin-1 binding activity. Involved in exocytosis; neurotransmitter receptor internalization; and regulation of neuron projection development. Acts upstream of or within several processes, including associative learning; long-term synaptic potentiation; and neurotransmitter secretion. Located in several cellular components, including presynaptic membrane; synaptic vesicle; and trans-Golgi network. Part of synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex. Is active in glutamatergic synapse. Is expressed in adrenal gland; jaw; nervous system; and sensory organ. Used to study attention deficit hyperactivity disorder; obesity; schizophrenia; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Down syndrome and congenital myasthenic syndrome 18. Orthologous to human SNAP25 (synaptosome associated protein 25).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Bd; Bdr; blind drunk; GENA 70; GENA70; SNA; SNAP-25; sp; SUP; super protein; synaptosomal-associated 25 kDa protein; synaptosomal-associated protein, 25 kDa
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392136,555,359 - 136,624,348 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2136,555,373 - 136,624,348 (+)EnsemblGRCm39 Ensembl
GRCm382136,713,439 - 136,782,428 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2136,713,453 - 136,782,428 (+)EnsemblGRCm38mm10GRCm38
MGSCv372136,539,186 - 136,608,164 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362136,404,944 - 136,473,857 (+)NCBIMGSCv36mm8
Celera2137,909,643 - 137,978,489 (+)NCBICelera
Cytogenetic Map2F3NCBI
cM Map267.56NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (EXP)
1,3-dinitrobenzene  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2,2-tetramine  (EXP)
2-methylcholine  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-aminopyridine  (ISO)
6-propyl-2-thiouracil  (ISO)
8-(4-chlorophenylthio)-cAMP  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (ISO)
aristolochic acid A  (ISO)
arsane  (EXP)
arsenic atom  (EXP)
arsenite(3-)  (ISO)
atrazine  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
bicalutamide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Botulinum toxin type A  (EXP,ISO)
C60 fullerene  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlordecone  (EXP)
cisplatin  (ISO)
clozapine  (ISO)
cobalt dichloride  (ISO)
colforsin daropate hydrochloride  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
cypermethrin  (ISO)
D-glucose  (ISO)
DDE  (ISO)
decabromodiphenyl ether  (ISO)
deguelin  (ISO)
dichlorine  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
ethanol  (ISO)
fisetin  (EXP)
flavonoids  (ISO)
glucose  (ISO)
haloperidol  (ISO)
heroin  (ISO)
hydrazines  (EXP)
hydrogen peroxide  (ISO)
ivermectin  (ISO)
Lappaconitine  (ISO)
lead diacetate  (EXP,ISO)
lead(0)  (EXP,ISO)
lead(2+)  (EXP,ISO)
lipopolysaccharide  (ISO)
methylamine  (EXP)
methylmercury chloride  (ISO)
methylphenidate  (ISO)
methylseleninic acid  (ISO)
minocycline  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
nitrofen  (ISO)
Nonylphenol  (ISO)
olanzapine  (ISO)
ozone  (ISO)
panobinostat  (ISO)
paraquat  (EXP,ISO)
PCB138  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
potassium chloride  (ISO)
potassium dichromate  (EXP)
pravastatin  (EXP)
propofol  (ISO)
risperidone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (EXP,ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
testosterone  (ISO)
thalidomide  (ISO)
thimerosal  (ISO)
trichostatin A  (ISO)
tunicamycin  (ISO)
valproic acid  (EXP,ISO)
vitamin E  (ISO)
vorinostat  (ISO)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal blood vessel morphology  (IAGP)
abnormal brain morphology  (IAGP)
abnormal cerebral cortex morphology  (IAGP)
abnormal CNS synaptic transmission  (IAGP)
abnormal dopamine level  (IAGP)
abnormal endplate potential  (IAGP)
abnormal hippocampus CA3 region morphology  (IAGP)
abnormal impulsive behavior control  (IAGP)
abnormal insulin secretion  (IAGP)
abnormal intercostal muscle morphology  (IAGP)
abnormal locomotor behavior  (IAGP)
abnormal miniature excitatory postsynaptic currents  (IAGP)
abnormal motor capabilities/coordination/movement  (IAGP)
abnormal object recognition memory  (IAGP)
abnormal pancreatic beta cell physiology  (IAGP)
abnormal PNS synaptic transmission  (IAGP)
abnormal serotonin level  (IAGP)
abnormal skin condition  (IAGP)
abnormal spatial learning  (IAGP)
akinesia  (IAGP)
ataxia  (IAGP)
blotchy skin  (IAGP)
convulsive seizures  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased circulating ghrelin level  (IAGP)
decreased embryo size  (IAGP)
decreased food intake  (IAGP)
decreased glucagon secretion  (IAGP)
decreased insulin secretion  (IAGP)
decreased locomotor activity  (IAGP)
decreased paired-pulse facilitation  (IAGP)
decreased prepulse inhibition  (IAGP)
decreased synaptic glutamate release  (IAGP)
decreased vertical activity  (IAGP)
decreased width of hypertrophic chondrocyte zone  (IAGP)
delayed eyelid opening  (IAGP)
disheveled coat  (IAGP)
enhanced paired-pulse facilitation  (IAGP)
hepatic steatosis  (IAGP)
hyperactivity  (IAGP)
hyperglycemia  (IAGP)
impaired coordination  (IAGP)
impaired hearing  (IAGP)
improved glucose tolerance  (IAGP)
increased anxiety-related response  (IAGP)
increased body mass index  (IAGP)
increased body weight  (IAGP)
increased circulating cholesterol level  (IAGP)
increased circulating insulin level  (IAGP)
increased circulating leptin level  (IAGP)
increased circulating triglyceride level  (IAGP)
increased food intake  (IAGP)
increased locomotor activity  (IAGP)
increased susceptibility to diet-induced obesity  (IAGP)
increased thigmotaxis  (IAGP)
increased white adipose tissue amount  (IAGP)
increased white fat cell size  (IAGP)
infertility  (IAGP)
insulin resistance  (IAGP)
myoclonus  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
no abnormal phenotype detected  (IEA)
no spontaneous movement  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
respiratory failure  (IAGP)
seizures  (IAGP)
thin diaphragm muscle  (IAGP)
tremors  (IAGP)
unresponsive to tactile stimuli  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Increased RNA levels of the 25 kDa synaptosomal associated protein in brain samples of adult patients with Down Syndrome. Greber-Platzer S, etal., Neurosci Lett. 2003 Jan 16;336(2):77-80.
2. Voltage-dependent K(+) channels in pancreatic beta cells: role, regulation and potential as therapeutic targets. MacDonald PE and Wheeler MB, Diabetologia. 2003 Aug;46(8):1046-62. Epub 2003 Jun 27.
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. MGD IEA MGD IEA
5. Mouse MP Annotation Import Pipeline RGD automated import pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1281194   PMID:1613559   PMID:1711221   PMID:2592413   PMID:7553862   PMID:7768895   PMID:7835704   PMID:7878010   PMID:7913715   PMID:7916325   PMID:7961761   PMID:8034018  
PMID:8168438   PMID:8617512   PMID:8622140   PMID:8672127   PMID:8738414   PMID:8878824   PMID:8889548   PMID:9223620   PMID:9346916   PMID:9349529   PMID:9452464   PMID:9696691  
PMID:9731768   PMID:9736654   PMID:10195194   PMID:10349636   PMID:10379359   PMID:10441734   PMID:10575087   PMID:10644763   PMID:10712642   PMID:10932191   PMID:10972938   PMID:11042159  
PMID:11076861   PMID:11217851   PMID:11389829   PMID:11471062   PMID:11739749   PMID:11753409   PMID:11753414   PMID:11829411   PMID:12047557   PMID:12145198   PMID:12438134   PMID:12451131  
PMID:12459461   PMID:12466851   PMID:12477932   PMID:12590134   PMID:12727443   PMID:12764042   PMID:12859899   PMID:12897243   PMID:14622145   PMID:14742706   PMID:15063781   PMID:15117968  
PMID:15145078   PMID:15154671   PMID:15175394   PMID:15226823   PMID:15240114   PMID:15240883   PMID:15277518   PMID:15355848   PMID:15451443   PMID:15459106   PMID:15466855   PMID:15470145  
PMID:15489334   PMID:15542596   PMID:15572149   PMID:15603741   PMID:15920476   PMID:15935055   PMID:16141072   PMID:16141073   PMID:16186258   PMID:16195346   PMID:16203731   PMID:16269331  
PMID:16506193   PMID:16565726   PMID:16573824   PMID:16602821   PMID:16615908   PMID:16672379   PMID:16720719   PMID:16763567   PMID:16870728   PMID:16904662   PMID:16939418   PMID:16945102  
PMID:17055430   PMID:17124501   PMID:17283335   PMID:17339028   PMID:17500595   PMID:17543467   PMID:17553942   PMID:17595323   PMID:17634366   PMID:17728451   PMID:17803915   PMID:18041776  
PMID:18162553   PMID:18216204   PMID:18227507   PMID:18373617   PMID:18385322   PMID:18579690   PMID:18596234   PMID:18625232   PMID:18703708   PMID:18706894   PMID:18721885   PMID:18774265  
PMID:18827011   PMID:19004828   PMID:19043548   PMID:19161385   PMID:19285662   PMID:19343206   PMID:19546860   PMID:19679075   PMID:19703397   PMID:19716167   PMID:19723784   PMID:19729413  
PMID:19756182   PMID:19805029   PMID:19859539   PMID:19892785   PMID:20053906   PMID:20114047   PMID:20142423   PMID:20522554   PMID:20562829   PMID:20643776   PMID:20798282   PMID:20823219  
PMID:20847232   PMID:20921140   PMID:21040848   PMID:21126476   PMID:21151134   PMID:21267068   PMID:21280044   PMID:21322090   PMID:21378973   PMID:21576241   PMID:21873635   PMID:21949876  
PMID:21957238   PMID:21986494   PMID:21994363   PMID:22119397   PMID:22187053   PMID:22261019   PMID:22264613   PMID:22293606   PMID:22357600   PMID:22406549   PMID:22500636   PMID:22508512  
PMID:22607004   PMID:22641083   PMID:22794259   PMID:22802532   PMID:22838834   PMID:22946563   PMID:23035094   PMID:23055939   PMID:23064108   PMID:23110146   PMID:23197711   PMID:23376809  
PMID:23395379   PMID:23497716   PMID:23732542   PMID:23821748   PMID:23868368   PMID:23949442   PMID:23961995   PMID:24210904   PMID:24374286   PMID:24423792   PMID:24427155   PMID:24488208  
PMID:24680688   PMID:24705552   PMID:24744148   PMID:24778312   PMID:25044020   PMID:25053427   PMID:25071457   PMID:25253725   PMID:25374362   PMID:25422940   PMID:25629685   PMID:25678324  
PMID:25741722   PMID:25959820   PMID:26195742   PMID:26220374   PMID:26300453   PMID:26514267   PMID:26518545   PMID:26519224   PMID:26523491   PMID:26727548   PMID:26745185   PMID:26777404  
PMID:26844833   PMID:27052163   PMID:27160897   PMID:27292642   PMID:27325702   PMID:27358447   PMID:27466336   PMID:27881774   PMID:28100774   PMID:28348137   PMID:28348167   PMID:28404788  
PMID:28413018   PMID:28436559   PMID:28794184   PMID:28798351   PMID:28801590   PMID:28932809   PMID:29043563   PMID:29056461   PMID:29056747   PMID:29318050   PMID:29382714   PMID:29445148  
PMID:29548989   PMID:29662940   PMID:29850799   PMID:29995325   PMID:30044227   PMID:30068389   PMID:30077356   PMID:30111840   PMID:30144509   PMID:30497498   PMID:30542508   PMID:30562941  
PMID:30728295   PMID:30783011   PMID:30811985   PMID:30870413   PMID:30870432   PMID:30883328   PMID:30901089   PMID:30995482   PMID:31024034   PMID:31038456   PMID:31095110   PMID:31235642  
PMID:31776518   PMID:31794878   PMID:31913121   PMID:31923400   PMID:32093363   PMID:32098606   PMID:32313222   PMID:32325033   PMID:32433957   PMID:32456820   PMID:32487695   PMID:32641826  
PMID:32698012   PMID:32855216   PMID:33056987   PMID:33087486   PMID:33096037   PMID:33113364   PMID:33147442   PMID:33222163   PMID:33332551   PMID:33367517   PMID:33571908   PMID:33789083  
PMID:34004146   PMID:34151409   PMID:34245686   PMID:34289870   PMID:34341585   PMID:34613375   PMID:34616072   PMID:34826585   PMID:35846561   PMID:36384119   PMID:36417873   PMID:36460641  
PMID:36483015  


Genomics

Comparative Map Data
Snap25
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392136,555,359 - 136,624,348 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2136,555,373 - 136,624,348 (+)EnsemblGRCm39 Ensembl
GRCm382136,713,439 - 136,782,428 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2136,713,453 - 136,782,428 (+)EnsemblGRCm38mm10GRCm38
MGSCv372136,539,186 - 136,608,164 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362136,404,944 - 136,473,857 (+)NCBIMGSCv36mm8
Celera2137,909,643 - 137,978,489 (+)NCBICelera
Cytogenetic Map2F3NCBI
cM Map267.56NCBI
SNAP25
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382010,218,830 - 10,307,418 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2010,172,395 - 10,308,258 (+)EnsemblGRCh38hg38GRCh38
GRCh372010,199,478 - 10,288,066 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362010,147,477 - 10,236,065 (+)NCBINCBI36Build 36hg18NCBI36
Build 342010,147,476 - 10,236,065NCBI
Celera2010,269,471 - 10,358,052 (+)NCBICelera
Cytogenetic Map20p12.2NCBI
HuRef2010,151,237 - 10,239,826 (+)NCBIHuRef
CHM1_12010,200,162 - 10,288,707 (+)NCBICHM1_1
T2T-CHM13v2.02010,261,695 - 10,350,292 (+)NCBIT2T-CHM13v2.0
Snap25
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23124,041,898 - 124,123,761 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3124,041,898 - 124,123,760 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3127,931,004 - 128,009,819 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.03136,507,987 - 136,586,804 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.03134,186,617 - 134,271,659 (+)NCBIRnor_WKY
Rnor_6.03129,697,408 - 129,788,417 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3129,599,353 - 129,788,400 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03136,182,051 - 136,269,422 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43124,806,637 - 124,894,653 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13124,712,177 - 124,800,221 (+)NCBI
Celera3122,761,455 - 122,842,679 (+)NCBICelera
Cytogenetic Map3q36NCBI
Snap25
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541520,133,201 - 20,219,023 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541520,133,361 - 20,218,840 (+)NCBIChiLan1.0ChiLan1.0
SNAP25
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12010,164,346 - 10,252,843 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2010,218,358 - 10,252,841 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02010,164,236 - 10,252,856 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
SNAP25
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12412,003,005 - 12,081,385 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2412,004,117 - 12,081,329 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2411,821,959 - 11,900,304 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02412,414,152 - 12,492,563 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2412,409,789 - 12,492,544 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12412,021,341 - 12,099,876 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02412,120,883 - 12,199,168 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02412,463,988 - 12,542,509 (-)NCBIUU_Cfam_GSD_1.0
Snap25
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640160,767,380 - 160,848,503 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364859,195,110 - 9,279,920 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049364859,198,744 - 9,279,854 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SNAP25
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1719,141,464 - 19,227,576 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11719,096,115 - 19,227,580 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21721,669,084 - 21,703,714 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SNAP25
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1227,857,093 - 27,944,487 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl227,858,319 - 27,944,496 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607116,634,204 - 16,722,155 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Snap25
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474111,274,490 - 11,302,813 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474111,218,259 - 11,303,406 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:618
Count of miRNA genes:349
Interacting mature miRNAs:395
Transcripts:ENSMUST00000028727, ENSMUST00000110098, ENSMUST00000125486
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302174Dssc2_mdextran sodium sulfate induced colitis QTL2 (mouse)Not determined224224632148700377Mouse
4141854T2dm2sa_mtype 2 diabetes mellitus 2 in SMXA RI mice (mouse)Not determined229307947148374934Mouse
1301344Lith1_mlithogenic gene 1 (mouse)Not determined245347635145312647Mouse
13824983Vclq1_mcurvilinear velocity QTL 1 (mouse)261830344136841920Mouse
5491197Mobq5_mmultigenic obesity QTL 5 (mouse)Not determined265269746162518926Mouse
4141155Plast2b_mplasma plant sterol 2b (mouse)Not determined284013198148522175Mouse
10412082Hylaq1_mHyperlocomotor activity related QTL 1 (mouse)Not determined284013198148667470Mouse
5491196Mobq6_mmultigenic obesity QTL 6 (mouse)Not determined285724269180896594Mouse
27226761Feml18_mfemur length 18, 16 week (mouse)294230345154241920Mouse
27226788Feml13_mfemur length 13, 10 week (mouse)2102630345159941920Mouse
11038702Ltpr2_mLeishmania tropica response 2 (mouse)2103095716167212356Mouse
1301825Pbrgcsf1_mperipheral blood stem cell response to granulocyte colony stimulating factor 1 (mouse)Not determined2106233580140233729Mouse
10043875Bw25_mbody weight QTL 25 (mouse)Not determined2107255676141255676Mouse
1301087Bbaa15_mB.burgdorferi-associated arthritis 15 (mouse)Not determined2110489658144489807Mouse
10045885Cplaq15_mcircadian period of locomotor activity 15 (mouse)Not determined2110916118154354667Mouse
1558990Skmw9_mskeletal muscle weight 9 (mouse)Not determined2111173704145173821Mouse
1300793Pcfm2_mperiosteal circumference and femur length 2 (mouse)Not determined2111173704145173821Mouse
1301905Lgth2_mbody length 2 (mouse)Not determined2111173704145173821Mouse
1301755Hrq1_mheart rate quantitative locus 1 (mouse)Not determined2111173704145173821Mouse
1301201Chab1_mcholesterol absorption 1 (mouse)Not determined2111551028145551163Mouse
1302033Nsv1_mNeuroadapted Sindbis viral RNA level 1 (mouse)Not determined2111623386145623526Mouse
11039520Ltpr2h_mLeishmania tropica response 2h (mouse)2112212746146213005Mouse
11038699Ltpr2b_mLeishmania tropica response 2b (mouse)2112212746146213005Mouse
11038700Ltpr2a_mLeishmania tropica response 2a (mouse)2112212746146213005Mouse
11039521Ltpr2g_mLeishmania tropica response 2g (mouse)2115212857149212994Mouse
11038696Ltpr2f_mLeishmania tropica response 2f (mouse)2115212857149212994Mouse
1301295Prdt1_mprion disease incubation time 1 (mouse)Not determined2116077623150077741Mouse
1558881Ses7_msalmonella enteritidis susceptibility 7 (mouse)Not determined2116306330150306474Mouse
1301618Bglu1_mblood glucose level 1 (mouse)Not determined2117942930174324863Mouse
12910795Pwbwq5_mpost-weaning body weight QTL 5 (mouse)2118589253160611165Mouse
12910799Pwgrq2_mpre-weaning growth rate QTL 2 (mouse)2118589253160611165Mouse
12910812Pwgrq1_mpre-weaning growth rate QTL 1 (mouse)2118589253160611165Mouse
12910814Pwbwq1_mpre-weaning body weight QTL 1 (mouse)2118589253160611165Mouse
1300712El2_mepilepsy 2 (mouse)Not determined2122207146142532135Mouse
1301294Hrtfm5_mheart failure modifier 5 (mouse)Not determined2122883015156883131Mouse
1301066Otx2m2_morthodenticle homolog 2 (Drosophila) modifier 2 (mouse)Not determined2123231973148700377Mouse
1301822Pgia2_mproteoglycan induced arthritis 2 (mouse)Not determined2123937311157937424Mouse
27226749Femd10_mfemur midshaft diameter 10, 16 week (mouse)2124441920168241920Mouse
1302143Bwq5_mbody weight (mouse)Not determined2127664019161664118Mouse
1301031Bdln3_mbody length 3 (mouse)Not determined2127664019161664118Mouse
12880427V25Dq3_mvitamin D inactive form serum level QTL 3 (mouse)2129341920163341920Mouse
13207586Mwmlpt2_mMorris water maze latency to platform, training, 2 (mouse)2131616184139216184Mouse
13207590Mwmlpa2_mMorris water maze latency to platform, all, 2 (mouse)2131616184139616184Mouse
1301961Bts1_mbladder tumor susceptibility 1 (mouse)Not determined2132024159166024330Mouse
11049567Lmr28f_mleishmaniasis resistance 28f (mouse)2133144911167145058Mouse
11049566Lmr28e_mleishmaniasis resistance 28e (mouse)2133144911167145058Mouse
11341717Rvfs1_mRift Valley fever susceptibility 1 (mouse)2135432544173449616Mouse
4141703Chlq13_mcirculating hormone level QTL 13 (mouse)Not determined2135699221169699361Mouse
1301907Rends_mrenal disease susceptibility (mouse)Not determined2135699221169699361Mouse
10043956Gnf5_mgrowth and fatness 5 (mouse)Not determined2135699221169699361Mouse
10054066Bwq9_mbody weight QTL 9 (mouse)Not determined2135699221169699361Mouse

Markers in Region
RH127050  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382136,763,866 - 136,764,083UniSTSGRCm38
MGSCv372136,589,602 - 136,589,819UniSTSGRCm37
Celera2137,959,987 - 137,960,204UniSTS
Cytogenetic Map2F3UniSTS
cM Map278.2UniSTS
Whitehead/MRC_RH21660.95UniSTS
D25  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2F3UniSTS
cM Map278.2UniSTS
Whitehead Genetic262.3UniSTS
D2Mit28.1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2F3UniSTS
cM Map278.2UniSTS
Whitehead Genetic262.3UniSTS
D2Mit28.3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2F3UniSTS
cM Map278.2UniSTS
Whitehead Genetic262.3UniSTS
D2Nds33  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2F3UniSTS
cM Map278.2UniSTS
MARC_11717-11718:1029180244:1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382136,781,559 - 136,781,893UniSTSGRCm38
MGSCv372136,607,295 - 136,607,629UniSTSGRCm37
Celera2137,977,620 - 137,977,954UniSTS
Cytogenetic Map2F3UniSTS
cM Map278.2UniSTS
Snap25  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2F3UniSTS
cM Map267.56UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001291056 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001355254 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001355255 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001412615 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001412616 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001412617 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001412618 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001412619 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001412620 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001412621 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001412622 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_011428 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_149318 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_182008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_182009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017316760 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017316761 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF483516 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF483517 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI843805 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK078038 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK138653 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK161896 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL732447 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AU080862 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC018249 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB232574 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466519 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M22012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U36796 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000028727   ⟹   ENSMUSP00000028727
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2136,555,373 - 136,624,348 (+)Ensembl
GRCm38.p6 Ensembl2136,713,453 - 136,782,428 (+)Ensembl
RefSeq Acc Id: ENSMUST00000110098   ⟹   ENSMUSP00000105725
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2136,555,398 - 136,623,271 (+)Ensembl
GRCm38.p6 Ensembl2136,713,478 - 136,781,351 (+)Ensembl
RefSeq Acc Id: ENSMUST00000125486
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2136,555,374 - 136,604,829 (+)Ensembl
GRCm38.p6 Ensembl2136,713,454 - 136,762,909 (+)Ensembl
RefSeq Acc Id: NM_001291056   ⟹   NP_001277985
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392136,555,370 - 136,624,348 (+)NCBI
GRCm382136,713,450 - 136,782,428 (+)NCBI
Celera2137,909,643 - 137,978,489 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001355254   ⟹   NP_001342183
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392136,555,606 - 136,624,348 (+)NCBI
GRCm382136,713,686 - 136,782,428 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001355255   ⟹   NP_001342184
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392136,555,370 - 136,624,348 (+)NCBI
GRCm382136,713,450 - 136,782,428 (+)NCBI
Sequence:
RefSeq Acc Id: NM_011428   ⟹   NP_035558
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392136,555,370 - 136,624,348 (+)NCBI
GRCm382136,713,450 - 136,782,428 (+)NCBI
MGSCv372136,539,186 - 136,608,164 (+)RGD
Celera2137,909,643 - 137,978,489 (+)RGD
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_149318
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392136,555,370 - 136,624,348 (+)NCBI
GRCm382136,713,450 - 136,782,428 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017316760   ⟹   XP_017172249
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392136,555,509 - 136,624,342 (+)NCBI
GRCm382136,713,643 - 136,782,422 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017316761   ⟹   XP_017172250
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392136,555,359 - 136,624,342 (+)NCBI
GRCm382136,713,439 - 136,782,422 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_035558   ⟸   NM_011428
- Peptide Label: isoform a
- UniProtKB: P60879 (UniProtKB/Swiss-Prot),   A0A6P5P4D6 (UniProtKB/TrEMBL),   A0A8C6MVV1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001277985   ⟸   NM_001291056
- Peptide Label: isoform b
- UniProtKB: P60879 (UniProtKB/Swiss-Prot),   A0A6P5PDU3 (UniProtKB/TrEMBL),   A0A8C6H616 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017172250   ⟸   XM_017316761
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017172249   ⟸   XM_017316760
- Peptide Label: isoform X1
- UniProtKB: P60879 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001342184   ⟸   NM_001355255
- Peptide Label: isoform c
RefSeq Acc Id: NP_001342183   ⟸   NM_001355254
- Peptide Label: isoform a
- UniProtKB: A0A6P5P4D6 (UniProtKB/TrEMBL),   A0A8C6MVV1 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSMUSP00000105725   ⟸   ENSMUST00000110098
RefSeq Acc Id: ENSMUSP00000028727   ⟸   ENSMUST00000028727
Protein Domains
t-SNARE coiled-coil homology

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P60879-F1-model_v2 AlphaFold P60879 1-206 view protein structure

Promoters
RGD ID:6832789
Promoter ID:MM_KWN:31927
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:NM_011428,   OTTMUST00000036956,   OTTMUST00000036957
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv362136,539,121 - 136,539,621 (+)MPROMDB
RGD ID:6878906
Promoter ID:EPDNEW_M2904
Type:initiation region
Name:Snap25_1
Description:Mus musculus synaptosomal-associated protein 25 , transcriptvariant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm382136,713,454 - 136,713,514EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:98331 AgrOrtholog
Ensembl Genes ENSMUSG00000027273 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000028727 ENTREZGENE
  ENSMUSP00000028727.5 UniProtKB/Swiss-Prot
  ENSMUSP00000105725 ENTREZGENE
  ENSMUSP00000105725.4 UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000028727 ENTREZGENE
  ENSMUST00000028727.11 UniProtKB/Swiss-Prot
  ENSMUST00000110098 ENTREZGENE
  ENSMUST00000110098.4 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.5.110 UniProtKB/Swiss-Prot
InterPro SNAP-25 UniProtKB/Swiss-Prot
  SNAP25 UniProtKB/Swiss-Prot
  T_SNARE_dom UniProtKB/Swiss-Prot
KEGG Report mmu:20614 UniProtKB/Swiss-Prot
MGD MGI:98331 ENTREZGENE
NCBI Gene 20614 ENTREZGENE
PANTHER PTHR19305:SF5 UniProtKB/Swiss-Prot
  SYNAPTOSOMAL ASSOCIATED PROTEIN UniProtKB/Swiss-Prot
Pfam SNAP-25 UniProtKB/Swiss-Prot
PhenoGen Snap25 PhenoGen
PROSITE T_SNARE UniProtKB/Swiss-Prot
SMART t_SNARE UniProtKB/Swiss-Prot
Superfamily-SCOP SNARE fusion complex UniProtKB/Swiss-Prot
UniProt A0A6P5P4D6 ENTREZGENE
  A0A6P5PDU3 ENTREZGENE
  A0A8C6H616 ENTREZGENE
  A0A8C6MVV1 ENTREZGENE
  P60879 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary A2AIC2 UniProtKB/Swiss-Prot
  A2AIC3 UniProtKB/Swiss-Prot
  P13795 UniProtKB/Swiss-Prot
  P36974 UniProtKB/Swiss-Prot
  P70557 UniProtKB/Swiss-Prot
  P70558 UniProtKB/Swiss-Prot
  Q8IXK3 UniProtKB/Swiss-Prot
  Q96FM2 UniProtKB/Swiss-Prot
  Q9BR45 UniProtKB/Swiss-Prot