(-)-demecolcine increases expression ISO RGD:1352527 6480464 Demecolcine results in increased expression of SMAD4 mRNA CTD PMID:23649840 (-)-epigallocatechin 3-gallate increases expression ISO RGD:69092 6480464 epigallocatechin gallate results in increased expression of SMAD4 protein CTD PMID:35863485 (-)-epigallocatechin 3-gallate decreases expression ISO RGD:69092 6480464 epigallocatechin gallate results in decreased expression of SMAD4 mRNA, epigallocatechin gallate results in decreased expression of SMAD4 protein CTD PMID:34600025 (-)-epigallocatechin 3-gallate increases methylation ISO RGD:69092 6480464 epigallocatechin gallate results in increased methylation of SMAD4 promoter CTD PMID:34600025 (1->4)-beta-D-glucan multiple interactions ISO RGD:69092 6480464 [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of SMAD4 mRNA CTD PMID:36331819 (R,R,R)-alpha-tocopherol multiple interactions ISO RGD:1352527 6480464 SMAD4 results in decreased susceptibility to [Fluorouracil co-treated with alpha-Tocopherol] CTD PMID:20562578 1,2-dimethylhydrazine decreases expression EXP 6480464 1, 2-Dimethylhydrazine results in decreased expression of SMAD4 mRNA CTD PMID:32387197 1,2-dimethylhydrazine decreases expression ISO RGD:69092 6480464 1, 2-Dimethylhydrazine results in decreased expression of SMAD4 mRNA CTD PMID:22206623 1,2-dimethylhydrazine multiple interactions ISO RGD:69092 6480464 [1, 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of SMAD4 mRNA CTD PMID:22206623 17alpha-ethynylestradiol multiple interactions ISO RGD:69092 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SMAD4 mRNA CTD PMID:17942748 17beta-hydroxy-5alpha-androstan-3-one decreases expression ISO RGD:1352527 6480464 Dihydrotestosterone results in decreased expression of SMAD4 mRNA CTD PMID:16597033 2,2,2-tetramine multiple interactions EXP 6480464 Trientine inhibits the reaction [Streptozocin results in increased expression of SMAD4 mRNA] CTD PMID:16973718 2,3',4,4',5-Pentachlorobiphenyl increases expression ISO RGD:69092 6480464 2 more ... CTD PMID:31388691 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:69092 6480464 Tetrachlorodibenzodioxin affects the expression of SMAD4 mRNA CTD PMID:24058054 , PMID:28213091 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1352527 6480464 AHR protein affects the reaction [Tetrachlorodibenzodioxin affects the expression of SMAD4 protein] CTD PMID:31887333 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1352527 6480464 Tetrachlorodibenzodioxin affects the expression of SMAD4 protein CTD PMID:31887333 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of SMAD4 mRNA CTD PMID:11752688 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:69092 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SMAD4 mRNA CTD PMID:17942748 2,4-dinitrotoluene affects expression EXP 6480464 2, 4-dinitrotoluene affects the expression of SMAD4 mRNA CTD PMID:21346803 2-acetamidofluorene decreases expression EXP 6480464 2-Acetylaminofluorene results in decreased expression of SMAD4 mRNA CTD PMID:22213190 2-methoxyethanol increases expression EXP 6480464 methyl cellosolve results in increased expression of SMAD4 mRNA CTD PMID:19643169 3H-1,2-dithiole-3-thione decreases expression EXP 6480464 1, 2-dithiol-3-thione results in decreased expression of SMAD4 mRNA CTD PMID:19162173 4,4'-sulfonyldiphenol increases expression ISO RGD:1352527 6480464 bis(4-hydroxyphenyl)sulfone results in increased expression of SMAD4 mRNA CTD PMID:25912373 5-fluorouracil multiple interactions ISO RGD:1352527 6480464 SMAD4 results in decreased susceptibility to [Fluorouracil co-treated with alpha-Tocopherol] CTD PMID:20562578 acetaldehyde multiple interactions ISO RGD:1352527 6480464 SMAD4 protein promotes the reaction [Acetaldehyde results in increased expression of COL1A2 mRNA] CTD PMID:16025520 aflatoxin B1 increases expression ISO RGD:69092 6480464 Aflatoxin B1 results in increased expression of SMAD4 mRNA CTD PMID:19770486 aflatoxin B1 decreases methylation ISO RGD:1352527 6480464 Aflatoxin B1 results in decreased methylation of SMAD4 gene CTD PMID:27153756 aldehydo-D-glucose increases expression ISO RGD:1352527 6480464 Glucose results in increased expression of SMAD4 protein CTD PMID:21367880 aldehydo-D-glucose multiple interactions EXP 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Glucose results in increased expression of SMAD4 protein] more ... CTD PMID:31838053 aldehydo-D-glucose increases expression EXP 6480464 Glucose results in increased expression of SMAD4 protein CTD PMID:31838053 aldehydo-D-glucose multiple interactions ISO RGD:1352527 6480464 isoangustone A inhibits the reaction [Glucose results in increased expression of SMAD4 protein] CTD PMID:21367880 all-trans-retinoic acid decreases expression ISO RGD:1352527 6480464 Tretinoin results in decreased expression of SMAD4 mRNA CTD PMID:15498508 all-trans-retinoic acid decreases expression ISO RGD:69092 6480464 Tretinoin results in decreased expression of SMAD4 protein CTD PMID:33493612 all-trans-retinoic acid multiple interactions ISO RGD:1352527 6480464 Tretinoin inhibits the reaction [TGFB1 results in increased expression of SMAD4 protein] CTD PMID:21274875 amlodipine multiple interactions ISO RGD:1352527 6480464 Amlodipine inhibits the reaction [[Doxorubicin co-treated with TGFB1 protein] results in increased expression of SMAD4 mRNA], Amlodipine inhibits the reaction [[Doxorubicin co-treated with TGFB1 protein] results in increased expression of SMAD4 protein] CTD PMID:21337027 ammonium chloride increases expression EXP 6480464 Ammonium Chloride results in increased expression of SMAD4 protein CTD PMID:16483693 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of SMAD4 mRNA CTD PMID:16483693 Aroclor 1254 decreases expression ISO RGD:1352527 6480464 Chlorodiphenyl (54% Chlorine) results in decreased expression of SMAD4 mRNA CTD PMID:16934159 arsane affects methylation ISO RGD:1352527 6480464 Arsenic affects the methylation of SMAD4 gene CTD PMID:25304211 arsenic atom affects methylation ISO RGD:1352527 6480464 Arsenic affects the methylation of SMAD4 gene CTD PMID:25304211 benzo[a]pyrene diol epoxide I decreases expression ISO RGD:1352527 6480464 7 more ... CTD PMID:20018196 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of SMAD4 mRNA CTD PMID:25181051 bisphenol A decreases expression ISO RGD:1352527 6480464 bisphenol A results in decreased expression of SMAD4 protein CTD PMID:33376534 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of SMAD4 mRNA CTD PMID:30816183 more ... bisphenol A increases methylation EXP 6480464 bisphenol A results in increased methylation of SMAD4 gene CTD PMID:28505145 bisphenol A affects methylation ISO RGD:69092 6480464 bisphenol A affects the methylation of SMAD4 promoter CTD PMID:27334623 cadmium atom multiple interactions ISO RGD:1352527 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SMAD4 protein, BMP4 protein inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SMAD4 protein] CTD PMID:36453845 cadmium dichloride multiple interactions ISO RGD:1352527 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SMAD4 protein, BMP4 protein inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SMAD4 protein] CTD PMID:36453845 Candesartan cilexetil multiple interactions EXP 6480464 candesartan cilexetil inhibits the reaction [sodium arsenite results in increased expression of SMAD4 protein] CTD PMID:27889505 carbamazepine affects expression ISO RGD:1352527 6480464 Carbamazepine affects the expression of SMAD4 mRNA CTD PMID:24752500 , PMID:25979313 carbon nanotube affects expression ISO RGD:69092 6480464 Nanotubes, Carbon affects the expression of SMAD4 mRNA CTD PMID:23845593 CGP 52608 multiple interactions ISO RGD:1352527 6480464 CGP 52608 promotes the reaction [RORA protein binds to SMAD4 gene] CTD PMID:28238834 chlordecone increases expression ISO RGD:69092 6480464 Chlordecone results in increased expression of SMAD4 mRNA CTD PMID:31084621 , PMID:33711761 chlorpyrifos increases expression ISO RGD:69092 6480464 Chlorpyrifos results in increased expression of SMAD4 mRNA CTD PMID:37019170 chromium atom increases expression EXP 6480464 Chromium results in increased expression of SMAD4 mRNA CTD PMID:17692352 copper atom multiple interactions ISO RGD:1352527 6480464 [Chelating Agents binds to Copper] which results in increased expression of SMAD4 mRNA CTD PMID:30911355 copper(0) multiple interactions ISO RGD:1352527 6480464 [Chelating Agents binds to Copper] which results in increased expression of SMAD4 mRNA CTD PMID:30911355 copper(II) sulfate decreases expression ISO RGD:1352527 6480464 Copper Sulfate results in decreased expression of SMAD4 mRNA CTD PMID:19549813 curcumin multiple interactions EXP 6480464 Curcumin inhibits the reaction [[SMAD4 protein binds to SMAD3 protein] which binds to PPARG promoter] CTD PMID:16959952 curcumin decreases expression ISO RGD:69092 6480464 Curcumin results in decreased expression of SMAD4 mRNA CTD PMID:27237783 cyclosporin A increases expression ISO RGD:1352527 6480464 Cyclosporine results in increased expression of SMAD4 mRNA CTD PMID:20106945 D-glucose increases expression ISO RGD:1352527 6480464 Glucose results in increased expression of SMAD4 protein CTD PMID:21367880 D-glucose increases expression EXP 6480464 Glucose results in increased expression of SMAD4 protein CTD PMID:31838053 D-glucose multiple interactions EXP 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Glucose results in increased expression of SMAD4 protein] more ... CTD PMID:31838053 D-glucose multiple interactions ISO RGD:1352527 6480464 isoangustone A inhibits the reaction [Glucose results in increased expression of SMAD4 protein] CTD PMID:21367880 deguelin multiple interactions ISO RGD:1352527 6480464 deguelin inhibits the reaction [TGFB1 protein affects the localization of SMAD4 protein] CTD PMID:22986522 dexamethasone multiple interactions ISO RGD:69092 6480464 [Ascorbic Acid co-treated with Dexamethasone co-treated with beta-glycerophosphoric acid] results in increased expression of SMAD4 mRNA more ... CTD PMID:26492236 dibenziodolium multiple interactions EXP 6480464 diphenyleneiodonium inhibits the reaction [Glucose results in increased expression of SMAD4 protein] CTD PMID:31838053 diclofenac affects expression ISO RGD:1352527 6480464 Diclofenac affects the expression of SMAD4 mRNA CTD PMID:24752500 dimethyl sulfoxide multiple interactions ISO RGD:1352527 6480464 [Dimethyl Sulfoxide co-treated with TGFB1 protein] results in increased expression of SMAD4 protein CTD PMID:35366062 dorsomorphin multiple interactions ISO RGD:1352527 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 doxazosin increases expression ISO RGD:1352527 6480464 Doxazosin results in increased expression of SMAD4 mRNA, Doxazosin results in increased expression of SMAD4 protein CTD PMID:12771931 , PMID:16007219 doxazosin multiple interactions ISO RGD:1352527 6480464 SERPINB5 protein promotes the reaction [Doxazosin results in increased expression of SMAD4 mRNA], SERPINB5 protein promotes the reaction [Doxazosin results in increased expression of SMAD4 protein] CTD PMID:16007219 doxorubicin decreases expression ISO RGD:1352527 6480464 Doxorubicin results in decreased expression of SMAD4 mRNA, Doxorubicin results in decreased expression of SMAD4 protein CTD PMID:18606404 , PMID:29803840 doxorubicin increases expression EXP 6480464 Doxorubicin results in increased expression of SMAD4 mRNA CTD PMID:21337027 doxorubicin multiple interactions ISO RGD:1352527 6480464 [Doxorubicin co-treated with TGFB1 protein] results in increased expression of SMAD4 mRNA more ... CTD PMID:21337027 enzyme inhibitor multiple interactions ISO RGD:1352527 6480464 [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of SMAD4 protein CTD PMID:23301498 ethanol multiple interactions ISO RGD:69092 6480464 BMP6 protein affects the reaction [Ethanol affects the localization of SMAD4 protein] more ... CTD PMID:24746831 ethanol increases expression ISO RGD:1352527 6480464 Ethanol results in increased expression of SMAD4 mRNA CTD PMID:23378141 ethanol multiple interactions ISO RGD:1352527 6480464 BMP6 protein inhibits the reaction [Ethanol results in decreased expression of SMAD4 mRNA] CTD PMID:24746831 ethanol decreases expression ISO RGD:69092 6480464 Ethanol results in decreased expression of SMAD4 mRNA, Ethanol results in decreased expression of SMAD4 protein CTD PMID:24746831 ethanol affects localization ISO RGD:69092 6480464 Ethanol affects the localization of SMAD4 protein CTD PMID:24746831 farrerol multiple interactions EXP 6480464 farrerol inhibits the reaction [Glucose results in increased expression of SMAD4 protein] CTD PMID:31838053 fenofibrate multiple interactions ISO RGD:1352527 6480464 Fenofibrate inhibits the reaction [SMAD4 protein results in increased expression of SERPINE1 mRNA], NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [SMAD4 protein results in increased expression of SERPINE1 mRNA]] CTD PMID:19593819 folic acid decreases expression ISO RGD:69092 6480464 Folic Acid results in decreased expression of SMAD4 mRNA CTD PMID:25629700 folic acid multiple interactions ISO RGD:69092 6480464 [1, 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of SMAD4 mRNA CTD PMID:22206623 galangin increases expression ISO RGD:1352527 6480464 galangin results in increased expression of SMAD4 mRNA CTD PMID:25268046 galangin multiple interactions ISO RGD:1352527 6480464 SMAD4 mutant form inhibits the reaction [galangin results in increased expression of ATG12 protein] more ... CTD PMID:25268046 gallic acid increases expression ISO RGD:1352527 6480464 Gallic Acid results in increased expression of SMAD4 mRNA CTD PMID:34408198 gentamycin increases expression EXP 6480464 Gentamicins results in increased expression of SMAD4 mRNA CTD PMID:22061828 glucose increases expression EXP 6480464 Glucose results in increased expression of SMAD4 protein CTD PMID:31838053 glucose multiple interactions EXP 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Glucose results in increased expression of SMAD4 protein] more ... CTD PMID:31838053 glucose multiple interactions ISO RGD:1352527 6480464 isoangustone A inhibits the reaction [Glucose results in increased expression of SMAD4 protein] CTD PMID:21367880 glucose increases expression ISO RGD:1352527 6480464 Glucose results in increased expression of SMAD4 protein CTD PMID:21367880 glycerol 2-phosphate multiple interactions ISO RGD:69092 6480464 [Ascorbic Acid co-treated with Dexamethasone co-treated with beta-glycerophosphoric acid] results in increased expression of SMAD4 mRNA more ... CTD PMID:26492236 glycyrrhizinic acid decreases expression ISO RGD:1352527 6480464 Glycyrrhizic Acid results in decreased expression of SMAD4 protein CTD PMID:33522686 glyphosate increases expression ISO RGD:1352527 6480464 glyphosate results in increased expression of SMAD4 mRNA CTD PMID:17984146 icariin increases expression ISO RGD:69092 6480464 icariin results in increased expression of SMAD4 mRNA CTD PMID:19747809 icariin multiple interactions ISO RGD:69092 6480464 NOG protein inhibits the reaction [icariin results in increased expression of SMAD4 mRNA] CTD PMID:19747809 Isoangustone A multiple interactions ISO RGD:1352527 6480464 isoangustone A inhibits the reaction [Glucose results in increased expression of SMAD4 protein] CTD PMID:21367880 ivermectin decreases expression ISO RGD:1352527 6480464 Ivermectin results in decreased expression of SMAD4 protein CTD PMID:32959892 L-ascorbic acid multiple interactions ISO RGD:69092 6480464 [Ascorbic Acid co-treated with Dexamethasone co-treated with beta-glycerophosphoric acid] results in increased expression of SMAD4 mRNA more ... CTD PMID:26492236 leptomycin B multiple interactions ISO RGD:69092 6480464 [leptomycin B results in decreased activity of XPO1 protein] which results in decreased export of SMAD4 protein CTD PMID:26354774 lipopolysaccharide increases expression ISO RGD:1352527 6480464 Lipopolysaccharides results in increased expression of SMAD4 mRNA CTD PMID:35953652 Methylazoxymethanol acetate affects expression EXP 6480464 Methylazoxymethanol Acetate affects the expression of SMAD4 mRNA CTD PMID:28349193 methylisothiazolinone decreases expression ISO RGD:1352527 6480464 2-methyl-4-isothiazolin-3-one results in decreased expression of SMAD4 mRNA CTD PMID:31629900 methylmercury chloride increases expression ISO RGD:69092 6480464 methylmercuric chloride results in increased expression of SMAD4 mRNA CTD PMID:20061341 methylmercury chloride decreases expression ISO RGD:1352527 6480464 methylmercuric chloride results in decreased expression of SMAD4 mRNA CTD PMID:26272509 , PMID:28001369 monosodium L-glutamate decreases expression EXP 6480464 Sodium Glutamate results in decreased expression of SMAD4 mRNA CTD PMID:28954212 N-ethyl-N-nitrosourea increases mutagenesis ISO RGD:69092 6480464 Ethylnitrosourea results in increased mutagenesis of SMAD4 gene CTD PMID:16724327 N-methyl-4-phenylpyridinium increases expression ISO RGD:1352527 6480464 1-Methyl-4-phenylpyridinium results in increased expression of SMAD4 mRNA CTD PMID:25234470 N-methyl-N-nitrosourea increases response to substance ISO RGD:69092 6480464 SMAD4 gene mutant form results in increased susceptibility to Methylnitrosourea CTD PMID:12096346 N-nitrosodiethylamine affects expression EXP 6480464 Diethylnitrosamine affects the expression of SMAD4 protein CTD PMID:18971187 N-nitrosodiethylamine multiple interactions ISO RGD:69092 6480464 [Diethylnitrosamine co-treated with Dietary Fats] results in increased expression of SMAD4 protein CTD PMID:30826251 nitric oxide multiple interactions EXP 6480464 [SMAD4 protein co-treated with SMAD3 protein] affects the susceptibility to Nitric Oxide, Nitric Oxide results in increased activity of [SMAD4 protein binds to SMAD3 protein] CTD PMID:15949472 nitrofen decreases expression ISO RGD:69092 6480464 nitrofen results in decreased expression of SMAD4 mRNA CTD PMID:12149686 osthole multiple interactions ISO RGD:1352527 6480464 [platycodin D co-treated with osthol] results in decreased expression of SMAD4 mRNA, [platycodin D co-treated with osthol] results in decreased expression of SMAD4 protein CTD PMID:23603464 ouabain decreases expression ISO RGD:1352527 6480464 Ouabain results in decreased expression of SMAD4 mRNA CTD PMID:28795476 paracetamol decreases expression ISO RGD:69092 6480464 Acetaminophen results in decreased expression of SMAD4 mRNA CTD PMID:22610607 paracetamol decreases expression ISO RGD:1352527 6480464 Acetaminophen results in decreased expression of SMAD4 mRNA CTD PMID:27761495 patulin increases expression EXP 6480464 Patulin results in increased expression of SMAD4 protein CTD PMID:34896196 pentacarbonyliron increases expression ISO RGD:69092 6480464 Iron Carbonyl Compounds results in increased expression of SMAD4 protein CTD PMID:24746831 pentacarbonyliron multiple interactions ISO RGD:69092 6480464 Ethanol inhibits the reaction [Iron Carbonyl Compounds results in increased expression of SMAD4 protein], Quercetin inhibits the reaction [Iron Carbonyl Compounds results in increased expression of SMAD4 protein] CTD PMID:24746831 perfluorooctane-1-sulfonic acid multiple interactions ISO RGD:69092 6480464 [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of SMAD4 mRNA CTD PMID:36331819 phenylmercury acetate decreases expression ISO RGD:1352527 6480464 Phenylmercuric Acetate results in decreased expression of SMAD4 mRNA CTD PMID:26272509 phenylmercury acetate multiple interactions ISO RGD:1352527 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SMAD4 mRNA CTD PMID:27188386 phosphane increases expression EXP 6480464 phosphine results in increased expression of SMAD4 mRNA CTD PMID:34427094 picoxystrobin decreases expression ISO RGD:1352527 6480464 picoxystrobin results in decreased expression of SMAD4 mRNA CTD PMID:33512557 platycodin D multiple interactions ISO RGD:1352527 6480464 [platycodin D co-treated with osthol] results in decreased expression of SMAD4 mRNA, [platycodin D co-treated with osthol] results in decreased expression of SMAD4 protein CTD PMID:23603464 progesterone affects expression ISO RGD:69092 6480464 Progesterone affects the expression of SMAD4 mRNA CTD PMID:17251523 quercetin multiple interactions ISO RGD:1352527 6480464 Quercetin inhibits the reaction [SMAD2 protein modified form binds to SMAD3 protein modified form binds to SMAD4 protein] CTD PMID:15580028 quercetin multiple interactions ISO RGD:69092 6480464 Quercetin affects the reaction [Ethanol affects the localization of SMAD4 protein] more ... CTD PMID:24746831 quercetin decreases expression ISO RGD:1352527 6480464 Quercetin results in decreased expression of SMAD4 protein CTD PMID:15580028 resveratrol increases expression EXP 6480464 resveratrol results in increased expression of SMAD4 mRNA CTD PMID:19228061 resveratrol multiple interactions ISO RGD:69092 6480464 resveratrol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of SMAD4 protein] CTD PMID:25234611 resveratrol decreases expression ISO RGD:1352527 6480464 resveratrol results in decreased expression of SMAD4 mRNA, resveratrol results in decreased expression of SMAD4 protein CTD PMID:18089832 more ... rotenone decreases expression EXP 6480464 Rotenone results in decreased expression of SMAD4 protein CTD PMID:35544339 rutin multiple interactions EXP 6480464 Rutin inhibits the reaction [Cholesterol, Dietary results in increased expression of SMAD4 mRNA] CTD PMID:27239252 SB 431542 multiple interactions ISO RGD:1352527 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 SB 431542 multiple interactions ISO RGD:69092 6480464 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [TGFB3 protein affects the localization of SMAD4 protein] CTD PMID:21586554 sodium arsenite increases expression ISO RGD:1352527 6480464 sodium arsenite results in increased expression of SMAD4 mRNA CTD PMID:12016162 , PMID:12760830 sodium arsenite increases expression EXP 6480464 sodium arsenite results in increased expression of SMAD4 protein CTD PMID:27889505 , PMID:34673086 sodium arsenite multiple interactions EXP 6480464 candesartan cilexetil inhibits the reaction [sodium arsenite results in increased expression of SMAD4 protein] CTD PMID:27889505 streptozocin multiple interactions EXP 6480464 Trientine inhibits the reaction [Streptozocin results in increased expression of SMAD4 mRNA] CTD PMID:16973718 streptozocin decreases expression ISO RGD:69092 6480464 Streptozocin results in decreased expression of SMAD4 mRNA CTD PMID:27629361 streptozocin multiple interactions ISO RGD:1352527 6480464 SOD1 protein inhibits the reaction [Streptozocin results in decreased expression of SMAD4 mRNA] CTD PMID:27629361 streptozocin increases expression EXP 6480464 Streptozocin results in increased expression of SMAD4 mRNA, Streptozocin results in increased expression of SMAD4 protein CTD PMID:16973718 , PMID:18246672 tamibarotene decreases expression ISO RGD:1352527 6480464 tamibarotene results in decreased expression of SMAD4 mRNA CTD PMID:15498508 testosterone enanthate affects expression ISO RGD:1352527 6480464 testosterone enanthate affects the expression of SMAD4 mRNA CTD PMID:17440010 tetrachloromethane increases expression EXP 6480464 Carbon Tetrachloride results in increased expression of SMAD4 mRNA, Carbon Tetrachloride results in increased expression of SMAD4 protein CTD PMID:16570350 more ... tetrachloromethane multiple interactions EXP 6480464 FR 167653 inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD4 protein] CTD PMID:17334410 theobromine multiple interactions EXP 127229954 [Theobromine co-treated with Theanine] inhibits the reaction [1, 2-dimethylhydrazine decreases expression of Smad4 mRNA in the colon] RGD trichostatin A increases expression ISO RGD:1352527 6480464 trichostatin A results in increased expression of SMAD4 mRNA CTD PMID:26272509 trichostatin A multiple interactions ISO RGD:1352527 6480464 [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SMAD4 mRNA CTD PMID:27188386 triptonide increases expression ISO RGD:69092 6480464 triptonide results in increased expression of SMAD4 mRNA CTD PMID:33045310 troglitazone decreases expression ISO RGD:69092 6480464 troglitazone results in decreased expression of SMAD4 mRNA CTD PMID:28973697 valproic acid decreases expression ISO RGD:69092 6480464 Valproic Acid results in decreased expression of SMAD4 mRNA CTD PMID:20546886 , PMID:21427059 valproic acid increases expression ISO RGD:69092 6480464 Valproic Acid results in increased expression of SMAD4 mRNA CTD PMID:27237783 valproic acid multiple interactions ISO RGD:1352527 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SMAD4 mRNA CTD PMID:27188386 valproic acid decreases expression ISO RGD:1352527 6480464 Valproic Acid results in decreased expression of SMAD4 mRNA CTD PMID:23179753 more ... valproic acid affects expression ISO RGD:1352527 6480464 Valproic Acid affects the expression of SMAD4 mRNA CTD PMID:25979313 vanadyl sulfate decreases expression ISO RGD:1352527 6480464 vanadyl sulfate results in decreased expression of SMAD4 mRNA CTD PMID:16330358 vincristine increases expression ISO RGD:1352527 6480464 Vincristine results in increased expression of SMAD4 mRNA CTD PMID:23649840 vorinostat decreases expression ISO RGD:1352527 6480464 vorinostat results in decreased expression of SMAD4 mRNA CTD PMID:27188386