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RGD ID: 3033
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Smad4
Name: SMAD family member 4
Acc ID: GO:0060395
Term: SMAD protein signal transduction
Definition: An intracellular signaling cassette that starts with the activation of a SMAD protein, leading to the formation of a complex with co-SMADs, which translocates to the nucleus and regulates transcription of specific target genes.
Definition Source(s): GOC:BHF
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Smad4acts_upstream_of_or_withinISOSmad4 (Mus musculus)1624291RGDMGI:1858049 PMID:9420335

Smad4involved_inISOSMAD4 (Homo sapiens)1624291RGD PMID:10823886 PMID:22821565 PMID:23221074 PMID:26747772 PMID:9311995 PMID:9707553 PMID:9732876

PMID:10823886 PMID:22821565 PMID:23221074 PMID:26747772 PMID:9311995 PMID:9707553 PMID:9732876
Smad4involved_inISOSmad4 (Mus musculus)1624291RGD MGI:2683382 PMID:14691138

MGI:2683382 PMID:14691138
Smad4involved_inIEAUniProtKB:P97471 or ensembl:ENSMUSP000000253931600115EnsemblGO_REF:0000107

Smad4involved_inIEAUniProtKB:Q13485 or ensembl:ENSP000003415511600115EnsemblGO_REF:0000107

Smad4involved_inIBAFB:FBgn0011648 or FB:FBgn0011655 or FB:FBgn0025800 or MGI:108051 or MGI:109452 or MGI:1201674 or MGI:1328787 or MGI:1859993 or MGI:894293 or PANTHER:PTN000344419 or Smad2 (Rattus norvegicus) or Smad3 (Rattus norvegicus) or UniProtKB:P84022 or UniProtKB:Q13485 or UniProtKB:Q15796 or UniProtKB:Q157971600115GO_CentralGO_REF:0000033

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