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RGD ID: 3033
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Smad4
Name: SMAD family member 4
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Smad4increases expressionEXP 6480464CTDresveratrol results in increased expression of SMAD4 mRNAPMID:19228061
Smad4decreases expressionISOSMAD4 (Homo sapiens)6480464CTDresveratrol results in decreased expression of SMAD4 mRNA; resveratrol results in decreased expression of SMAD4 proteinPMID:18089832 PMID:25721869 PMID:27008654
Smad4multiple interactionsISOSmad4 (Mus musculus)6480464CTDresveratrol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of SMAD4 protein]PMID:25234611
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