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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3033
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Smad4
Name: SMAD family member 4
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Smad4increases expressionEXP 6480464CTDDoxorubicin results in increased expression of SMAD4 mRNAPMID:21337027
Smad4decreases expressionISOSMAD4 (Homo sapiens)6480464CTDDoxorubicin results in decreased expression of SMAD4 mRNA; Doxorubicin results in decreased expression of SMAD4 proteinPMID:18606404 PMID:29803840
Smad4multiple interactionsISOSMAD4 (Homo sapiens)6480464CTD[Doxorubicin co-treated with TGFB1 protein] results in increased expression of SMAD4 mRNA; [Doxorubicin co-treated with TGFB1 protein] results in increased expression of SMAD4 protein; Amlodipine inhibits the reaction [[Doxorubicin co-treated with TGFB1 protein] results in increased expression of SMAD4 mRNA]; Amlodipine inhibits the reaction [[Doxorubicin co-treated with TGFB1 protein] results in increased expression of SMAD4 protein]PMID:21337027
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