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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3033
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Smad4
Name: SMAD family member 4
Acc ID: CHEBI:9288
Term: streptozocin
Definition: An N-nitrosourea that is an antibiotic produced by Streptomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
Chemical ID: MESH:D013311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Smad4increases expressionEXP 6480464CTDStreptozocin results in increased expression of SMAD4 mRNA; Streptozocin results in increased expression of SMAD4 proteinPMID:16973718 PMID:18246672
Smad4multiple interactionsEXP 6480464CTDTrientine inhibits the reaction [Streptozocin results in increased expression of SMAD4 mRNA]PMID:16973718
Smad4decreases expressionISOSmad4 (Mus musculus)6480464CTDStreptozocin results in decreased expression of SMAD4 mRNAPMID:27629361
Smad4multiple interactionsISOSMAD4 (Homo sapiens)6480464CTDSOD1 protein inhibits the reaction [Streptozocin results in decreased expression of SMAD4 mRNA]PMID:27629361
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