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RGD ID: 3033
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Smad4
Name: SMAD family member 4
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Smad4decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of SMAD4 mRNAPMID:25181051 PMID:36803626
Smad4increases expressionEXP 6480464CTDbisphenol A results in increased expression of SMAD4 mRNAPMID:30816183 PMID:32528016 PMID:34947998
Smad4increases methylationEXP 6480464CTDbisphenol A results in increased methylation of SMAD4 genePMID:28505145
Smad4affects methylationISOSmad4 (Mus musculus)6480464CTDbisphenol A affects the methylation of SMAD4 promoterPMID:27334623
Smad4decreases expressionISOSMAD4 (Homo sapiens)6480464CTDbisphenol A results in decreased expression of SMAD4 proteinPMID:33376534 PMID:37567409
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