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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3033
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Smad4
Name: SMAD family member 4
Acc ID: CHEBI:15367
Term: all-trans-retinoic acid
Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.
Chemical ID: MESH:D014212
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Smad4decreases expressionISOSMAD4 (Homo sapiens)6480464CTDTretinoin results in decreased expression of SMAD4 mRNAPMID:15498508
Smad4decreases expressionISOSmad4 (Mus musculus)6480464CTDTretinoin results in decreased expression of SMAD4 proteinPMID:33493612
Smad4multiple interactionsISOSMAD4 (Homo sapiens)6480464CTDTretinoin inhibits the reaction [TGFB1 results in increased expression of SMAD4 protein]PMID:21274875
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