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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3033
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Smad4
Name: SMAD family member 4
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Smad4decreases expressionISOSMAD4 (Homo sapiens)6480464CTDQuercetin results in decreased expression of SMAD4 proteinPMID:15580028
Smad4multiple interactionsISOSMAD4 (Homo sapiens)6480464CTDQuercetin inhibits the reaction [SMAD2 protein modified form binds to SMAD3 protein modified form binds to SMAD4 protein]PMID:15580028
Smad4multiple interactionsISOSmad4 (Mus musculus)6480464CTDQuercetin affects the reaction [Ethanol affects the localization of SMAD4 protein]; Quercetin inhibits the reaction [Ethanol inhibits the reaction [SMAD4 protein binds to HAMP promoter]]; Quercetin inhibits the reaction [Ethanol results in decreased expression of SMAD4 mRNA]; Quercetin inhibits the reaction [Ethanol results in decreased expression of SMAD4 protein]; Quercetin inhibits the reaction [Iron Carbonyl Compounds results in increased expression of SMAD4 protein]PMID:24746831
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