Smad4 (SMAD family member 4) - Rat Genome Database

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Gene: Smad4 (SMAD family member 4) Ictidomys tridecemlineatus
Analyze
Symbol: Smad4
Name: SMAD family member 4
RGD ID: 12709646
Description: ENCODES a protein that exhibits chromatin binding (ortholog); collagen binding (ortholog); DNA binding (ortholog); INVOLVED IN adrenal gland development (ortholog); aging (ortholog); anatomical structure morphogenesis (ortholog); PARTICIPATES IN altered transforming growth factor-beta Smad dependent signaling pathway; Bone morphogenetic proteins signaling pathway; colorectal cancer pathway; ASSOCIATED WITH 17-beta hydroxysteroid dehydrogenase 3 deficiency (ortholog); Acro-Osteolysis (ortholog); aortic disease (ortholog); FOUND IN activin responsive factor complex (ortholog); centrosome (ortholog); chromatin (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: mothers against decapentaplegic homolog 4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494437,008,523 - 37,038,961 (-)NCBI
SpeTri2.0NW_00493649712,242,869 - 12,278,012 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
17-beta hydroxysteroid dehydrogenase 3 deficiency  (ISO)
Acro-Osteolysis  (ISO)
aortic disease  (ISO)
brachydactyly  (ISO)
Breast Neoplasms  (ISO)
cervical cancer  (ISO)
cholangiocarcinoma  (ISO)
Chronic Hepatitis C  (ISO)
chronic myeloid leukemia  (ISO)
chronic obstructive pulmonary disease  (ISO)
Cicatrix  (ISO)
cognitive disorder  (ISO)
colorectal adenoma  (ISO)
colorectal cancer  (ISO)
colorectal carcinoma  (ISO)
Colorectal Neoplasms  (ISO)
Craniofacial Abnormalities  (ISO)
Cronkhite-Canada syndrome  (ISO)
Deafness  (ISO)
endometrial carcinoma  (ISO)
esophageal carcinoma  (ISO)
esophagus adenocarcinoma  (ISO)
Experimental Colitis  (ISO)
Experimental Liver Cirrhosis  (ISO)
Gallstones  (ISO)
gastric adenocarcinoma  (ISO)
gastrointestinal system cancer  (ISO)
genetic disease  (ISO)
Growth Mental Deficiency Syndrome of Myhre  (ISO)
head and neck squamous cell carcinoma  (ISO)
hemorrhagic disease  (ISO)
hepatocellular carcinoma  (ISO)
hereditary hemorrhagic telangiectasia  (ISO)
Hereditary Hemorrhagic Telangiectasia, Type 1  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
Heterotopic Ossification  (ISO)
Human Viral Hepatitis  (ISO)
Hypoglossal Nerve Injuries  (ISO)
intellectual disability  (ISO)
intrahepatic cholangiocarcinoma  (ISO)
invasive ductal carcinoma  (ISO)
juvenile polyposis syndrome  (ISO)
juvenile polyposis-hereditary hemorrhagic telangiectasia syndrome  (ISO)
Laryngotracheal Stenosis, Progressive, with Short Stature and Arthropathy  (ISO)
Liver Metastasis  (ISO)
lung adenocarcinoma  (ISO)
Lymphatic Metastasis  (ISO)
Lynch syndrome  (ISO)
Microphthalmia, Cataracts, and Iris Abnormalities  (ISO)
muscular disease  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
Neoplasm Metastasis  (ISO)
nephroblastoma  (ISO)
non-alcoholic steatohepatitis  (ISO)
Odontogenic Cysts  (ISO)
ovarian cancer  (ISO)
pancreatic adenocarcinoma  (ISO)
pancreatic cancer  (ISO)
pancreatic carcinoma  (ISO)
pancreatic ductal carcinoma  (ISO)
Parasitic Liver Diseases  (ISO)
pre-malignant neoplasm  (ISO)
Primary Pulmonary Hypertension, 1  (ISO)
prostate adenocarcinoma  (ISO)
prostate carcinoma in situ  (ISO)
Prostatic Neoplasms  (ISO)
prostatitis  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
renal cell carcinoma  (ISO)
seminoma  (ISO)
Stomach Neoplasms  (ISO)
thoracic aortic aneurysm  (ISO)
thrombocytopenia  (ISO)
transitional cell carcinoma  (ISO)
type 2 diabetes mellitus  (ISO)
urinary bladder cancer  (ISO)
Uterine Cervical Neoplasms  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adrenal gland development  (ISO)
aging  (ISO)
anatomical structure morphogenesis  (ISO)
anterior/posterior pattern specification  (ISO)
atrioventricular canal development  (ISO)
atrioventricular valve formation  (ISO)
axon guidance  (ISO)
BMP signaling pathway  (ISO)
brainstem development  (ISO)
branching involved in ureteric bud morphogenesis  (ISO)
cardiac septum development  (ISO)
cell differentiation  (ISO)
cell population proliferation  (ISO)
cellular iron ion homeostasis  (ISO)
cellular response to glucose stimulus  (ISO)
developmental growth  (ISO)
embryonic digit morphogenesis  (ISO)
endocardial cell differentiation  (ISO)
endoderm development  (ISO)
endothelial cell activation  (ISO)
epithelial to mesenchymal transition involved in endocardial cushion formation  (ISO)
ERK1 and ERK2 cascade  (ISO)
female gonad development  (ISO)
female gonad morphogenesis  (ISO)
formation of anatomical boundary  (ISO)
gastrulation  (ISO)
gastrulation with mouth forming second  (ISO)
in utero embryonic development  (ISO)
interleukin-6-mediated signaling pathway  (ISO)
intracellular signal transduction  (ISO)
kidney development  (ISO)
left ventricular cardiac muscle tissue morphogenesis  (ISO)
male gonad development  (ISO)
mesendoderm development  (ISO)
mesoderm development  (ISO)
metanephric mesenchyme morphogenesis  (ISO)
negative regulation of cardiac muscle hypertrophy  (ISO)
negative regulation of cardiac myofibril assembly  (ISO)
negative regulation of cell death  (ISO)
negative regulation of cell growth  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of ERK1 and ERK2 cascade  (ISO)
negative regulation of protein catabolic process  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of transcription, DNA-templated  (ISO)
nephrogenic mesenchyme morphogenesis  (ISO)
neural crest cell differentiation  (ISO)
neuron fate commitment  (ISO)
osteoblast differentiation  (ISO)
outflow tract septum morphogenesis  (ISO)
ovarian follicle development  (ISO)
positive regulation of BMP signaling pathway  (ISO)
positive regulation of cardiac muscle cell apoptotic process  (ISO)
positive regulation of cell proliferation involved in heart valve morphogenesis  (ISO)
positive regulation of epithelial to mesenchymal transition  (ISO)
positive regulation of follicle-stimulating hormone secretion  (ISO)
positive regulation of histone H3-K4 methylation  (ISO)
positive regulation of histone H3-K9 acetylation  (ISO)
positive regulation of luteinizing hormone secretion  (ISO)
positive regulation of pathway-restricted SMAD protein phosphorylation  (ISO)
positive regulation of pri-miRNA transcription by RNA polymerase II  (ISO)
positive regulation of SMAD protein signal transduction  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription, DNA-templated  (ISO)
positive regulation of transforming growth factor beta receptor signaling pathway  (ISO)
regulation of binding  (ISO)
regulation of cell population proliferation  (ISO)
regulation of hair follicle development  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
regulation of transforming growth factor beta receptor signaling pathway  (ISO)
regulation of transforming growth factor beta2 production  (ISO)
response to hypoxia  (ISO)
response to transforming growth factor beta  (ISO)
sebaceous gland development  (ISO)
secondary palate development  (ISO)
seminiferous tubule development  (ISO)
single fertilization  (ISO)
SMAD protein complex assembly  (ISO)
SMAD protein signal transduction  (ISO)
somite rostral/caudal axis specification  (ISO)
spermatogenesis  (ISO)
tissue morphogenesis  (ISO)
transforming growth factor beta receptor signaling pathway  (ISO)
uterus development  (ISO)
ventricular septum morphogenesis  (ISO)
wound healing  (ISO)

References

Genomics

Comparative Map Data
Smad4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494437,008,523 - 37,038,961 (-)NCBI
SpeTri2.0NW_00493649712,242,869 - 12,278,012 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SMAD4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1851,028,394 - 51,085,045 (+)EnsemblGRCh38hg38GRCh38
GRCh381851,030,213 - 51,085,042 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371848,556,583 - 48,611,412 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361846,810,611 - 46,860,145 (+)NCBINCBI36hg18NCBI36
Build 341846,810,610 - 46,860,144NCBI
Celera1845,413,367 - 45,468,195 (+)NCBI
Cytogenetic Map18q21.2NCBI
HuRef1845,411,927 - 45,466,923 (+)NCBIHuRef
CHM1_11848,551,997 - 48,606,836 (+)NCBICHM1_1
Smad4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391873,767,861 - 73,836,862 (-)NCBIGRCm39mm39
GRCm39 Ensembl1873,772,080 - 73,836,851 (-)Ensembl
GRCm381873,634,790 - 73,703,791 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1873,639,009 - 73,703,780 (-)EnsemblGRCm38mm10GRCm38
MGSCv371873,798,667 - 73,863,395 (-)NCBIGRCm37mm9NCBIm37
MGSCv361873,764,382 - 73,829,110 (-)NCBImm8
Celera1874,884,056 - 74,923,073 (-)NCBICelera
Cytogenetic Map18E2NCBI
cM Map1849.51NCBI
Smad4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21867,243,742 - 67,274,438 (-)NCBI
Rnor_6.0 Ensembl1869,627,757 - 69,671,199 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01869,626,682 - 69,657,373 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01868,773,326 - 68,802,354 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41870,432,705 - 70,461,541 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11870,504,785 - 70,534,814 (-)NCBI
Celera1865,246,042 - 65,276,480 (-)NCBICelera
Cytogenetic Map18q12.2NCBI
Smad4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540235,961,165 - 35,994,538 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540235,956,080 - 36,001,746 (+)NCBIChiLan1.0ChiLan1.0
SMAD4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11847,692,311 - 47,802,530 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1847,764,568 - 47,797,359 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01844,402,112 - 44,456,779 (+)NCBIMhudiblu_PPA_v0panPan3
SMAD4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1123,875,989 - 23,930,027 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl123,882,139 - 23,969,405 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha124,868,005 - 24,956,178 (-)NCBI
ROS_Cfam_1.0123,767,402 - 23,821,366 (-)NCBI
UMICH_Zoey_3.1123,833,038 - 23,921,205 (-)NCBI
UNSW_CanFamBas_1.0123,719,264 - 23,807,404 (-)NCBI
UU_Cfam_GSD_1.0123,987,158 - 24,041,139 (-)NCBI
SMAD4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1100,514,791 - 100,628,029 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11100,521,843 - 100,633,501 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21110,456,997 - 110,568,659 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SMAD4
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11829,894,157 - 29,951,445 (-)NCBI
ChlSab1.1 Ensembl1829,897,621 - 29,934,478 (-)Ensembl
Smad4
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462477814,570,025 - 14,629,950 (+)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_005323061   ⟹   XP_005323118
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494437,008,523 - 37,038,960 (-)NCBI
SpeTri2.0NW_00493649712,242,869 - 12,278,012 (-)NCBI
Sequence:
RefSeq Acc Id: XM_040273040   ⟹   XP_040128974
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494437,008,523 - 37,038,961 (-)NCBI
RefSeq Acc Id: XM_040273048   ⟹   XP_040128982
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494437,008,523 - 37,038,961 (-)NCBI
RefSeq Acc Id: XR_001229701
RefSeq Status:
Type: NON-CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494437,010,178 - 37,038,961 (-)NCBI
SpeTri2.0NW_00493649712,242,869 - 12,278,012 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005323118 (Get FASTA)   NCBI Sequence Viewer  
  XP_040128974 (Get FASTA)   NCBI Sequence Viewer  
  XP_040128982 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005323118   ⟸   XM_005323061
- Peptide Label: isoform X1
- UniProtKB: I3MX09 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_040128982   ⟸   XM_040273048
- Peptide Label: isoform X3
RefSeq Acc Id: XP_040128974   ⟸   XM_040273040
- Peptide Label: isoform X2
Protein Domains
MH1   MH2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000028580 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSTOP00000016654 ENTREZGENE, UniProtKB/TrEMBL
  ENSSTOP00000029786 UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000026730 UniProtKB/TrEMBL
  ENSSTOT00000033240 UniProtKB/TrEMBL
Gene3D-CATH 2.60.200.10 UniProtKB/TrEMBL
  3.90.520.10 UniProtKB/TrEMBL
InterPro Dwarfin UniProtKB/TrEMBL
  MAD_homology1_Dwarfin-type UniProtKB/TrEMBL
  MAD_homology_MH1 UniProtKB/TrEMBL
  SMAD-like_dom_sf UniProtKB/TrEMBL
  SMAD_dom_Dwarfin-type UniProtKB/TrEMBL
  SMAD_FHA_dom_sf UniProtKB/TrEMBL
  SMAD_MH1_sf UniProtKB/TrEMBL
NCBI Gene Smad4 ENTREZGENE
PANTHER PTHR13703 UniProtKB/TrEMBL
Pfam MH1 UniProtKB/TrEMBL
  MH2 UniProtKB/TrEMBL
PROSITE MH1 UniProtKB/TrEMBL
  MH2 UniProtKB/TrEMBL
SMART DWA UniProtKB/TrEMBL
  DWB UniProtKB/TrEMBL
Superfamily-SCOP SSF49879 UniProtKB/TrEMBL
  SSF56366 UniProtKB/TrEMBL
UniProt A0A287D8E9_ICTTR UniProtKB/TrEMBL
  I3MX09 ENTREZGENE, UniProtKB/TrEMBL