Mir146 (microRNA 146) - Rat Genome Database
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Gene: Mir146 (microRNA 146) Mus musculus
Analyze
Symbol: Mir146
Name: microRNA 146
RGD ID: 1608327
MGI Page MGI
Description: Involved in several processes, including cellular response to estrogen stimulus; cellular response to leukemia inhibitory factor; and cellular response to lipopolysaccharide. Localizes to synapse. Is expressed in lung. Human ortholog(s) of this gene implicated in hepatocellular carcinoma and type 1 diabetes mellitus. Orthologous to human MIR146A (microRNA 146a).
Type: ncrna
RefSeq Status: PROVISIONAL
Also known as: miR-1; miR-146a; Mirn; Mirn146; mmu-mir-1; mmu-mir-146
RGD Orthologs
Human
Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391143,265,224 - 43,265,288 (-)NCBIGRCm39mm39
GRCm381143,374,397 - 43,374,461 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1143,374,397 - 43,374,461 (-)EnsemblGRCm38mm10GRCm38
MGSCv371143,187,899 - 43,187,963 (-)NCBIGRCm37mm9NCBIm37
Celera1148,002,809 - 48,002,873 (-)NCBICelera
Cytogenetic Map11A5NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
synapse  (IDA)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal bone marrow cell morphology/development  (IAGP)
abnormal bone marrow cell physiology  (IAGP)
abnormal hematopoietic stem cell morphology  (IAGP)
abnormal immune system physiology  (IAGP)
abnormal immune tolerance  (IAGP)
abnormal lymphocyte physiology  (IAGP)
abnormal lymphopoiesis  (IAGP)
abnormal macrophage physiology  (IAGP)
abnormal regulatory T cell physiology  (IAGP)
abnormal spleen B cell follicle morphology  (IAGP)
abnormal T cell activation  (IAGP)
anemia  (IAGP)
blepharitis  (IAGP)
conjunctivitis  (IAGP)
decreased erythrocyte cell number  (IAGP)
decreased hematocrit  (IAGP)
decreased hemoglobin content  (IAGP)
decreased interferon-gamma secretion  (IAGP)
decreased leukocyte cell number  (IAGP)
decreased lymphocyte cell number  (IAGP)
decreased monocyte cell number  (IAGP)
decreased neutrophil cell number  (IAGP)
dermatitis  (IAGP)
enlarged lymph nodes  (IAGP)
enlarged spleen  (IAGP)
extramedullary hematopoiesis  (IAGP)
increased acute inflammation  (IAGP)
increased anti-double stranded DNA antibody level  (IAGP)
increased B cell derived lymphoma incidence  (IAGP)
increased bone marrow cell number  (IAGP)
increased circulating interleukin-1 beta level  (IAGP)
increased circulating interleukin-10 level  (IAGP)
increased circulating interleukin-6 level  (IAGP)
increased circulating tumor necrosis factor level  (IAGP)
increased follicular lymphoma incidence  (IAGP)
increased germinal center B cell number  (IAGP)
increased hemolymphoid system tumor incidence  (IAGP)
increased IgG level  (IAGP)
increased IgG1 level  (IAGP)
increased interleukin-1 beta secretion  (IAGP)
increased interleukin-6 secretion  (IAGP)
increased macrophage nitric oxide production  (IAGP)
increased myeloid sarcoma incidence  (IAGP)
increased plasma cell number  (IAGP)
increased regulatory T cell number  (IAGP)
increased spleen germinal center number  (IAGP)
increased spleen germinal center size  (IAGP)
increased spleen neoplasm incidence  (IAGP)
increased spleen weight  (IAGP)
increased susceptibility to bacterial infection induced morbidity/mortality  (IAGP)
increased susceptibility to endotoxin shock  (IAGP)
increased T cell derived lymphoma incidence  (IAGP)
increased T follicular helper cell number  (IAGP)
increased tumor incidence  (IAGP)
increased tumor necrosis factor secretion  (IAGP)
myelofibrosis  (IAGP)
myeloid hyperplasia  (IAGP)
premature aging  (IAGP)
premature death  (IAGP)
thrombocytopenia  (IAGP)
References

Additional References at PubMed
PMID:12007417   PMID:16381832   PMID:17369397   PMID:17604727   PMID:17613256   PMID:18452032   PMID:18723672   PMID:18791161   PMID:19026611   PMID:19147652   PMID:19559694   PMID:19596990  
PMID:19965651   PMID:20215419   PMID:20413612   PMID:20439489   PMID:20495188   PMID:20709800   PMID:20850013   PMID:20933052   PMID:20951969   PMID:21037258   PMID:21247879   PMID:21263019  
PMID:21267068   PMID:21555486   PMID:21557898   PMID:21576471   PMID:21730286   PMID:21822254   PMID:21885871   PMID:21975861   PMID:21981419   PMID:22113163   PMID:22210724   PMID:22363497  
PMID:22415194   PMID:22545247   PMID:22551553   PMID:22570807   PMID:22580216   PMID:22851573   PMID:22891274   PMID:22897173   PMID:23143100   PMID:23200854   PMID:23221399   PMID:23572509  
PMID:23588407   PMID:23589616   PMID:23619365   PMID:23645835   PMID:23646144   PMID:23698745   PMID:23699512   PMID:23705069   PMID:23733368   PMID:23744481   PMID:23952003   PMID:23974950  
PMID:24092752   PMID:24184056   PMID:24277697   PMID:24291840   PMID:24316060   PMID:24427314   PMID:24470395   PMID:24472607   PMID:24582962   PMID:24719463   PMID:24735967   PMID:24771509  
PMID:24828499   PMID:24962817   PMID:24967703   PMID:24987958   PMID:25199827   PMID:25205119   PMID:25311550   PMID:25367574   PMID:25406379   PMID:25515214   PMID:25697406   PMID:25712341  
PMID:25743066   PMID:25896300   PMID:25904598   PMID:25906746   PMID:25957028   PMID:26048146   PMID:26084661   PMID:26165466   PMID:26166175   PMID:26199426   PMID:26456940   PMID:26458771  
PMID:26492575   PMID:26505653   PMID:26537990   PMID:26538391   PMID:26549232   PMID:26634350   PMID:26647423   PMID:26681446   PMID:26700406   PMID:26800097   PMID:27025258   PMID:27163405  
PMID:27221467   PMID:27250735   PMID:27444565   PMID:27568078   PMID:27635087   PMID:27733775   PMID:27908889   PMID:27913625   PMID:28190197   PMID:28219659   PMID:28279663   PMID:28346483  
PMID:28399410   PMID:28484267   PMID:28510617   PMID:28595995   PMID:28596252   PMID:28611091   PMID:28637783   PMID:28784800   PMID:28810531   PMID:28811005   PMID:28872459   PMID:28882869  
PMID:28963073   PMID:28975995   PMID:29021573   PMID:29101850   PMID:29107863   PMID:29133238   PMID:29181576   PMID:29183039   PMID:29263441   PMID:29288795   PMID:29437577   PMID:29441948  
PMID:29505740   PMID:29544526   PMID:29550454   PMID:29575548   PMID:29587465   PMID:29593734   PMID:29728425   PMID:29902229   PMID:29925839   PMID:30013024   PMID:30015963   PMID:30018336  
PMID:30103197   PMID:30134242   PMID:30337925   PMID:30355233   PMID:30387844   PMID:30425059   PMID:30610163   PMID:30613275   PMID:30633643   PMID:30651631   PMID:30768595   PMID:30777858  
PMID:30972735   PMID:30979483   PMID:31156641   PMID:31356686   PMID:31412923   PMID:31434993   PMID:31477775   PMID:31479774   PMID:31486503   PMID:31511497   PMID:31666653   PMID:31682635  
PMID:31798643   PMID:31894315   PMID:32092902   PMID:32161096   PMID:32228681   PMID:32612165   PMID:33166004  


Genomics

Comparative Map Data
Mir146
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391143,265,224 - 43,265,288 (-)NCBIGRCm39mm39
GRCm381143,374,397 - 43,374,461 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1143,374,397 - 43,374,461 (-)EnsemblGRCm38mm10GRCm38
MGSCv371143,187,899 - 43,187,963 (-)NCBIGRCm37mm9NCBIm37
Celera1148,002,809 - 48,002,873 (-)NCBICelera
Cytogenetic Map11A5NCBI
MIR146A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl5160,485,352 - 160,485,450 (+)EnsemblGRCh38hg38GRCh38
GRCh385160,485,352 - 160,485,450 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh375159,912,359 - 159,912,457 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365159,844,936 - 159,845,034 (+)NCBINCBI36hg18NCBI36
Celera5155,944,832 - 155,944,930 (+)NCBI
Cytogenetic Map5q33.3NCBI
HuRef5155,005,782 - 155,005,880 (+)NCBIHuRef
CHM1_15159,345,261 - 159,345,359 (+)NCBICHM1_1
Mir146a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21027,848,516 - 27,848,610 (-)NCBI
Rnor_6.0 Ensembl1028,962,476 - 28,962,570 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01028,962,476 - 28,962,570 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01028,806,739 - 28,806,833 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1027,342,093 - 27,342,187 (-)NCBICelera
Cytogenetic Map10q21NCBI


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27095909Scvln6_msacral vertebrae length 2, 5 week (mouse)11330000044200000Mouse
27226798Scvln18_msacral vertebrae length 2, 16 week (mouse)11330000060800000Mouse
26884446Sklq10_mskull length QTL 10, 10 week (mouse)11330000063000000Mouse
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11330000072800000Mouse
13208559Wght10_mweight 10 (mouse)11400000089000000Mouse
13208558Lgth12_mbody length 12 (mouse)11400000095000000Mouse
27226741Metcl5_mmetatarsal-calcaneal length 5, 5 week (mouse)11470000046400000Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11693027789128908Mouse
27226738Metcl11_mmetatarsal-calcaneal length 11, 10 week (mouse)11890000061500000Mouse
13463472Mcvq15_mmean corpuscular volume QTL 15 (mouse)111100123245001464Mouse
13463479Mchq19_mmean corpuscular hemoglobin QTL 19 (mouse)111100123245001464Mouse
26884401Huml4_mhumerus length 4, 10 week (mouse)111160000068600000Mouse
27226762Feml21_mfemur length 21, 16 week (mouse)111180000066100000Mouse
4141966Tailq1_mtail length QTL 1 (mouse)Not determined1231863768609504Mouse
1357851Scfq3_msubcutaneous fat pad weight QTL 3 (mouse)Not determined111231863768609504Mouse
1357437Epfq4_mepididymal fat pad weight QTL 4 (mouse)Not determined111231863768609504Mouse
4141127W3q4_mweight 3 weeks QTL 4 (mouse)Not determined1231863768609504Mouse
4142216Lgq1_mlate growth QTL 1 (mouse)Not determined1231863768609504Mouse
4142308W6q3_mweight 6 weeks QTL 3 (mouse)Not determined111231863768609504Mouse
4141582Lgaq1_mlate growth adjusted QTL 1 (mouse)Not determined1231863768609504Mouse
4142109W10q2_mweight 10 weeks QTL 2 (mouse)Not determined1231863768609504Mouse
4141470Egq4_mearly growth QTL 4 (mouse)Not determined1231863768609504Mouse
1357640Orq2_movulation rate QTL 2 (mouse)Not determined111231863768609504Mouse
1357720Kidpq1_mkidney weight percentage QTL 1 (mouse)Not determined111231863768609504Mouse
1559002Lmrq4_mLeishmania major resistance QTL 4 (mouse)Not determined111231863769794121Mouse
1357859Lvrq7_mliver weight QTL 7 (mouse)Not determined1112318637118131898Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112318637118131898Mouse
1558945Orgwq8_morgan weight QTL 8 (mouse)Not determined111710617567187585Mouse
10053687Eae6_msusceptibility to experimental allergic encephalomyelitis 6 (mouse)Not determined111783196668609504Mouse
1300938Bulb3_mbulb size 3 (mouse)Not determined111868778952687889Mouse
12801457Intmrm2_mintima/media ratio modifier 2 (mouse)111868778952687889Mouse
12801459Leuf1_mleukocyte filtration 1 (mouse)111868778952687889Mouse
12801460Intim2_mintima modifier 2 (mouse)111868778952687889Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1917420497007000Mouse
1300579Thypr1_mthymocyte proliferative response 1 (mouse)Not determined111939175053391888Mouse
14746971Manh70_mmandible shape 70 (mouse)112001506354015063Mouse
4141398Tgq22_mtriglyceride QTL 22 (mouse)Not determined2127257955272579Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112185736495990405Mouse
10044006Hbnr13_mHeligmosomoides bakeri nematode resistance 13 (mouse)Not determined112588179959881914Mouse
1301814Bbaa7_mB.burgdorferi-associated arthritis 7 (mouse)Not determined112606178044373868Mouse
12910801Pwbwq14_mpost-weaning body weight QTL 14 (mouse)112724805750745267Mouse
12910804Pwbwq16_mpost-weaning body weight QTL 16 (mouse)112724805750745267Mouse
12910806Pwbwq15_mpost-weaning body weight QTL 15 (mouse)112724805750745267Mouse
12910817Pwgrq20_mpost-weaning growth rate QTL 20 (mouse)112724805750745267Mouse
12910818Ogrq5_moverall growth rate QTL 5 (mouse)112724805750745267Mouse
1357844Si5lq5_mserum IGFBP-5 level QTL 5 (mouse)Not determined112827504662275149Mouse
13524848Ppiq7_mprepulse inhibition QTL 7 (mouse)112867832062678320Mouse
1301426Desp2_mdespair 2 (mouse)Not determined112881775462817873Mouse
11522752Cocia18_mcocaine-induced activity, QTL 18 (mouse)113111738265117382Mouse
11059563Lmr31_mleishmaniasis resistance 31 (mouse)113220975066209867Mouse
1558769Zolw1_mzolpidem withdrawal 1 (mouse)Not determined113568778944175104Mouse
1301718Pbw3_mpentobarbital withdrawal QTL 3 (mouse)Not determined113568778944175104Mouse
10043922Alcw9_malcohol withdrawal 9 (mouse)Not determined113568778944175104Mouse
1357782Char8_mP. chabaudi malaria resistance QTL 8 (mouse)Not determined113568778969794161Mouse
13208569Bmiq10_mbody mass index QTL 10 (mouse)113600000085000000Mouse
1301328Mol4_mmodifier of LPS-response 4 (mouse)Not determined113639175083590530Mouse
1301788Lbw8_mlupus NZB x NZW 8 (mouse)Not determined113661246070618665Mouse
1301896Tria1_mT-cell receptor induced activation 1 (mouse)Not determined113672273870723028Mouse
4141853Skmw17_mskeletal muscle weight 17 (mouse)Not determined113719011571190238Mouse
4142475Ity2a_mimmunity to S. typhimurium 2a (mouse)Not determined113787775360511890Mouse
10766457Nwa3_mNew Zealand White autoimmunity 3 (mouse)113812528972125383Mouse
1300569Eae6b_msusceptibility to experimental allergic encephalomyelitis 6b (mouse)Not determined114005990154203622Mouse
10053675Eae44b_mexperimental allergic encephalomyelitis susceptibility 44b (mouse)Not determined114005990154203622Mouse
11532698Sluc36a_msusceptibility to lung cancer 36a (mouse)114236579176365904Mouse
11532699Sluc36b_msusceptibility to lung cancer 36b (mouse)114236579176365904Mouse
1300713Vmbic10_mventral midbrain iron content 10 (mouse)Not determined114288179954190238Mouse

miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Notch1mmu-miR-146a-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI21730286
Ifngmmu-miR-146a-5pMirtarbaseexternal_infoWestern blotFunctional MTI18791161
Irak2mmu-miR-146a-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI19596990
Irak1mmu-miR-146a-5pMirtarbaseexternal_infoWestern blotFunctional MTI19596990
Irak1mmu-miR-146a-5pMirtarbaseexternal_infoImmunoblot//Luciferase reporter assay//qRT-PCR//WeFunctional MTI20850013
Med1mmu-miR-146a-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23221399
Wasf2mmu-miR-146a-5pOncomiRDBexternal_infoNANA23435376
Card10mmu-miR-146a-5pOncomiRDBexternal_infoNANA22992343
L1cammmu-miR-146a-5pOncomiRDBexternal_infoNANA22711166
Mmp16mmu-miR-146a-5pOncomiRDBexternal_infoNANA22348245
Traf2mmu-miR-146a-5pOncomiRDBexternal_infoNANA22167321
Smad4mmu-miR-146a-5pOncomiRDBexternal_infoNANA22020746
Notch1mmu-miR-146a-5pOncomiRDBexternal_infoNANA21730286
Egfrmmu-miR-146a-5pOncomiRDBexternal_infoNANA21632853
Brca1mmu-miR-146a-5pOncomiRDBexternal_infoNANA21472990
Thrbmmu-miR-146a-5pOncomiRDBexternal_infoNANA21159845
Smad4mmu-miR-146a-5pOncomiRDBexternal_infoNANA20577838
Cxcr4mmu-miR-146a-5pOncomiRDBexternal_infoNANA20023696
Irak1mmu-miR-146a-3pMirecordsexternal_infoNANA18791161
Irak2mmu-miR-146a-3pMirecordsexternal_info{changed}NA19596990
Fasmmu-miR-146a-3pMirecordsexternal_infoNANA20656888
Egfrmmu-miR-146a-5pOncomiRDBexternal_infoNANA22161865

Predicted Targets
Summary Value
Count of predictions:21623
Count of gene targets:8644
Count of transcripts:14011
Interacting mature miRNAs:mmu-miR-146a-3p, mmu-miR-146a-5p
Prediction methods:Microtar, Miranda, Pita, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000083667
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1143,374,397 - 43,374,461 (-)Ensembl
RefSeq Acc Id: NR_029558
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391143,265,224 - 43,265,288 (-)NCBI
GRCm381143,374,397 - 43,374,461 (-)ENTREZGENE
MGSCv371143,187,899 - 43,187,963 (-)RGD
Celera1148,002,809 - 48,002,873 (-)RGD
cM Map11 ENTREZGENE
Sequence:
Promoters
RGD ID:8674334
Promoter ID:EPDNEW_M15198
Type:single initiation site
Name:Mir146_1
Description:Mus musculus microRNA 146 , microRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381143,374,396 - 43,374,456EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2676831 AgrOrtholog
Ensembl Genes ENSMUSG00000065601 Ensembl, ENTREZGENE
Ensembl Transcript ENSMUST00000083667 ENTREZGENE
MGD MGI:2676831 ENTREZGENE
miRBase MI0000170 ENTREZGENE
NCBI Gene 387164 ENTREZGENE
PhenoGen Mir146 PhenoGen
RNAcentral URS0000121576 RNACentral
  URS000050B527 RNACentral
  URS000075DF9E RNACentral