Tab2 (TGF-beta activated kinase 1/MAP3K7 binding protein 2) - Rat Genome Database

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Gene: Tab2 (TGF-beta activated kinase 1/MAP3K7 binding protein 2) Rattus norvegicus
Analyze
Symbol: Tab2
Name: TGF-beta activated kinase 1/MAP3K7 binding protein 2
RGD ID: 1309527
Description: Predicted to enable K63-linked polyubiquitin modification-dependent protein binding activity and zinc ion binding activity. Predicted to be involved in several processes, including positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of protein kinase activity; and response to lipopolysaccharide. Predicted to be located in cytosol; endosome membrane; and lysosomal membrane. Orthologous to human TAB2 (TGF-beta activated kinase 1 (MAP3K7) binding protein 2); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; interleukin-1 signaling pathway; nuclear factor kappa B signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; C60 fullerene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC308267; Map3k7ip2; mitogen-activated protein kinase kinase kinase 7 interacting protein 2; mitogen-activated protein kinase kinase kinase 7-interacting protein 2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2; TGF-beta-activated kinase 1-binding protein 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.212,375,026 - 2,424,759 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl12,375,490 - 2,424,756 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx12,024,841 - 2,074,950 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.018,025,244 - 8,075,354 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.012,306,955 - 2,357,065 (-)NCBIRnor_WKY
Rnor_6.011,999,574 - 2,017,574 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl11,999,596 - 2,073,896 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013,695,737 - 3,770,496 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.412,568,536 - 2,617,742 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.112,568,544 - 2,617,742 (-)NCBI
Celera1924,327 - 972,936 (-)NCBICelera
Cytogenetic Map1p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. TLR-signaling networks: an integration of adaptor molecules, kinases, and cross-talk. Brown J, etal., J Dent Res. 2011 Apr;90(4):417-27. Epub 2010 Oct 12.
2. Protein molecular modeling techniques investigating novel TAB2 variant R347X causing cardiomyopathy and congenital heart defects in multigenerational family. Caulfield TR, etal., Mol Genet Genomic Med. 2018 Apr 26. doi: 10.1002/mgg3.401.
3. 6q25.1 (TAB2) microdeletion syndrome: Congenital heart defects and cardiomyopathy. Cheng A, etal., Am J Med Genet A. 2017 Jul;173(7):1848-1857. doi: 10.1002/ajmg.a.38254. Epub 2017 May 2.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Circular RNA WHSC1 exerts oncogenic properties by regulating miR-7/TAB2 in lung cancer. Guan S, etal., J Cell Mol Med. 2021 Oct;25(20):9784-9795. doi: 10.1111/jcmm.16925. Epub 2021 Sep 22.
7. Associations between TAB2 Gene Polymorphisms and Epithelial Ovarian Cancer in a Chinese Population. Huang X, etal., Dis Markers. 2019 Aug 14;2019:8012979. doi: 10.1155/2019/8012979. eCollection 2019.
8. The ubiquitin E3 ligase TRAF6 exacerbates pathological cardiac hypertrophy via TAK1-dependent signalling. Ji YX, etal., Nat Commun. 2016 Jun 1;7:11267. doi: 10.1038/ncomms11267.
9. microRNA-149-5p mediates the PM2.5-induced inflammatory response by targeting TAB2 via MAPK and NF-κB signaling pathways in vivo and in vitro. Li Q, etal., Cell Biol Toxicol. 2021 Jul 31. pii: 10.1007/s10565-021-09638-5. doi: 10.1007/s10565-021-09638-5.
10. Expanding role of ubiquitination in NF-kappaB signaling. Liu S and Chen ZJ, Cell Res. 2011 Jan;21(1):6-21. Epub 2010 Dec 7.
11. NUMBL interacts with TAB2 and inhibits TNFalpha and IL-1beta-induced NF-kappaB activation. Ma Q, etal., Cell Signal. 2008 Jun;20(6):1044-51. Epub 2008 Jan 31.
12. TAK1 kinase signaling regulates embryonic angiogenesis by modulating endothelial cell survival and migration. Morioka S, etal., Blood. 2012 Nov 1;120(18):3846-57. doi: 10.1182/blood-2012-03-416198. Epub 2012 Sep 12.
13. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
14. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Comprehensive gene review and curation RGD comprehensive gene curation
18. In vivo therapeutic success of MicroRNA-155 antagomir in a mouse model of pulmonary fibrosis induced by bleomycin. Sun X, etal., Korean J Intern Med. 2021 Mar;36(Suppl 1):S160-S169. doi: 10.3904/kjim.2019.098. Epub 2020 Jun 9.
19. Haploinsufficiency of TAB2 causes congenital heart defects in humans. Thienpont B, etal., Am J Hum Genet. 2010 Jun 11;86(6):839-49. doi: 10.1016/j.ajhg.2010.04.011. Epub 2010 May 20.
20. TLR-4, IL-1R and TNF-R signaling to NF-kappaB: variations on a common theme. Verstrepen L, etal., Cell Mol Life Sci. 2008 Oct;65(19):2964-78.
21. Interleukin-1 (IL-1) pathway. Weber A, etal., Sci Signal. 2010 Jan 19;3(105):cm1. doi: 10.1126/scisignal.3105cm1.
22. Assigning pathogenicity for TAB2 variants using a novel scalable functional assay and expanding TAB2 disease spectrum. Xu W, etal.
23. TAB2 deficiency induces dilated cardiomyopathy by promoting RIPK1-dependent apoptosis and necroptosis. Yin H, etal., J Clin Invest. 2022 Feb 15;132(4). pii: 152297. doi: 10.1172/JCI152297.
24. The microRNA miR-23b suppresses IL-17-associated autoimmune inflammation by targeting TAB2, TAB3 and IKK-α. Zhu S, etal., Nat Med. 2012 Jul;18(7):1077-86. doi: 10.1038/nm.2815.
Additional References at PubMed
PMID:11460167   PMID:12477932   PMID:12761501   PMID:15489334   PMID:19193853   PMID:19935683   PMID:35982795   PMID:36322021  


Genomics

Comparative Map Data
Tab2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.212,375,026 - 2,424,759 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl12,375,490 - 2,424,756 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx12,024,841 - 2,074,950 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.018,025,244 - 8,075,354 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.012,306,955 - 2,357,065 (-)NCBIRnor_WKY
Rnor_6.011,999,574 - 2,017,574 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl11,999,596 - 2,073,896 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013,695,737 - 3,770,496 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.412,568,536 - 2,617,742 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.112,568,544 - 2,617,742 (-)NCBI
Celera1924,327 - 972,936 (-)NCBICelera
Cytogenetic Map1p13NCBI
TAB2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386149,217,926 - 149,411,607 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl6149,218,641 - 149,411,613 (+)EnsemblGRCh38hg38GRCh38
GRCh376149,539,062 - 149,732,743 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366149,680,756 - 149,774,440 (+)NCBINCBI36Build 36hg18NCBI36
Build 346149,680,755 - 149,774,440NCBI
Celera6150,374,542 - 150,467,843 (+)NCBICelera
Cytogenetic Map6q25.1NCBI
HuRef6147,206,396 - 147,299,504 (+)NCBIHuRef
CHM1_16149,904,215 - 149,997,498 (+)NCBICHM1_1
T2T-CHM13v2.06150,417,736 - 150,611,453 (+)NCBIT2T-CHM13v2.0
Tab2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39107,781,412 - 7,832,039 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl107,781,417 - 7,831,994 (-)EnsemblGRCm39 Ensembl
GRCm38107,905,648 - 7,956,255 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl107,905,653 - 7,956,230 (-)EnsemblGRCm38mm10GRCm38
MGSCv37107,625,446 - 7,675,921 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36107,596,328 - 7,615,052 (-)NCBIMGSCv36mm8
Celera107,785,153 - 7,804,378 (-)NCBICelera
Cytogenetic Map10A1NCBI
Tab2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543911,826,469 - 11,903,103 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543911,826,469 - 11,903,103 (-)NCBIChiLan1.0ChiLan1.0
TAB2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.16151,868,513 - 151,936,841 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6151,868,513 - 151,936,841 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v06147,138,553 - 147,231,559 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
TAB2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1140,125,842 - 40,216,455 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl140,149,569 - 40,215,385 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha140,963,295 - 41,053,932 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0140,305,492 - 40,396,387 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl140,326,467 - 40,396,378 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1140,182,019 - 40,272,887 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0140,047,126 - 40,137,980 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0140,387,856 - 40,478,641 (+)NCBIUU_Cfam_GSD_1.0
Tab2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946135,120,261 - 135,169,883 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364892,372,216 - 2,424,515 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049364892,371,953 - 2,421,882 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TAB2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl116,533,285 - 16,611,884 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1116,533,364 - 16,611,879 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2118,852,316 - 18,930,145 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TAB2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11322,234,736 - 22,312,985 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1322,234,012 - 22,282,562 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040198,258,272 - 198,349,280 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tab2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247858,690,039 - 8,747,160 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tab2
179 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:786
Count of miRNA genes:289
Interacting mature miRNAs:358
Transcripts:ENSRNOT00000021905, ENSRNOT00000061999
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354647Despr8Despair related QTL 80.0000341locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1124744506Rat
2298546Neuinf4Neuroinflammation QTL 45.1nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1128736750Rat
2313053Bss51Bone structure and strength QTL 513.80.0001tibia length (VT:0004357)tibia length (CMO:0000450)1132356093Rat
2313070Bss52Bone structure and strength QTL 524.40.0001body length (VT:0001256)body length (CMO:0000013)1132356093Rat
2313090Bmd69Bone mineral density QTL 694.40.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)1132356093Rat
738020Pia8Pristane induced arthritis QTL 84.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1165833076Rat
1578650Bmd6Bone mineral density QTL 612.2femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)150910843284926Rat
1578651Bmd7Bone mineral density QTL 714.2femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)150910843284926Rat
1578669Bss9Bone structure and strength QTL 96.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)150910843284926Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
1600360Mcs16Mammary carcinoma susceptibility QTL 162.4mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1224439043433040Rat

Markers in Region
RH131330  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.212,375,247 - 2,375,432 (+)MAPPERmRatBN7.2
Rnor_6.011,999,344 - 1,999,528NCBIRnor6.0
Rnor_5.013,695,959 - 3,696,143UniSTSRnor5.0
RGSC_v3.412,568,306 - 2,568,490UniSTSRGSC3.4
Celera1924,097 - 924,281UniSTS
Cytogenetic Map1p13UniSTS
STS-T59224  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.212,388,872 - 2,389,060 (+)MAPPERmRatBN7.2
Rnor_6.012,012,969 - 2,013,156NCBIRnor6.0
Rnor_5.013,709,584 - 3,709,771UniSTSRnor5.0
RGSC_v3.412,581,931 - 2,582,118UniSTSRGSC3.4
Celera1937,722 - 937,909UniSTS
Cytogenetic Map1p13UniSTS
RH139417  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.212,375,570 - 2,375,784 (+)MAPPERmRatBN7.2
Rnor_6.011,999,667 - 1,999,880NCBIRnor6.0
Rnor_5.013,696,282 - 3,696,495UniSTSRnor5.0
RGSC_v3.412,568,629 - 2,568,842UniSTSRGSC3.4
Celera1924,420 - 924,633UniSTS
Cytogenetic Map1p13UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 39 11 8
Low 2
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000021905   ⟹   ENSRNOP00000021904
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl12,375,490 - 2,424,756 (-)Ensembl
Rnor_6.0 Ensembl12,000,923 - 2,017,488 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000061999   ⟹   ENSRNOP00000058709
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl12,375,490 - 2,424,756 (-)Ensembl
Rnor_6.0 Ensembl11,999,596 - 2,073,896 (-)Ensembl
RefSeq Acc Id: NM_001012062   ⟹   NP_001012062
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.212,375,478 - 2,424,756 (-)NCBI
Rnor_6.011,999,574 - 2,017,574 (-)NCBI
Rnor_5.013,695,737 - 3,770,496 (-)NCBI
RGSC_v3.412,568,536 - 2,617,742 (-)RGD
Celera1924,327 - 972,936 (-)RGD
Sequence:
RefSeq Acc Id: XM_039110915   ⟹   XP_038966843
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.212,383,696 - 2,424,759 (-)NCBI
RefSeq Acc Id: XM_039110917   ⟹   XP_038966845
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.212,383,696 - 2,424,747 (-)NCBI
RefSeq Acc Id: XM_039110919   ⟹   XP_038966847
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.212,383,696 - 2,424,756 (-)NCBI
RefSeq Acc Id: XM_039110921   ⟹   XP_038966849
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.212,383,696 - 2,424,756 (-)NCBI
RefSeq Acc Id: XM_039110922   ⟹   XP_038966850
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.212,375,026 - 2,424,759 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_001012062   ⟸   NM_001012062
- Sequence:
RefSeq Acc Id: ENSRNOP00000021904   ⟸   ENSRNOT00000021905
RefSeq Acc Id: ENSRNOP00000058709   ⟸   ENSRNOT00000061999
RefSeq Acc Id: XP_038966850   ⟸   XM_039110922
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038966843   ⟸   XM_039110915
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038966849   ⟸   XM_039110921
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038966847   ⟸   XM_039110919
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038966845   ⟸   XM_039110917
- Peptide Label: isoform X1
Protein Domains
CUE

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5U303-F1-model_v2 AlphaFold Q5U303 1-693 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309527 AgrOrtholog
BioCyc Gene G2FUF-62443 BioCyc
Ensembl Genes ENSRNOG00000016054 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000021904 ENTREZGENE
  ENSRNOP00000021904.3 UniProtKB/Swiss-Prot
  ENSRNOP00000058709.2 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000021905 ENTREZGENE
  ENSRNOT00000021905.7 UniProtKB/Swiss-Prot
  ENSRNOT00000061999.6 UniProtKB/Swiss-Prot
Gene3D-CATH DNA helicase RuvA subunit, C-terminal domain UniProtKB/Swiss-Prot
  Zn-finger domain of Sec23/24 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7108689 IMAGE-MGC_LOAD
InterPro CUE UniProtKB/Swiss-Prot
  TAB2/3_CUE UniProtKB/Swiss-Prot
  Znf_RanBP2 UniProtKB/Swiss-Prot
  Znf_RanBP2_sf UniProtKB/Swiss-Prot
KEGG Report rno:308267 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93764 IMAGE-MGC_LOAD
NCBI Gene 308267 ENTREZGENE
PANTHER TGF-BETA-ACTIVATED KINASE 1 AND MAP3K7-BINDING PROTEIN 2 UniProtKB/Swiss-Prot
  TGF-BETA-ACTIVATED KINASE 1 AND MAP3K7-BINDING PROTEIN TAB UniProtKB/Swiss-Prot
Pfam CUE UniProtKB/Swiss-Prot
PhenoGen Tab2 PhenoGen
PROSITE CUE UniProtKB/Swiss-Prot
  ZF_RANBP2_1 UniProtKB/Swiss-Prot
  ZF_RANBP2_2 UniProtKB/Swiss-Prot
SMART CUE UniProtKB/Swiss-Prot
  ZnF_RBZ UniProtKB/Swiss-Prot
Superfamily-SCOP SSF90209 UniProtKB/Swiss-Prot
UniProt Q5U303 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-02 Tab2  TGF-beta activated kinase 1/MAP3K7 binding protein 2  Map3k7ip2  mitogen-activated protein kinase kinase kinase 7 interacting protein 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Map3k7ip2  mitogen-activated protein kinase kinase kinase 7 interacting protein 2  Map3k7ip2_predicted  mitogen-activated protein kinase kinase kinase 7 interacting protein 2 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Map3k7ip2_predicted  mitogen-activated protein kinase kinase kinase 7 interacting protein 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED