RGD Reference Report - Cytokine profiles in aqueous humor of patients with different clinical entities of endogenous uveitis. - Rat Genome Database

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Cytokine profiles in aqueous humor of patients with different clinical entities of endogenous uveitis.

Authors: El-Asrar, AM  Struyf, S  Kangave, D  Al-Obeidan, SS  Opdenakker, G  Geboes, K  Van Damme, J 
Citation: El-Asrar AM, etal., Clin Immunol. 2011 May;139(2):177-84. doi: 10.1016/j.clim.2011.01.014. Epub 2011 Jan 31.
RGD ID: 8142356
Pubmed: (View Article at PubMed) PMID:21334264
DOI: Full-text: DOI:10.1016/j.clim.2011.01.014

We assayed aqueous humor (AH) samples from patients with Behcet's disease (BD), Vogt-Koyanagi-Harada (VKH) disease, and HLA-B27-associated uveitis and control patients for the proinflammatory cytokines IL-15, IL-17, interferon-gamma and tumor necrosis factor-alpha and the immunosuppressive cytokine IL-10. Cytokine levels were significantly higher in the three disease groups than in controls. In patients with similar disease activity, levels of IL-15 and IFN-gamma were significantly higher in BD patients than in VKH and HLA-B27-associated uveitis groups. Logistic regression identified a significant negative correlation between BD and high levels of IL-10 and a significant positive correlation between VKH disease and high levels of IL-10. The proinflammatory cytokines versus IL-10 ratios were significantly higher in BD compared with other groups. These data suggest that both T helper (Th) 1 and Th17 cells are involved in endogenous uveitis immunopathogenesis. BD is characterized by extensive Th1 polarization, severe proinflammatory conditions and a low immunosuppressive status.

Annotation

Disease Annotations    

Objects Annotated

Genes (Rattus norvegicus)
Ifng  (interferon gamma)
Tnf  (tumor necrosis factor)

Genes (Mus musculus)
Ifng  (interferon gamma)
Tnf  (tumor necrosis factor)

Genes (Homo sapiens)
IFNG  (interferon gamma)
TNF  (tumor necrosis factor)


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