RGD Reference Report - Sensorineural hearing loss in patients with mixed connective tissue disease: immunological markers and cytokine levels. - Rat Genome Database

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Sensorineural hearing loss in patients with mixed connective tissue disease: immunological markers and cytokine levels.

Authors: Hajas, A  Szodoray, P  Barath, S  Sipka, S  Rezes, S  Zeher, M  Sziklai, I  Szegedi, G  Bodolay, E 
Citation: Hajas A, etal., J Rheumatol. 2009 Sep;36(9):1930-6. doi: 10.3899/jrheum.081314. Epub 2009 Aug 14.
RGD ID: 8142347
Pubmed: PMID:19684145   (View Abstract at PubMed)
DOI: DOI:10.3899/jrheum.081314   (Journal Full-text)

OBJECTIVE: To investigate the frequency of sensorineural hearing loss (SNHL) in patients with mixed connective tissue disease (MCTD). METHODS: The study population consisted of 71 patients with MCTD (69 female; 2 male), with a mean age of 57.1 +/- 7.9 years and a mean disease duration of 14.5 +/- 8.0 years. All patients underwent audiological evaluation that included pure tone and speech audiometry. In addition, the systemic manifestations of the disease and drug therapy were recorded. All patients were tested for presence of autoantibodies. Fifty-one age-matched healthy subjects served as controls. RESULTS: SNHL was found in 33 (46.4%) of the 71 patients with MCTD. There was no correlation between SNHL and age and disease duration. An association was found between Raynaud's phenomenon (p < 0.03), secondary antiphospholipid syndrome (APS) (p < 0.05), and SNHL. MCTD patients with SNHL had higher serum levels of anti-U1RNP (p < 0.05), antiendothelial cell antibodies (p < 0.001), and IgG type anticardiolipin antibodies (p < 0.0001) than patients without SNHL. Serum levels of interferon-gamma and tumor necrosis factor-alpha were increased in MCTD patients with SNHL compared to patients without SNHL. The absolute number of natural (CD4+CD25(high)FoxP+) regulatory T cells (Treg) was lower compared to patients without SNHL. CONCLUSION: In MCTD, SNHL is a specific organ manifestation and appears frequently. We have found that pathogenic autoantibodies, decreased levels of regulatory T cells, and overexpression of proinflammatory cytokines may play a role in the pathogenesis of immune mediated inner ear disorders in MCTD.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
IFNGHumanmixed connective tissue disease  IEP protein:increased expression:serum:RGD 
IfngMousemixed connective tissue disease  ISOIFNG (Homo sapiens)protein:increased expression:serum:RGD 
IfngRatmixed connective tissue disease  ISOIFNG (Homo sapiens)protein:increased expression:serum:RGD 
TNFHumanmixed connective tissue disease  IEP protein:increased expression:serum:RGD 
TnfRatmixed connective tissue disease  ISOTNF (Homo sapiens)protein:increased expression:serum:RGD 
TnfMousemixed connective tissue disease  ISOTNF (Homo sapiens)protein:increased expression:serum:RGD 
IFNGHumansensorineural hearing loss  IEP associated with Hearing Loss more ...RGD 
IfngRatsensorineural hearing loss  ISOIFNG (Homo sapiens)associated with Hearing Loss more ...RGD 
IfngMousesensorineural hearing loss  ISOIFNG (Homo sapiens)associated with Hearing Loss more ...RGD 
TNFHumansensorineural hearing loss  IEP associated with Hearing Loss more ...RGD 
TnfRatsensorineural hearing loss  ISOTNF (Homo sapiens)associated with Hearing Loss more ...RGD 
TnfMousesensorineural hearing loss  ISOTNF (Homo sapiens)associated with Hearing Loss more ...RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ifng  (interferon gamma)
Tnf  (tumor necrosis factor)

Genes (Mus musculus)
Ifng  (interferon gamma)
Tnf  (tumor necrosis factor)

Genes (Homo sapiens)
IFNG  (interferon gamma)
TNF  (tumor necrosis factor)


Additional Information