RGD Reference Report - TNF-alpha gene polymorphism and TNF-alpha levels in obese Asian Indians with obstructive sleep apnea. - Rat Genome Database

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TNF-alpha gene polymorphism and TNF-alpha levels in obese Asian Indians with obstructive sleep apnea.

Authors: Bhushan, B  Guleria, R  Misra, A  Luthra, K  Vikram, NK 
Citation: Bhushan B, etal., Respir Med. 2009 Mar;103(3):386-92. Epub 2008 Nov 20.
RGD ID: 4143442
Pubmed: PMID:19022640   (View Abstract at PubMed)
DOI: DOI:10.1016/j.rmed.2008.10.001   (Journal Full-text)

BACKGROUND: Obstructive sleep apnea (OSA) is emerging as a significant disorder in India. Tumor necrosis factor-alpha (TNFalpha) is an important marker of inflammation. Recent data indicate that inflammation may be an important correlate of OSA. The relationships of OSA with TNFalpha levels and TNFalpha gene promoter polymorphism (-308G/A) have not been investigated in obese Asian Indians with OSA. OBJECTIVE: To look for the correlation if any, between TNFalpha gene promoter polymorphism (-308G/A) in obese Asian Indians with and without OSA and correlation of TNFalpha levels with severity of OSA. METHODS AND RESULTS: We studied 207 obese (BMI>25kg/m(2)) subjects; 104 with OSA and 103 without OSA. Both groups were matched for age, body mass index (BMI) and percentage body fat (%BF). Measurements included anthropometric and biochemical (fasting blood glucose, lipid profile and serum TNFalpha levels) parameters and TNFalpha gene promoter polymorphism (-308G/A). The frequency of '-308A'allele in TNFalpha gene was significantly higher in obese subjects with OSA (28.8%; 60/208), when compared with obese subjects without OSA (12.6%; 26/206, p=0.001). Serum TNFalpha levels were significantly higher in obese subjects with OSA [(3.6+/-0.8)pg/ml], when compared with obese subjects without OSA [(3.3+/-0.6)pg/ml, p=0.009]. CONCLUSIONS: Frequency of TNFalpha (-308A) allele and serum TNFalpha level was significantly higher in obese Asian Indians with OSA.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
TNFHumanobstructive sleep apnea susceptibilityIAGP DNA:polymorphism:promoter: c.-308G>A (human)RGD 
TnfRatobstructive sleep apnea susceptibilityISOTNF (Homo sapiens)DNA:polymorphism:promoter: c.-308G>A (human)RGD 
TnfMouseobstructive sleep apnea susceptibilityISOTNF (Homo sapiens)DNA:polymorphism:promoter: c.-308G>A (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Tnf  (tumor necrosis factor)

Genes (Mus musculus)
Tnf  (tumor necrosis factor)

Genes (Homo sapiens)
TNF  (tumor necrosis factor)


Additional Information