RGD Reference Report - Triptolide inhibits amyloid-beta1-42-induced TNF-alpha and IL-1beta production in cultured rat microglia. - Rat Genome Database

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Triptolide inhibits amyloid-beta1-42-induced TNF-alpha and IL-1beta production in cultured rat microglia.

Authors: Jiao, Jian  Xue, Bing  Zhang, Lei  Gong, Yuntao  Li, Kairong  Wang, Haomin  Jing, Liming  Xie, Junxia  Wang, Xiaomin 
Citation: Jiao J, etal., J Neuroimmunol. 2008 Dec 15;205(1-2):32-6. doi: 10.1016/j.jneuroim.2008.08.006. Epub 2008 Nov 12.
RGD ID: 13825252
Pubmed: PMID:19004508   (View Abstract at PubMed)
DOI: DOI:10.1016/j.jneuroim.2008.08.006   (Journal Full-text)

Microglia plays an important role in mediating neuroinflammation in Alzheimer's disease (AD). Intervention in microglia activation may exert a neuroprotective effect. In the present study, we reported that oligomeric Abeta1-42 dramatically increased the level of tumor necrosis factor (TNF)-alpha and interleukin (IL)-1beta compared to monomeric and fibrillar Abeta1-42 in rat microglial cultures. Pretreatment of the cultures with triptolide, an anti-inflammatory reagent, alleviated the elevation of TNF-alpha and IL-1beta level induced by oligomeric Abeta1-42. Our results showed that oligomeric Abeta played an important role in mediating neuroinflammation and triptolide was able to suppress the production of pro-inflammatory cytokines from microglia.




Biological Process

  
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Original Reference(s)
TnfRatcellular response to amyloid-beta  IEP  RGD 


Genes (Rattus norvegicus)
Tnf  (tumor necrosis factor)