Tnf (tumor necrosis factor) - Rat Genome Database

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Gene: Tnf (tumor necrosis factor) Chinchilla lanigera
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Symbol: Tnf
Name: tumor necrosis factor
RGD ID: 8789275
Description: ENCODES a protein that exhibits cytokine activity (ortholog); death receptor agonist activity (ortholog); histone H3K9ac reader activity (ortholog); INVOLVED IN animal organ morphogenesis (ortholog); antiviral innate immune response (ortholog); apoptotic signaling pathway (ortholog); PARTICIPATES IN ceramide signaling pathway; Fc epsilon receptor mediated signaling pathway; interleukin-23 signaling pathway; ASSOCIATED WITH otitis media; Streptococcal Infections; acne (ortholog); FOUND IN cell surface (ortholog); external side of plasma membrane (ortholog); extracellular region (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: TNF-alpha
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955437117,206 - 120,700 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955437117,267 - 119,899 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acne  (ISO)
acquired immunodeficiency syndrome  (ISO)
Acute Coronary Syndrome  (ISO)
Acute Experimental Pancreatitis  (ISO)
Acute Hepatitis  (ISO)
acute kidney failure  (ISO)
Acute Liver Failure  (ISO)
Acute Lung Injury  (ISO)
acute myocardial infarction  (ISO)
adenocarcinoma  (ISO)
adult respiratory distress syndrome  (ISO)
Aggressive Fibromatosis  (ISO)
Albuminuria  (ISO)
alcohol use disorder  (ISO)
alcoholic gastritis  (ISO)
alcoholic hepatitis  (ISO)
alcoholic liver cirrhosis  (ISO)
Alcoholic Liver Diseases  (ISO)
allergic bronchopulmonary aspergillosis  (ISO)
allergic contact dermatitis  (ISO)
allergic disease  (ISO)
Alveolar Bone Loss  (ISO)
Alzheimer's disease  (ISO)
Amebic Liver Abscess  (ISO)
amyloidosis  (ISO)
amyotrophic lateral sclerosis  (ISO)
amyotrophic lateral sclerosis type 1  (ISO)
anemia  (ISO)
Animal Disease Models  (ISO)
anogenital venereal wart  (ISO)
Anorexia  (ISO)
anterior uveitis  (ISO)
anthracosis  (ISO)
anthrax disease  (ISO)
anti-basement membrane glomerulonephritis  (ISO)
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis  (ISO)
anxiety disorder  (ISO)
aortic valve stenosis  (ISO)
aplastic anemia  (ISO)
Arsenic Poisoning  (ISO)
asbestosis  (ISO)
aspiration pneumonia  (ISO)
asthma  (ISO)
atherosclerosis  (ISO)
atopic dermatitis  (ISO)
atrial fibrillation  (ISO)
autistic disorder  (ISO)
autoimmune hepatitis  (ISO)
autoimmune thyroiditis  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
bacterial pneumonia  (ISO)
Behcet's disease  (ISO)
berylliosis  (ISO)
beta thalassemia  (ISO)
bilirubin metabolic disorder  (ISO)
Binge Drinking  (ISO)
Brain Contusion  (ISO)
brain edema  (ISO)
brain infarction  (ISO)
Brain Injuries  (ISO)
brain ischemia  (ISO)
breast adenocarcinoma  (ISO)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
Bronchial Hyperreactivity  (ISO)
bronchiectasis  (ISO)
bronchopulmonary dysplasia  (ISO)
Burns  (ISO)
Cachexia  (ISO)
calcinosis  (ISO)
Carbon Tetrachloride Poisoning  (ISO)
cardiac arrest  (ISO)
Cardiomegaly  (ISO)
cardiomyopathy  (ISO)
Cardiotoxicity  (ISO)
Cardiovascular Pregnancy Complications  (ISO)
Cardiovirus Infections  (ISO)
Cerebral Hemorrhage  (ISO)
cerebral infarction  (ISO)
cervical cancer  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Chemically-Induced Disorders  (ISO)
chlamydia  (ISO)
cholestasis  (ISO)
cholesteatoma of middle ear  (ISO)
chorioamnionitis  (ISO)
Chronic Allograft Dysfunction  (ISO)
Chronic Hepatitis C  (ISO)
Chronic Intermittent Hypoxia  (ISO)
chronic obstructive pulmonary disease  (ISO)
cicatricial pemphigoid  (ISO)
cochlear disease  (ISO)
colitis  (ISO)
Colonic Neoplasms  (ISO)
Colorectal Neoplasms  (ISO)
congenital diaphragmatic hernia  (ISO)
congestive heart failure  (ISO)
Cor pulmonale  (ISO)
corneal ulcer  (ISO)
coronary artery disease  (ISO)
coronary restenosis  (ISO)
Coronavirus infectious disease  (ISO)
Cough  (ISO)
COVID-19  (ISO)
Coxsackievirus Infections  (ISO)
Crohn's disease  (ISO)
cryoglobulinemia  (ISO)
cutaneous leishmaniasis  (ISO)
cystic fibrosis  (ISO)
cystitis  (ISO)
Cytomegalovirus Infections  (ISO)
cytomegalovirus retinitis  (ISO)
degenerative disc disease  (ISO)
demyelinating disease  (ISO)
dermatitis  (ISO)
dermatitis herpetiformis  (ISO)
dermatomyositis  (ISO)
diabetic angiopathy  (ISO)
Diabetic Cardiomyopathies  (ISO)
Diabetic Nephropathies  (ISO)
diabetic neuropathy  (ISO)
diabetic retinopathy  (ISO)
Diaphragmatic Hernia  (ISO)
dilated cardiomyopathy  (ISO)
dilated cardiomyopathy 1H  (ISO)
disease by infectious agent  (ISO)
Disease Progression  (ISO)
disseminated intravascular coagulation  (ISO)
drug allergy  (ISO)
Drug Eruptions  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
dry eye syndrome  (ISO)
Eales Disease  (ISO)
Edema  (ISO)
Emphysema  (ISO)
encephalitis  (ISO)
encephalomyelitis  (ISO)
end stage renal disease  (ISO)
endometriosis  (ISO)
endophthalmitis  (ISO)
Endotoxemia  (ISO)
epididymitis  (ISO)
epilepsy  (ISO)
erythema nodosum  (ISO)
Escherichia Coli Infections  (ISO)
esophagitis  (ISO)
essential hypertension  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Neuritis  (ISO)
Experimental Colitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Liver Neoplasms  (ISO)
Experimental Mammary Neoplasms  (ISO)
Experimental Neoplasms  (ISO)
Experimental Radiation Injuries  (ISO)
Experimental Seizures  (ISO)
extrahepatic cholestasis  (ISO)
extrinsic allergic alveolitis  (ISO)
eye disease  (ISO)
Fanconi anemia  (ISO)
farmer's lung  (ISO)
Fever  (ISO)
Fibrosis  (ISO)
focal segmental glomerulosclerosis  (ISO)
Fungal Lung Diseases  (ISO)
gastric ulcer  (ISO)
gastritis  (ISO)
Gaucher's disease  (ISO)
glaucoma  (ISO)
glomerulonephritis  (ISO)
Graves ophthalmopathy  (ISO)
Graves' disease  (ISO)
Hearing Loss  (ISO)
Hearing Loss, Noise-Induced  (ISO)
Heart Injuries  (ISO)
heart valve disease  (ISO)
Heat Stroke  (ISO)
hemochromatosis  (ISO)
hemolytic-uremic syndrome  (ISO)
Hemorrhagic Shock  (ISO)
hepatic encephalopathy  (ISO)
hepatitis  (ISO)
hepatitis A  (ISO)
hepatitis B  (ISO)
hepatocellular carcinoma  (ISO)
hepatopulmonary syndrome  (ISO)
hepatorenal syndrome  (ISO)
hereditary hemorrhagic telangiectasia  (ISO)
heroin dependence  (ISO)
herpes simplex virus keratitis  (ISO)
herpes zoster  (ISO)
hidradenitis suppurativa  (ISO)
high grade glioma  (ISO)
High-Frequency Hearing Loss  (ISO)
HIV Wasting Syndrome  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Human Influenza  (ISO)
Hyperalgesia  (ISO)
hypercalcemia  (ISO)
hyperhomocysteinemia  (ISO)
hyperinsulinism  (ISO)
Hyperoxia  (ISO)
hypertension  (ISO)
hypochromic microcytic anemia  (ISO)
hypoglycemia  (ISO)
Hypotension  (ISO)
Hypothermia  (ISO)
idiopathic pulmonary fibrosis  (ISO)
IgA glomerulonephritis  (ISO)
immunodeficiency 127  (ISO)
impotence  (ISO)
inclusion body myopathy with Paget disease of bone and frontotemporal dementia  (ISO)
Inflammation  (ISO)
inflammatory bowel disease  (ISO)
Insulin Resistance  (ISO)
intermediate uveitis  (ISO)
interstitial cystitis  (ISO)
Intervertebral Disc Displacement  (ISO)
Intestinal Reperfusion Injury  (ISO)
intracranial aneurysm  (ISO)
Intracranial Hemorrhages  (ISO)
intrahepatic cholestasis of pregnancy  (ISO)
iron deficiency anemia  (ISO)
Kawasaki disease  (ISO)
keratoconjunctivitis sicca  (ISO)
kidney disease  (ISO)
Kidney Reperfusion Injury  (ISO)
labyrinthitis  (ISO)
leishmaniasis  (ISO)
leprosy  (ISO)
listeriosis  (ISO)
liver cirrhosis  (ISO)
liver disease  (ISO)
Liver Injury  (ISO)
Liver Neoplasms  (ISO)
Liver Reperfusion Injury  (ISO)
localized scleroderma  (ISO)
low tension glaucoma  (ISO)
lung disease  (ISO)
Lung Injury  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
Lung Reperfusion Injury  (ISO)
lupus nephritis  (ISO)
lymphopenia  (ISO)
malaria  (ISO)
Manganese Poisoning  (ISO)
megacolon  (ISO)
melanoma  (ISO)
Meningeal Tuberculosis  (ISO)
metabolic dysfunction and alcohol associated liver disease  (ISO)
metabolic dysfunction-associated steatohepatitis  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
Metabolic Syndrome  (ISO)
mevalonic aciduria  (ISO)
Micronuclei, Chromosome-Defective  (ISO)
middle cerebral artery infarction  (ISO)
Middle East respiratory syndrome  (ISO)
migraine  (ISO)
migraine without aura  (ISO)
mitochondrial myopathy  (ISO)
mixed connective tissue disease  (ISO)
mucocutaneous leishmaniasis  (ISO)
mucopolysaccharidosis VI  (ISO)
multiple myeloma  (ISO)
Multiple Organ Failure  (ISO)
multiple sclerosis  (ISO)
muscular atrophy  (ISO)
muscular dystrophy  (ISO)
Mycobacterium avium complex disease  (ISO)
Mycoplasma pneumoniae pneumonia  (ISO)
myelodysplastic syndrome  (ISO)
myocardial infarction  (ISO)
Myocardial Ischemia  (ISO)
Myocardial Reperfusion Injury  (ISO)
myocardial stunning  (ISO)
myocarditis  (ISO)
myositis  (ISO)
Nasal Polyps  (ISO)
Nausea  (ISO)
Necrosis  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Nerve Degeneration  (ISO)
nervous system disease  (ISO)
Neuralgia  (ISO)
neuroblastoma  (ISO)
Neurogenic Inflammation  (ISO)
neutropenia  (ISO)
obesity  (ISO)
obstructive sleep apnea  (ISO)
occupational asthma  (ISO)
open-angle glaucoma  (ISO)
opiate withdrawal syndrome  (ISO)
oral squamous cell carcinoma  (ISO)
oral submucous fibrosis  (ISO)
Osteolysis  (ISO)
otitis media  (IEP)
Otitis Media with Effusion  (ISO)
ovarian cancer  (ISO)
Oxygen-Induced Retinopathy  (ISO)
Pain  (ISO)
Painful Neuropathy  (ISO)
pancreatic cancer  (ISO)
paracoccidioidomycosis  (ISO)
Parkinson's disease  (ISO)
Parkinsonism  (ISO)
Pediatric Crohn's Disease  (ISO)
Penetrating Wounds  (ISO)
peptic esophagitis  (ISO)
perinatal necrotizing enterocolitis  (ISO)
periodontitis  (ISO)
Peripheral Nerve Injuries  (ISO)
peritonitis  (ISO)
periventricular leukomalacia  (ISO)
Picornaviridae Infections  (ISO)
placenta disease  (ISO)
Plaque, Atherosclerotic  (ISO)
plasmacytoma  (ISO)
Plasmodium falciparum malaria  (ISO)
Pleural Effusion  (ISO)
pleurisy  (ISO)
Pneumococcal Meningitis  (ISO)
Pneumococcal Pneumonia  (ISO)
pneumonia  (ISO)
polymyositis  (ISO)
portal hypertension  (ISO)
Postmenopausal Osteoporosis  (ISO)
Postoperative Cognitive Dysfunction  (ISO)
pre-eclampsia  (ISO)
Pregnancy-Induced Hypertension  (ISO)
Premature Birth  (ISO)
Prenatal Exposure Delayed Effects  (ISO)
primary biliary cholangitis  (ISO)
Primary Graft Dysfunction  (ISO)
primary open angle glaucoma  (ISO)
primary sclerosing cholangitis  (ISO)
prostate cancer  (ISO)
proteasome-associated autoinflammatory syndrome 1  (ISO)
Pseudomonas Infections  (ISO)
psoriasis  (ISO)
psoriatic arthritis  (ISO)
pulmonary edema  (ISO)
pulmonary emphysema  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
pulmonary sarcoidosis  (ISO)
pulmonary tuberculosis  (ISO)
pustulosis of palm and sole  (ISO)
Radiation Pneumonitis  (ISO)
radiculopathy  (ISO)
Refractory Anemia  (ISO)
relapsing polychondritis  (ISO)
renal cell carcinoma  (ISO)
renal hypertension  (ISO)
Reperfusion Injury  (ISO)
respiratory allergy  (ISO)
respiratory syncytial virus infectious disease  (ISO)
respiratory system disease  (ISO)
Respiratory Tract Infections  (ISO)
Retina Reperfusion Injury  (ISO)
retinal artery occlusion  (ISO)
retinal detachment  (ISO)
retinal disease  (ISO)
rheumatoid arthritis  (ISO)
rhinitis  (ISO)
Rhinosinusitis  (ISO)
Right Ventricular Hypertrophy  (ISO)
root resorption  (ISO)
SAPHO syndrome  (ISO)
sarcoma  (ISO)
schizophrenia  (ISO)
sciatic neuropathy  (ISO)
scleritis  (ISO)
sensorineural hearing loss  (ISO)
Sepsis  (ISO)
septic arthritis  (ISO)
severe acute respiratory syndrome  (ISO)
Shock  (ISO)
sickle cell anemia  (ISO)
silicosis  (ISO)
Sjogren's syndrome  (ISO)
skin disease  (ISO)
small cell carcinoma  (ISO)
Soft Tissue Neoplasms  (ISO)
Spinal Cord Compression  (ISO)
Spinal Cord Injuries  (ISO)
Spine Osteoarthritis  (ISO)
spondyloarthropathy  (ISO)
Stable Angina  (ISO)
status epilepticus  (ISO)
steatotic liver disease  (ISO)
Stevens-Johnson syndrome  (ISO)
Stomach Neoplasms  (ISO)
Streptococcal Infections  (IEP)
Streptococcus pneumonia  (ISO)
stress-related disorder  (ISO)
Stroke  (ISO)
Subarachnoid Hemorrhage  (ISO)
Sudden Hearing Loss  (ISO)
Systemic Candidiasis  (ISO)
systemic lupus erythematosus  (ISO)
Tachycardia  (ISO)
Temporomandibular Joint Disorders  (ISO)
thalassemia  (ISO)
thrombocytopenia  (ISO)
thrombosis  (ISO)
Thyroid Neoplasms  (ISO)
Tinnitus  (ISO)
Tongue Neoplasms  (ISO)
toxic shock syndrome  (ISO)
trachoma  (ISO)
transient cerebral ischemia  (ISO)
transitional cell carcinoma  (ISO)
Transplant Rejection  (ISO)
traumatic brain injury  (ISO)
trichinosis  (ISO)
trigeminal neuralgia  (ISO)
tuberculosis  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
typhoid fever  (ISO)
ulcerative colitis  (ISO)
ureteral obstruction  (ISO)
urinary bladder cancer  (ISO)
urticaria  (ISO)
uveitis  (ISO)
vascular dementia  (ISO)
vascular disease  (ISO)
Vascular System Injuries  (ISO)
Venous Thromboembolism  (ISO)
Ventricular Dysfunction  (ISO)
Viral Bronchiolitis  (ISO)
viral pneumonia  (ISO)
visceral leishmaniasis  (ISO)
vitiligo  (ISO)
Vogt-Koyanagi-Harada disease  (ISO)
Vulvar Vestibulitis  (ISO)
Weight Gain  (ISO)
Weill-Marchesani syndrome  (ISO)
Wilson disease  (ISO)
Wounds and Injuries  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ morphogenesis  (ISO)
antiviral innate immune response  (ISO)
apoptotic signaling pathway  (ISO)
calcium-mediated signaling  (ISO)
canonical NF-kappaB signal transduction  (ISO)
cell surface receptor signaling pathway via JAK-STAT  (ISO)
cellular extravasation  (ISO)
cellular response to amino acid stimulus  (ISO)
cellular response to amyloid-beta  (ISO)
cellular response to ionizing radiation  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to molecule of bacterial origin  (ISO)
cellular response to nicotine  (ISO)
cellular response to retinoic acid  (ISO)
cellular response to toxic substance  (ISO)
cellular response to type II interferon  (ISO)
chronic inflammatory response to antigenic stimulus  (ISO)
circadian rhythm  (ISO)
defense response  (ISO)
defense response to bacterium  (ISO)
defense response to Gram-positive bacterium  (ISO)
detection of mechanical stimulus involved in sensory perception of pain  (ISO)
embryonic digestive tract development  (ISO)
endothelial cell apoptotic process  (ISO)
epithelial cell proliferation involved in salivary gland morphogenesis  (ISO)
extracellular matrix organization  (ISO)
extrinsic apoptotic signaling pathway  (ISO)
extrinsic apoptotic signaling pathway via death domain receptors  (ISO)
glucose metabolic process  (ISO)
humoral immune response  (ISO)
inflammatory response  (ISO)
inflammatory response to wounding  (ISO)
intrinsic apoptotic signaling pathway in response to DNA damage  (ISO)
JNK cascade  (ISO)
leukocyte migration  (ISO)
leukocyte tethering or rolling  (ISO)
liver regeneration  (ISO)
macrophage activation involved in immune response  (ISO)
microglial cell activation  (ISO)
mRNA stabilization  (ISO)
necroptotic signaling pathway  (ISO)
negative regulation of amyloid-beta clearance  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of apoptotic signaling pathway  (ISO)
negative regulation of bicellular tight junction assembly  (ISO)
negative regulation of bile acid secretion  (ISO)
negative regulation of blood vessel endothelial cell migration  (ISO)
negative regulation of branching involved in lung morphogenesis  (ISO)
negative regulation of canonical NF-kappaB signal transduction  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of cytokine production involved in immune response  (ISO)
negative regulation of D-glucose import  (ISO)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of endothelial cell proliferation  (ISO)
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  (ISO)
negative regulation of fat cell differentiation  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of heart rate  (ISO)
negative regulation of interleukin-6 production  (ISO)
negative regulation of L-glutamate import across plasma membrane  (ISO)
negative regulation of lipid catabolic process  (ISO)
negative regulation of mitotic cell cycle  (ISO)
negative regulation of myelination  (ISO)
negative regulation of myoblast differentiation  (ISO)
negative regulation of osteoblast differentiation  (ISO)
negative regulation of oxidative phosphorylation  (ISO)
negative regulation of protein-containing complex disassembly  (ISO)
negative regulation of systemic arterial blood pressure  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of vascular wound healing  (ISO)
negative regulation of viral genome replication  (ISO)
neuron apoptotic process  (ISO)
non-canonical NF-kappaB signal transduction  (ISO)
osteoclast differentiation  (ISO)
phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of action potential  (ISO)
positive regulation of amide metabolic process  (ISO)
positive regulation of amyloid-beta formation  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of blood microparticle formation  (ISO)
positive regulation of calcineurin-NFAT signaling cascade  (ISO)
positive regulation of canonical NF-kappaB signal transduction  (ISO)
positive regulation of cell adhesion  (ISO)
positive regulation of chemokine (C-X-C motif) ligand 2 production  (ISO)
positive regulation of chemokine production  (ISO)
positive regulation of chronic inflammatory response to antigenic stimulus  (ISO)
positive regulation of cytokine production  (ISO)
positive regulation of cytokine production involved in inflammatory response  (ISO)
positive regulation of DNA biosynthetic process  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of endothelial cell apoptotic process  (ISO)
positive regulation of estradiol secretion  (ISO)
positive regulation of extrinsic apoptotic signaling pathway  (ISO)
positive regulation of fever generation  (ISO)
positive regulation of fractalkine production  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of glial cell proliferation  (ISO)
positive regulation of hair follicle development  (ISO)
positive regulation of hepatocyte proliferation  (ISO)
positive regulation of heterotypic cell-cell adhesion  (ISO)
positive regulation of humoral immune response mediated by circulating immunoglobulin  (ISO)
positive regulation of immunoglobulin production  (ISO)
positive regulation of interleukin-1 beta production  (ISO)
positive regulation of interleukin-18 production  (ISO)
positive regulation of interleukin-33 production  (ISO)
positive regulation of interleukin-6 production  (ISO)
positive regulation of interleukin-8 production  (ISO)
positive regulation of JNK cascade  (ISO)
positive regulation of JUN kinase activity  (ISO)
positive regulation of leukocyte adhesion to arterial endothelial cell  (ISO)
positive regulation of leukocyte adhesion to vascular endothelial cell  (ISO)
positive regulation of lipid metabolic process  (ISO)
positive regulation of macrophage derived foam cell differentiation  (ISO)
positive regulation of MAP kinase activity  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of membrane protein ectodomain proteolysis  (ISO)
positive regulation of miRNA transcription  (ISO)
positive regulation of mitotic nuclear division  (ISO)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of neutrophil activation  (ISO)
positive regulation of NF-kappaB transcription factor activity  (ISO)
positive regulation of nitric oxide biosynthetic process  (ISO)
positive regulation of nitric-oxide synthase activity  (ISO)
positive regulation of non-canonical NF-kappaB signal transduction  (ISO)
positive regulation of osteoclast differentiation  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of podosome assembly  (ISO)
positive regulation of programmed cell death  (ISO)
positive regulation of protein catabolic process  (ISO)
positive regulation of protein localization to cell surface  (ISO)
positive regulation of protein localization to plasma membrane  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of protein transport  (ISO)
positive regulation of protein-containing complex assembly  (ISO)
positive regulation of protein-containing complex disassembly  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of synaptic transmission  (ISO)
positive regulation of synoviocyte proliferation  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of translational initiation by iron  (ISO)
positive regulation of type II interferon production  (ISO)
positive regulation of vascular associated smooth muscle cell proliferation  (ISO)
positive regulation of vitamin D biosynthetic process  (ISO)
protein localization to plasma membrane  (ISO)
protein polyubiquitination  (ISO)
reactive gliosis  (ISO)
regulation of branching involved in salivary gland morphogenesis  (ISO)
regulation of canonical NF-kappaB signal transduction  (ISO)
regulation of cell population proliferation  (ISO)
regulation of endothelial cell apoptotic process  (ISO)
regulation of establishment of endothelial barrier  (ISO)
regulation of fat cell differentiation  (ISO)
regulation of immunoglobulin production  (ISO)
regulation of inflammatory response  (ISO)
regulation of insulin secretion  (ISO)
regulation of membrane lipid metabolic process  (ISO)
regulation of osteoclast differentiation  (ISO)
regulation of protein phosphorylation  (ISO)
regulation of protein secretion  (ISO)
regulation of reactive oxygen species metabolic process  (ISO)
regulation of synapse organization  (ISO)
response to 3,3',5-triiodo-L-thyronine  (ISO)
response to activity  (ISO)
response to amphetamine  (ISO)
response to antibiotic  (ISO)
response to bacterium  (ISO)
response to ethanol  (ISO)
response to fructose  (ISO)
response to glucocorticoid  (ISO)
response to gold nanoparticle  (ISO)
response to Gram-negative bacterium  (ISO)
response to hydrogen sulfide  (ISO)
response to hypoxia  (ISO)
response to isolation stress  (ISO)
response to L-glutamate  (ISO)
response to lipopolysaccharide  (ISO)
response to macrophage colony-stimulating factor  (ISO)
response to mechanical stimulus  (ISO)
response to nutrient levels  (ISO)
response to quercetin  (ISO)
response to resveratrol  (ISO)
response to virus  (ISO)
response to xenobiotic stimulus  (ISO)
skeletal muscle contraction  (ISO)
toll-like receptor 3 signaling pathway  (ISO)
tumor necrosis factor-mediated signaling pathway  (ISO)
vascular endothelial growth factor production  (ISO)
vasodilation  (ISO)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. Cytokines in experimental otitis media with effusion. Johnson MD, etal., Laryngoscope. 1994 Feb;104(2):191-6.
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. Middle ear fluid cytokine and inflammatory cell kinetics in the chinchilla otitis media model. Sato K, etal., Infect Immun. 1999 Apr;67(4):1943-6.
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Tnf
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955437117,206 - 120,700 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955437117,267 - 119,899 (+)NCBIChiLan1.0ChiLan1.0
TNF
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38631,575,565 - 31,578,336 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl631,575,565 - 31,578,336 (+)EnsemblGRCh38hg38GRCh38
GRCh37631,543,342 - 31,546,113 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36631,651,329 - 31,654,091 (+)NCBINCBI36Build 36hg18NCBI36
Build 34631,651,328 - 31,654,091NCBI
Celera633,141,565 - 33,144,327 (+)NCBICelera
Cytogenetic Map6p21.33NCBI
HuRef631,330,078 - 31,332,847 (+)NCBIHuRef
CHM1_1631,545,476 - 31,548,245 (+)NCBICHM1_1
T2T-CHM13v2.0631,428,617 - 31,431,388 (+)NCBIT2T-CHM13v2.0
Tnf
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391735,418,343 - 35,420,983 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1735,418,357 - 35,420,983 (-)EnsemblGRCm39 Ensembl
GRCm381735,199,367 - 35,202,007 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1735,199,381 - 35,202,007 (-)EnsemblGRCm38mm10GRCm38
MGSCv371735,336,335 - 35,338,941 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361734,807,442 - 34,810,048 (-)NCBIMGSCv36mm8
Celera1738,296,090 - 38,298,699 (-)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1718.59NCBI
Tnf
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8203,626,685 - 3,629,303 (+)NCBIGRCr8
GRCr8 Ensembl203,626,532 - 3,629,303 (+)EnsemblGRCr8 Ensembl
mRatBN7.2203,622,011 - 3,624,629 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl203,622,011 - 3,624,629 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx204,321,864 - 4,324,463 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0203,683,924 - 3,686,523 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0204,221,516 - 4,224,112 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0205,189,382 - 5,192,000 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl205,189,390 - 5,192,000 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl204,855,829 - 4,858,447 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0206,936,229 - 6,938,847 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4203,661,000 - 3,663,618 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera204,400,860 - 4,403,478 (-)NCBICelera
RH 3.4 Map20 RGD
Cytogenetic Map20p12NCBI
TNF
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2546,052,507 - 46,055,280 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1642,014,074 - 42,016,847 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0631,236,650 - 31,239,423 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1632,126,618 - 32,129,389 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl632,126,618 - 32,129,381 (+)Ensemblpanpan1.1panPan2
TNF
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1121,074,561 - 1,076,425 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl121,074,552 - 1,076,425 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha121,211,002 - 1,212,867 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0121,219,807 - 1,221,672 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl121,219,798 - 1,221,672 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1121,078,543 - 1,080,407 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0121,146,468 - 1,148,336 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0121,213,251 - 1,215,120 (+)NCBIUU_Cfam_GSD_1.0
Tnf
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494635,623,427 - 35,626,009 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367271,936,066 - 1,937,766 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367271,936,066 - 1,937,766 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TNF
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl723,699,628 - 23,702,415 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1723,699,635 - 23,702,393 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2727,549,619 - 27,552,377 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap7p11-q11NCBI
TNF
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366604431,477,411 - 31,480,675 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tnf
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475424,623,425 - 24,625,531 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475424,623,059 - 24,625,647 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCLAT00000021683   ⟹   ENSCLAP00000021480
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_004955437117,206 - 120,700 (+)Ensembl
RefSeq Acc Id: XM_005389324   ⟹   XP_005389381
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_004955437117,267 - 119,899 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005389381 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000021480
  ENSCLAP00000021480.1
RefSeq Acc Id: XP_005389381   ⟸   XM_005389324
- UniProtKB: A0A8C2VYS8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCLAP00000021480   ⟸   ENSCLAT00000021683
Protein Domains
THD


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000014712 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000021683 ENTREZGENE
  ENSCLAT00000021683.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.40 UniProtKB/TrEMBL
InterPro TNF UniProtKB/TrEMBL
  TNF_alpha UniProtKB/TrEMBL
  TNF_CS UniProtKB/TrEMBL
  TNF_dom UniProtKB/TrEMBL
  Tumour_necrosis_fac-like_dom UniProtKB/TrEMBL
NCBI Gene Tnf ENTREZGENE
PANTHER PTHR11471:SF23 UniProtKB/TrEMBL
  TUMOR NECROSIS FACTOR FAMILY MEMBER UniProtKB/TrEMBL
Pfam TNF UniProtKB/TrEMBL
PRINTS TNECROSISFCT UniProtKB/TrEMBL
  TNFALPHA UniProtKB/TrEMBL
PROSITE TNF_1 UniProtKB/TrEMBL
  TNF_2 UniProtKB/TrEMBL
SMART TNF UniProtKB/TrEMBL
Superfamily-SCOP SSF49842 UniProtKB/TrEMBL
UniProt A0A8C2VYS8 ENTREZGENE, UniProtKB/TrEMBL