RGD Reference Report - [Studies on the expression of mRNA of anti- and pro-inflammatory cytokines in acute lung injury induced by lipopolysaccharide in rat] - Rat Genome Database

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[Studies on the expression of mRNA of anti- and pro-inflammatory cytokines in acute lung injury induced by lipopolysaccharide in rat]

Authors: Zhang, Q  Li, Q  Mao, BL  Qian, GS  Xu, JC  Chen, ZT 
Citation: Zhang Q, etal., Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2004 Oct;16(10):585-8.
RGD ID: 4145512
Pubmed: PMID:15461830   (View Abstract at PubMed)

OBJECTIVE: To study the role of pro-inflammatory cytokines including tumor necrosis factor-alpha(TNF-alpha), interleukin-1beta(IL-1beta), IL-6, and anti-inflammatory cytokines including IL-4, IL-10, and IL-13 in acute lung injury(ALI). METHODS: Reverse transcription-polymerase chain reaction(RT-PCR) were used to assess the expressions of mRNA of TNF-alpha, IL-1beta, IL-6, IL-4, IL-10 and IL-13 in the lung tissue after lipopolysaccharide challenge. RESULTS: The expression of TNF-alpha mRNA was seen to peak at 1 hour and IL-6 mRNA at 4 hours in lung tissue after the challenge. The highest expression of mRNA of other cytokines, such as IL-1beta, IL-4, IL-10 and IL-13 in lung tissue appeared 2 hours after LPS-induced lung injury. CONCLUSION: TNF-alpha is an early presenting cytokine in ALI, and IL-6 may play an important role in delayed development of ALI. The over-expression of anti-inflammatory cytokines IL-4, IL-10 and IL-13 may act as promoters rather than protectors in amplification of inflammatory process.




  
Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
IL13HumanAcute Lung Injury  ISOIl13 (Rattus norvegicus)mRNA:increased expression:lungRGD 
Il13RatAcute Lung Injury  IEP mRNA:increased expression:lungRGD 
Il13MouseAcute Lung Injury  ISOIl13 (Rattus norvegicus)mRNA:increased expression:lungRGD 
TNFHumanlung disease  ISOTnf (Rattus norvegicus)acute lung injury and mRNA:increased expression:lungRGD 
TnfRatlung disease  IEP acute lung injury and mRNA:increased expression:lungRGD 
TnfMouselung disease  ISOTnf (Rattus norvegicus)acute lung injury and mRNA:increased expression:lungRGD 


Genes (Rattus norvegicus)
Il13  (interleukin 13) Tnf  (tumor necrosis factor)

Genes (Mus musculus)
Il13  (interleukin 13) Tnf  (tumor necrosis factor)

Genes (Homo sapiens)
IL13  (interleukin 13) TNF  (tumor necrosis factor)