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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3876
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnf
Name: tumor necrosis factor
Acc ID: CHEBI:17226
Term: rosmarinic acid
Definition: The 1-carboxy-2-(2,4-dihydroxyphenyl)ethyl ester of trans-caffeic acid.
Chemical ID: MESH:C041376
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfaffects expressionEXP 6480464CTDrosmarinic acid affects the expression of TNF protein

PMID:28744220
Tnfdecreases expressionEXP 6480464CTDrosmarinic acid results in decreased expression of TNF mRNA, rosmarinic acid results in decreased expression of TNF protein

PMID:25455894, PMID:28789951
Tnfmultiple interactionsEXP 6480464CTD2-chloro-5-nitrobenzanilide inhibits the reaction [rosmarinic acid affects the expression of TNF protein], rosmarinic acid inhibits the reaction [Doxorubicin results in increased expression of TNF protein], T 0070907 inhibits the reaction [rosmarinic acid affects the expression of TNF protein]

PMID:28744220, PMID:28815802
Tnfmultiple interactionsISORGD:13441926480464CTD[rosmarinic acid results in decreased expression of ADAM17 protein] inhibits the reaction [TNF protein affects the localization of PROCR protein], [rosmarinic acid results in decreased expression of ADAM17 protein] inhibits the reaction [TNF protein results in increased cleavage of and results in increased secretion of PROCR protein]

PMID:23774263
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.