RGD Reference Report - Acute portal hypertension increases ileal vulnerability to platelet-activating factor in rats. - Rat Genome Database

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Acute portal hypertension increases ileal vulnerability to platelet-activating factor in rats.

Authors: Sakaguchi, T  Nakamura, S  Suzuki, S  Oda, T  Ichiyama, A  Baba, S 
Citation: Sakaguchi T, etal., J Surg Res. 1999 Sep;86(1):116-22. doi: 10.1006/jsre.1999.5697.
RGD ID: 38508900
Pubmed: PMID:10452877   (View Abstract at PubMed)
DOI: DOI:10.1006/jsre.1999.5697   (Journal Full-text)


BACKGROUND: Patients with portal hypertension can easily develop sepsis of enteric origin after suffering severe trauma and hemorrhagic shock. Platelet-activating factor (PAF) is one of the key mediators of such stress. The aim of this study was to investigate whether portal hypertension increases the vulnerability of the ileum to PAF.
MATERIALS AND METHODS: Seven days after surgery, PAF (1.5 microg/kg) was intravenously injected into portal stenosis (PS) rats and sham-operated rats. The levels of tumor necrosis factor-alpha (TNF-alpha), cytokine-induced neutrophil chemoattractant (CINC), and endotoxin in portal plasma were determined. The levels of PAF receptor (PAFR), TNF-alpha, and CINC mRNA in the ileum were also investigated.
RESULTS: After PAF administration, PS rats showed (1) significantly higher portal plasma levels of TNF-alpha, CINC, and endotoxin; (2) higher histological damage scores in the ileum; (3) more infiltrating neutrophils in the ileum; and (4) a significantly higher mortality rate than sham-operated rats (P < 0.01). However, PAFR mRNA levels were similar in the two groups. The CINC mRNA level in the ileum of PS rats was increased from 1 to 4 h after PAF administration, while that of the sham-operated rats was transiently increased at 1 h.
CONCLUSIONS: Portal hypertension increases the vulnerability of the ileum to PAF. These findings suggest that conditions which causes PAF production may be dangerous in patients with portal hypertension.



Gene-Chemical Interaction Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
TNFHuman2-O-acetyl-1-O-octadecyl-sn-glycero-3-phosphocholine increases expression ISOTnf (Rattus norvegicus)platelet-activating factor increases expression of Tnf protein in portal stenosis rat plasmaRGD 
TnfRat2-O-acetyl-1-O-octadecyl-sn-glycero-3-phosphocholine increases expression EXP platelet-activating factor increases expression of Tnf protein in portal stenosis rat plasmaRGD 
TnfMouse2-O-acetyl-1-O-octadecyl-sn-glycero-3-phosphocholine increases expression ISOTnf (Rattus norvegicus)platelet-activating factor increases expression of Tnf protein in portal stenosis rat plasmaRGD 

Objects Annotated

Genes (Rattus norvegicus)
Tnf  (tumor necrosis factor)

Genes (Mus musculus)
Tnf  (tumor necrosis factor)

Genes (Homo sapiens)
TNF  (tumor necrosis factor)


Additional Information