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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3876
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnf
Name: tumor necrosis factor
Acc ID: CHEBI:3181
Term: bromocriptine
Definition: An indole alkaloid that has formula C32H40BrN5O5.
Chemical ID: MESH:D001971
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfmultiple interactionsEXP 6480464CTDBromocriptine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]PMID:11752888
Tnfmultiple interactionsISOTnf (Mus musculus)6480464CTDBromocriptine inhibits the reaction [[SOD1 protein mutant form co-treated with Lipopolysaccharides] results in increased secretion of TNF protein]; Bromocriptine inhibits the reaction [SOD1 mutant form results in increased expression of TNF protein]PMID:21867702
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