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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3876
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnf
Name: tumor necrosis factor
Acc ID: CHEBI:37550
Term: sphingosine 1-phosphate
Definition: A phosphosphingolipid that consists of sphingosine having a phospho group attached at position 1
Chemical ID: MESH:C060506
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfincreases expressionISORGD:13441926480464CTDsphingosine 1-phosphate results in increased expression of TNF mRNA

PMID:26518876
Tnfmultiple interactionsISORGD:13441926480464CTDJTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of TNF mRNA] sphingosine 1-phosphate inhibits the reaction [TNF results in increased expression of VCAM1]

PMID:18981156 PMID:26518876
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