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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3876
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnf
Name: tumor necrosis factor
Acc ID: CHEBI:3435
Term: carrageenan
Definition: A family of sulfated polysaccharides extracted from red seaweeds. The name is derived from a common name of red algae Chondrus crispus, 'carrageen moss' (Irish moss).
Chemical ID: MESH:D002351
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfincreases expressionEXP 6480464CTDCarrageenan results in increased expression of TNF proteinPMID:18429935 PMID:22330755 PMID:23774260 PMID:23872256 PMID:24412305 PMID:28844677
Tnfincreases secretionEXP 6480464CTDCarrageenan results in increased secretion of TNF proteinPMID:11181422 PMID:17320857 PMID:21549112
Tnfmultiple interactionsEXP 6480464CTD3-methylquercetin inhibits the reaction [Carrageenan results in increased expression of TNF protein]; adelmidrol inhibits the reaction [Carrageenan results in increased expression of TNF protein]; budlein A inhibits the reaction [Carrageenan results in increased secretion of TNF protein]; Dexamethasone inhibits the reaction [Carrageenan results in increased expression of TNF protein]; imisopasem manganese inhibits the reaction [Carrageenan results in increased expression of TNF protein]; IMMLG5521 inhibits the reaction [Carrageenan results in increased secretion of TNF protein]; isoquercitrin inhibits the reaction [Carrageenan results in increased expression of TNF protein]; N-(2-hydroxybenzoyl)tyramine inhibits the reaction [Carrageenan results in increased expression of TNF protein]; procyanidin B2 inhibits the reaction [Carrageenan results in increased expression of TNF protein]; Quercetin inhibits the reaction [Carrageenan results in increased expression of TNF protein]; Rutin inhibits the reaction [Carrageenan results in increased expression of TNF protein]; Thiazolidines analog inhibits the reaction [Carrageenan results in increased expression of TNF protein]PMID:11181422 PMID:14654164 PMID:17320857 PMID:18429935 PMID:21549112 PMID:23774260 PMID:23872256 PMID:24412305 PMID:28844677
Tnfincreases expressionISOTnf (Mus musculus)6480464CTDCarrageenan results in increased expression of TNF proteinPMID:12444156 PMID:15380531 PMID:20383154 PMID:26571085
Tnfincreases secretionISOTnf (Mus musculus)6480464CTDCarrageenan results in increased secretion of TNF proteinPMID:16368644 PMID:29499192
Tnfmultiple interactionsISOTnf (Mus musculus)6480464CTD5S,12R,18R-trihydroxy-6Z,8E,10E,14Z,16E-eicosapentaenoic acid inhibits the reaction [Carrageenan results in increased expression of TNF protein]; diaoxinxuekang inhibits the reaction [Carrageenan results in increased expression of TNF protein]; IL1R1 protein promotes the reaction [Carrageenan results in increased expression of TNF protein]; indole-3-guanylhydrazone hydrochloride inhibits the reaction [Carrageenan results in increased secretion of TNF protein]; Indomethacin inhibits the reaction [Carrageenan results in increased secretion of TNF protein]; PEGylated soluble tumor necrosis factor receptor I inhibits the reaction [Carrageenan results in increased expression of TNF protein]; TNFSF8 protein promotes the reaction [Carrageenan results in increased expression of TNF protein]PMID:15380531 PMID:20383154 PMID:26571085 PMID:29499192
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