Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3876
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnf
Name: tumor necrosis factor
Acc ID: CHEBI:180664
Term: 4-hydroxy-TEMPO
Definition: A member of the class of aminoxyls that is TEMPO carrying a hydroxy substituent at position 4. It is a radical scavenger which exhibits anti-inflammatory and analgesic properties.
Chemical ID: MESH:C001803
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfmultiple interactionsEXP 6480464CTDtempol inhibits the reaction [copper histidine results in increased expression of TNF protein]; tempol inhibits the reaction [Copper results in increased expression of TNF protein]PMID:16987042
Tnfmultiple interactionsISOTnf (Mus musculus)6480464CTDtempol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; tempol inhibits the reaction [Tobacco Smoke Pollution results in increased expression of TNF mRNA]PMID:15795323 PMID:32726580
Tnfmultiple interactionsISOTNF (Homo sapiens)6480464CTDtempol inhibits the reaction [[sulindac sulfide co-treated with TNF protein] results in increased activity of CASP3 protein]; tempol inhibits the reaction [[sulindac sulfide co-treated with TNF protein] results in increased activity of CASP7 protein]PMID:20371263
Go Back to source page   Continue to Ontology report