RGD Reference Report - Galantamine anti-colitic effect: Role of alpha-7 nicotinic acetylcholine receptor in modulating Jak/STAT3, NF-κB/HMGB1/RAGE and p-AKT/Bcl-2 pathways.

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Galantamine anti-colitic effect: Role of alpha-7 nicotinic acetylcholine receptor in modulating Jak/STAT3, NF-κB/HMGB1/RAGE and p-AKT/Bcl-2 pathways.
Authors:	Wazea, Shakeeb A Wadie, Walaa Bahgat, Ashraf K El-Abhar, Hanan S
Citation:	Wazea SA, etal., Sci Rep. 2018 Mar 23;8(1):5110. doi: 10.1038/s41598-018-23359-6.
RGD ID:	152995414
Pubmed:	PMID:29572553 (View Abstract at PubMed)
PMCID:	PMC5865178 (View Article at PubMed Central)
DOI:	DOI:10.1038/s41598-018-23359-6 (Journal Full-text)
Vagal stimulation controls systemic inflammation and modulates the immune response in different inflammatory conditions, including inflammatory bowel diseases (IBD). The released acetylcholine binds to alpha-7 nicotinic acetylcholine receptor (α7 nAChR) to suppress pro-inflammatory cytokines. This provides a new range of potential therapeutic approaches for controlling inflammatory responses. The present study aimed to assess whether galantamine (Galan) anti-inflammatory action involves α7 nAChR in a 2,4,6-trinitrobenzene sulfonic acid (TNBS) model of colitis and to estimate its possible molecular pathways. Rats were assigned into normal, TNBS, sulfasalazine (Sulfz), Galan treated (10 mg/kg), methyllycaconitine (MLA; 5.6 mg/kg), and MLA + Galan groups. Drugs were administered orally once per day (11 days) and colitis was induced on the 8th day. Galan reduced the TNBS-induced ulceration, colon mass index, colonic MDA, neutrophils adhesion and infiltration (ICAM-1/MPO), inflammatory mediators (NF-κB, TNF-α, HMGB1, and RAGE), while increased the anti-apoptotic pathway (p-Akt/Bcl-2). Mechanistic study revealed that Galan increased the anti-inflammatory cytokine IL-10, phosphorylated Jak2, while reduced the inflammation controller SOCS3. However, combining MLA with Galan abrogated the beneficial anti-inflammatory/anti-apoptotic signals. The results of the present study indicate that Galan anti-inflammatory/-apoptotic/ -oxidant effects originate from the stimulation of the peripheral α7 nAChR, with the involvement of the Jak2/SOCS3 signaling pathway.

Annotation Click to see Annotation Detail View

RGD Manual Disease Annotations Click to see Annotation Detail View

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Notes	Source	Original Reference(s)
AGER	Human	Experimental Colitis	treatment	ISO	Ager (Rattus norvegicus)		RGD
AKT1	Human	Experimental Colitis	treatment	ISO	Akt1 (Rattus norvegicus)		RGD
Ager	Mouse	Experimental Colitis	treatment	ISO	Ager (Rattus norvegicus)		RGD
Ager	Rat	Experimental Colitis	treatment	IEP			RGD
Akt1	Rat	Experimental Colitis	treatment	IEP			RGD
Akt1	Mouse	Experimental Colitis	treatment	ISO	Akt1 (Rattus norvegicus)		RGD
BCL2	Human	Experimental Colitis	treatment	ISO	Bcl2 (Rattus norvegicus)		RGD
Bcl2	Mouse	Experimental Colitis	treatment	ISO	Bcl2 (Rattus norvegicus)		RGD
Bcl2	Rat	Experimental Colitis	treatment	IEP			RGD
CHRNA7	Human	Experimental Colitis	treatment	ISO	Chrna7 (Rattus norvegicus)		RGD
Chrna7	Rat	Experimental Colitis	treatment	IMP			RGD
Chrna7	Mouse	Experimental Colitis	treatment	ISO	Chrna7 (Rattus norvegicus)		RGD
HMGB1	Human	Experimental Colitis	treatment	ISO	Hmgb1 (Rattus norvegicus)		RGD
Hmgb1	Mouse	Experimental Colitis	treatment	ISO	Hmgb1 (Rattus norvegicus)		RGD
Hmgb1	Rat	Experimental Colitis	treatment	IEP			RGD
ICAM1	Human	Experimental Colitis	treatment	ISO	Icam1 (Rattus norvegicus)		RGD
IL10	Human	Experimental Colitis	treatment	ISO	Il10 (Rattus norvegicus)		RGD
Icam1	Mouse	Experimental Colitis	treatment	ISO	Icam1 (Rattus norvegicus)		RGD
Icam1	Rat	Experimental Colitis	treatment	IEP			RGD
Il10	Mouse	Experimental Colitis	treatment	ISO	Il10 (Rattus norvegicus)		RGD
Il10	Rat	Experimental Colitis	treatment	IEP			RGD
JAK2	Human	Experimental Colitis	treatment	ISO	Jak2 (Rattus norvegicus)		RGD
Jak2	Rat	Experimental Colitis	treatment	IEP			RGD
Jak2	Mouse	Experimental Colitis	treatment	ISO	Jak2 (Rattus norvegicus)		RGD
MPO	Human	Experimental Colitis	treatment	ISO	Mpo (Rattus norvegicus)		RGD
Mpo	Rat	Experimental Colitis	treatment	IEP			RGD
Mpo	Mouse	Experimental Colitis	treatment	ISO	Mpo (Rattus norvegicus)		RGD
RELA	Human	Experimental Colitis	treatment	ISO	Rela (Rattus norvegicus)		RGD
Rela	Mouse	Experimental Colitis	treatment	ISO	Rela (Rattus norvegicus)		RGD
Rela	Rat	Experimental Colitis	treatment	IEP			RGD
SOCS3	Human	Experimental Colitis	treatment	ISO	Socs3 (Rattus norvegicus)		RGD
Socs3	Mouse	Experimental Colitis	treatment	ISO	Socs3 (Rattus norvegicus)		RGD
Socs3	Rat	Experimental Colitis	treatment	IEP			RGD
TNF	Human	Experimental Colitis	treatment	ISO	Tnf (Rattus norvegicus)		RGD
Tnf	Rat	Experimental Colitis	treatment	IEP			RGD
Tnf	Mouse	Experimental Colitis	treatment	ISO	Tnf (Rattus norvegicus)		RGD

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Notes	Source	Original Reference(s)
AGER	Human	2,4,6-trinitrobenzenesulfonic acid	increases abundance	ISO	Ager (Rattus norvegicus)	2,4,6-trinitrobenzenesulfonic acid increases abundance of Ager protein in rat colon	RGD
Ager	Rat	2,4,6-trinitrobenzenesulfonic acid	increases abundance	EXP		2,4,6-trinitrobenzenesulfonic acid increases abundance of Ager protein in rat colon	RGD
Ager	Mouse	2,4,6-trinitrobenzenesulfonic acid	increases abundance	ISO	Ager (Rattus norvegicus)	2,4,6-trinitrobenzenesulfonic acid increases abundance of Ager protein in rat colon	RGD
BCL2	Human	2,4,6-trinitrobenzenesulfonic acid	decreases abundance	ISO	Bcl2 (Rattus norvegicus)	2,4,6-trinitrobenzenesulfonic acid decreases abundance of Bcl-2 protein in rat colon	RGD
Bcl2	Mouse	2,4,6-trinitrobenzenesulfonic acid	decreases abundance	ISO	Bcl2 (Rattus norvegicus)	2,4,6-trinitrobenzenesulfonic acid decreases abundance of Bcl-2 protein in rat colon	RGD
Bcl2	Rat	2,4,6-trinitrobenzenesulfonic acid	decreases abundance	EXP		2,4,6-trinitrobenzenesulfonic acid decreases abundance of Bcl-2 protein in rat colon	RGD
HMGB1	Human	2,4,6-trinitrobenzenesulfonic acid	increases abundance	ISO	Hmgb1 (Rattus norvegicus)	2,4,6-trinitrobenzenesulfonic acid increases abundance of Hmgb1 protein in rat colon	RGD
Hmgb1	Mouse	2,4,6-trinitrobenzenesulfonic acid	increases abundance	ISO	Hmgb1 (Rattus norvegicus)	2,4,6-trinitrobenzenesulfonic acid increases abundance of Hmgb1 protein in rat colon	RGD
Hmgb1	Rat	2,4,6-trinitrobenzenesulfonic acid	increases abundance	EXP		2,4,6-trinitrobenzenesulfonic acid increases abundance of Hmgb1 protein in rat colon	RGD
ICAM1	Human	2,4,6-trinitrobenzenesulfonic acid	increases abundance	ISO	Icam1 (Rattus norvegicus)	2,4,6-trinitrobenzenesulfonic acid increases abundance of Icam-1 protein in rat colon	RGD
IL10	Human	2,4,6-trinitrobenzenesulfonic acid	decreases abundance	ISO	Il10 (Rattus norvegicus)	2,4,6-trinitrobenzenesulfonic acid decreases abundance of IL-10 protein in rat colon	RGD
Icam1	Rat	2,4,6-trinitrobenzenesulfonic acid	increases abundance	EXP		2,4,6-trinitrobenzenesulfonic acid increases abundance of Icam-1 protein in rat colon	RGD
Icam1	Mouse	2,4,6-trinitrobenzenesulfonic acid	increases abundance	ISO	Icam1 (Rattus norvegicus)	2,4,6-trinitrobenzenesulfonic acid increases abundance of Icam-1 protein in rat colon	RGD
Il10	Mouse	2,4,6-trinitrobenzenesulfonic acid	decreases abundance	ISO	Il10 (Rattus norvegicus)	2,4,6-trinitrobenzenesulfonic acid decreases abundance of IL-10 protein in rat colon	RGD
Il10	Rat	2,4,6-trinitrobenzenesulfonic acid	decreases abundance	EXP		2,4,6-trinitrobenzenesulfonic acid decreases abundance of IL-10 protein in rat colon	RGD
MPO	Human	2,4,6-trinitrobenzenesulfonic acid	increases activity	ISO	Mpo (Rattus norvegicus)	2,4,6-trinitrobenzenesulfonic acid increases myeloperoxidase enzyme activity in rat colon	RGD
Mpo	Rat	2,4,6-trinitrobenzenesulfonic acid	increases activity	EXP		2,4,6-trinitrobenzenesulfonic acid increases myeloperoxidase enzyme activity in rat colon	RGD
Mpo	Mouse	2,4,6-trinitrobenzenesulfonic acid	increases activity	ISO	Mpo (Rattus norvegicus)	2,4,6-trinitrobenzenesulfonic acid increases myeloperoxidase enzyme activity in rat colon	RGD
RELA	Human	2,4,6-trinitrobenzenesulfonic acid	increases abundance	ISO	Rela (Rattus norvegicus)	2,4,6-trinitrobenzenesulfonic acid increases abundance of Nf-Kb protein in rat colon	RGD
Rela	Mouse	2,4,6-trinitrobenzenesulfonic acid	increases abundance	ISO	Rela (Rattus norvegicus)	2,4,6-trinitrobenzenesulfonic acid increases abundance of Nf-Kb protein in rat colon	RGD
Rela	Rat	2,4,6-trinitrobenzenesulfonic acid	increases abundance	EXP		2,4,6-trinitrobenzenesulfonic acid increases abundance of Nf-Kb protein in rat colon	RGD
SOCS3	Human	2,4,6-trinitrobenzenesulfonic acid	increases abundance	ISO	Socs3 (Rattus norvegicus)	2,4,6-trinitrobenzenesulfonic acid increases abundance of Socs3 protein in rat colon	RGD
Socs3	Mouse	2,4,6-trinitrobenzenesulfonic acid	increases abundance	ISO	Socs3 (Rattus norvegicus)	2,4,6-trinitrobenzenesulfonic acid increases abundance of Socs3 protein in rat colon	RGD
Socs3	Rat	2,4,6-trinitrobenzenesulfonic acid	increases abundance	EXP		2,4,6-trinitrobenzenesulfonic acid increases abundance of Socs3 protein in rat colon	RGD
TNF	Human	2,4,6-trinitrobenzenesulfonic acid	increases abundance	ISO	Tnf (Rattus norvegicus)	2,4,6-trinitrobenzenesulfonic acid increases abundance of Tnfa protein in rat colon	RGD
Tnf	Rat	2,4,6-trinitrobenzenesulfonic acid	increases abundance	EXP		2,4,6-trinitrobenzenesulfonic acid increases abundance of Tnfa protein in rat colon	RGD
Tnf	Mouse	2,4,6-trinitrobenzenesulfonic acid	increases abundance	ISO	Tnf (Rattus norvegicus)	2,4,6-trinitrobenzenesulfonic acid increases abundance of Tnfa protein in rat colon	RGD
AGER	Human	galanthamine	multiple interactions	ISO	Ager (Rattus norvegicus)	Galan inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases abundance of Ager protein] in rat colon	RGD
Ager	Mouse	galanthamine	multiple interactions	ISO	Ager (Rattus norvegicus)	Galan inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases abundance of Ager protein] in rat colon	RGD
Ager	Rat	galanthamine	multiple interactions	EXP		Galan inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases abundance of Ager protein] in rat colon	RGD
BCL2	Human	galanthamine	multiple interactions	ISO	Bcl2 (Rattus norvegicus)	Galan inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid decreases abundance of Bcl-2 protein] in rat colon	RGD
Bcl2	Rat	galanthamine	multiple interactions	EXP		Galan inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid decreases abundance of Bcl-2 protein] in rat colon	RGD
Bcl2	Mouse	galanthamine	multiple interactions	ISO	Bcl2 (Rattus norvegicus)	Galan inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid decreases abundance of Bcl-2 protein] in rat colon	RGD
HMGB1	Human	galanthamine	multiple interactions	ISO	Hmgb1 (Rattus norvegicus)	Galan inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases abundance of Hmgb1 protein] in rat colon	RGD
Hmgb1	Rat	galanthamine	multiple interactions	EXP		Galan inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases abundance of Hmgb1 protein] in rat colon	RGD
Hmgb1	Mouse	galanthamine	multiple interactions	ISO	Hmgb1 (Rattus norvegicus)	Galan inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases abundance of Hmgb1 protein] in rat colon	RGD
ICAM1	Human	galanthamine	multiple interactions	ISO	Icam1 (Rattus norvegicus)	Galan inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases abundance of Icam-1 protein] in rat colon	RGD
IL10	Human	galanthamine	multiple interactions	ISO	Il10 (Rattus norvegicus)	Galan inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid decreases abundance of IL-10 protein] in rat colon	RGD
Icam1	Rat	galanthamine	multiple interactions	EXP		Galan inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases abundance of Icam-1 protein] in rat colon	RGD
Icam1	Mouse	galanthamine	multiple interactions	ISO	Icam1 (Rattus norvegicus)	Galan inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases abundance of Icam-1 protein] in rat colon	RGD
Il10	Rat	galanthamine	multiple interactions	EXP		Galan inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid decreases abundance of IL-10 protein] in rat colon	RGD
Il10	Mouse	galanthamine	multiple interactions	ISO	Il10 (Rattus norvegicus)	Galan inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid decreases abundance of IL-10 protein] in rat colon	RGD
MPO	Human	galanthamine	multiple interactions	ISO	Mpo (Rattus norvegicus)	Galan inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases myeloperoxidase enzyme activity] in rat colon	RGD
Mpo	Mouse	galanthamine	multiple interactions	ISO	Mpo (Rattus norvegicus)	Galan inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases myeloperoxidase enzyme activity] in rat colon	RGD
Mpo	Rat	galanthamine	multiple interactions	EXP		Galan inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases myeloperoxidase enzyme activity] in rat colon	RGD
RELA	Human	galanthamine	multiple interactions	ISO	Rela (Rattus norvegicus)	Galan inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases abundance of Nf-Kb protein] in rat colon	RGD
Rela	Rat	galanthamine	multiple interactions	EXP		Galan inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases abundance of Nf-Kb protein] in rat colon	RGD
Rela	Mouse	galanthamine	multiple interactions	ISO	Rela (Rattus norvegicus)	Galan inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases abundance of Nf-Kb protein] in rat colon	RGD
SOCS3	Human	galanthamine	multiple interactions	ISO	Socs3 (Rattus norvegicus)	Galan inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases abundance of Socs3 protein] in rat colon	RGD
Socs3	Rat	galanthamine	multiple interactions	EXP		Galan inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases abundance of Socs3 protein] in rat colon	RGD
Socs3	Mouse	galanthamine	multiple interactions	ISO	Socs3 (Rattus norvegicus)	Galan inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases abundance of Socs3 protein] in rat colon	RGD
TNF	Human	galanthamine	multiple interactions	ISO	Tnf (Rattus norvegicus)	Galan inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases abundance of Tnfa protein] in rat colon	RGD
Tnf	Rat	galanthamine	multiple interactions	EXP		Galan inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases abundance of Tnfa protein] in rat colon	RGD
Tnf	Mouse	galanthamine	multiple interactions	ISO	Tnf (Rattus norvegicus)	Galan inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases abundance of Tnfa protein] in rat colon	RGD
AGER	Human	sulfasalazine	multiple interactions	ISO	Ager (Rattus norvegicus)	sulfasalazine inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases abundance of Ager protein] in rat colon	RGD
Ager	Rat	sulfasalazine	multiple interactions	EXP		sulfasalazine inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases abundance of Ager protein] in rat colon	RGD
Ager	Mouse	sulfasalazine	multiple interactions	ISO	Ager (Rattus norvegicus)	sulfasalazine inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases abundance of Ager protein] in rat colon	RGD
BCL2	Human	sulfasalazine	multiple interactions	ISO	Bcl2 (Rattus norvegicus)	sulfasalazine inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid decreases abundance of Bcl-2 protein] in rat colon	RGD
Bcl2	Mouse	sulfasalazine	multiple interactions	ISO	Bcl2 (Rattus norvegicus)	sulfasalazine inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid decreases abundance of Bcl-2 protein] in rat colon	RGD
Bcl2	Rat	sulfasalazine	multiple interactions	EXP		sulfasalazine inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid decreases abundance of Bcl-2 protein] in rat colon	RGD
HMGB1	Human	sulfasalazine	multiple interactions	ISO	Hmgb1 (Rattus norvegicus)	sulfasalazine inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases abundance of Hmgb1 protein] in rat colon	RGD
Hmgb1	Mouse	sulfasalazine	multiple interactions	ISO	Hmgb1 (Rattus norvegicus)	sulfasalazine inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases abundance of Hmgb1 protein] in rat colon	RGD
Hmgb1	Rat	sulfasalazine	multiple interactions	EXP		sulfasalazine inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases abundance of Hmgb1 protein] in rat colon	RGD
ICAM1	Human	sulfasalazine	multiple interactions	ISO	Icam1 (Rattus norvegicus)	sulfasalazine inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases abundance of Icam-1 protein] in rat colon	RGD
IL10	Human	sulfasalazine	multiple interactions	ISO	Il10 (Rattus norvegicus)	sulfasalazine inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid decreases abundance of IL-10 protein] in rat colon	RGD
Icam1	Mouse	sulfasalazine	multiple interactions	ISO	Icam1 (Rattus norvegicus)	sulfasalazine inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases abundance of Icam-1 protein] in rat colon	RGD
Icam1	Rat	sulfasalazine	multiple interactions	EXP		sulfasalazine inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases abundance of Icam-1 protein] in rat colon	RGD
Il10	Mouse	sulfasalazine	multiple interactions	ISO	Il10 (Rattus norvegicus)	sulfasalazine inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid decreases abundance of IL-10 protein] in rat colon	RGD
Il10	Rat	sulfasalazine	multiple interactions	EXP		sulfasalazine inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid decreases abundance of IL-10 protein] in rat colon	RGD
MPO	Human	sulfasalazine	multiple interactions	ISO	Mpo (Rattus norvegicus)	sulfasalazine inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases myeloperoxidase enzyme activity] in rat colon	RGD
Mpo	Rat	sulfasalazine	multiple interactions	EXP		sulfasalazine inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases myeloperoxidase enzyme activity] in rat colon	RGD
Mpo	Mouse	sulfasalazine	multiple interactions	ISO	Mpo (Rattus norvegicus)	sulfasalazine inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases myeloperoxidase enzyme activity] in rat colon	RGD
RELA	Human	sulfasalazine	multiple interactions	ISO	Rela (Rattus norvegicus)	sulfasalazine inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases abundance of Nf-Kb protein] in rat colon	RGD
Rela	Mouse	sulfasalazine	multiple interactions	ISO	Rela (Rattus norvegicus)	sulfasalazine inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases abundance of Nf-Kb protein] in rat colon	RGD
Rela	Rat	sulfasalazine	multiple interactions	EXP		sulfasalazine inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases abundance of Nf-Kb protein] in rat colon	RGD
SOCS3	Human	sulfasalazine	multiple interactions	ISO	Socs3 (Rattus norvegicus)	sulfasalazine inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases abundance of Socs3 protein] in rat colon	RGD
Socs3	Mouse	sulfasalazine	multiple interactions	ISO	Socs3 (Rattus norvegicus)	sulfasalazine inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases abundance of Socs3 protein] in rat colon	RGD
Socs3	Rat	sulfasalazine	multiple interactions	EXP		sulfasalazine inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases abundance of Socs3 protein] in rat colon	RGD
TNF	Human	sulfasalazine	multiple interactions	ISO	Tnf (Rattus norvegicus)	sulfasalazine inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases abundance of Tnfa protein] in rat colon	RGD
Tnf	Rat	sulfasalazine	multiple interactions	EXP		sulfasalazine inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases abundance of Tnfa protein] in rat colon	RGD
Tnf	Mouse	sulfasalazine	multiple interactions	ISO	Tnf (Rattus norvegicus)	sulfasalazine inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases abundance of Tnfa protein] in rat colon	RGD

Objects Annotated

Genes (Rattus norvegicus)

Ager (advanced glycosylation end product-specific receptor)

Akt1 (AKT serine/threonine kinase 1)

Bcl2 (BCL2, apoptosis regulator)

Chrna7 (cholinergic receptor nicotinic alpha 7 subunit)

Hmgb1 (high mobility group box 1)

Icam1 (intercellular adhesion molecule 1)

Il10 (interleukin 10)

Jak2 (Janus kinase 2)

Mpo (myeloperoxidase)

Rela (RELA proto-oncogene, NF-kB subunit)

Socs3 (suppressor of cytokine signaling 3)

Tnf (tumor necrosis factor)

Genes (Mus musculus)

Ager (advanced glycosylation end product-specific receptor)

Akt1 (thymoma viral proto-oncogene 1)

Bcl2 (B cell leukemia/lymphoma 2)

Chrna7 (cholinergic receptor, nicotinic, alpha polypeptide 7)

Hmgb1 (high mobility group box 1)

Icam1 (intercellular adhesion molecule 1)

Il10 (interleukin 10)

Jak2 (Janus kinase 2)

Mpo (myeloperoxidase)

Rela (v-rel reticuloendotheliosis viral oncogene homolog A (avian))

Socs3 (suppressor of cytokine signaling 3)

Tnf (tumor necrosis factor)

Genes (Homo sapiens)

AGER (advanced glycosylation end-product specific receptor)

AKT1 (AKT serine/threonine kinase 1)

BCL2 (BCL2 apoptosis regulator)

CHRNA7 (cholinergic receptor nicotinic alpha 7 subunit)

HMGB1 (high mobility group box 1)

ICAM1 (intercellular adhesion molecule 1)

IL10 (interleukin 10)

JAK2 (Janus kinase 2)

MPO (myeloperoxidase)

RELA (RELA proto-oncogene, NF-kB subunit)

SOCS3 (suppressor of cytokine signaling 3)

TNF (tumor necrosis factor)

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Galantamine anti-colitic effect: Role of alpha-7 nicotinic acetylcholine receptor in modulating Jak/STAT3, NF-κB/HMGB1/RAGE and p-AKT/Bcl-2 pathways.