GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Tnf | decreases expression | EXP | | 6480464 | CTD | Capsaicin results in decreased expression of TNF mRNA; Capsaicin results in decreased expression of TNF protein | PMID:12024109 PMID:15502055 PMID:18460982 | Tnf | increases expression | EXP | | 6480464 | CTD | Capsaicin results in increased expression of TNF mRNA; Capsaicin results in increased expression of TNF protein | PMID:15265675 PMID:20712533 PMID:22150557 | Tnf | increases response to substance | EXP | | 6480464 | CTD | TNF protein results in increased susceptibility to Capsaicin | PMID:18582539 | Tnf | multiple interactions | EXP | | 6480464 | CTD | [Capsaicin results in increased susceptibility to Formaldehyde] which results in increased expression of TNF mRNA; [Capsaicin results in increased susceptibility to Glyoxal] which results in increased expression of TNF mRNA; [Lipopolysaccharides co-treated with Capsaicin] results in increased expression of TNF protein; [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TNF protein]; Capsaicin inhibits the reaction [Dietary Fats results in decreased expression of TNF mRNA]; Capsaicin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Capsaicin inhibits the reaction [monophosphoryl lipid A results in decreased expression of TNF protein]; Capsaicin inhibits the reaction [Nitroglycerin results in decreased expression of TNF protein]; capsazepine inhibits the reaction [Capsaicin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; Ketotifen inhibits the reaction [Capsaicin results in increased expression of TNF protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of TNF protein]; NOX3 mutant form inhibits the reaction [Capsaicin results in increased expression of TNF mRNA]; NOX3 mutant form inhibits the reaction [Capsaicin results in increased expression of TNF protein]; Ranitidine inhibits the reaction [Capsaicin results in increased expression of TNF protein]; spantide II inhibits the reaction [Capsaicin results in increased expression of TNF protein]; STAT1 mutant form inhibits the reaction [Capsaicin results in increased expression of TNF mRNA]; STAT1 mutant form inhibits the reaction [Capsaicin results in increased expression of TNF protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of TNF protein] | PMID:11408036 PMID:11744139 PMID:15265675 PMID:15579495 PMID:18508045 PMID:20359164 PMID:20712533 PMID:22150557 PMID:28005965 PMID:29496360 | Tnf | affects response to substance | ISO | Tnf (Mus musculus) | 6480464 | CTD | TNF protein affects the susceptibility to Capsaicin | PMID:18463260 | Tnf | decreases expression | ISO | Tnf (Mus musculus) | 6480464 | CTD | Capsaicin results in decreased expression of TNF mRNA; Capsaicin results in decreased expression of TNF protein | PMID:19798065 | Tnf | decreases secretion | ISO | Tnf (Mus musculus) | 6480464 | CTD | Capsaicin results in decreased secretion of TNF protein | PMID:17719033 | Tnf | increases expression | ISO | TNF (Homo sapiens) | 6480464 | CTD | Capsaicin results in increased expression of TNF mRNA | PMID:21474332 | Tnf | increases secretion | ISO | TNF (Homo sapiens) | 6480464 | CTD | Capsaicin results in increased secretion of TNF protein | PMID:21474332 | Tnf | multiple interactions | ISO | Tnf (Mus musculus) | 6480464 | CTD | Capsaicin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein]; TRPV1 gene mutant form inhibits the reaction [Capsaicin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein]] | PMID:19878665 | Tnf | multiple interactions | ISO | TNF (Homo sapiens) | 6480464 | CTD | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Capsaicin results in increased secretion of TNF protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Capsaicin results in increased secretion of TNF protein]; bisindolylmaleimide inhibits the reaction [Capsaicin results in increased secretion of TNF protein]; CALCA protein alternative form inhibits the reaction [Capsaicin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein]]; Capsaicin inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; Capsaicin inhibits the reaction [TNF protein results in increased expression of CXCL8 protein]; Capsaicin inhibits the reaction [TNF protein results in increased expression of GSTP1 mRNA]; Capsaicin promotes the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; capsazepine inhibits the reaction [Capsaicin results in increased secretion of TNF protein] | PMID:12034025 PMID:15313406 PMID:16540674 PMID:19878665 PMID:21474332 PMID:30244119 | | ||||||||||||||||||||||
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